Crossref
journal-article
Elsevier BV
Journal of Molecular Biology (78)
References
51
Referenced
165
10.1126/science.1072994
/ Science / The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics by Hardy (2002)10.1016/S0165-6147(02)02038-2
/ Trends Pharmacol. Sci. / Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease by Dominguez (2002)10.1021/jm030247h
/ J. Med. Chem. / Human β-secretase (BACE) and BACE inhibitors by John (2003)10.1006/mcne.1999.0811
/ Mol. Cell. Neurosci. / Identification of a novel aspartic protease (Asp2) as β-secretase by Hussain (1999)10.1073/pnas.97.4.1456
/ Proc. Natl Acad. Sci USA / Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein by Lin (2000)10.1038/990114
/ Nature / Purification and cloning of amyloid precursor protein β-secretase from human brain by Sinha (1999)10.1126/science.286.5440.735
/ Science / β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE by Vassar (1999)10.1038/85064
/ Nature Neurosci. / BACE1 is the major beta-secretase for generation of Aβ peptides by neurons by Cai (2001)10.1038/85059
/ Nature Neurosci. / Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation by Luo (2001)10.1016/S0896-6273(03)00810-9
/ Neuron / BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease by Ohno (2004)10.1126/science.290.5489.150
/ Science / Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor by Hong (2000)10.1021/bi026232n
/ Biochemistry / Crystal structure of memapsin 2 (β-secretase) complexed with an inhibitor OM00-3 by Hong (2002)10.1385/JMN:20:3:299
/ J. Mol. Neurosci. / Study of memapsin 2 (β-secretase) and strategy of inhibitor design by Tang (2003)10.1016/S1359-6446(02)02245-6
/ Drug Discov. Today / Structure-based screening of low-affinity compounds by Carr (2002)10.1021/jm010425b
/ J. Med. Chem. / Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles by Bursavich (2002)10.2174/1568026024607490
/ Curr. Top. Med. Chem. / Inhibition of BACE, a promising approach to Alzheimer's disease therapy by Roggo (2002)10.1021/jm025619l
/ J. Med. Chem. / Design and synthesis of statine-based cell-permeable inhibitors of human β-secretase by Hom (2003)10.1016/j.bmcl.2003.09.084
/ Bioorg. Med. Chem. Letters / Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR by Lamar (2004)10.1016/j.pep.2003.12.014
/ Protein Expr. Purif. / A general procedure for the purification of human β-secretase expressed in Escherichia coli by Sardana (2004)10.1016/S1046-5928(02)00516-8
/ Protein Expr. Purif. / Recombinant insect cell expression and purification of human β-secretase (BACE-1) for X-ray crystallography by Bruinzeel (2002)10.1074/jbc.M005339200
/ J. Biol. Chem. / A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase by Bennett (2000)10.1021/bi001494f
/ Biochemistry / Proteolytic activation of recombinant pro-memapsin 2 (pro-β-secretase) studied with new fluorogenic substrates by Ermolieff (2000)10.1016/S1074-5521(00)00134-4
/ Chem. Biol. / Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin by Raheul (2000)10.1016/S0006-291X(03)01451-7
/ Biochem. Biophys. Res. Commun. / Structure-based design of aliskiren, a novel orally effective renin inhibitor by Wood (2003)10.1021/bi0498252
/ Biochemistry / Flap position of free memapsin 2 (β-secretase), a model for flap opening in aspartic protease catalysis by Hong (2004)10.1002/prot.340080110
/ Proteins: Struct. Funct. Genet. / The three-dimensional structure of recombinant bovine chymosin at 2.3A resolution by Gilliland (1990)10.1016/S1074-5521(99)89004-8
/ Chem. Biol. / Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteases? by Oefner (1999)10.1016/S0960-894X(99)00196-1
/ Bioorg. Med. Chem. Letters / Piperidine–renin inhibitors with improved physicochemical properties by Güller (1999)10.1016/S0960-894X(99)00195-X
/ Bioorg. Med. Chem. Letters / Substituted piperidines—highly potent renin inhibitors due to induced fit adaption of the active site by Vieira (1999)10.1002/hlca.200390176
/ Helvet. Chim. Acta / Development of a new class of inhibitors for the malarial aspartic protease plasmepsin II based on a central 7-azabicyclo[2.2.1]heptane scaffold by Carcache (2003)10.1016/S0021-9258(18)54894-8
/ J. Biol. Chem. / Crystallographic analysis at 3.0A resolution of the binding to human thrombin of four active site-directed inhibitors by Banner (1991)10.1107/S0907444994003112
/ Acta Crystallog. sect. D / The CCP4 suite: programs for protein crystallography (1994){'key': '10.1016/j.jmb.2004.08.018_bib33', 'article-title': 'Recent changes to the MOSFLM package for processing film and image plate data', 'author': 'Leslie', 'year': '1992'}
/ Recent changes to the MOSFLM package for processing film and image plate data by Leslie (1992)10.1107/S0907444998012517
/ Acta Crystallog. sect. D / Rapid automated molecular replacement by evolutionary search by Kissinger (1999)10.1107/S0907444997005696
/ Acta Crystallog. sect. D / wARP: improvement and extension of crystallographic phases by weighted averaging of multiple refined dummy atomic models by Perrakis (1997)10.1023/A:1023813504011
/ J. Comput. Aided Mol. Des. / AstexViewer: a visualisation aid for structure-based drug design by Hartshorn (2002)10.1006/jmbi.1993.1351
/ J. Mol. Biol. / Main-chain bond lengths and bond angles in protein structures by Laskowski (1993)10.1002/pro.5560040516
/ Protein Sci. / Crystal structure of human pepsin and its complex with pepstatin by Fujinaga (1995)10.1016/0022-2836(90)90153-D
/ J. Mol. Biol. / Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8Å resolution by Sielecki (1990)10.1016/0022-2836(90)90156-G
/ J. Mol. Biol. / X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3Å resolution by Cooper (1990)10.1038/357466a0
/ Nature / X-ray analyses of peptide–inhibitor complexes define the structural basis of specificity for human and mouse renins by Dhanaraj (1992)10.1126/science.2493678
/ Science / Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5Å resolution by Sielecki (1989)10.1073/pnas.90.14.6796
/ Proc. Natl Acad. Sci. USA / Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design by Baldwin (1993)10.1107/S0907444901005972
/ Acta Crystallog. sect. D / Structure of aspergillopepsin I from Aspergillus phoenicis: variations of the S1′-S2 subsite in aspartic proteinases by Cho (2001)10.1016/0014-5793(84)81085-6
/ FEBS Letters / The active site of aspartic proteinases by Pearl (1984){'key': '10.1016/j.jmb.2004.08.018_bib46', 'first-page': '260', 'article-title': 'X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0A resolution of the aspartic proteinase from Mucor pusillus', 'volume': '230', 'author': 'Newman', 'year': '1993', 'journal-title': 'J. Mol. Biol.'}
/ J. Mol. Biol. / X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0A resolution of the aspartic proteinase from Mucor pusillus by Newman (1993)10.1006/jmbi.1997.0968
/ J. Mol. Biol. / Crystal structure of the aspartic proteinase from Rhizomucor miehei at 2.15Å resolution by Yang (1997)10.1016/0022-2836(87)90411-6
/ J. Mol. Biol. / Structure and refinement at 1.8Å resolution of the aspartic proteinase from Rhizopus chinensis by Suguna (1987)10.1016/S0006-291X(02)00742-8
/ Biochem. Biophys. Res. Commun. / An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae by Gustchina (2002)10.1016/S0022-2836(03)00078-0
/ J. Mol. Biol. / Crystal structures of Aspergillus oryzae aspartic proteinase and its complex with an inhibitor pepstatin at 1.9Å resolution by Kamitori (2003)10.1016/0022-2836(83)90008-6
/ J. Mol. Biol. / Structure and refinement of penicillopepsin at 1.8Å resolution by James (1983)
Dates
Type | When |
---|---|
Created | 21 years ago (Aug. 27, 2004, 2:24 p.m.) |
Deposited | 4 years, 2 months ago (June 25, 2021, 3:13 a.m.) |
Indexed | 4 months, 3 weeks ago (April 14, 2025, 9:25 a.m.) |
Issued | 20 years, 11 months ago (Oct. 1, 2004) |
Published | 20 years, 11 months ago (Oct. 1, 2004) |
Published Print | 20 years, 11 months ago (Oct. 1, 2004) |
@article{Patel_2004, title={Apo and Inhibitor Complex Structures of BACE (β-secretase)}, volume={343}, ISSN={0022-2836}, url={http://dx.doi.org/10.1016/j.jmb.2004.08.018}, DOI={10.1016/j.jmb.2004.08.018}, number={2}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Patel, Sahil and Vuillard, Laurent and Cleasby, Anne and Murray, Christopher W. and Yon, Jeff}, year={2004}, month=oct, pages={407–416} }