References
66
Referenced
136
10.4049/jimmunol.156.3.1166
/ J. Immunol. / A20 zinc finger protein inhibits TNF and IL-1 signaling by Jaattela (1996)10.1074/jbc.271.30.18068
/ J. Biol. Chem. / A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism by Cooper (1996)10.1016/S0041-1345(96)00184-4
/ Transplant. Proc. / Adenovirus-mediated gene transfer of A20 renders endothelial cells resistant to activation: a means of evaluating the role of endothelial cell activation in xenograft rejection by Ferran (1997)10.1084/jem.190.8.1135
/ J. Exp. Med. / A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets by Grey (1999)10.1016/S0006-2952(00)00404-4
/ Biochem. Pharmacol. / A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis by Beyaert (2000)10.1016/S0006-291X(03)00389-9
/ Biochem. Biophys. Res. Commun. / Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein by O'Reilly (2003)10.1016/S0021-9258(19)39896-5
/ J. Biol. Chem. / Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin by Dixit (1990)10.1016/S0021-9258(18)77165-2
/ J. Biol. Chem. / The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein by Opipari (1990)10.1016/S0021-9258(19)37138-8
/ J. Biol. Chem. / Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements by Krikos (1992)10.1016/S0021-9258(18)35741-7
/ J. Biol. Chem. / The Epstein–Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B by Laherty (1992)10.1016/S0021-9258(18)53498-0
/ J. Biol. Chem. / Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B by Laherty (1993)10.4049/jimmunol.154.4.1699
/ J. Immunol. / Lymphoid expression and regulation of A20, an inhibitor of programmed cell death by Tewari (1995)10.1074/jbc.270.21.12343
/ J. Biol. Chem. / Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis by Sarma (1995)10.1182/blood.V92.8.2759
/ Blood / Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells by Hu (1998)10.1002/path.1351
/ J. Pathol. / Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation by Durkop (2003)10.1126/science.289.5488.2350
/ Science / Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice by Lee (2000)10.1038/ni1110
/ Nat. Immunol. / The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses by Boone (2004)10.1074/jbc.M510326200
/ J. Biol. Chem. / Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20 by Lin (2006)10.1016/j.febslet.2004.08.071
/ FEBS Lett. / A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter by Wang (2004)10.4049/jimmunol.174.3.1507
/ J. Immunol. / A20 is a negative regulator of IFN regulatory factor 3 signaling by Saitoh (2005)10.1101/gad.1228704
/ Genes Dev. / Signaling to NF-kappaB by Hayden (2004)10.1016/S0014-5793(98)01645-7
/ FEBS Lett. / The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6 by Heyninck (1999)10.1083/jcb.145.7.1471
/ J. Cell Biol. / The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN by Heyninck (1999)10.1038/nature02794
/ Nature / De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling by Wertz (2004)10.1016/S1074-7613(00)80183-1
/ Immunity / Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation by Zhang (2000)10.1038/ncb0805-758
/ Nat. Cell Biol. / Ubiquitin signalling in the NF-kappaB pathway by Chen (2005)10.1016/S0092-8674(00)00126-4
/ Cell / Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain by Deng (2000)10.1038/35085597
/ Nature / TAK1 is a ubiquitin-dependent kinase of MKK and IKK by Wang (2001)10.1074/jbc.M609503200
/ J. Biol. Chem. / Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation by Lamothe (2007)10.1038/18465
/ Nature / The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway by Ninomiya-Tsuji (1999)10.1074/jbc.M004376200
/ J. Biol. Chem. / The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation by Holtmann (2001)10.1016/S0014-5793(00)01146-7
/ FEBS Lett. / TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages by Irie (2000)10.1189/jlb.68.6.909
/ J. Leukocyte Biol. / TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide by Lee (2000)10.1074/jbc.M300562200
/ J. Biol. Chem. / Poly(I–C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3–TRAF6–TAK1–TAB2–PKR by Jiang (2003)10.1128/MCB.22.4.992-1000.2002
/ Mol. Cell Biol. / Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6 by Mizukami (2002)10.1126/science.272.5265.1179
/ Science / TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction by Shibuya (1996)10.1016/S1097-2765(00)80244-0
/ Mol. Cell / TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway by Takaesu (2000)10.1093/emboj/cdg605
/ EMBO J. / Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling by Ishitani (2003)10.1042/bj20031794
/ Biochem. J. / TAB3, a new binding partner of the protein kinase TAK1 by Cheung (2004)10.1073/pnas.0307314101
/ Proc. Natl Acad. Sci. USA / Identification of a human NF-{kappa}B-activating protein, TAB3 by Jin (2004)10.1074/jbc.M608867200
/ J. Biol. Chem. / TAK1-dependent signaling requires functional interaction with TAB2/TAB3 by Besse (2007)10.1016/j.molcel.2004.08.008
/ Mol. Cell / TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains by Kanayama (2004)10.1016/j.tibs.2004.11.001
/ Trends Biochem. Sci. / A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions by Heyninck (2005)10.1042/bj20031377
/ Biochem. J. / Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity by Evans (2004)10.1016/S0014-5793(01)02504-2
/ FEBS Lett. / Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein–protein interactions by Klinkenberg (2001)10.1016/j.bbamcr.2004.10.003
/ Biochim. Biophys. Acta / Mechanism and function of deubiquitinating enzymes by Amerik (2004)10.1016/j.cell.2005.11.007
/ Cell / A genomic and functional inventory of deubiquitinating enzymes by Nijman (2005)10.1016/S0968-0004(99)01530-3
/ Trends Biochem. Sci. / A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae by Makarova (2000)10.1016/S0076-6879(97)76068-3
/ Methods Enzymol. / Detecting and overcoming crystal twinning by Yeates (1997)10.1107/S0907444903019942
/ Acta Crystallogr. Sect. D / Structure of superoxide dismutase from Pyrobaculum aerophilum presents a challenging case in molecular replacement with multiple molecules, pseudo-symmetry and twinning by Lee (2003)10.1042/bj3570617
/ Biochem. J. / Isolation and characterization of two novel A20-like proteins by Evans (2001)10.1093/emboj/18.14.3877
/ EMBO J. / Structural basis for the specificity of ubiquitin C-terminal hydrolases by Johnston (1999)10.1074/jbc.M410770200
/ J. Biol. Chem. / Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate by Misaghi (2005)10.1016/S0092-8674(02)01199-6
/ Cell / Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde by Hu (2002)10.1038/sj.emboj.7600832
/ EMBO J. / Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14 by Hu (2005)10.1016/j.str.2006.06.012
/ Structure / Structural basis of ubiquitin recognition by the deubiquitinating protease USP2 by Renatus (2006)10.1038/sj.embor.7400201
/ EMBO Rep. / Crystal structure of human otubain 2 by Nanao (2004)10.1002/bies.950080106
/ Bioessays / The role of the otu gene in Drosophila oogenesis by King (1988)10.1093/nar/30.1.343
/ Nucleic Acids Res. / MEROPS: the protease database by Rawlings (2002)10.1073/pnas.84.7.1829
/ Proc. Natl Acad. Sci. USA / Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes by Hershko (1987)10.1016/S1074-5521(02)00248-X
/ Chem. Biol. / Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family by Borodovsky (2002)10.1016/S0021-9258(18)67512-X
/ J. Biol. Chem. / Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin by Pickart (1986)10.1021/bi9723360
/ Biochemistry / Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes by Dang (1998)10.1160/TH06-08-0471
/ Thromb. Haemost. / Ubiquitylation within signaling pathways in- and outside of inflammation by Hochrainer (2007)10.1042/BJ20071399
/ Biochem J. / Structure of the A20 OTU domain and mechanistic insights into deubiquitination by Komander (2008)10.1107/S0907444903007947
/ Acta Crystallogr. Sect. D / A statistic for local intensity differences: robustness to anisotropy and pseudo-centering and utility for detecting twinning by Padilla (2003)
Dates
Type | When |
---|---|
Created | 17 years, 8 months ago (Dec. 5, 2007, 9:48 a.m.) |
Deposited | 1 year, 6 months ago (Feb. 23, 2024, 12:19 p.m.) |
Indexed | 4 months, 3 weeks ago (April 11, 2025, 6:49 a.m.) |
Issued | 17 years, 7 months ago (Feb. 1, 2008) |
Published | 17 years, 7 months ago (Feb. 1, 2008) |
Published Print | 17 years, 7 months ago (Feb. 1, 2008) |
Funders
6
U.S. Department of Energy
10.13039/100000015
Region: Americas
gov (National government)
Labels
8
- Energy Department
- Department of Energy
- United States Department of Energy
- ENERGY.GOV
- US Department of Energy
- USDOE
- DOE
- USADOE
National Center for Research Resources
10.13039/100000097
Region: Americas
gov (National government)
Labels
1
- NCRR
Cancer Research Institute
10.13039/100000884
Region: Americas
gov (Research institutes and centers)
Labels
2
- Cancer Research Institute, Inc.
- CRI
American Heart Association
10.13039/100000968
Region: Americas
gov (Associations and societies (private and public))
Labels
5
- American Heart Association, Inc.
- AMERICAN HEART ASSOC.
- American Heart Assn
- Association for the Prevention and Relief of Heart Disease
- AHA
Awards
1
- RR-15301
Basic Energy Sciences
10.13039/100006151
Region: Americas
gov (National government)
Labels
6
- Office of Basic Energy Sciences
- DOE Office of Basic Energy Sciences
- US Department of Energy's Basic Energy Sciences
- DOE Basic Energy Sciences
- Department of Energy Basic Energy Sciences Program
- BES
Awards
1
- DE-AC02-06CH11357
National Institutes of Health
10.13039/100000002
Region: Americas
gov (National government)
Labels
3
- Institutos Nacionales de la Salud
- US National Institutes of Health
- NIH
Awards
2
- RO1 AR053540
- RO1 AI045937
@article{Lin_2008, title={Molecular Basis for the Unique Deubiquitinating Activity of the NF-κB Inhibitor A20}, volume={376}, ISSN={0022-2836}, url={http://dx.doi.org/10.1016/j.jmb.2007.11.092}, DOI={10.1016/j.jmb.2007.11.092}, number={2}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Lin, Su-Chang and Chung, Jee Y. and Lamothe, Betty and Rajashankar, Kanagalaghatta and Lu, Miao and Lo, Yu-Chih and Lam, Amy Y. and Darnay, Bryant G. and Wu, Hao}, year={2008}, month=feb, pages={526–540} }