DOI: 10.1016/j.jmb.2005.12.046. Location of Trp265 in Metarhodopsin II: Implications for the Activation Mechanism of the Visual Receptor Rhodopsin

Location of Trp265 in Metarhodopsin II: Implications for the Activation Mechanism of the Visual Receptor Rhodopsin

10.1016/j.jmb.2005.12.046

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

Crocker, E., Eilers, M., Ahuja, S., Hornak, V., Hirshfeld, A., Sheves, M., & Smith, S. O. (2006). Location of Trp265 in Metarhodopsin II: Implications for the Activation Mechanism of the Visual Receptor Rhodopsin. Journal of Molecular Biology, 357(1), 163â172.

Authors 7

Evan Crocker (first)
Markus Eilers (additional)
Shivani Ahuja (additional)
Viktor Hornak (additional)
Amiram Hirshfeld (additional)
Mordechai Sheves (additional)
Steven O. Smith (additional)

References 60 Referenced 118

10.1152/physrev.2001.81.4.1659 / Physiol. Rev. / Rhodopsin: structural basis of molecular physiology by Menon (2001)
10.1074/jbc.273.29.17979 / J. Biol. Chem. / G protein-coupled receptors. II. Mechanism of agonist activation by Gether (1998)
10.1074/jbc.M312671200 / J. Biol. Chem. / Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions by Madabushi (2004)
10.1016/j.tem.2003.09.007 / Trends Endocrinol. Metab. / Activation of G-protein-coupled receptors: a common molecular mechanism by Karnik (2003)
10.1016/S0065-3233(03)63010-X / Advan. Protein Chem. / Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking by Hubbell (2003)
10.1126/science.274.5288.768 / Science / Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin by Farrens (1996)
10.1038/383347a0 / Nature / Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F by Sheikh (1996)
10.1126/science.289.5480.739 / Science / Crystal structure of rhodopsin: a G protein-coupled receptor by Palczewski (2000)
10.1016/j.jmb.2004.07.044 / J. Mol. Biol. / The retinal conformation and its environment in rhodopsin in light of a new 2.2Å crystal structure by Okada (2004)
10.1073/pnas.0402848101 / Proc. Natl Acad. Sci. USA / Coupling of retinal isomerization to the activation of rhodopsin by Patel (2004)
Crocker, E. (2005). Structural changes of a light-activated G protein-coupled receptor determined by solid-state NMR: channeling light energy into the visual pigment rhodopsin. PhD thesis, Stony Brook University.
10.1016/j.jmb.2004.08.090 / J. Mol. Biol. / Structure of bovine rhodopsin in a trigonal crystal form by Li (2004)
10.1126/science.286.5438.255 / Science / Structural changes in bacteriorhodopsin during ion transport at 2 angstrom resolution by Luecke (1999)
10.1021/jp027702q / J. Phys. Chem. Ser. B / Protein-β-ionone ring interactions enhance the light-induced dipole of the chromophore in bacteriorhodopsin by Aharoni (2003)
10.1093/protein/7.12.1441 / Protein Eng. / Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor by Luo (1994)
10.1016/S0165-6147(00)01553-4 / Trends Pharmacol. Sci. / Hinges, swivels and switches: the role of prolines in signalling via transmembrane α-helices by Sansom (2000)
10.1093/emboj/16.22.6737 / EMBO J. / Agonists induce conformational changes in transmembrane domains III and VI of the β2 adrenoceptor by Gether (1997)
10.1074/jbc.M206801200 / J. Biol. Chem. / β2 Adrenergic receptor activation—modulation of the proline kink in transmembrane 6 by a rotamer toggle switch by Shi (2002)
10.1146/annurev.pharmtox.42.091101.144224 / Annu. Rev. Pharmacol. Toxicol. / The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop by Shi (2002)
10.1126/science.288.5474.2209 / Science / Movement of retinal along the visual transduction path by Borhan (2000)
10.1016/j.jmb.2004.08.049 / J. Mol. Biol. / The ring of the rhodopsin chromophore in a hydrophobic activation switch within the binding pocket by Spooner (2004)
10.1074/jbc.272.37.23081 / J. Biol. Chem. / Partial agonist activity of 11-cis-retinal in rhodopsin mutants by Han (1997)
10.1074/jbc.271.50.32330 / J. Biol. Chem. / The effects of amino acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin by Han (1996)
10.1074/jbc.271.50.32337 / J. Biol. Chem. / Functional interaction of transmembrane helices 3 and 6 in rhodopsin—replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant by Han (1996)
10.1016/S0066-4103(08)60006-X / Annu. Rep. NMR Spectrosc. / Empirical versus nonempirical evaluation of secondary structure of fibrous and membrane proteins by solid-state NMR: a practical approach by Saito (1998)
10.1002/bip.1978.360170908 / Biopolymers / C-13 NMR chemical-shifts of common amino acid residues measured in aqueous solutions of linear tetrapeptides H-Gly-Gly-X-L-Ala-OH by Richarz (1978)
Schmidt-Rohr, K. & Spiess, H. W. (1994). Multidimensional Solid-State NMR and Polymers. pp. 1–496. Academic Press, London. (10.1016/B978-0-08-092562-2.50006-0)
10.1023/B:JNMR.0000019521.79321.3c / J. Biomol. NMR / Dipolar assisted rotational resonance NMR of tryptophan and tyrosine in rhodopsin by Crocker (2004)
10.1021/bi00487a025 / Biochemistry / Solid-state NMR studies of the mechanism of the opsin shift in the visual pigment rhodopsin by Smith (1990)
10.1021/ja00303a001 / J. Am. Chem. Soc. / High-resolution carbon-13 NMR of retinal derivatives in the solid state by Harbison (1985)
10.1021/bi00074a024 / Biochemistry / Constitutive activation of opsin: influence of charge at position 134 and size at position 296 by Cohen (1993)
10.1073/pnas.94.26.14273 / Proc. Natl Acad. Sci. USA / Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state by Kim (1997)
10.1074/jbc.M103747200 / J. Biol. Chem. / Activation of the β2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6 by Ballesteros (2001)
10.1002/qua.10078 / Int. J. Quantum Chem. / Structural motifs as functional microdomains in G-protein-coupled receptors: energetic considerations in the mechanism of activation of the serotonin 5-HT2A receptor by disruption of the ionic lock of the arginine cage by Visiers (2002)
10.1073/pnas.1531970100 / Proc. Natl Acad. Sci. USA / Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin by Yan (2003)
10.1016/j.jmb.2004.02.001 / J. Mol. Biol. / Helix packing moments reveal diversity and conservation in membrane protein structure by Liu (2004)
10.1016/S0006-3495(02)75613-0 / Biophys. J. / Comparison of helix interactions in membrane and soluble α-bundle proteins by Eilers (2002)
10.1016/j.jmb.2005.01.069 / J. Mol. Biol. / Changes in interhelical hydrogen bonding upon rhodopsin activation by Patel (2005)
10.1021/bi960858u / Biochemistry / Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state by Lin (1996)
10.1124/mol.63.1.36 / Mol. Pharmacol. / Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy by Ebersole (2003)
10.1111/j.1751-1097.1979.tb07150.x / Photochem. Photobiol. / Orientation of aromatic residues in rhodopsin. Rotation of one tryptophan upon the meta I to meta II transition after illumination by Chabre (1979)
10.1038/sj.emboj.7600374 / EMBO J. / Electron crystallography reveals the structure of metarhodopsin I by Ruprecht (2004)
10.1146/annurev.neuro.24.1.779 / Annu. Rev. Neurosci. / Activation, deactivation, and adaptation in vertebrate, photoreceptor cells by Burns (2001)
10.1038/nsmb913 / Nature Struct. Mol. Biol. / Essential role for the second extracellular loop in C5a receptor activation by Klco (2005)
10.1111/j.1749-6632.2003.tb03156.x / Ann. NY Acad. Sci. / Molecular mechanism of agonism and inverse agonism in the melanocortin receptors—Zn2+ as a structural and functional probe by Holst (2003)
10.1073/pnas.212519199 / Proc. Natl Acad. Sci. USA / Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants by Reeves (2002)
10.1073/pnas.93.21.11487 / Proc. Natl Acad. Sci. USA / Structure and function in rhodopsin: high level expression of a synthetic bovine opsin gene and its mutants in stable mammalian cell lines by Reeves (1996)
10.1073/pnas.96.2.487 / Proc. Natl Acad. Sci. USA / Magic angle spinning NMR of the protonated retinylidene schiff base nitrogen in rhodopsin: expression of 15N-lysine and 13C-glycine labeled opsin in a stable cell line by Eilers (1999)
10.1016/0042-6822(59)90043-1 / Virology / Plaque production by the polyoma virus by Dulbecco (1959)
10.1016/S0076-6879(02)43137-0 / Methods Enzymol. / Magic angle spinning nuclear magnetic resonance of isotopically labeled rhodopsin by Eilers (2002)
10.1351/pac198557050753 / Pure Appl. Chem. / The synthesis of 13C-labeled retinals by Lugtenburg (1985)
10.1016/S0021-9258(18)42106-0 / J. Biol. Chem. / Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin by Franke (1992)
10.1021/bi972060w / Biochemistry / Role of the C9 methyl group in rhodopsin activation: characterization of mutant opsins with the artificial chromophore 11-cis-9-demethylretinal by Han (1998)
10.1073/pnas.90.21.10206 / Proc. Natl Acad. Sci. USA / Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants by Fahmy (1993)
10.1016/S0014-5793(98)01156-9 / FEBS Letters / Evidence for the specific interaction of a lipid molecule with rhodopsin which is altered in the transition to the active state metarhodopsin II by Beck (1998)
10.1073/pnas.90.16.7849 / Proc. Natl Acad. Sci. USA / Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state by Arnis (1993)
10.1006/jmra.1994.1208 / J. Magn. Reson. ser. A / Ramped-amplitude cross polarization in magic angle spinning NMR by Metz (1994)
10.1063/1.470372 / J. Chem. Phys. / Heteronuclear decoupling in rotating solids by Bennett (1995)
10.1016/S0009-2614(01)00791-6 / Chem. Phys. Letters / 13C–1H dipolar-assisted rotational resonance in magic-angle spinning NMR by Takegoshi (2001)
10.1016/S1043-9471(05)80049-7 / Methods Neurosci. / Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein coupled receptors by Ballesteros (1995)

Dates

Type	When
Created	19 years, 7 months ago (Jan. 19, 2006, 2 p.m.)
Deposited	4 years, 1 month ago (July 22, 2021, 5:08 p.m.)
Indexed	5 months, 1 week ago (March 19, 2025, 6:22 a.m.)
Issued	19 years, 5 months ago (March 1, 2006)
Published	19 years, 5 months ago (March 1, 2006)
Published Print	19 years, 5 months ago (March 1, 2006)

Funders 0

None

BibTeX

@article{Crocker_2006, title={Location of Trp265 in Metarhodopsin II: Implications for the Activation Mechanism of the Visual Receptor Rhodopsin}, volume={357}, ISSN={0022-2836}, url={http://dx.doi.org/10.1016/j.jmb.2005.12.046}, DOI={10.1016/j.jmb.2005.12.046}, number={1}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Crocker, Evan and Eilers, Markus and Ahuja, Shivani and Hornak, Viktor and Hirshfeld, Amiram and Sheves, Mordechai and Smith, Steven O.}, year={2006}, month=mar, pages={163–172} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        3,
        19
      ]
    ],
    "date-time": "2025-03-19T10:22:58Z",
    "timestamp": 1742379778515
  },
  "reference-count": 60,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            3,
            1
          ]
        ],
        "date-time": "2006-03-01T00:00:00Z",
        "timestamp": 1141171200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2006,
        3
      ]
    ]
  },
  "DOI": "10.1016/j.jmb.2005.12.046",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        1,
        19
      ]
    ],
    "date-time": "2006-01-19T19:00:46Z",
    "timestamp": 1137697246000
  },
  "page": "163-172",
  "source": "Crossref",
  "is-referenced-by-count": 118,
  "title": "Location of Trp265 in Metarhodopsin II: Implications for the Activation Mechanism of the Visual Receptor Rhodopsin",
  "prefix": "10.1016",
  "volume": "357",
  "author": [
    {
      "given": "Evan",
      "family": "Crocker",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Markus",
      "family": "Eilers",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shivani",
      "family": "Ahuja",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Viktor",
      "family": "Hornak",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Amiram",
      "family": "Hirshfeld",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mordechai",
      "family": "Sheves",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Steven O.",
      "family": "Smith",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.jmb.2005.12.046_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "1659",
      "DOI": "10.1152/physrev.2001.81.4.1659",
      "article-title": "Rhodopsin: structural basis of molecular physiology",
      "volume": "81",
      "author": "Menon",
      "year": "2001",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "17979",
      "DOI": "10.1074/jbc.273.29.17979",
      "article-title": "G protein-coupled receptors. II. Mechanism of agonist activation",
      "volume": "273",
      "author": "Gether",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "8126",
      "DOI": "10.1074/jbc.M312671200",
      "article-title": "Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions",
      "volume": "279",
      "author": "Madabushi",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "431",
      "DOI": "10.1016/j.tem.2003.09.007",
      "article-title": "Activation of G-protein-coupled receptors: a common molecular mechanism",
      "volume": "14",
      "author": "Karnik",
      "year": "2003",
      "journal-title": "Trends Endocrinol. Metab."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1016/S0065-3233(03)63010-X",
      "article-title": "Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking",
      "volume": "63",
      "author": "Hubbell",
      "year": "2003",
      "journal-title": "Advan. Protein Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "768",
      "DOI": "10.1126/science.274.5288.768",
      "article-title": "Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin",
      "volume": "274",
      "author": "Farrens",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1038/383347a0",
      "article-title": "Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F",
      "volume": "383",
      "author": "Sheikh",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "739",
      "DOI": "10.1126/science.289.5480.739",
      "article-title": "Crystal structure of rhodopsin: a G protein-coupled receptor",
      "volume": "289",
      "author": "Palczewski",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "571",
      "DOI": "10.1016/j.jmb.2004.07.044",
      "article-title": "The retinal conformation and its environment in rhodopsin in light of a new 2.2\u00c5 crystal structure",
      "volume": "342",
      "author": "Okada",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "10048",
      "DOI": "10.1073/pnas.0402848101",
      "article-title": "Coupling of retinal isomerization to the activation of rhodopsin",
      "volume": "101",
      "author": "Patel",
      "year": "2004",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib11",
      "unstructured": "Crocker, E. (2005). Structural changes of a light-activated G protein-coupled receptor determined by solid-state NMR: channeling light energy into the visual pigment rhodopsin. PhD thesis, Stony Brook University."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "1409",
      "DOI": "10.1016/j.jmb.2004.08.090",
      "article-title": "Structure of bovine rhodopsin in a trigonal crystal form",
      "volume": "343",
      "author": "Li",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1126/science.286.5438.255",
      "article-title": "Structural changes in bacteriorhodopsin during ion transport at 2 angstrom resolution",
      "volume": "286",
      "author": "Luecke",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "6221",
      "DOI": "10.1021/jp027702q",
      "article-title": "Protein-\u03b2-ionone ring interactions enhance the light-induced dipole of the chromophore in bacteriorhodopsin",
      "volume": "107",
      "author": "Aharoni",
      "year": "2003",
      "journal-title": "J. Phys. Chem. Ser. B"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "1441",
      "DOI": "10.1093/protein/7.12.1441",
      "article-title": "Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor",
      "volume": "7",
      "author": "Luo",
      "year": "1994",
      "journal-title": "Protein Eng."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "445",
      "DOI": "10.1016/S0165-6147(00)01553-4",
      "article-title": "Hinges, swivels and switches: the role of prolines in signalling via transmembrane \u03b1-helices",
      "volume": "21",
      "author": "Sansom",
      "year": "2000",
      "journal-title": "Trends Pharmacol. Sci."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "6737",
      "DOI": "10.1093/emboj/16.22.6737",
      "article-title": "Agonists induce conformational changes in transmembrane domains III and VI of the \u03b22 adrenoceptor",
      "volume": "16",
      "author": "Gether",
      "year": "1997",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "40989",
      "DOI": "10.1074/jbc.M206801200",
      "article-title": "\u03b22 Adrenergic receptor activation\u2014modulation of the proline kink in transmembrane 6 by a rotamer toggle switch",
      "volume": "277",
      "author": "Shi",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1146/annurev.pharmtox.42.091101.144224",
      "article-title": "The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop",
      "volume": "42",
      "author": "Shi",
      "year": "2002",
      "journal-title": "Annu. Rev. Pharmacol. Toxicol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "2209",
      "DOI": "10.1126/science.288.5474.2209",
      "article-title": "Movement of retinal along the visual transduction path",
      "volume": "288",
      "author": "Borhan",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "719",
      "DOI": "10.1016/j.jmb.2004.08.049",
      "article-title": "The ring of the rhodopsin chromophore in a hydrophobic activation switch within the binding pocket",
      "volume": "343",
      "author": "Spooner",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "23081",
      "DOI": "10.1074/jbc.272.37.23081",
      "article-title": "Partial agonist activity of 11-cis-retinal in rhodopsin mutants",
      "volume": "272",
      "author": "Han",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "32330",
      "DOI": "10.1074/jbc.271.50.32330",
      "article-title": "The effects of amino acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin",
      "volume": "271",
      "author": "Han",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "32337",
      "DOI": "10.1074/jbc.271.50.32337",
      "article-title": "Functional interaction of transmembrane helices 3 and 6 in rhodopsin\u2014replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant",
      "volume": "271",
      "author": "Han",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/S0066-4103(08)60006-X",
      "article-title": "Empirical versus nonempirical evaluation of secondary structure of fibrous and membrane proteins by solid-state NMR: a practical approach",
      "volume": "36",
      "author": "Saito",
      "year": "1998",
      "journal-title": "Annu. Rep. NMR Spectrosc."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "2133",
      "DOI": "10.1002/bip.1978.360170908",
      "article-title": "C-13 NMR chemical-shifts of common amino acid residues measured in aqueous solutions of linear tetrapeptides H-Gly-Gly-X-L-Ala-OH",
      "volume": "17",
      "author": "Richarz",
      "year": "1978",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib27",
      "doi-asserted-by": "crossref",
      "unstructured": "Schmidt-Rohr, K. & Spiess, H. W. (1994). Multidimensional Solid-State NMR and Polymers. pp. 1\u2013496. Academic Press, London.",
      "DOI": "10.1016/B978-0-08-092562-2.50006-0"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1023/B:JNMR.0000019521.79321.3c",
      "article-title": "Dipolar assisted rotational resonance NMR of tryptophan and tyrosine in rhodopsin",
      "volume": "29",
      "author": "Crocker",
      "year": "2004",
      "journal-title": "J. Biomol. NMR"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "8158",
      "DOI": "10.1021/bi00487a025",
      "article-title": "Solid-state NMR studies of the mechanism of the opsin shift in the visual pigment rhodopsin",
      "volume": "29",
      "author": "Smith",
      "year": "1990",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "4809",
      "DOI": "10.1021/ja00303a001",
      "article-title": "High-resolution carbon-13 NMR of retinal derivatives in the solid state",
      "volume": "107",
      "author": "Harbison",
      "year": "1985",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "6111",
      "DOI": "10.1021/bi00074a024",
      "article-title": "Constitutive activation of opsin: influence of charge at position 134 and size at position 296",
      "volume": "32",
      "author": "Cohen",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "14273",
      "DOI": "10.1073/pnas.94.26.14273",
      "article-title": "Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state",
      "volume": "94",
      "author": "Kim",
      "year": "1997",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "29171",
      "DOI": "10.1074/jbc.M103747200",
      "article-title": "Activation of the \u03b22-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6",
      "volume": "276",
      "author": "Ballesteros",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1002/qua.10078",
      "article-title": "Structural motifs as functional microdomains in G-protein-coupled receptors: energetic considerations in the mechanism of activation of the serotonin 5-HT2A receptor by disruption of the ionic lock of the arginine cage",
      "volume": "88",
      "author": "Visiers",
      "year": "2002",
      "journal-title": "Int. J. Quantum Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "9262",
      "DOI": "10.1073/pnas.1531970100",
      "article-title": "Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin",
      "volume": "100",
      "author": "Yan",
      "year": "2003",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1016/j.jmb.2004.02.001",
      "article-title": "Helix packing moments reveal diversity and conservation in membrane protein structure",
      "volume": "337",
      "author": "Liu",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "2720",
      "DOI": "10.1016/S0006-3495(02)75613-0",
      "article-title": "Comparison of helix interactions in membrane and soluble \u03b1-bundle proteins",
      "volume": "82",
      "author": "Eilers",
      "year": "2002",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "803",
      "DOI": "10.1016/j.jmb.2005.01.069",
      "article-title": "Changes in interhelical hydrogen bonding upon rhodopsin activation",
      "volume": "347",
      "author": "Patel",
      "year": "2005",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "11149",
      "DOI": "10.1021/bi960858u",
      "article-title": "Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state",
      "volume": "35",
      "author": "Lin",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "36",
      "DOI": "10.1124/mol.63.1.36",
      "article-title": "Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy",
      "volume": "63",
      "author": "Ebersole",
      "year": "2003",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1111/j.1751-1097.1979.tb07150.x",
      "article-title": "Orientation of aromatic residues in rhodopsin. Rotation of one tryptophan upon the meta I to meta II transition after illumination",
      "volume": "30",
      "author": "Chabre",
      "year": "1979",
      "journal-title": "Photochem. Photobiol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "3609",
      "DOI": "10.1038/sj.emboj.7600374",
      "article-title": "Electron crystallography reveals the structure of metarhodopsin I",
      "volume": "23",
      "author": "Ruprecht",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1146/annurev.neuro.24.1.779",
      "article-title": "Activation, deactivation, and adaptation in vertebrate, photoreceptor cells",
      "volume": "24",
      "author": "Burns",
      "year": "2001",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "320",
      "DOI": "10.1038/nsmb913",
      "article-title": "Essential role for the second extracellular loop in C5a receptor activation",
      "volume": "12",
      "author": "Klco",
      "year": "2005",
      "journal-title": "Nature Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1111/j.1749-6632.2003.tb03156.x",
      "article-title": "Molecular mechanism of agonism and inverse agonism in the melanocortin receptors\u2014Zn2+ as a structural and functional probe",
      "volume": "994",
      "author": "Holst",
      "year": "2003",
      "journal-title": "Ann. NY Acad. Sci."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "13413",
      "DOI": "10.1073/pnas.212519199",
      "article-title": "Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants",
      "volume": "99",
      "author": "Reeves",
      "year": "2002",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "11487",
      "DOI": "10.1073/pnas.93.21.11487",
      "article-title": "Structure and function in rhodopsin: high level expression of a synthetic bovine opsin gene and its mutants in stable mammalian cell lines",
      "volume": "93",
      "author": "Reeves",
      "year": "1996",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1073/pnas.96.2.487",
      "article-title": "Magic angle spinning NMR of the protonated retinylidene schiff base nitrogen in rhodopsin: expression of 15N-lysine and 13C-glycine labeled opsin in a stable cell line",
      "volume": "96",
      "author": "Eilers",
      "year": "1999",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "396",
      "DOI": "10.1016/0042-6822(59)90043-1",
      "article-title": "Plaque production by the polyoma virus",
      "volume": "8",
      "author": "Dulbecco",
      "year": "1959",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "212",
      "DOI": "10.1016/S0076-6879(02)43137-0",
      "article-title": "Magic angle spinning nuclear magnetic resonance of isotopically labeled rhodopsin",
      "volume": "343",
      "author": "Eilers",
      "year": "2002",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "753",
      "DOI": "10.1351/pac198557050753",
      "article-title": "The synthesis of 13C-labeled retinals",
      "volume": "57",
      "author": "Lugtenburg",
      "year": "1985",
      "journal-title": "Pure Appl. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "14767",
      "DOI": "10.1016/S0021-9258(18)42106-0",
      "article-title": "Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin",
      "volume": "267",
      "author": "Franke",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "538",
      "DOI": "10.1021/bi972060w",
      "article-title": "Role of the C9 methyl group in rhodopsin activation: characterization of mutant opsins with the artificial chromophore 11-cis-9-demethylretinal",
      "volume": "37",
      "author": "Han",
      "year": "1998",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "10206",
      "DOI": "10.1073/pnas.90.21.10206",
      "article-title": "Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants",
      "volume": "90",
      "author": "Fahmy",
      "year": "1993",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "304",
      "DOI": "10.1016/S0014-5793(98)01156-9",
      "article-title": "Evidence for the specific interaction of a lipid molecule with rhodopsin which is altered in the transition to the active state metarhodopsin II",
      "volume": "436",
      "author": "Beck",
      "year": "1998",
      "journal-title": "FEBS Letters"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "7849",
      "DOI": "10.1073/pnas.90.16.7849",
      "article-title": "Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state",
      "volume": "90",
      "author": "Arnis",
      "year": "1993",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "219",
      "DOI": "10.1006/jmra.1994.1208",
      "article-title": "Ramped-amplitude cross polarization in magic angle spinning NMR",
      "volume": "110",
      "author": "Metz",
      "year": "1994",
      "journal-title": "J. Magn. Reson. ser. A"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "6951",
      "DOI": "10.1063/1.470372",
      "article-title": "Heteronuclear decoupling in rotating solids",
      "volume": "103",
      "author": "Bennett",
      "year": "1995",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "631",
      "DOI": "10.1016/S0009-2614(01)00791-6",
      "article-title": "13C\u20131H dipolar-assisted rotational resonance in magic-angle spinning NMR",
      "volume": "344",
      "author": "Takegoshi",
      "year": "2001",
      "journal-title": "Chem. Phys. Letters"
    },
    {
      "key": "10.1016/j.jmb.2005.12.046_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "366",
      "DOI": "10.1016/S1043-9471(05)80049-7",
      "article-title": "Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein coupled receptors",
      "volume": "25",
      "author": "Ballesteros",
      "year": "1995",
      "journal-title": "Methods Neurosci."
    }
  ],
  "container-title": "Journal of Molecular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283605016207?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283605016207?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        22
      ]
    ],
    "date-time": "2021-07-22T21:08:25Z",
    "timestamp": 1626988105000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0022283605016207"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        3
      ]
    ]
  },
  "references-count": 60,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2006,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022283605016207"
  ],
  "URL": "http://dx.doi.org/10.1016/j.jmb.2005.12.046",
  "relation": {},
  "ISSN": [
    "0022-2836"
  ],
  "subject": [],
  "container-title-short": "Journal of Molecular Biology",
  "published": {
    "date-parts": [
      [
        2006,
        3
      ]
    ]
  }
}