DOI: 10.1016/j.jmb.2007.02.049. Multivariate Analysis of Conserved Sequence–Structure Relationships in Kinesins: Coupling of the Active Site and a Tubulin-binding Sub-domain

Multivariate Analysis of Conserved Sequence–Structure Relationships in Kinesins: Coupling of the Active Site and a Tubulin-binding Sub-domain

10.1016/j.jmb.2007.02.049

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

Grant, B. J., McCammon, J. A., Caves, L. S. D., & Cross, R. A. (2007). Multivariate Analysis of Conserved SequenceâStructure Relationships in Kinesins: Coupling of the Active Site and a Tubulin-binding Sub-domain. Journal of Molecular Biology, 368(5), 1231â1248.

Authors 4

Barry J. Grant (first)
J. Andrew McCammon (additional)
Leo S.D. Caves (additional)
Robert A. Cross (additional)

References 95 Referenced 45

10.1016/0022-2836(87)90521-3 / J. Mol. Biol. / Determinants of a protein fold. Unique features of the globin amino acid sequences by Bashford (1987)
10.1006/jmbi.1998.1653 / J. Mol. Biol. / Structural determinants in the sequences of immunoglobin variable domain by Chothia (1998)
10.1110/ps.9.11.2170 / Protein Sci. / The identification of conserved interactions within the SH3 domain by alignment of sequences and structures by Larson (2000)
10.1006/jmbi.1996.0264 / J. Mol. Biol. / Conservation and variability in the structures of serine proteinases of the chymotrypsin family by Lesk (1996)
10.1016/S1359-0278(98)00035-2 / Fold. Des. / A strategy for detecting the conservation of folding nucleus residues in protein superfamilies by Michnick (1998)
10.1126/science.286.5438.295 / Science / Evolutionarily conserved pathways of energetic connectivity in protein families by Lockless (1999)
10.1038/380550a0 / Nature / Crystal structure of the kinesin motor domain reveals a structural similarity to myosin by Kull (1996)
10.1016/S0092-8674(00)80489-4 / Cell / The crystal structure of dimeric kinesin and implications for microtubule-dependent motility by Kozielski (1997)
10.1016/S0969-2126(00)80030-1 / Structure / The crystal structure of a minus-end directed microtubule motor protein ncd reveals variabledimer conformations by Kozielski (1999)
10.1038/35078000 / Nature / Switch-based mechanism of kinesin motors by Kikkawa (2001)
10.1074/jbc.M100395200 / J. Biol. Chem. / Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker by Turner (2001)
10.1038/380555a0 / Nature / Crystal structure of the motor domain of the kinesin-related motor ncd by Sablin (1996)
10.1021/bi972504o / Biochemistry / X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution by Gulick (1998)
10.1093/emboj/20.11.2611 / EMBO J. / A structural pathway for activation of the kinesin motor ATPase by Yun (2001)
10.1093/emboj/20.22.6213 / EMBO J. / Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules by Song (2001)
10.1093/emboj/cdg531 / EMBO J. / Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd by Yun (2003)
10.1038/sj.emboj.7600165 / EMBO J. / Structure of a kinesin microtubule depolymerization machine by Shipley (2004)
10.1016/j.jmb.2003.10.074 / J. Mol. Biol. / Inhibition of a mitotic motor protein: where, how, and conformational consequences by Yan (2004)
{'key': '10.1016/j.jmb.2007.02.049_bib19', 'first-page': '844', 'article-title': 'Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy', 'volume': '9', 'author': 'Sindelar', 'year': '2002', 'journal-title': 'Nature Struct. Biol.'} / Nature Struct. Biol. / Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy by Sindelar (2002)
10.1074/jbc.M400741200 / J. Biol. Chem. / Crystal structure of kinesin regulated by Ca(2+)-calmodulin by Vinogradova (2004)
10.1016/j.jmb.2004.05.053 / J. Mol. Biol. / Crystal structure of the motor domain of the human kinetochore protein CENP-E by Garcia-Saez (2004)
10.1016/S0092-8674(04)00129-1 / Cell / A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops by Ogawa (2004)
10.1126/science.1096621 / Science / KIF1A alternately uses two loops to bind microtubules by Nitta (2004)
10.1016/j.bmcl.2005.02.055 / Bioorg. Med. Chem. Leters / Kinesin spindle protein (KSP) inhibitors. Part 1: the discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP by Cox (2005)
10.1038/27463 / Nature / Direction determination in the minus-end-directed kinesin motor ncd by Sablin (1998)
10.1021/bi9722498 / Biochemistry / X-ray structure of motor and neck domains from rat brain kinesin by Sack (1997)
10.1016/j.bmcl.2006.01.030 / Bioorg. Med. Chem. Letters / Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP by Fraley (2006)
10.1016/j.bmcl.2006.01.056 / Bioorg. Med. Chem. Letters / Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series by Tarby (2006)
10.1016/j.bmcl.2006.05.037 / Bioorg. Med. Chem. Letters / Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors by Kim (2006)
10.1016/j.bmcl.2006.03.040 / Bioorg. Med. Chem. Letters / Kinesin spindle protein (KSP) inhibitors. Part 4: structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP by Cox (2006)
10.1093/emboj/17.4.945 / EMBO J. / Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12 by Alonso (1998)
10.1016/S0092-8674(00)80329-3 / Cell / Microtubule interaction site of the kinesin motor by Woehlke (1997)
10.1016/j.molcel.2006.07.020 / Mol. Cell / Large conformational changes in a kinesin motor catalyzed by interaction with microtubules by Hirose (2006)
10.1038/sj.emboj.7601299 / EMBO J. / High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations by Kikkawa (2006)
10.1023/A:1005489907021 / J. Musc. Res. Cell Motil. / The case for a common ancestor: kinesin and myosin motor proteins and G proteins by Kull (1998)
10.1083/jcb.135.2.291 / J. Cell Biol. / Switches, latches, and amplifiers: common themes of G proteins and molecular motors by Vale (1996)
10.1126/science.288.5463.88 / Science / The way things move: looking under the hood of molecular motor proteins by Vale (2000)
10.1016/S0960-9822(00)00368-7 / Curr. Biol. / Molecular motors by Cross (2000)
10.1046/j.1432-1327.1999.00341.x / Eur. J. Biochem. / Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites by Sack (1999)
10.1242/jcs.115.1.15 / J. Cell Sci. / Kinesin: switch I and II and the motor mechanism by Kull (2002)
{'key': '10.1016/j.jmb.2007.02.049_bib41', 'series-title': 'Molecular Motors', 'first-page': '287', 'article-title': 'Structures of kinesin motor domains: implications for conformational switching involved in mechanochemical coupling', 'author': 'Song', 'year': '2003'} / Molecular Motors / Structures of kinesin motor domains: implications for conformational switching involved in mechanochemical coupling by Song (2003)
10.1091/mbc.E05-11-1090 / Mol. Biol. Cell / A “holistic” kinesin phylogeny reveals new kinesin families and predicts protein functions by Wickstead (2006)
10.1016/j.tcb.2005.07.006 / Trends Cell Biol. / Analysis of the kinesin superfamily: insights into structure and function by Miki (2005)
10.1083/jcb.200408113 / J. Cell Biol. / A standardized kinesin nomenclature by Lawrence (2004)
10.1093/bioinformatics/14.9.755 / Bioinformatics / Profile hidden Markov models by Eddy (1998)
10.1242/jcs.113.21.3681 / J. Cell Sci. / A kinesin family tree by Kim (2000)
10.1093/nar/28.1.45 / Nucl. Acids Res. / The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 by Bairoch (2000)
10.1038/nsb881 / Nature Struct. Biol. / Evolutionarily conserved networks of residues mediate allosteric communication in proteins by Süel (2002)
10.1073/pnas.1835919100 / Proc. Natl Acad. Sci. USA / Allosteric determinants in guanine nucleotide-binding proteins by Hatlry (2003)
10.1093/nar/28.1.235 / Nucl. Acids Res. / The Protein Data Bank by Berman (2002)
10.1016/0263-7855(96)00018-5 / J. Mol. Graph. / VMD–visual molecular dynamics by Humphrey (1996)
10.1002/prot.10146 / Proteins: Struct. Funct. Genet. / Scoring residue conservation by Valdar (2002)
10.1042/bse0350061 / Essays Biochem. / Motor proteins of the kinesin superfamily: structure and mechanism by Kull (2000)
10.1002/pro.5560041017 / Protein Sci. / C alpha-based torsion angles: a simple tool to analyze protein conformational changes by Flocco (1995)
10.1016/S0960-9822(00)00316-X / Curr. Biol. / Role of the kinesin neck linker and catalytic core in microtubule-based motility by Case (2000)
10.1073/pnas.200376897 / Proc. Natl Acad. Sci. USA / Three conformational states of scallop myosin S1 by Houdusse (2000)
10.1515/BC.1999.122 / Biol. Chem. / The structure of the nucleotide-binding site of kinesin by Muller (1999)
10.1126/science.1062023 / Science / The guanine nucleotide-binding switch in three dimensions by Vetter (2001)
10.1016/S0968-0004(96)10064-5 / Trends Biochem. Sci. / How Ras related proteins talk to their effectors by Wittinghofer (1996)
10.1016/j.tibs.2004.04.010 / Trends Biochem. Sci. / The kinetic mechanism of kinesin by Cross (2004)
10.1006/jmbi.1995.0423 / J. Mol. Biol. / Average core structures and variability measures for protein families: application to the immunoglobulins by Gerstein (1995)
10.1016/0968-0004(93)90015-F / Trends Biochem. Sci. / Are enzymes mechanical devices? by Williams (1993)
10.1091/mbc.10.6.2063 / Mol. Biol. Cell / Congruent docking of dimeric kinesin and ncd into three-dimensional electron cryomicroscopy maps of microtubule-motor ADP complexes by Hirose (1999)
10.1073/pnas.93.18.9539 / Proc. Natl Acad. Sci. USA / Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules by Hirose (1996)
10.1038/376277a0 / Nature / Nucleotide-dependent angular change in kinesin motor domain bound to tubulin by Hirose (1995)
10.1093/emboj/19.20.5308 / EMBO J. / Structural comparison of dimeric Eg5, Neurospora kinesin (Nkin) and Ncd head-Nkin neck chimera with conventional kinesin by Hirose (2000)
10.1006/jsbi.1997.3840 / J. Struct. Biol. / Three-dimensional cryo-electron microscopy of 16-protofilament microtubules: structure, polarity, and interaction with motor proteins by Hirose (1997)
10.1006/jmbi.2000.3627 / J. Mol. Biol. / A new look at the microtubule binding patterns of dimeric kinesins by Hoenger (2000)
10.1083/jcb.141.2.419 / J. Cell Biol. / Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with X-ray structure and implications for motility by Hoenger (1998)
10.1038/376271a0 / Nature / Three-dimensional structure of a tubulin-motor-protein complex by Hoenger (1995)
10.1016/S0092-8674(00)80330-X / Cell / A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis by Sosa (1997)
{'key': '10.1016/j.jmb.2007.02.049_bib72', 'first-page': '429', 'article-title': 'Structural determinants of allosteric ligand activation in RXR heterodimers', 'volume': '116', 'author': 'Shulman', 'year': '2003', 'journal-title': 'Cell'} / Cell / Structural determinants of allosteric ligand activation in RXR heterodimers by Shulman (2003)
10.1093/bioinformatics/bth128 / Bioinformatics / A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments by Dekker (2004)
10.1002/prot.10180 / Proteins: Struct. Funct. Genet. / Mapping pathways of allosteric communication in GROEL by analysis of correlated mutations by Kass (2002)
10.1083/jcb.140.6.1407 / J. Cell Biol. / Role of the kinesin neck region in processive microtubule-based motility by Romberg (1998)
10.1038/45483 / Nature / A structural change in the kinesin motor protein that drives motility by Rice (1999)
10.1098/rstb.2000.0586 / Phil. Trans. Roy. Soc. ser. B / Searching for kinesin's mechanical amplifier by Vale (2000)
10.1002/prot.21146 / Proteins: Struct. Funct. Genet. / Pump-probe molecular dynamics as a tool for studying protein motion and long range coupling by Sharp (2006)
10.1016/S0092-8674(04)00125-4 / Cell / Allostery and coupled sequence variation in nuclear hormone receptors by Kuriyan (2004)
10.1126/science.1082374 / Science / Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules by Naber (2003)
10.1016/S0959-440X(01)00265-2 / Curr. Opin. Struct. Biol. / Nucleotide switches in molecular motors: structural analysis of kinesins and myosins by Sablin (2001)
10.1016/S0014-5793(01)03064-2 / FEBS Letters / A look into kinesin's powerhouse by Woehlke (2001)
10.1038/nsmb1109 / Nature Struct. Mol. Biol. / Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region by Asenjo (2006)
10.1093/bioinformatics/btl461 / Bioinformatics / Bio3d: an R package for the comparative analysis of protein structures by Grant (2006)
10.1002/prot.20921 / Proteins: Struct. Funct. Genet. / MUSTANG: a multiple structural alignment algorithm by Konagurthu (2006)
10.1073/pnas.89.22.10915 / Proc. Natl Acad. Sci. USA / Amino acid substitution matrices from protein blocks by Henikoff (1992)
10.1016/0022-2836(87)90038-6 / J. Mol. Biol. / Interior and surface of monomeric proteins by Miller (1987)
10.1002/prot.340110408 / Proteins: Struct. Funct. Genet. / Information-theoretical entropy as a measure of sequence variability by Shehkin (1991)
10.1002/j.1538-7305.1948.tb01338.x / Bell Syst. Tech. J. / The mathematical theory of communication by Shannon (1948)
10.1002/j.1538-7305.1948.tb00917.x / Bell Syst. Tech. J. / The mathematical theory of communication by Shannon (1948)
10.1093/nar/gki888 / Nuclei. Acids Res. / The physical determinants of the DNA conformational landscape by Elsawy (2005)
10.1016/S0006-3495(97)78317-6 / Biophys. J. / Protein dynamics derived from clusters of crystal structures by van Aalten (1997)
10.1002/(SICI)1097-0134(19980601)31:4<370::AID-PROT4>3.0.CO;2-M / Proteins: Struct. Funct. Genet. / Essential spaces defined by NMR structure ensembles and molecular dynamics simulation show significant overlap by Abseher (1998)
{'key': '10.1016/j.jmb.2007.02.049_bib94', 'series-title': 'Molecular Dynamics: Applications in molecular biology', 'first-page': '27', 'article-title': 'Conformational variability of insulin: a molecular dynamics analysis', 'author': 'Caves', 'year': '1991'} / Molecular Dynamics: Applications in molecular biology / Conformational variability of insulin: a molecular dynamics analysis by Caves (1991)
10.1002/pro.5560070314 / Protein Sci. / Locally accessible conformations of proteins: multiple molecular dynamics simulations of crambin by Caves (1998)

Dates

Type	When
Created	18 years, 4 months ago (March 31, 2007, 7:19 a.m.)
Deposited	4 years ago (Aug. 11, 2021, 8:39 p.m.)
Indexed	3 months, 4 weeks ago (April 29, 2025, 9:30 a.m.)
Issued	18 years, 3 months ago (May 1, 2007)
Published	18 years, 3 months ago (May 1, 2007)
Published Print	18 years, 3 months ago (May 1, 2007)

Funders 0

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BibTeX

@article{Grant_2007, title={Multivariate Analysis of Conserved Sequence–Structure Relationships in Kinesins: Coupling of the Active Site and a Tubulin-binding Sub-domain}, volume={368}, ISSN={0022-2836}, url={http://dx.doi.org/10.1016/j.jmb.2007.02.049}, DOI={10.1016/j.jmb.2007.02.049}, number={5}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Grant, Barry J. and McCammon, J. Andrew and Caves, Leo S.D. and Cross, Robert A.}, year={2007}, month=may, pages={1231–1248} }

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      "author": "Larson",
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      "volume": "3",
      "author": "Michnick",
      "year": "1998",
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      "article-title": "Evolutionarily conserved pathways of energetic connectivity in protein families",
      "volume": "286",
      "author": "Lockless",
      "year": "1999",
      "journal-title": "Science"
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    {
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      "first-page": "550",
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      "author": "Kull",
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      "author": "Kozielski",
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    },
    {
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      "first-page": "1407",
      "DOI": "10.1016/S0969-2126(00)80030-1",
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      "volume": "7",
      "author": "Kozielski",
      "year": "1999",
      "journal-title": "Structure"
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      "article-title": "Switch-based mechanism of kinesin motors",
      "volume": "411",
      "author": "Kikkawa",
      "year": "2001",
      "journal-title": "Nature"
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    {
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      "volume": "276",
      "author": "Turner",
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      "article-title": "Crystal structure of the motor domain of the kinesin-related motor ncd",
      "volume": "380",
      "author": "Sablin",
      "year": "1996",
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    {
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      "first-page": "1769",
      "DOI": "10.1021/bi972504o",
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      "volume": "37",
      "author": "Gulick",
      "year": "1998",
      "journal-title": "Biochemistry"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "2611",
      "DOI": "10.1093/emboj/20.11.2611",
      "article-title": "A structural pathway for activation of the kinesin motor ATPase",
      "volume": "20",
      "author": "Yun",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "6213",
      "DOI": "10.1093/emboj/20.22.6213",
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      "volume": "20",
      "author": "Song",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "5382",
      "DOI": "10.1093/emboj/cdg531",
      "article-title": "Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd",
      "volume": "22",
      "author": "Yun",
      "year": "2003",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "1422",
      "DOI": "10.1038/sj.emboj.7600165",
      "article-title": "Structure of a kinesin microtubule depolymerization machine",
      "volume": "23",
      "author": "Shipley",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "547",
      "DOI": "10.1016/j.jmb.2003.10.074",
      "article-title": "Inhibition of a mitotic motor protein: where, how, and conformational consequences",
      "volume": "333",
      "author": "Yan",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib19",
      "first-page": "844",
      "article-title": "Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy",
      "volume": "9",
      "author": "Sindelar",
      "year": "2002",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "23504",
      "DOI": "10.1074/jbc.M400741200",
      "article-title": "Crystal structure of kinesin regulated by Ca(2+)-calmodulin",
      "volume": "279",
      "author": "Vinogradova",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1107",
      "DOI": "10.1016/j.jmb.2004.05.053",
      "article-title": "Crystal structure of the motor domain of the human kinetochore protein CENP-E",
      "volume": "340",
      "author": "Garcia-Saez",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "591",
      "DOI": "10.1016/S0092-8674(04)00129-1",
      "article-title": "A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops",
      "volume": "116",
      "author": "Ogawa",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "678",
      "DOI": "10.1126/science.1096621",
      "article-title": "KIF1A alternately uses two loops to bind microtubules",
      "volume": "305",
      "author": "Nitta",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "2041",
      "DOI": "10.1016/j.bmcl.2005.02.055",
      "article-title": "Kinesin spindle protein (KSP) inhibitors. Part 1: the discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP",
      "volume": "15",
      "author": "Cox",
      "year": "2005",
      "journal-title": "Bioorg. Med. Chem. Leters"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "813",
      "DOI": "10.1038/27463",
      "article-title": "Direction determination in the minus-end-directed kinesin motor ncd",
      "volume": "395",
      "author": "Sablin",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "16155",
      "DOI": "10.1021/bi9722498",
      "article-title": "X-ray structure of motor and neck domains from rat brain kinesin",
      "volume": "36",
      "author": "Sack",
      "year": "1997",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "1775",
      "DOI": "10.1016/j.bmcl.2006.01.030",
      "article-title": "Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP",
      "volume": "16",
      "author": "Fraley",
      "year": "2006",
      "journal-title": "Bioorg. Med. Chem. Letters"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "2095",
      "DOI": "10.1016/j.bmcl.2006.01.056",
      "article-title": "Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series",
      "volume": "16",
      "author": "Tarby",
      "year": "2006",
      "journal-title": "Bioorg. Med. Chem. Letters"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "3937",
      "DOI": "10.1016/j.bmcl.2006.05.037",
      "article-title": "Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors",
      "volume": "16",
      "author": "Kim",
      "year": "2006",
      "journal-title": "Bioorg. Med. Chem. Letters"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "3175",
      "DOI": "10.1016/j.bmcl.2006.03.040",
      "article-title": "Kinesin spindle protein (KSP) inhibitors. Part 4: structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP",
      "volume": "16",
      "author": "Cox",
      "year": "2006",
      "journal-title": "Bioorg. Med. Chem. Letters"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "945",
      "DOI": "10.1093/emboj/17.4.945",
      "article-title": "Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12",
      "volume": "17",
      "author": "Alonso",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1016/S0092-8674(00)80329-3",
      "article-title": "Microtubule interaction site of the kinesin motor",
      "volume": "90",
      "author": "Woehlke",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "913",
      "DOI": "10.1016/j.molcel.2006.07.020",
      "article-title": "Large conformational changes in a kinesin motor catalyzed by interaction with microtubules",
      "volume": "23",
      "author": "Hirose",
      "year": "2006",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "4187",
      "DOI": "10.1038/sj.emboj.7601299",
      "article-title": "High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations",
      "volume": "25",
      "author": "Kikkawa",
      "year": "2006",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "877",
      "DOI": "10.1023/A:1005489907021",
      "article-title": "The case for a common ancestor: kinesin and myosin motor proteins and G proteins",
      "volume": "19",
      "author": "Kull",
      "year": "1998",
      "journal-title": "J. Musc. Res. Cell Motil."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1083/jcb.135.2.291",
      "article-title": "Switches, latches, and amplifiers: common themes of G proteins and molecular motors",
      "volume": "135",
      "author": "Vale",
      "year": "1996",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1126/science.288.5463.88",
      "article-title": "The way things move: looking under the hood of molecular motor proteins",
      "volume": "288",
      "author": "Vale",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "R177",
      "DOI": "10.1016/S0960-9822(00)00368-7",
      "article-title": "Molecular motors",
      "volume": "10",
      "author": "Cross",
      "year": "2000",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1046/j.1432-1327.1999.00341.x",
      "article-title": "Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites",
      "volume": "262",
      "author": "Sack",
      "year": "1999",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1242/jcs.115.1.15",
      "article-title": "Kinesin: switch I and II and the motor mechanism",
      "volume": "115",
      "author": "Kull",
      "year": "2002",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib41",
      "series-title": "Molecular Motors",
      "first-page": "287",
      "article-title": "Structures of kinesin motor domains: implications for conformational switching involved in mechanochemical coupling",
      "author": "Song",
      "year": "2003"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "1734",
      "DOI": "10.1091/mbc.E05-11-1090",
      "article-title": "A \u201cholistic\u201d kinesin phylogeny reveals new kinesin families and predicts protein functions",
      "volume": "17",
      "author": "Wickstead",
      "year": "2006",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "467",
      "DOI": "10.1016/j.tcb.2005.07.006",
      "article-title": "Analysis of the kinesin superfamily: insights into structure and function",
      "volume": "15",
      "author": "Miki",
      "year": "2005",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1083/jcb.200408113",
      "article-title": "A standardized kinesin nomenclature",
      "volume": "167",
      "author": "Lawrence",
      "year": "2004",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "755",
      "DOI": "10.1093/bioinformatics/14.9.755",
      "article-title": "Profile hidden Markov models",
      "volume": "14",
      "author": "Eddy",
      "year": "1998",
      "journal-title": "Bioinformatics"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "3681",
      "DOI": "10.1242/jcs.113.21.3681",
      "article-title": "A kinesin family tree",
      "volume": "113",
      "author": "Kim",
      "year": "2000",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1093/nar/28.1.45",
      "article-title": "The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000",
      "volume": "28",
      "author": "Bairoch",
      "year": "2000",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1038/nsb881",
      "article-title": "Evolutionarily conserved networks of residues mediate allosteric communication in proteins",
      "volume": "10",
      "author": "S\u00fcel",
      "year": "2002",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "14445",
      "DOI": "10.1073/pnas.1835919100",
      "article-title": "Allosteric determinants in guanine nucleotide-binding proteins",
      "volume": "100",
      "author": "Hatlry",
      "year": "2003",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1093/nar/28.1.235",
      "article-title": "The Protein Data Bank",
      "volume": "28",
      "author": "Berman",
      "year": "2002",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1016/0263-7855(96)00018-5",
      "article-title": "VMD\u2013visual molecular dynamics",
      "volume": "14",
      "author": "Humphrey",
      "year": "1996",
      "journal-title": "J. Mol. Graph."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1002/prot.10146",
      "article-title": "Scoring residue conservation",
      "volume": "48",
      "author": "Valdar",
      "year": "2002",
      "journal-title": "Proteins: Struct. Funct. Genet."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "61",
      "DOI": "10.1042/bse0350061",
      "article-title": "Motor proteins of the kinesin superfamily: structure and mechanism",
      "volume": "35",
      "author": "Kull",
      "year": "2000",
      "journal-title": "Essays Biochem."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "2118",
      "DOI": "10.1002/pro.5560041017",
      "article-title": "C alpha-based torsion angles: a simple tool to analyze protein conformational changes",
      "volume": "4",
      "author": "Flocco",
      "year": "1995",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/S0960-9822(00)00316-X",
      "article-title": "Role of the kinesin neck linker and catalytic core in microtubule-based motility",
      "volume": "10",
      "author": "Case",
      "year": "2000",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "11238",
      "DOI": "10.1073/pnas.200376897",
      "article-title": "Three conformational states of scallop myosin S1",
      "volume": "97",
      "author": "Houdusse",
      "year": "2000",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "841",
      "DOI": "10.1515/BC.1999.122",
      "article-title": "The structure of the nucleotide-binding site of kinesin",
      "volume": "380",
      "author": "Muller",
      "year": "1999",
      "journal-title": "Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "1299",
      "DOI": "10.1126/science.1062023",
      "article-title": "The guanine nucleotide-binding switch in three dimensions",
      "volume": "294",
      "author": "Vetter",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "488",
      "DOI": "10.1016/S0968-0004(96)10064-5",
      "article-title": "How Ras related proteins talk to their effectors",
      "volume": "21",
      "author": "Wittinghofer",
      "year": "1996",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1016/j.tibs.2004.04.010",
      "article-title": "The kinetic mechanism of kinesin",
      "volume": "29",
      "author": "Cross",
      "year": "2004",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "161",
      "DOI": "10.1006/jmbi.1995.0423",
      "article-title": "Average core structures and variability measures for protein families: application to the immunoglobulins",
      "volume": "251",
      "author": "Gerstein",
      "year": "1995",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1016/0968-0004(93)90015-F",
      "article-title": "Are enzymes mechanical devices?",
      "volume": "18",
      "author": "Williams",
      "year": "1993",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "2063",
      "DOI": "10.1091/mbc.10.6.2063",
      "article-title": "Congruent docking of dimeric kinesin and ncd into three-dimensional electron cryomicroscopy maps of microtubule-motor ADP complexes",
      "volume": "10",
      "author": "Hirose",
      "year": "1999",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "9344",
      "DOI": "10.1073/pnas.93.18.9539",
      "article-title": "Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules",
      "volume": "93",
      "author": "Hirose",
      "year": "1996",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1038/376277a0",
      "article-title": "Nucleotide-dependent angular change in kinesin motor domain bound to tubulin",
      "volume": "376",
      "author": "Hirose",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "5308",
      "DOI": "10.1093/emboj/19.20.5308",
      "article-title": "Structural comparison of dimeric Eg5, Neurospora kinesin (Nkin) and Ncd head-Nkin neck chimera with conventional kinesin",
      "volume": "19",
      "author": "Hirose",
      "year": "2000",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "140",
      "DOI": "10.1006/jsbi.1997.3840",
      "article-title": "Three-dimensional cryo-electron microscopy of 16-protofilament microtubules: structure, polarity, and interaction with motor proteins",
      "volume": "118",
      "author": "Hirose",
      "year": "1997",
      "journal-title": "J. Struct. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "1087",
      "DOI": "10.1006/jmbi.2000.3627",
      "article-title": "A new look at the microtubule binding patterns of dimeric kinesins",
      "volume": "297",
      "author": "Hoenger",
      "year": "2000",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "419",
      "DOI": "10.1083/jcb.141.2.419",
      "article-title": "Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with X-ray structure and implications for motility",
      "volume": "141",
      "author": "Hoenger",
      "year": "1998",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1038/376271a0",
      "article-title": "Three-dimensional structure of a tubulin-motor-protein complex",
      "volume": "376",
      "author": "Hoenger",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1016/S0092-8674(00)80330-X",
      "article-title": "A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis",
      "volume": "90",
      "author": "Sosa",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib72",
      "first-page": "429",
      "article-title": "Structural determinants of allosteric ligand activation in RXR heterodimers",
      "volume": "116",
      "author": "Shulman",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "1565",
      "DOI": "10.1093/bioinformatics/bth128",
      "article-title": "A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments",
      "volume": "20",
      "author": "Dekker",
      "year": "2004",
      "journal-title": "Bioinformatics"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1002/prot.10180",
      "article-title": "Mapping pathways of allosteric communication in GROEL by analysis of correlated mutations",
      "volume": "48",
      "author": "Kass",
      "year": "2002",
      "journal-title": "Proteins: Struct. Funct. Genet."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "1407",
      "DOI": "10.1083/jcb.140.6.1407",
      "article-title": "Role of the kinesin neck region in processive microtubule-based motility",
      "volume": "140",
      "author": "Romberg",
      "year": "1998",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "778",
      "DOI": "10.1038/45483",
      "article-title": "A structural change in the kinesin motor protein that drives motility",
      "volume": "402",
      "author": "Rice",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1098/rstb.2000.0586",
      "article-title": "Searching for kinesin's mechanical amplifier",
      "volume": "355",
      "author": "Vale",
      "year": "2000",
      "journal-title": "Phil. Trans. Roy. Soc. ser. B"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1002/prot.21146",
      "article-title": "Pump-probe molecular dynamics as a tool for studying protein motion and long range coupling",
      "volume": "65",
      "author": "Sharp",
      "year": "2006",
      "journal-title": "Proteins: Struct. Funct. Genet."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "354",
      "DOI": "10.1016/S0092-8674(04)00125-4",
      "article-title": "Allostery and coupled sequence variation in nuclear hormone receptors",
      "volume": "116",
      "author": "Kuriyan",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "798",
      "DOI": "10.1126/science.1082374",
      "article-title": "Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules",
      "volume": "300",
      "author": "Naber",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib81",
      "doi-asserted-by": "crossref",
      "first-page": "716",
      "DOI": "10.1016/S0959-440X(01)00265-2",
      "article-title": "Nucleotide switches in molecular motors: structural analysis of kinesins and myosins",
      "volume": "11",
      "author": "Sablin",
      "year": "2001",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1016/S0014-5793(01)03064-2",
      "article-title": "A look into kinesin's powerhouse",
      "volume": "508",
      "author": "Woehlke",
      "year": "2001",
      "journal-title": "FEBS Letters"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib83",
      "doi-asserted-by": "crossref",
      "first-page": "648",
      "DOI": "10.1038/nsmb1109",
      "article-title": "Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region",
      "volume": "13",
      "author": "Asenjo",
      "year": "2006",
      "journal-title": "Nature Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib84",
      "doi-asserted-by": "crossref",
      "first-page": "2695",
      "DOI": "10.1093/bioinformatics/btl461",
      "article-title": "Bio3d: an R package for the comparative analysis of protein structures",
      "volume": "22",
      "author": "Grant",
      "year": "2006",
      "journal-title": "Bioinformatics"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib85",
      "doi-asserted-by": "crossref",
      "first-page": "559",
      "DOI": "10.1002/prot.20921",
      "article-title": "MUSTANG: a multiple structural alignment algorithm",
      "volume": "64",
      "author": "Konagurthu",
      "year": "2006",
      "journal-title": "Proteins: Struct. Funct. Genet."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib86",
      "doi-asserted-by": "crossref",
      "first-page": "10915",
      "DOI": "10.1073/pnas.89.22.10915",
      "article-title": "Amino acid substitution matrices from protein blocks",
      "volume": "89",
      "author": "Henikoff",
      "year": "1992",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib87",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1016/0022-2836(87)90038-6",
      "article-title": "Interior and surface of monomeric proteins",
      "volume": "196",
      "author": "Miller",
      "year": "1987",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib88",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1002/prot.340110408",
      "article-title": "Information-theoretical entropy as a measure of sequence variability",
      "volume": "11",
      "author": "Shehkin",
      "year": "1991",
      "journal-title": "Proteins: Struct. Funct. Genet."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib89",
      "doi-asserted-by": "crossref",
      "first-page": "379",
      "DOI": "10.1002/j.1538-7305.1948.tb01338.x",
      "article-title": "The mathematical theory of communication",
      "volume": "27",
      "author": "Shannon",
      "year": "1948",
      "journal-title": "Bell Syst. Tech. J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib90",
      "doi-asserted-by": "crossref",
      "first-page": "623",
      "DOI": "10.1002/j.1538-7305.1948.tb00917.x",
      "article-title": "The mathematical theory of communication",
      "volume": "27",
      "author": "Shannon",
      "year": "1948",
      "journal-title": "Bell Syst. Tech. J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib91",
      "doi-asserted-by": "crossref",
      "first-page": "5749",
      "DOI": "10.1093/nar/gki888",
      "article-title": "The physical determinants of the DNA conformational landscape",
      "volume": "33",
      "author": "Elsawy",
      "year": "2005",
      "journal-title": "Nuclei. Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib92",
      "doi-asserted-by": "crossref",
      "first-page": "2891",
      "DOI": "10.1016/S0006-3495(97)78317-6",
      "article-title": "Protein dynamics derived from clusters of crystal structures",
      "volume": "73",
      "author": "van Aalten",
      "year": "1997",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib93",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1002/(SICI)1097-0134(19980601)31:4<370::AID-PROT4>3.0.CO;2-M",
      "article-title": "Essential spaces defined by NMR structure ensembles and molecular dynamics simulation show significant overlap",
      "volume": "31",
      "author": "Abseher",
      "year": "1998",
      "journal-title": "Proteins: Struct. Funct. Genet."
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib94",
      "series-title": "Molecular Dynamics: Applications in molecular biology",
      "first-page": "27",
      "article-title": "Conformational variability of insulin: a molecular dynamics analysis",
      "author": "Caves",
      "year": "1991"
    },
    {
      "key": "10.1016/j.jmb.2007.02.049_bib95",
      "doi-asserted-by": "crossref",
      "first-page": "649",
      "DOI": "10.1002/pro.5560070314",
      "article-title": "Locally accessible conformations of proteins: multiple molecular dynamics simulations of crambin",
      "volume": "7",
      "author": "Caves",
      "year": "1998",
      "journal-title": "Protein Sci."
    }
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