DOI: 10.1016/j.jconrel.2012.06.002. Improvement of drug safety by the use of lipid-based nanocarriers

Improvement of drug safety by the use of lipid-based nanocarriers

10.1016/j.jconrel.2012.06.002

Crossref journal-article

Elsevier BV

Journal of Controlled Release (78)

Bibliography

Lim, S. B., Banerjee, A., & ÃnyÃ¼ksel, H. (2012). Improvement of drug safety by the use of lipid-based nanocarriers. Journal of Controlled Release, 163(1), 34â45.

Authors 3

Sok Bee Lim (first)
Amrita Banerjee (additional)
Hayat Önyüksel (additional)

References 143 Referenced 268

10.4155/fmc.09.37 / Future Med. Chem. / Medicinal chemistry at a crossroads: challenges and new possibilities by Ojima (2009)
10.1007/s11948-006-0014-y / Sci. Eng. Ethics / Evaluation of drug toxicity in clinical trials by Splawinski (2006)
10.1056/NEJMp058029 / N. Engl. J. Med. / Safety in numbers—monitoring risk in approved drugs by Okie (2005)
{'key': '10.1016/j.jconrel.2012.06.002_bb0020', 'first-page': '617', 'article-title': 'Cardiovascular effects of cyclooxygenase-2 inhibitors', 'volume': '23', 'author': 'Brophy', 'year': '2007', 'journal-title': 'Curr. Opin. Gastroenterol.'} / Curr. Opin. Gastroenterol. / Cardiovascular effects of cyclooxygenase-2 inhibitors by Brophy (2007)
10.1016/j.sapharm.2008.10.002 / Res. Soc. Adm. Pharm. / Pharmaceutical product withdrawal: attributions of blame and its impact on trust by Bunniran (2009)
10.1001/archinte.167.16.1752 / Arch. Intern. Med. / Serious adverse drug events reported to the food and drug administration, 1998–2005 by Moore (2007)
10.1211/jpp.57.10.0001 / J. Pharm. Pharmacol. / Drug delivery to tumours: recent strategies by Reddy (2005)
10.3816/CLM.2008.n.001 / Clin. Lymphoma Myeloma / Clinical pharmacology of liposomal anthracyclines: focus on pegylated liposomal doxorubicin by Soloman (2008)
10.1016/S0300-9084(98)80009-6 / Biochimie / Preclinical development of camptothecin derivatives and clinical trials in pediatric oncology by Vassal (1998)
{'key': '10.1016/j.jconrel.2012.06.002_bb0050', 'first-page': '233', 'article-title': 'Dose and outcome: the hurdle of neutropenia (review)', 'volume': '16', 'author': 'Marangolo', 'year': '2006', 'journal-title': 'Oncol. Rep.'} / Oncol. Rep. / Dose and outcome: the hurdle of neutropenia (review) by Marangolo (2006)
10.1053/j.seminhematol.2005.12.009 / Semin. Hematol. / Purine analogue-based chemotherapy regimens for second-line therapy in patients with chronic lymphocytic leukemia by Lamanna (2006)
{'key': '10.1016/j.jconrel.2012.06.002_bb0060', 'first-page': '1245', 'article-title': 'Taxanes and gemcitabine doublets in the management of HER-2 negative metastatic breast cancer: towards optimization of association and schedule', 'volume': '28', 'author': 'Metro', 'year': '2008', 'journal-title': 'Anticancer. Res.'} / Anticancer. Res. / Taxanes and gemcitabine doublets in the management of HER-2 negative metastatic breast cancer: towards optimization of association and schedule by Metro (2008)
{'key': '10.1016/j.jconrel.2012.06.002_bb0065', 'first-page': '455', 'article-title': 'Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management', 'volume': '6', 'author': 'Swain', 'year': '2008', 'journal-title': 'Clin. Adv. Hematol. Oncol.'} / Clin. Adv. Hematol. Oncol. / Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management by Swain (2008)
10.2165/00003088-200342070-00005 / Clin. Pharmacokinet. / Pharmacological effects of formulation vehicles: implications for cancer chemotherapy by ten Tije (2003)
10.1016/j.addr.2007.08.044 / Adv. Drug Deliv. Rev. / Protein nanoparticles as drug carriers in clinical medicine by Hawkins (2008)
10.1177/089686080702702s52 / Perit. Dial. Int. / Pure red-cell aplasia “epidemic”—mystery completely revealed? by Locatelli (2007)
10.1093/ndt/gfh1092 / Nephrol. Dial. Transplant. / Factors influencing the immunogenicity of therapeutic proteins by Schellekens (2005)
10.1002/jps.2600840427 / J. Pharm. Sci. / Effect of pH on injection phlebitis by Simamora (1995)
10.1208/pt070105 / AAPS PharmSciTech / Reformulation of a new vancomycin analog: an example of the importance of buffer species and strength by Johnson (2006)
10.1016/j.peptides.2006.03.003 / Peptides / Human VIP-alpha: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension by Onyuksel (2006)
10.1248/yakushi.128.269 / Yakugaku Zasshi / Lipid carriers: a versatile delivery vehicle for proteins and peptides by Rawat (2008)
10.1016/j.addr.2007.10.013 / Adv. Drug Deliv. Rev. / Advances in lipid nanodispersions for parenteral drug delivery and targeting by Constantinides (2008)
10.1007/s11095-006-9132-0 / Pharm. Res. / Micellar nanocarriers: pharmaceutical perspectives by Torchilin (2007)
10.1002/jps.20150 / J. Pharm. Sci. / In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: effects of PEG chain length and PC incorporation by Ashok (2004)
{'key': '10.1016/j.jconrel.2012.06.002_bb0125', 'first-page': '595', 'article-title': 'Lipid-based colloidal carriers for peptide and protein delivery—liposomes versus lipid nanoparticles', 'volume': '2', 'author': 'Martins', 'year': '2007', 'journal-title': 'Int. J. Nanomedicine'} / Int. J. Nanomedicine / Lipid-based colloidal carriers for peptide and protein delivery—liposomes versus lipid nanoparticles by Martins (2007)
10.2174/156720105774370267 / Curr. Drug Deliv. / Engineering of nanoemulsions for drug delivery by Sarker (2005)
10.1023/A:1022243709003 / Pharm. Res. / Sterically stabilized phospholipid mixed micelles: in vitro evaluation as a novel carrier for water-insoluble drugs by Krishnadas (2003)
10.2174/156720107782151269 / Curr. Drug Deliv. / Liposomal drug delivery systems: an update review by Samad (2007)
10.2147/nano.2006.1.4.417 / Int. J. Nanomedicine / Optimizing efficacy of amphotericin B through nanomodification by Vyas (2006)
10.1093/annonc/mdj100 / Ann. Oncol. / Novel formulations of taxanes: a review. Old wine in a new bottle? by Hennenfent (2006)
10.1093/jnci/djm027 / J. Natl. Cancer Inst. / Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin by Tang (2007)
10.1007/s11095-010-0330-4 / Pharm. Res. / Actively targeted low-dose camptothecin as a safe, long-acting, disease-modifying nanomedicine for rheumatoid arthritis by Koo (2011)
10.1023/A:1018847501985 / Pharm. Res. / A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo by Onyuksel (1999)
10.2147/IJN.S25363 / Int. J. Nanomedicine / Rehydrated sterically stabilized phospholipid nanomicelles of budesonide for nebulization: physicochemical characterization and in vitro, in vivo evaluations by Sahib (2011)
10.1016/j.ijpharm.2007.10.014 / Int. J. Pharm. / Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis by Ye (2008)
10.1016/j.jconrel.2005.02.028 / J. Control. Release / Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in dalton's lymphoma tumor bearing mice by Harivardhan Reddy (2005)
10.1016/j.jconrel.2004.01.002 / J. Control. Release / Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice by Oyewumi (2004)
{'key': '10.1016/j.jconrel.2012.06.002_bb0190', 'article-title': 'FDA approvals: nascobal nasal spray, PTC 124, tocosol paclitaxel', 'author': 'Waknine', 'year': '2005', 'journal-title': 'Medscape Med. News'} / Medscape Med. News / FDA approvals: nascobal nasal spray, PTC 124, tocosol paclitaxel by Waknine (2005)
10.1016/j.ijpharm.2007.06.035 / Int. J. Pharm. / Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine by Singh (2008)
10.1038/sj.leu.2401921 / Leukemia / A phase I/II study of multiple-dose intravenous busulfan as myeloablation prior to stem cell transplantation by Olavarria (2000)
10.1093/jac/45.1.77 / J. Antimicrob. Chemother. / Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine mycobacterium avium infection by Peters (2000)
10.1111/j.1440-1711.2005.01315.x / Immunol. Cell Biol. / Lipid based particulate formulations for the delivery of antigen by Copland (2005)
10.1016/j.nano.2005.06.004 / Nanomed. Nanotechnol. Biol. Med. / Role of nanotechnology in targeted drug delivery and imaging: a concise review by Koo (2005)
10.1016/j.ijpharm.2010.04.027 / Int. J. Pharm. / Dendrimer toxicity: let's meet the challenge by Jain (2010)
10.1038/nbt0708-774 / Nat. Biotechnol. / The long and short of carbon nanotube toxicity by Kostarelos (2008)
10.1021/bc049951i / Bioconjug. Chem. / Toxicity of gold nanoparticles functionalized with cationic and anionic side chains by Goodman (2004)
10.2217/nnm.10.106 / Nanomedicine (Lond.) / Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects by Soenen (2010)
{'key': '10.1016/j.jconrel.2012.06.002_bb0240', 'first-page': '3351', 'article-title': 'Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model', 'volume': '6', 'author': 'Hu', 'year': '2011', 'journal-title': 'Int. J. Nanomedicine'} / Int. J. Nanomedicine / Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model by Hu (2011)
{'key': '10.1016/j.jconrel.2012.06.002_bb0245', 'series-title': 'Phospholipids Handbook', 'author': 'Cevc', 'year': '1993'} / Phospholipids Handbook by Cevc (1993)
10.1016/S0899-9007(00)00381-6 / Nutrition / Lipid clearance and total parenteral nutrition: the importance of monitoring plasma lipids by Crook (2000)
10.2174/0929867033457430 / Curr. Med. Chem. / Cationic liposomes for gene delivery: from biophysics to biological applications by Pedroso de Lima (2003)
10.1016/S0169-409X(97)00128-2 / Adv. Drug Deliv. Rev. / Interactions of liposomes and lipid-based carrier systems with blood proteins: relation to clearance behaviour in vivo by Semple (1998)
10.1016/j.jconrel.2010.04.003 / J. Control. Release / Complement activation cascade triggered by PEG-PL engineered nanomedicines and carbon nanotubes: the challenges ahead by Moghimi (2010)
10.1016/j.molimm.2008.08.276 / Mol. Immunol. / Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process by Hamad (2008)
10.1021/bc200551b / Bioconjug. Chem. / Role of the methoxy group in immune responses to mPEG-protein conjugates by Sherman (2012)
{'key': '10.1016/j.jconrel.2012.06.002_bb0280', 'first-page': '297', 'article-title': 'The effect of nonionic surfactant structure on hemolysis', 'volume': '70', 'author': 'Ohnish', 'year': '1993', 'journal-title': 'J. Am. Oil Chem. Soc.'} / J. Am. Oil Chem. Soc. / The effect of nonionic surfactant structure on hemolysis by Ohnish (1993)
10.1016/0006-2952(90)90399-6 / Biochem. Pharmacol. / Surfactant-induced cell toxicity and cell lysis: a study using B16 melanoma cells by Partearroyo (1990)
10.1016/j.addr.2007.11.008 / Adv. Drug Deliv. Rev. / Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects by Wong (2008)
10.1016/j.ijpharm.2008.08.024 / Int. J. Pharm. / VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: a novel targeted nanomedicine for breast cancer by Onyuksel (2009)
10.1016/j.nano.2008.09.001 / Nanomedicine / Self-associated indisulam in phospholipid-based nanomicelles: a potential nanomedicine for cancer by Cesur (2009)
10.1016/j.ejpb.2008.04.016 / Eur. J. Pharm. Biopharm. / Mixed PEG–PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity by Sawant (2008)
10.1097/00006982-198707040-00005 / Retina / Intravitreal injection of liposome-encapsulated ganciclovir in a rabbit model by Peyman (1987)
10.1016/j.ejpb.2008.06.020 / Eur. J. Pharm. Biopharm. / Exploring the use of novel drug delivery systems for antiretroviral drugs by Ojewole (2008)
10.1016/j.ijpharm.2008.08.008 / Int. J. Pharm. / A novel liposomal formulation of flavopiridol by Yang (2009)
10.1016/S0168-3659(99)00007-3 / J. Control. Release / Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain by Yang (1999)
10.1016/j.jconrel.2004.07.032 / J. Control. Release / Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders by Lim (2004)
10.1211/jpp.59.7.0004 / J. Pharm. Pharmacol. / Transferrin-conjugated solid lipid nanoparticles for enhanced delivery of quinine dihydrochloride to the brain by Gupta (2007)
10.1016/j.jconrel.2005.06.006 / J. Control. Release / Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration by Manjunath (2005)
10.1016/j.ijpharm.2004.02.018 / Int. J. Pharm. / Structural characterisation of water—Tween 40®/Imwitor 308®–isopropyl myristate microemulsions using different experimental methods by Podlogar (2004)
10.1021/mp8000556 / Mol. Pharm. / Nanoemulsion preparations of the anticancer drug dacarbazine significantly increase its efficacy in a xenograft mouse melanoma model by Tagne (2008)
10.1021/mp700091j / Mol. Pharm. / A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line by Tagne (2008)
10.1038/nrd1494 / Nat. Rev. Drug Discov. / Nanosuspensions in drug delivery by Rabinow (2004)
10.1016/S0140-6736(02)07952-7 / Lancet / Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study by Zander (2002)
10.2174/1381612033455206 / Curr. Pharm. Des. / Interactions of VIP, secretin and PACAP(1–38) with phospholipids: a biological paradox revisited by Krishnadas (2003)
10.1016/S0196-9781(02)00092-X / Peptides / Interactions of human secretin with sterically stabilized phospholipid micelles amplify peptide-induced vasodilation in vivo by Gandhi (2002)
10.1016/j.ijpharm.2008.01.014 / Int. J. Pharm. / Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles by Lim (2008)
10.1016/j.peptides.2004.05.013 / Peptides / Effects of peptide molecular mass and PEG chain length on the vasoreactivity of VIP and PACAP1–38 in pegylated phospholipid micelles by Ashok (2004)
10.1016/j.peptides.2003.08.007 / Peptides / Human galanin expresses amphipathic properties that modulate its vasoreactivity in vivo by Dagar (2003)
10.1007/s11095-012-0718-4 / Pharm. Res. / Human pancreatic polypeptide in a phospholipid based micellar formulation by Banerjee (2012)
10.1016/j.nano.2011.01.004 / Nanomed. Nanotechnol. Biol. Med. / Micellar nanomedicine of human neuropeptide Y by Kuzmis (2011)
10.1016/j.ejphar.2003.11.046 / Eur. J. Pharmacol. / α-Helical structure in the C-terminus of vasoactive intestinal peptide: functional and structural consequences by Onoue (2004)
10.1016/j.colsurfb.2008.02.001 / Colloids Surf., B / Membrane interactions of ternary phospholipid/cholesterol bilayers and encapsulation efficiencies of a RIP II protein by Manojlovic (2008)
10.1016/j.ijpharm.2008.01.046 / Int. J. Pharm. / Inhalable liposomal formulation for vasoactive intestinal peptide by Hajos (2008)
V. Sethi, H. Onyuksel, I. Rubinstein, Liposomal vasoactive intestinal peptide, in: Methods in Enzymology, vol. 391, Academic Press, 2005, pp. 377–395. (10.1016/S0076-6879(05)91021-5)
10.1111/j.1538-7836.2007.02856.x / J. Thromb. Haemost. / Safety and pharmacokinetics of a recombinant factor VIII with pegylated liposomes in severe hemophilia A by Powell (2008)
10.1016/j.ijpharm.2006.02.028 / Int. J. Pharm. / Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in spontaneously hypertensive hamsters by Rubinstein (2006)
10.1016/j.ejpb.2007.07.006 / Eur. J. Pharm. Biopharm. / Cyclosporine-loaded solid lipid nanoparticles (SLN®): drug–lipid physicochemical interactions and characterization of drug incorporation by Müller (2008)
10.1016/j.addr.2007.04.007 / Adv. Drug Deliv. Rev. / Solid lipid nanoparticles as a drug delivery system for peptides and proteins by Almeida (2007)
{'key': '10.1016/j.jconrel.2012.06.002_bb0445', 'first-page': '743', 'article-title': 'Oral insulin delivery by means of solid lipid nanoparticles', 'volume': '2', 'author': 'Sarmento', 'year': '2007', 'journal-title': 'Int. J. Nanomedicine'} / Int. J. Nanomedicine / Oral insulin delivery by means of solid lipid nanoparticles by Sarmento (2007)
10.1016/j.addr.2003.12.002 / Adv. Drug Deliv. Rev. / Solid lipid nanoparticles for parenteral drug delivery by Wissing (2004)
10.1007/s00262-008-0539-9 / Cancer Immunol. Immunother. / The antitumor immune responses induced by nanoemulsion-encapsulated MAGE1-HSP70/SEA complex protein vaccine following peroral administration route by Ge (2009)
10.1166/jnn.2006.459 / J. Nanosci. Nanotechnol. / Development and comparative anti-microbial evaluation of lipid nanoparticles and nanoemulsion of polymyxin B by Pattani (2006)
10.1016/j.phrs.2003.12.015 / Pharmacol. Res. / Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome by Namiki (2004)
10.1016/S0168-3659(02)00442-X / J. Control. Release / Lipid-derivatized poly(ethylene glycol) micellar formulations of benzoporphyrin derivatives by Zhang (2003)
10.1080/10611860802102175 / J. Drug Target. / Photodynamic therapy of experimental B-16 melanoma in mice with tumor-targeted 5,10,15,20-tetraphenylporphin-loaded PEG-PE micelles by Skidan (2008)
10.1021/mp060015p / Mol. Pharm. / Diacyllipid micelle-based nanocarrier for magnetically guided delivery of drugs in photodynamic therapy by Cinteza (2006)
10.1016/j.addr.2012.02.006 / Adv. Drug Deliv. Rev. / Photochemical mechanisms of light-triggered release from nanocarriers by Fomina (2012)
10.1093/annonc/mdh097 / Ann. Oncol. / Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer by O'Brien (2004)
10.1200/JCO.2001.19.5.1444 / J. Clin. Oncol. / Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer by Batist (2001)
10.1016/j.ejpb.2008.09.003 / Eur. J. Pharm. Biopharm. / Lipid nanoparticles for parenteral delivery of actives by Joshi (2009)
10.1038/nmat2992 / Nat. Mater. / The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers by Ashley (2011)
10.1016/j.cbi.2007.03.008 / Chem. Biol. Interact. / Intracellular delivery of VIP-grafted sterically stabilized phospholipid mixed nanomicelles in human breast cancer cells by Rubinstein (2008)
10.1016/j.canlet.2008.09.041 / Cancer Lett. / Nanomicellar paclitaxel increases cytotoxicity of multidrug resistant breast cancer cells by Onyuksel (2009)
10.1016/S0168-3659(03)00242-6 / J. Control. Release / VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: In vivo studies by Dagar (2003)
10.1038/nmat2986 / Nat. Mater. / Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents by Lovell (2011)
10.2174/187152011796817682 / Anticancer Agents Med. Chem. / Nanoparticles in oncology: the new theragnostic molecules by Allegra (2011)
10.2174/138161207780618966 / Curr. Pharm. Des. / Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator by Gonzalez-Rey (2007)
10.1016/j.biomaterials.2007.06.011 / Biomaterials / Active targeting of brain tumors using nanocarriers by Béduneau (2007)
10.3109/10611869808997876 / J. Drug Target. / In vitro targeting of acoustically reflective immunoliposomes to fibrin under various flow conditions by Demos (1998)
10.1016/j.ijpharm.2008.01.041 / Int. J. Pharm. / Tumor-specific antibody-mediated targeted delivery of doxil® reduces the manifestation of auricular erythema side effect in mice by Elbayoumi (2008)
10.1158/0008-5472.CAN-06-2731 / Cancer Res. / Anti-HER2 cationic immunoemulsion as a potential targeted drug delivery system for the treatment of prostate cancer by Goldstein (2007)
10.1016/S1474-4422(08)70110-8 / Lancet Neurol. / Getting specific: monoclonal antibodies in multiple sclerosis by Lutterotti (2008)
10.1007/s11882-008-0012-z / Curr. Allergy Asthma Rep. / Cutaneous adverse reactions to therapeutic monoclonal antibodies for cancer by Myskowski (2008)
10.1021/bc060080h / Bioconjug. Chem. / "SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers by Sawant (2006)
10.1016/j.ejpb.2008.09.026 / Eur. J. Pharm. Biopharm. / Multifunctional and stimuli-sensitive pharmaceutical nanocarriers by Torchilin (2009)
10.1016/j.jconrel.2007.12.017 / J. Control. Release / A review of stimuli-responsive nanocarriers for drug and gene delivery by Ganta (2008)
10.1158/1535-7163.MCT-05-0543 / Mol. Cancer Ther. / Intracellular uptake and intracavitary targeting of folate-conjugated liposomes in a mouse lymphoma model with up-regulated folate receptors by Shmeeda (2006)
10.1158/1535-7163.MCT-05-0543 / J. Drug Target. / Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumor cells by Gupta (2007)
10.1080/10611860701289719 / Cancer Chemother. Pharmacol. / Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study by Pires (2009)
10.1007/s00280-008-0738-2 / Mol. Imaging / Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents by Glickson (2008)
{'key': '10.1016/j.jconrel.2012.06.002_bb0610', 'first-page': '948', 'article-title': 'Investigation of a new injectable thermosensitive hydrogel loading solid lipid nanoparticles', 'volume': '66', 'author': 'Guo', 'year': '2011', 'journal-title': 'Pharmazie'} / Pharmazie / Investigation of a new injectable thermosensitive hydrogel loading solid lipid nanoparticles by Guo (2011)
10.1152/ajpheart.2000.279.3.H1319 / Am. J. Physiol. Heart Circ. Physiol. / Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction by Szebeni (2000)
10.1016/j.addr.2009.03.009 / Adv. Drug Deliv. Rev. / Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy by Aggarwal (2009)
10.1016/j.addr.2009.03.009 / Proc. Natl. Acad. Sci. U. S. A. / Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts by Lundqvist (2008)
10.1073/pnas.0805135105 / Langmuir / Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol) by Zahr (2006)
10.1021/la060951b / Pharmazie / Pegnology: a review of PEG-ylated systems by Bhadra (2002)
10.2147/IJN.S28531 / Int. J. Nanomedicine / Size and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages by Yu (2012)
10.2147/IJN.S28531 / Cell. Mol. Biol. (Noisy-le-grand) / Polyethyleneglycols and immunocamouflage of the cells tissues and organs for transplantation by Eugene (2004)
{'issue': 'Suppl. 1', 'key': '10.1016/j.jconrel.2012.06.002_bb0650', 'first-page': '13', 'article-title': 'Engineering improved pharmaceuticals for enhanced therapy', 'volume': '28', 'author': 'Pegylation', 'year': '2002', 'journal-title': 'Cancer Treat. Rev.'} / Cancer Treat. Rev. / Engineering improved pharmaceuticals for enhanced therapy by Pegylation (2002)
10.1089/cbr.2005.20.620 / Cancer Biother. Radiopharm. / Polyethylene glycol (PEG) modified 99mTc-HMPAO-liposome for improving blood circulation and biodistribution: the effect of the extent of PEGylation by Lee (2005)
10.1089/cbr.2005.20.620 / Eur. J. Pharm. Biopharm. / Long-circulating poly(ethylene glycol)-coated emulsions to target solid tumors by Rossi (2007)
10.1016/j.ejpb.2007.03.016 / Controlled Drug Delivery: Fundamentals and Applications by Robinson (1993)
10.2165/00003088-200140070-00005 / Clin. Pharmacokinet. / Pegylation: a novel process for modifying pharmacokinetics by Harris (2001)
10.2165/00003088-200140070-00005 / Pharmacol. Rev. / Long-circulating and target-specific nanoparticles: theory to practice by Moghimi (2001)
10.1016/j.addr.2003.12.004 / Adv. Drug Deliv. Rev. / Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs by Lukyanov (2004)
10.1016/j.addr.2003.12.004 / J. Drug Target. / The architecture of ligand attachment to nanocarriers controls their specific interaction with target cells by Sawant (2008)
10.1080/10611860802230240 / Clin. Pharmacokinet. / Pharmacokinetic drug interactions with phenytoin (part I) by Nation (1990)
10.2165/00003088-199018010-00003 / Drugs / Protein binding displacement interactions and their clinical importance by McElnay (1983)
10.2165/00003495-198325050-00003 / Clin. Pharmacokinet. / Disease-induced variations in plasma protein levels. Implications for drug dosage regimens (part I) by Zini (1990)
10.2165/00003088-199019020-00004 / Int. J. Pharm. / Solid lipid nanoparticles as drug carriers: II. Plasma stability and biodistribution of solid lipid nanoparticles containing the lipophilic prodrug 3′-azido-3′-deoxythymidine palmitate in mice by Heiati (1998)
10.1016/S0378-5173(98)00236-1 / J. Liposome Res. / Avoiding untoward immune responses to novel gene products by Sehon (2002)
10.1081/LPR-120004793 / BioDrugs / Current and future applications of immunological attenuation via pegylation of cells and tissue by Chen (2001)
10.2165/00063030-200115120-00005 / Curr. Drug Deliv. / Development of novel lyophilized mixed micelle amphotericin B formulation for treatment of systemic fungal infection by Naik (2005)

Dates

Type	When
Created	13 years, 2 months ago (June 12, 2012, 2:15 p.m.)
Deposited	3 years, 7 months ago (Jan. 17, 2022, 2:52 p.m.)
Indexed	2 days, 8 hours ago (Aug. 24, 2025, 6:51 p.m.)
Issued	12 years, 10 months ago (Oct. 1, 2012)
Published	12 years, 10 months ago (Oct. 1, 2012)
Published Print	12 years, 10 months ago (Oct. 1, 2012)

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BibTeX

@article{Lim_2012, title={Improvement of drug safety by the use of lipid-based nanocarriers}, volume={163}, ISSN={0168-3659}, url={http://dx.doi.org/10.1016/j.jconrel.2012.06.002}, DOI={10.1016/j.jconrel.2012.06.002}, number={1}, journal={Journal of Controlled Release}, publisher={Elsevier BV}, author={Lim, Sok Bee and Banerjee, Amrita and Önyüksel, Hayat}, year={2012}, month=oct, pages={34–45} }

JSON

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      "DOI": "10.4155/fmc.09.37",
      "article-title": "Medicinal chemistry at a crossroads: challenges and new possibilities",
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      "author": "Ojima",
      "year": "2009",
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    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0010",
      "doi-asserted-by": "crossref",
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      "DOI": "10.1007/s11948-006-0014-y",
      "article-title": "Evaluation of drug toxicity in clinical trials",
      "volume": "12",
      "author": "Splawinski",
      "year": "2006",
      "journal-title": "Sci. Eng. Ethics"
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    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0015",
      "doi-asserted-by": "crossref",
      "first-page": "1173",
      "DOI": "10.1056/NEJMp058029",
      "article-title": "Safety in numbers\u2014monitoring risk in approved drugs",
      "volume": "352",
      "author": "Okie",
      "year": "2005",
      "journal-title": "N. Engl. J. Med."
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    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0020",
      "first-page": "617",
      "article-title": "Cardiovascular effects of cyclooxygenase-2 inhibitors",
      "volume": "23",
      "author": "Brophy",
      "year": "2007",
      "journal-title": "Curr. Opin. Gastroenterol."
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    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0025",
      "doi-asserted-by": "crossref",
      "first-page": "262",
      "DOI": "10.1016/j.sapharm.2008.10.002",
      "article-title": "Pharmaceutical product withdrawal: attributions of blame and its impact on trust",
      "volume": "5",
      "author": "Bunniran",
      "year": "2009",
      "journal-title": "Res. Soc. Adm. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0030",
      "doi-asserted-by": "crossref",
      "first-page": "1752",
      "DOI": "10.1001/archinte.167.16.1752",
      "article-title": "Serious adverse drug events reported to the food and drug administration, 1998\u20132005",
      "volume": "167",
      "author": "Moore",
      "year": "2007",
      "journal-title": "Arch. Intern. Med."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0035",
      "doi-asserted-by": "crossref",
      "first-page": "1231",
      "DOI": "10.1211/jpp.57.10.0001",
      "article-title": "Drug delivery to tumours: recent strategies",
      "volume": "57",
      "author": "Reddy",
      "year": "2005",
      "journal-title": "J. Pharm. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0040",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.3816/CLM.2008.n.001",
      "article-title": "Clinical pharmacology of liposomal anthracyclines: focus on pegylated liposomal doxorubicin",
      "volume": "8",
      "author": "Soloman",
      "year": "2008",
      "journal-title": "Clin. Lymphoma Myeloma"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0045",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1016/S0300-9084(98)80009-6",
      "article-title": "Preclinical development of camptothecin derivatives and clinical trials in pediatric oncology",
      "volume": "80",
      "author": "Vassal",
      "year": "1998",
      "journal-title": "Biochimie"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0050",
      "first-page": "233",
      "article-title": "Dose and outcome: the hurdle of neutropenia (review)",
      "volume": "16",
      "author": "Marangolo",
      "year": "2006",
      "journal-title": "Oncol. Rep."
    },
    {
      "issue": "Suppl. 2",
      "key": "10.1016/j.jconrel.2012.06.002_bb0055",
      "doi-asserted-by": "crossref",
      "first-page": "S44",
      "DOI": "10.1053/j.seminhematol.2005.12.009",
      "article-title": "Purine analogue-based chemotherapy regimens for second-line therapy in patients with chronic lymphocytic leukemia",
      "volume": "43",
      "author": "Lamanna",
      "year": "2006",
      "journal-title": "Semin. Hematol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0060",
      "first-page": "1245",
      "article-title": "Taxanes and gemcitabine doublets in the management of HER-2 negative metastatic breast cancer: towards optimization of association and schedule",
      "volume": "28",
      "author": "Metro",
      "year": "2008",
      "journal-title": "Anticancer. Res."
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    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0065",
      "first-page": "455",
      "article-title": "Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management",
      "volume": "6",
      "author": "Swain",
      "year": "2008",
      "journal-title": "Clin. Adv. Hematol. Oncol."
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    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0070",
      "doi-asserted-by": "crossref",
      "first-page": "665",
      "DOI": "10.2165/00003088-200342070-00005",
      "article-title": "Pharmacological effects of formulation vehicles: implications for cancer chemotherapy",
      "volume": "42",
      "author": "ten Tije",
      "year": "2003",
      "journal-title": "Clin. Pharmacokinet."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0075",
      "doi-asserted-by": "crossref",
      "first-page": "876",
      "DOI": "10.1016/j.addr.2007.08.044",
      "article-title": "Protein nanoparticles as drug carriers in clinical medicine",
      "volume": "60",
      "author": "Hawkins",
      "year": "2008",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "issue": "Suppl. 2",
      "key": "10.1016/j.jconrel.2012.06.002_bb0080",
      "doi-asserted-by": "crossref",
      "first-page": "S303",
      "DOI": "10.1177/089686080702702s52",
      "article-title": "Pure red-cell aplasia \u201cepidemic\u201d\u2014mystery completely revealed?",
      "volume": "27",
      "author": "Locatelli",
      "year": "2007",
      "journal-title": "Perit. Dial. Int."
    },
    {
      "issue": "Suppl. 6",
      "key": "10.1016/j.jconrel.2012.06.002_bb0085",
      "doi-asserted-by": "crossref",
      "first-page": "vi3",
      "DOI": "10.1093/ndt/gfh1092",
      "article-title": "Factors influencing the immunogenicity of therapeutic proteins",
      "volume": "20",
      "author": "Schellekens",
      "year": "2005",
      "journal-title": "Nephrol. Dial. Transplant."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0090",
      "doi-asserted-by": "crossref",
      "first-page": "520",
      "DOI": "10.1002/jps.2600840427",
      "article-title": "Effect of pH on injection phlebitis",
      "volume": "84",
      "author": "Simamora",
      "year": "1995",
      "journal-title": "J. Pharm. Sci."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0095",
      "doi-asserted-by": "crossref",
      "first-page": "E5",
      "DOI": "10.1208/pt070105",
      "article-title": "Reformulation of a new vancomycin analog: an example of the importance of buffer species and strength",
      "volume": "7",
      "author": "Johnson",
      "year": "2006",
      "journal-title": "AAPS PharmSciTech"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0100",
      "doi-asserted-by": "crossref",
      "first-page": "2271",
      "DOI": "10.1016/j.peptides.2006.03.003",
      "article-title": "Human VIP-alpha: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension",
      "volume": "27",
      "author": "Onyuksel",
      "year": "2006",
      "journal-title": "Peptides"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0105",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1248/yakushi.128.269",
      "article-title": "Lipid carriers: a versatile delivery vehicle for proteins and peptides",
      "volume": "128",
      "author": "Rawat",
      "year": "2008",
      "journal-title": "Yakugaku Zasshi"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0110",
      "doi-asserted-by": "crossref",
      "first-page": "757",
      "DOI": "10.1016/j.addr.2007.10.013",
      "article-title": "Advances in lipid nanodispersions for parenteral drug delivery and targeting",
      "volume": "60",
      "author": "Constantinides",
      "year": "2008",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0115",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1007/s11095-006-9132-0",
      "article-title": "Micellar nanocarriers: pharmaceutical perspectives",
      "volume": "24",
      "author": "Torchilin",
      "year": "2007",
      "journal-title": "Pharm. Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0120",
      "doi-asserted-by": "crossref",
      "first-page": "2476",
      "DOI": "10.1002/jps.20150",
      "article-title": "In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: effects of PEG chain length and PC incorporation",
      "volume": "93",
      "author": "Ashok",
      "year": "2004",
      "journal-title": "J. Pharm. Sci."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0125",
      "first-page": "595",
      "article-title": "Lipid-based colloidal carriers for peptide and protein delivery\u2014liposomes versus lipid nanoparticles",
      "volume": "2",
      "author": "Martins",
      "year": "2007",
      "journal-title": "Int. J. Nanomedicine"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0130",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.2174/156720105774370267",
      "article-title": "Engineering of nanoemulsions for drug delivery",
      "volume": "2",
      "author": "Sarker",
      "year": "2005",
      "journal-title": "Curr. Drug Deliv."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0135",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1023/A:1022243709003",
      "article-title": "Sterically stabilized phospholipid mixed micelles: in vitro evaluation as a novel carrier for water-insoluble drugs",
      "volume": "20",
      "author": "Krishnadas",
      "year": "2003",
      "journal-title": "Pharm. Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0140",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.2174/156720107782151269",
      "article-title": "Liposomal drug delivery systems: an update review",
      "volume": "4",
      "author": "Samad",
      "year": "2007",
      "journal-title": "Curr. Drug Deliv."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0145",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.2147/nano.2006.1.4.417",
      "article-title": "Optimizing efficacy of amphotericin B through nanomodification",
      "volume": "1",
      "author": "Vyas",
      "year": "2006",
      "journal-title": "Int. J. Nanomedicine"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0150",
      "doi-asserted-by": "crossref",
      "first-page": "735",
      "DOI": "10.1093/annonc/mdj100",
      "article-title": "Novel formulations of taxanes: a review. Old wine in a new bottle?",
      "volume": "17",
      "author": "Hennenfent",
      "year": "2006",
      "journal-title": "Ann. Oncol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0155",
      "doi-asserted-by": "crossref",
      "first-page": "1004",
      "DOI": "10.1093/jnci/djm027",
      "article-title": "Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin",
      "volume": "99",
      "author": "Tang",
      "year": "2007",
      "journal-title": "J. Natl. Cancer Inst."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0160",
      "doi-asserted-by": "crossref",
      "first-page": "776",
      "DOI": "10.1007/s11095-010-0330-4",
      "article-title": "Actively targeted low-dose camptothecin as a safe, long-acting, disease-modifying nanomedicine for rheumatoid arthritis",
      "volume": "28",
      "author": "Koo",
      "year": "2011",
      "journal-title": "Pharm. Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0165",
      "doi-asserted-by": "crossref",
      "first-page": "155",
      "DOI": "10.1023/A:1018847501985",
      "article-title": "A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo",
      "volume": "16",
      "author": "Onyuksel",
      "year": "1999",
      "journal-title": "Pharm. Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0170",
      "doi-asserted-by": "crossref",
      "first-page": "2351",
      "DOI": "10.2147/IJN.S25363",
      "article-title": "Rehydrated sterically stabilized phospholipid nanomicelles of budesonide for nebulization: physicochemical characterization and in vitro, in vivo evaluations",
      "volume": "6",
      "author": "Sahib",
      "year": "2011",
      "journal-title": "Int. J. Nanomedicine"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0175",
      "doi-asserted-by": "crossref",
      "first-page": "273",
      "DOI": "10.1016/j.ijpharm.2007.10.014",
      "article-title": "Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis",
      "volume": "352",
      "author": "Ye",
      "year": "2008",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0180",
      "doi-asserted-by": "crossref",
      "first-page": "185",
      "DOI": "10.1016/j.jconrel.2005.02.028",
      "article-title": "Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in dalton's lymphoma tumor bearing mice",
      "volume": "105",
      "author": "Harivardhan Reddy",
      "year": "2005",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0185",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1016/j.jconrel.2004.01.002",
      "article-title": "Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice",
      "volume": "95",
      "author": "Oyewumi",
      "year": "2004",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0190",
      "article-title": "FDA approvals: nascobal nasal spray, PTC 124, tocosol paclitaxel",
      "author": "Waknine",
      "year": "2005",
      "journal-title": "Medscape Med. News"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0195",
      "doi-asserted-by": "crossref",
      "first-page": "136",
      "DOI": "10.1016/j.ijpharm.2007.06.035",
      "article-title": "Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine",
      "volume": "347",
      "author": "Singh",
      "year": "2008",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0200",
      "doi-asserted-by": "crossref",
      "first-page": "1954",
      "DOI": "10.1038/sj.leu.2401921",
      "article-title": "A phase I/II study of multiple-dose intravenous busulfan as myeloablation prior to stem cell transplantation",
      "volume": "14",
      "author": "Olavarria",
      "year": "2000",
      "journal-title": "Leukemia"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0205",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1093/jac/45.1.77",
      "article-title": "Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine mycobacterium avium infection",
      "volume": "45",
      "author": "Peters",
      "year": "2000",
      "journal-title": "J. Antimicrob. Chemother."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0210",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1111/j.1440-1711.2005.01315.x",
      "article-title": "Lipid based particulate formulations for the delivery of antigen",
      "volume": "83",
      "author": "Copland",
      "year": "2005",
      "journal-title": "Immunol. Cell Biol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0215",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1016/j.nano.2005.06.004",
      "article-title": "Role of nanotechnology in targeted drug delivery and imaging: a concise review",
      "volume": "1",
      "author": "Koo",
      "year": "2005",
      "journal-title": "Nanomed. Nanotechnol. Biol. Med."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0220",
      "doi-asserted-by": "crossref",
      "first-page": "122",
      "DOI": "10.1016/j.ijpharm.2010.04.027",
      "article-title": "Dendrimer toxicity: let's meet the challenge",
      "volume": "394",
      "author": "Jain",
      "year": "2010",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0225",
      "doi-asserted-by": "crossref",
      "first-page": "774",
      "DOI": "10.1038/nbt0708-774",
      "article-title": "The long and short of carbon nanotube toxicity",
      "volume": "26",
      "author": "Kostarelos",
      "year": "2008",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0230",
      "doi-asserted-by": "crossref",
      "first-page": "897",
      "DOI": "10.1021/bc049951i",
      "article-title": "Toxicity of gold nanoparticles functionalized with cationic and anionic side chains",
      "volume": "15",
      "author": "Goodman",
      "year": "2004",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0235",
      "doi-asserted-by": "crossref",
      "first-page": "1261",
      "DOI": "10.2217/nnm.10.106",
      "article-title": "Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects",
      "volume": "5",
      "author": "Soenen",
      "year": "2010",
      "journal-title": "Nanomedicine (Lond.)"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0240",
      "first-page": "3351",
      "article-title": "Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model",
      "volume": "6",
      "author": "Hu",
      "year": "2011",
      "journal-title": "Int. J. Nanomedicine"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0245",
      "series-title": "Phospholipids Handbook",
      "author": "Cevc",
      "year": "1993"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0250",
      "doi-asserted-by": "crossref",
      "first-page": "774",
      "DOI": "10.1016/S0899-9007(00)00381-6",
      "article-title": "Lipid clearance and total parenteral nutrition: the importance of monitoring plasma lipids",
      "volume": "16",
      "author": "Crook",
      "year": "2000",
      "journal-title": "Nutrition"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0255",
      "doi-asserted-by": "crossref",
      "first-page": "1221",
      "DOI": "10.2174/0929867033457430",
      "article-title": "Cationic liposomes for gene delivery: from biophysics to biological applications",
      "volume": "10",
      "author": "Pedroso de Lima",
      "year": "2003",
      "journal-title": "Curr. Med. Chem."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0260",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/S0169-409X(97)00128-2",
      "article-title": "Interactions of liposomes and lipid-based carrier systems with blood proteins: relation to clearance behaviour in vivo",
      "volume": "32",
      "author": "Semple",
      "year": "1998",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0265",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1016/j.jconrel.2010.04.003",
      "article-title": "Complement activation cascade triggered by PEG-PL engineered nanomedicines and carbon nanotubes: the challenges ahead",
      "volume": "146",
      "author": "Moghimi",
      "year": "2010",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0270",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1016/j.molimm.2008.08.276",
      "article-title": "Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process",
      "volume": "46",
      "author": "Hamad",
      "year": "2008",
      "journal-title": "Mol. Immunol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0275",
      "doi-asserted-by": "crossref",
      "first-page": "485",
      "DOI": "10.1021/bc200551b",
      "article-title": "Role of the methoxy group in immune responses to mPEG-protein conjugates",
      "volume": "23",
      "author": "Sherman",
      "year": "2012",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0280",
      "first-page": "297",
      "article-title": "The effect of nonionic surfactant structure on hemolysis",
      "volume": "70",
      "author": "Ohnish",
      "year": "1993",
      "journal-title": "J. Am. Oil Chem. Soc."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0285",
      "doi-asserted-by": "crossref",
      "first-page": "1323",
      "DOI": "10.1016/0006-2952(90)90399-6",
      "article-title": "Surfactant-induced cell toxicity and cell lysis: a study using B16 melanoma cells",
      "volume": "40",
      "author": "Partearroyo",
      "year": "1990",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0290",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1016/j.addr.2007.11.008",
      "article-title": "Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects",
      "volume": "60",
      "author": "Wong",
      "year": "2008",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0295",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/j.ijpharm.2008.08.024",
      "article-title": "VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: a novel targeted nanomedicine for breast cancer",
      "volume": "365",
      "author": "Onyuksel",
      "year": "2009",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0300",
      "doi-asserted-by": "crossref",
      "first-page": "178",
      "DOI": "10.1016/j.nano.2008.09.001",
      "article-title": "Self-associated indisulam in phospholipid-based nanomicelles: a potential nanomedicine for cancer",
      "volume": "5",
      "author": "Cesur",
      "year": "2009",
      "journal-title": "Nanomedicine"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0305",
      "doi-asserted-by": "crossref",
      "first-page": "51",
      "DOI": "10.1016/j.ejpb.2008.04.016",
      "article-title": "Mixed PEG\u2013PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity",
      "volume": "70",
      "author": "Sawant",
      "year": "2008",
      "journal-title": "Eur. J. Pharm. Biopharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0310",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1097/00006982-198707040-00005",
      "article-title": "Intravitreal injection of liposome-encapsulated ganciclovir in a rabbit model",
      "volume": "7",
      "author": "Peyman",
      "year": "1987",
      "journal-title": "Retina"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0315",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1016/j.ejpb.2008.06.020",
      "article-title": "Exploring the use of novel drug delivery systems for antiretroviral drugs",
      "volume": "70",
      "author": "Ojewole",
      "year": "2008",
      "journal-title": "Eur. J. Pharm. Biopharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0320",
      "doi-asserted-by": "crossref",
      "first-page": "170",
      "DOI": "10.1016/j.ijpharm.2008.08.008",
      "article-title": "A novel liposomal formulation of flavopiridol",
      "volume": "365",
      "author": "Yang",
      "year": "2009",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0325",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1016/S0168-3659(99)00007-3",
      "article-title": "Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain",
      "volume": "59",
      "author": "Yang",
      "year": "1999",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0330",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1016/j.jconrel.2004.07.032",
      "article-title": "Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders",
      "volume": "100",
      "author": "Lim",
      "year": "2004",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0335",
      "doi-asserted-by": "crossref",
      "first-page": "935",
      "DOI": "10.1211/jpp.59.7.0004",
      "article-title": "Transferrin-conjugated solid lipid nanoparticles for enhanced delivery of quinine dihydrochloride to the brain",
      "volume": "59",
      "author": "Gupta",
      "year": "2007",
      "journal-title": "J. Pharm. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0340",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1016/j.jconrel.2005.06.006",
      "article-title": "Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration",
      "volume": "107",
      "author": "Manjunath",
      "year": "2005",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0345",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1016/j.ijpharm.2004.02.018",
      "article-title": "Structural characterisation of water\u2014Tween 40\u00ae/Imwitor 308\u00ae\u2013isopropyl myristate microemulsions using different experimental methods",
      "volume": "276",
      "author": "Podlogar",
      "year": "2004",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0350",
      "doi-asserted-by": "crossref",
      "first-page": "1055",
      "DOI": "10.1021/mp8000556",
      "article-title": "Nanoemulsion preparations of the anticancer drug dacarbazine significantly increase its efficacy in a xenograft mouse melanoma model",
      "volume": "5",
      "author": "Tagne",
      "year": "2008",
      "journal-title": "Mol. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0355",
      "doi-asserted-by": "crossref",
      "first-page": "280",
      "DOI": "10.1021/mp700091j",
      "article-title": "A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line",
      "volume": "5",
      "author": "Tagne",
      "year": "2008",
      "journal-title": "Mol. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0360",
      "doi-asserted-by": "crossref",
      "first-page": "785",
      "DOI": "10.1038/nrd1494",
      "article-title": "Nanosuspensions in drug delivery",
      "volume": "3",
      "author": "Rabinow",
      "year": "2004",
      "journal-title": "Nat. Rev. Drug Discov."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0365",
      "doi-asserted-by": "crossref",
      "first-page": "824",
      "DOI": "10.1016/S0140-6736(02)07952-7",
      "article-title": "Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and \u03b2-cell function in type 2 diabetes: a parallel-group study",
      "volume": "359",
      "author": "Zander",
      "year": "2002",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0370",
      "doi-asserted-by": "crossref",
      "first-page": "1005",
      "DOI": "10.2174/1381612033455206",
      "article-title": "Interactions of VIP, secretin and PACAP(1\u201338) with phospholipids: a biological paradox revisited",
      "volume": "9",
      "author": "Krishnadas",
      "year": "2003",
      "journal-title": "Curr. Pharm. Des."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0375",
      "doi-asserted-by": "crossref",
      "first-page": "1433",
      "DOI": "10.1016/S0196-9781(02)00092-X",
      "article-title": "Interactions of human secretin with sterically stabilized phospholipid micelles amplify peptide-induced vasodilation in vivo",
      "volume": "23",
      "author": "Gandhi",
      "year": "2002",
      "journal-title": "Peptides"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0380",
      "doi-asserted-by": "crossref",
      "first-page": "345",
      "DOI": "10.1016/j.ijpharm.2008.01.014",
      "article-title": "Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles",
      "volume": "356",
      "author": "Lim",
      "year": "2008",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0385",
      "doi-asserted-by": "crossref",
      "first-page": "1253",
      "DOI": "10.1016/j.peptides.2004.05.013",
      "article-title": "Effects of peptide molecular mass and PEG chain length on the vasoreactivity of VIP and PACAP1\u201338 in pegylated phospholipid micelles",
      "volume": "25",
      "author": "Ashok",
      "year": "2004",
      "journal-title": "Peptides"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0390",
      "doi-asserted-by": "crossref",
      "first-page": "1373",
      "DOI": "10.1016/j.peptides.2003.08.007",
      "article-title": "Human galanin expresses amphipathic properties that modulate its vasoreactivity in vivo",
      "volume": "24",
      "author": "Dagar",
      "year": "2003",
      "journal-title": "Peptides"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0395",
      "doi-asserted-by": "crossref",
      "first-page": "1698",
      "DOI": "10.1007/s11095-012-0718-4",
      "article-title": "Human pancreatic polypeptide in a phospholipid based micellar formulation",
      "volume": "29",
      "author": "Banerjee",
      "year": "2012",
      "journal-title": "Pharm. Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0400",
      "doi-asserted-by": "crossref",
      "first-page": "464",
      "DOI": "10.1016/j.nano.2011.01.004",
      "article-title": "Micellar nanomedicine of human neuropeptide Y",
      "volume": "7",
      "author": "Kuzmis",
      "year": "2011",
      "journal-title": "Nanomed. Nanotechnol. Biol. Med."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0405",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1016/j.ejphar.2003.11.046",
      "article-title": "\u03b1-Helical structure in the C-terminus of vasoactive intestinal peptide: functional and structural consequences",
      "volume": "485",
      "author": "Onoue",
      "year": "2004",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0410",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1016/j.colsurfb.2008.02.001",
      "article-title": "Membrane interactions of ternary phospholipid/cholesterol bilayers and encapsulation efficiencies of a RIP II protein",
      "volume": "64",
      "author": "Manojlovic",
      "year": "2008",
      "journal-title": "Colloids Surf., B"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0415",
      "doi-asserted-by": "crossref",
      "first-page": "286",
      "DOI": "10.1016/j.ijpharm.2008.01.046",
      "article-title": "Inhalable liposomal formulation for vasoactive intestinal peptide",
      "volume": "357",
      "author": "Hajos",
      "year": "2008",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0420",
      "doi-asserted-by": "crossref",
      "unstructured": "V. Sethi, H. Onyuksel, I. Rubinstein, Liposomal vasoactive intestinal peptide, in: Methods in Enzymology, vol. 391, Academic Press, 2005, pp. 377\u2013395.",
      "DOI": "10.1016/S0076-6879(05)91021-5"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0425",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1111/j.1538-7836.2007.02856.x",
      "article-title": "Safety and pharmacokinetics of a recombinant factor VIII with pegylated liposomes in severe hemophilia A",
      "volume": "6",
      "author": "Powell",
      "year": "2008",
      "journal-title": "J. Thromb. Haemost."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0430",
      "doi-asserted-by": "crossref",
      "first-page": "144",
      "DOI": "10.1016/j.ijpharm.2006.02.028",
      "article-title": "Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in spontaneously hypertensive hamsters",
      "volume": "316",
      "author": "Rubinstein",
      "year": "2006",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0435",
      "doi-asserted-by": "crossref",
      "first-page": "535",
      "DOI": "10.1016/j.ejpb.2007.07.006",
      "article-title": "Cyclosporine-loaded solid lipid nanoparticles (SLN\u00ae): drug\u2013lipid physicochemical interactions and characterization of drug incorporation",
      "volume": "68",
      "author": "M\u00fcller",
      "year": "2008",
      "journal-title": "Eur. J. Pharm. Biopharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0440",
      "doi-asserted-by": "crossref",
      "first-page": "478",
      "DOI": "10.1016/j.addr.2007.04.007",
      "article-title": "Solid lipid nanoparticles as a drug delivery system for peptides and proteins",
      "volume": "59",
      "author": "Almeida",
      "year": "2007",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0445",
      "first-page": "743",
      "article-title": "Oral insulin delivery by means of solid lipid nanoparticles",
      "volume": "2",
      "author": "Sarmento",
      "year": "2007",
      "journal-title": "Int. J. Nanomedicine"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0450",
      "doi-asserted-by": "crossref",
      "first-page": "1257",
      "DOI": "10.1016/j.addr.2003.12.002",
      "article-title": "Solid lipid nanoparticles for parenteral drug delivery",
      "volume": "56",
      "author": "Wissing",
      "year": "2004",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0455",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1007/s00262-008-0539-9",
      "article-title": "The antitumor immune responses induced by nanoemulsion-encapsulated MAGE1-HSP70/SEA complex protein vaccine following peroral administration route",
      "volume": "58",
      "author": "Ge",
      "year": "2009",
      "journal-title": "Cancer Immunol. Immunother."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0460",
      "doi-asserted-by": "crossref",
      "first-page": "2986",
      "DOI": "10.1166/jnn.2006.459",
      "article-title": "Development and comparative anti-microbial evaluation of lipid nanoparticles and nanoemulsion of polymyxin B",
      "volume": "6",
      "author": "Pattani",
      "year": "2006",
      "journal-title": "J. Nanosci. Nanotechnol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0465",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1016/j.phrs.2003.12.015",
      "article-title": "Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome",
      "volume": "50",
      "author": "Namiki",
      "year": "2004",
      "journal-title": "Pharmacol. Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0470",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1016/S0168-3659(02)00442-X",
      "article-title": "Lipid-derivatized poly(ethylene glycol) micellar formulations of benzoporphyrin derivatives",
      "volume": "86",
      "author": "Zhang",
      "year": "2003",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0475",
      "doi-asserted-by": "crossref",
      "first-page": "486",
      "DOI": "10.1080/10611860802102175",
      "article-title": "Photodynamic therapy of experimental B-16 melanoma in mice with tumor-targeted 5,10,15,20-tetraphenylporphin-loaded PEG-PE micelles",
      "volume": "16",
      "author": "Skidan",
      "year": "2008",
      "journal-title": "J. Drug Target."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0480",
      "doi-asserted-by": "crossref",
      "first-page": "415",
      "DOI": "10.1021/mp060015p",
      "article-title": "Diacyllipid micelle-based nanocarrier for magnetically guided delivery of drugs in photodynamic therapy",
      "volume": "3",
      "author": "Cinteza",
      "year": "2006",
      "journal-title": "Mol. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0485",
      "doi-asserted-by": "crossref",
      "first-page": "1005",
      "DOI": "10.1016/j.addr.2012.02.006",
      "article-title": "Photochemical mechanisms of light-triggered release from nanocarriers",
      "volume": "64",
      "author": "Fomina",
      "year": "2012",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0490",
      "doi-asserted-by": "crossref",
      "first-page": "440",
      "DOI": "10.1093/annonc/mdh097",
      "article-title": "Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer",
      "volume": "15",
      "author": "O'Brien",
      "year": "2004",
      "journal-title": "Ann. Oncol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0495",
      "doi-asserted-by": "crossref",
      "first-page": "1444",
      "DOI": "10.1200/JCO.2001.19.5.1444",
      "article-title": "Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer",
      "volume": "19",
      "author": "Batist",
      "year": "2001",
      "journal-title": "J. Clin. Oncol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0505",
      "doi-asserted-by": "crossref",
      "first-page": "161",
      "DOI": "10.1016/j.ejpb.2008.09.003",
      "article-title": "Lipid nanoparticles for parenteral delivery of actives",
      "volume": "71",
      "author": "Joshi",
      "year": "2009",
      "journal-title": "Eur. J. Pharm. Biopharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0510",
      "doi-asserted-by": "crossref",
      "first-page": "389",
      "DOI": "10.1038/nmat2992",
      "article-title": "The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers",
      "volume": "10",
      "author": "Ashley",
      "year": "2011",
      "journal-title": "Nat. Mater."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0515",
      "doi-asserted-by": "crossref",
      "first-page": "190",
      "DOI": "10.1016/j.cbi.2007.03.008",
      "article-title": "Intracellular delivery of VIP-grafted sterically stabilized phospholipid mixed nanomicelles in human breast cancer cells",
      "volume": "171",
      "author": "Rubinstein",
      "year": "2008",
      "journal-title": "Chem. Biol. Interact."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0520",
      "doi-asserted-by": "crossref",
      "first-page": "327",
      "DOI": "10.1016/j.canlet.2008.09.041",
      "article-title": "Nanomicellar paclitaxel increases cytotoxicity of multidrug resistant breast cancer cells",
      "volume": "274",
      "author": "Onyuksel",
      "year": "2009",
      "journal-title": "Cancer Lett."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0525",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1016/S0168-3659(03)00242-6",
      "article-title": "VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: In vivo studies",
      "volume": "91",
      "author": "Dagar",
      "year": "2003",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0530",
      "doi-asserted-by": "crossref",
      "first-page": "324",
      "DOI": "10.1038/nmat2986",
      "article-title": "Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents",
      "volume": "10",
      "author": "Lovell",
      "year": "2011",
      "journal-title": "Nat. Mater."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0535",
      "doi-asserted-by": "crossref",
      "first-page": "669",
      "DOI": "10.2174/187152011796817682",
      "article-title": "Nanoparticles in oncology: the new theragnostic molecules",
      "volume": "11",
      "author": "Allegra",
      "year": "2011",
      "journal-title": "Anticancer Agents Med. Chem."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0540",
      "doi-asserted-by": "crossref",
      "first-page": "1113",
      "DOI": "10.2174/138161207780618966",
      "article-title": "Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator",
      "volume": "13",
      "author": "Gonzalez-Rey",
      "year": "2007",
      "journal-title": "Curr. Pharm. Des."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0545",
      "doi-asserted-by": "crossref",
      "first-page": "4947",
      "DOI": "10.1016/j.biomaterials.2007.06.011",
      "article-title": "Active targeting of brain tumors using nanocarriers",
      "volume": "28",
      "author": "B\u00e9duneau",
      "year": "2007",
      "journal-title": "Biomaterials"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0550",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.3109/10611869808997876",
      "article-title": "In vitro targeting of acoustically reflective immunoliposomes to fibrin under various flow conditions",
      "volume": "5",
      "author": "Demos",
      "year": "1998",
      "journal-title": "J. Drug Target."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0555",
      "doi-asserted-by": "crossref",
      "first-page": "272",
      "DOI": "10.1016/j.ijpharm.2008.01.041",
      "article-title": "Tumor-specific antibody-mediated targeted delivery of doxil\u00ae reduces the manifestation of auricular erythema side effect in mice",
      "volume": "357",
      "author": "Elbayoumi",
      "year": "2008",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0560",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1158/0008-5472.CAN-06-2731",
      "article-title": "Anti-HER2 cationic immunoemulsion as a potential targeted drug delivery system for the treatment of prostate cancer",
      "volume": "67",
      "author": "Goldstein",
      "year": "2007",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0565",
      "doi-asserted-by": "crossref",
      "first-page": "538",
      "DOI": "10.1016/S1474-4422(08)70110-8",
      "article-title": "Getting specific: monoclonal antibodies in multiple sclerosis",
      "volume": "7",
      "author": "Lutterotti",
      "year": "2008",
      "journal-title": "Lancet Neurol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0570",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1007/s11882-008-0012-z",
      "article-title": "Cutaneous adverse reactions to therapeutic monoclonal antibodies for cancer",
      "volume": "8",
      "author": "Myskowski",
      "year": "2008",
      "journal-title": "Curr. Allergy Asthma Rep."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0575",
      "doi-asserted-by": "crossref",
      "first-page": "943",
      "DOI": "10.1021/bc060080h",
      "article-title": "\"SMART\" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers",
      "volume": "17",
      "author": "Sawant",
      "year": "2006",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0580",
      "doi-asserted-by": "crossref",
      "first-page": "431",
      "DOI": "10.1016/j.ejpb.2008.09.026",
      "article-title": "Multifunctional and stimuli-sensitive pharmaceutical nanocarriers",
      "volume": "71",
      "author": "Torchilin",
      "year": "2009",
      "journal-title": "Eur. J. Pharm. Biopharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0585",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1016/j.jconrel.2007.12.017",
      "article-title": "A review of stimuli-responsive nanocarriers for drug and gene delivery",
      "volume": "126",
      "author": "Ganta",
      "year": "2008",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0590",
      "doi-asserted-by": "crossref",
      "first-page": "818",
      "DOI": "10.1158/1535-7163.MCT-05-0543",
      "article-title": "Intracellular uptake and intracavitary targeting of folate-conjugated liposomes in a mouse lymphoma model with up-regulated folate receptors",
      "volume": "5",
      "author": "Shmeeda",
      "year": "2006",
      "journal-title": "Mol. Cancer Ther."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0595",
      "doi-asserted-by": "crossref",
      "first-page": "231",
      "DOI": "10.1158/1535-7163.MCT-05-0543",
      "article-title": "Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumor cells",
      "volume": "15",
      "author": "Gupta",
      "year": "2007",
      "journal-title": "J. Drug Target."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0600",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1080/10611860701289719",
      "article-title": "Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study",
      "volume": "63",
      "author": "Pires",
      "year": "2009",
      "journal-title": "Cancer Chemother. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0605",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1007/s00280-008-0738-2",
      "article-title": "Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents",
      "volume": "7",
      "author": "Glickson",
      "year": "2008",
      "journal-title": "Mol. Imaging"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0610",
      "first-page": "948",
      "article-title": "Investigation of a new injectable thermosensitive hydrogel loading solid lipid nanoparticles",
      "volume": "66",
      "author": "Guo",
      "year": "2011",
      "journal-title": "Pharmazie"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0615",
      "doi-asserted-by": "crossref",
      "first-page": "H1319",
      "DOI": "10.1152/ajpheart.2000.279.3.H1319",
      "article-title": "Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction",
      "volume": "279",
      "author": "Szebeni",
      "year": "2000",
      "journal-title": "Am. J. Physiol. Heart Circ. Physiol."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0620",
      "doi-asserted-by": "crossref",
      "first-page": "428",
      "DOI": "10.1016/j.addr.2009.03.009",
      "article-title": "Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy",
      "volume": "61",
      "author": "Aggarwal",
      "year": "2009",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0625",
      "doi-asserted-by": "crossref",
      "first-page": "14265",
      "DOI": "10.1016/j.addr.2009.03.009",
      "article-title": "Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts",
      "volume": "105",
      "author": "Lundqvist",
      "year": "2008",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0630",
      "doi-asserted-by": "crossref",
      "first-page": "8178",
      "DOI": "10.1073/pnas.0805135105",
      "article-title": "Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol)",
      "volume": "22",
      "author": "Zahr",
      "year": "2006",
      "journal-title": "Langmuir"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0635",
      "doi-asserted-by": "crossref",
      "first-page": "5",
      "DOI": "10.1021/la060951b",
      "article-title": "Pegnology: a review of PEG-ylated systems",
      "volume": "57",
      "author": "Bhadra",
      "year": "2002",
      "journal-title": "Pharmazie"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0640",
      "doi-asserted-by": "crossref",
      "first-page": "799",
      "DOI": "10.2147/IJN.S28531",
      "article-title": "Size and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages",
      "volume": "2012",
      "author": "Yu",
      "year": "2012",
      "journal-title": "Int. J. Nanomedicine"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0645",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.2147/IJN.S28531",
      "article-title": "Polyethyleneglycols and immunocamouflage of the cells tissues and organs for transplantation",
      "volume": "50",
      "author": "Eugene",
      "year": "2004",
      "journal-title": "Cell. Mol. Biol. (Noisy-le-grand)"
    },
    {
      "issue": "Suppl. 1",
      "key": "10.1016/j.jconrel.2012.06.002_bb0650",
      "first-page": "13",
      "article-title": "Engineering improved pharmaceuticals for enhanced therapy",
      "volume": "28",
      "author": "Pegylation",
      "year": "2002",
      "journal-title": "Cancer Treat. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0655",
      "doi-asserted-by": "crossref",
      "first-page": "620",
      "DOI": "10.1089/cbr.2005.20.620",
      "article-title": "Polyethylene glycol (PEG) modified 99mTc-HMPAO-liposome for improving blood circulation and biodistribution: the effect of the extent of PEGylation",
      "volume": "20",
      "author": "Lee",
      "year": "2005",
      "journal-title": "Cancer Biother. Radiopharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0660",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1089/cbr.2005.20.620",
      "article-title": "Long-circulating poly(ethylene glycol)-coated emulsions to target solid tumors",
      "volume": "67",
      "author": "Rossi",
      "year": "2007",
      "journal-title": "Eur. J. Pharm. Biopharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0665",
      "series-title": "Controlled Drug Delivery: Fundamentals and Applications",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/j.ejpb.2007.03.016",
      "author": "Robinson",
      "year": "1993"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0670",
      "doi-asserted-by": "crossref",
      "first-page": "539",
      "DOI": "10.2165/00003088-200140070-00005",
      "article-title": "Pegylation: a novel process for modifying pharmacokinetics",
      "volume": "40",
      "author": "Harris",
      "year": "2001",
      "journal-title": "Clin. Pharmacokinet."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0675",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.2165/00003088-200140070-00005",
      "article-title": "Long-circulating and target-specific nanoparticles: theory to practice",
      "volume": "53",
      "author": "Moghimi",
      "year": "2001",
      "journal-title": "Pharmacol. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0680",
      "doi-asserted-by": "crossref",
      "first-page": "1273",
      "DOI": "10.1016/j.addr.2003.12.004",
      "article-title": "Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs",
      "volume": "56",
      "author": "Lukyanov",
      "year": "2004",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0685",
      "doi-asserted-by": "crossref",
      "first-page": "596",
      "DOI": "10.1016/j.addr.2003.12.004",
      "article-title": "The architecture of ligand attachment to nanocarriers controls their specific interaction with target cells",
      "volume": "16",
      "author": "Sawant",
      "year": "2008",
      "journal-title": "J. Drug Target."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0690",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1080/10611860802230240",
      "article-title": "Pharmacokinetic drug interactions with phenytoin (part I)",
      "volume": "18",
      "author": "Nation",
      "year": "1990",
      "journal-title": "Clin. Pharmacokinet."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0695",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.2165/00003088-199018010-00003",
      "article-title": "Protein binding displacement interactions and their clinical importance",
      "volume": "25",
      "author": "McElnay",
      "year": "1983",
      "journal-title": "Drugs"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0700",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.2165/00003495-198325050-00003",
      "article-title": "Disease-induced variations in plasma protein levels. Implications for drug dosage regimens (part I)",
      "volume": "19",
      "author": "Zini",
      "year": "1990",
      "journal-title": "Clin. Pharmacokinet."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0705",
      "doi-asserted-by": "crossref",
      "first-page": "71",
      "DOI": "10.2165/00003088-199019020-00004",
      "article-title": "Solid lipid nanoparticles as drug carriers: II. Plasma stability and biodistribution of solid lipid nanoparticles containing the lipophilic prodrug 3\u2032-azido-3\u2032-deoxythymidine palmitate in mice",
      "volume": "174",
      "author": "Heiati",
      "year": "1998",
      "journal-title": "Int. J. Pharm."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0710",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1016/S0378-5173(98)00236-1",
      "article-title": "Avoiding untoward immune responses to novel gene products",
      "volume": "12",
      "author": "Sehon",
      "year": "2002",
      "journal-title": "J. Liposome Res."
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0715",
      "doi-asserted-by": "crossref",
      "first-page": "833",
      "DOI": "10.1081/LPR-120004793",
      "article-title": "Current and future applications of immunological attenuation via pegylation of cells and tissue",
      "volume": "15",
      "author": "Chen",
      "year": "2001",
      "journal-title": "BioDrugs"
    },
    {
      "key": "10.1016/j.jconrel.2012.06.002_bb0720",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.2165/00063030-200115120-00005",
      "article-title": "Development of novel lyophilized mixed micelle amphotericin B formulation for treatment of systemic fungal infection",
      "volume": "2",
      "author": "Naik",
      "year": "2005",
      "journal-title": "Curr. Drug Deliv."
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