DOI: 10.1016/j.jconrel.2005.03.007. Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity

Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity

10.1016/j.jconrel.2005.03.007

Crossref journal-article

Elsevier BV

Journal of Controlled Release (78)

Bibliography

Dos Santos, N., Waterhouse, D., Masin, D., Tardi, P. G., Karlsson, G., Edwards, K., & Bally, M. B. (2005). Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity. Journal of Controlled Release, 105(1â2), 89â105.

Authors 7

Nancy Dos Santos (first)
Dawn Waterhouse (additional)
Dana Masin (additional)
Paul G. Tardi (additional)
Göran Karlsson (additional)
Katarina Edwards (additional)
Marcel B. Bally (additional)

References 47 Referenced 39

{'key': '10.1016/j.jconrel.2005.03.007_bib1', 'first-page': '891', 'article-title': 'Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes', 'volume': '52', 'author': 'Gabizon', 'year': '1992', 'journal-title': 'Cancer Res.'} / Cancer Res. / Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes by Gabizon (1992)
10.1002/j.1552-4604.1996.tb04152.x / J. Clin. Pharmacol. / Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma by Northfelt (1996)
10.1200/JCO.1996.14.8.2353 / J. Clin. Oncol. / Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma by Gill (1996)
{'key': '10.1016/j.jconrel.2005.03.007_bib4', 'series-title': 'Anthracyclines: Current Status and New Developments', 'first-page': '403', 'article-title': 'Effects of modifications in position 4 of the chromophore or in position 4′ of the aminosugar, on the antitumor acitivity and toxicity of daunorubicin and doxorubicin', 'author': 'Casazza', 'year': '1980'} / Anthracyclines: Current Status and New Developments / Effects of modifications in position 4 of the chromophore or in position 4′ of the aminosugar, on the antitumor acitivity and toxicity of daunorubicin and doxorubicin by Casazza (1980)
{'key': '10.1016/j.jconrel.2005.03.007_bib5', 'first-page': '829', 'article-title': 'Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7,9-diepidaunorubicin, and their beta anomers', 'volume': '60', 'author': 'Arcamone', 'year': '1976', 'journal-title': 'Cancer Treat. Rep.'} / Cancer Treat. Rep. / Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7,9-diepidaunorubicin, and their beta anomers by Arcamone (1976)
{'key': '10.1016/j.jconrel.2005.03.007_bib6', 'first-page': '70', 'article-title': 'Selected pharmacologic characteristics of idarubicin and idarubicinol', 'volume': '6', 'author': 'Ames', 'year': '1992', 'journal-title': 'Leukemia'} / Leukemia / Selected pharmacologic characteristics of idarubicin and idarubicinol by Ames (1992)
{'key': '10.1016/j.jconrel.2005.03.007_bib7', 'first-page': '835', 'article-title': 'Experimental evaluation of anthracycline analogs', 'volume': '63', 'author': 'Casazza', 'year': '1979', 'journal-title': 'Cancer Treat. Rep.'} / Cancer Treat. Rep. / Experimental evaluation of anthracycline analogs by Casazza (1979)
10.1016/S0006-2952(02)00920-6 / Biochem. Pharmacol. / Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells by Willmore (2002)
10.1007/BF02897289 / Cancer Chemother. Pharmacol. / Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells by Limonta (1990)
10.1016/0006-2952(95)02069-1 / Biochem. Pharmacol. / Susceptibility of idarubicin, daunorubicin, and their C-13 alcohol metabolites to transport-mediated multidrug resistance by Ross (1995)
10.1007/BF00686485 / Cancer Chemother. Pharmacol. / Anthracyclines and their C-13 alcohol metabolites: growth inhibition and DNA damage following incubation with human tumor cells in culture by Kuffel (1992)
10.1016/S0145-2126(99)00041-7 / Leuk. Res. / Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines by Roovers (1999)
10.1016/0145-2126(94)00157-6 / Leuk. Res. / Evaluation of resistance index of several anticancer agents on parental and resistant P-388 cell lines by Testi (1995)
10.1182/blood.V79.12.3267.3267 / Blood / Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells by Berman (1992)
10.1182/blood.V79.2.313.313 / Blood / Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia by Wiernik (1992)
10.1182/blood.V77.8.1666.1666 / Blood / Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia by Berman (1991)
10.1159/000226863 / Oncology / Comparative phase II study of idarubicin versus doxorubicin in advanced breast cancer by Martoni (1990)
{'key': '10.1016/j.jconrel.2005.03.007_bib18', 'first-page': '739', 'article-title': 'Activity and distribution of iv and oral 4-demethoxydaunorubicin in murine experimental tumors', 'volume': '68', 'author': 'Broggini', 'year': '1984', 'journal-title': 'Cancer Treat. Rep.'} / Cancer Treat. Rep. / Activity and distribution of iv and oral 4-demethoxydaunorubicin in murine experimental tumors by Broggini (1984)
{'key': '10.1016/j.jconrel.2005.03.007_bib19', 'first-page': '665', 'article-title': 'Synthesis, antitumor activity, and cardiac toxicity of new 4-demethoxyanthracyclines', 'volume': '67', 'author': 'Penco', 'year': '1983', 'journal-title': 'Cancer Treat. Rep.'} / Cancer Treat. Rep. / Synthesis, antitumor activity, and cardiac toxicity of new 4-demethoxyanthracyclines by Penco (1983)
10.1111/j.1432-1033.1996.00879.x / Eur. J. Biochem. / The overall partitioning of anthracyclines into phosphatidyl-containing model membranes depends neither on the drug charge nor the presence of anionic phospholipids by Gallois (1996)
10.1016/0006-2952(95)00221-K / Biochem. Pharmacol. / The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity by Mulder (1995)
10.1016/S0005-2736(02)00345-0 / Biochim. Biophys. Acta / Improved retention of idarubicin after intravenous injection obtained for cholesterol-free liposomes by Dos Santos (2002)
10.1016/0005-2736(79)90085-3 / Biochim. Biophys. Acta / Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes by Olson (1979)
10.1016/0167-4889(87)90047-4 / Biochim. Biophys. Acta / Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages by Derksen (1987)
10.1016/0005-2736(86)90105-7 / Biochim. Biophys. Acta / Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient by Mayer (1986)
10.1016/S0006-3495(89)82684-0 / Biophys. J. / Proton flux in large unilamellar vesicles in response to membrane potentials and pH gradients by Redelmeier (1989)
10.1016/S1359-0294(96)80015-X / Curr. Opin. Colloid Interface Sci. / Cryo-transmission electron microscopy of thin vitrified samples by Almgren (1996)
10.1016/0005-2736(90)90018-J / Biochim. Biophys. Acta / Liposomes with entrapped doxorubicin exhibit extended blood residence times by Bally (1990)
10.1016/0022-1759(83)90303-4 / J. Immunol. Methods / Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays by Mosmann (1983)
{'key': '10.1016/j.jconrel.2005.03.007_bib30', 'first-page': '589', 'article-title': 'Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay', 'volume': '48', 'author': 'Alley', 'year': '1988', 'journal-title': 'Cancer Res.'} / Cancer Res. / Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay by Alley (1988)
10.1016/S0006-3495(93)81385-7 / Biophys. J. / Osmotic properties of large unilamellar vesicles prepared by extrusion by Mui (1993)
{'key': '10.1016/j.jconrel.2005.03.007_bib32', 'first-page': '205', 'article-title': 'P-glycoprotein modulates ceramide-mediated sensitivity of human breast cancer cells to tubulin-binding anticancer drugs', 'volume': '1', 'author': 'Shabbits', 'year': '2002', 'journal-title': 'Mol. Cancer Ther.'} / Mol. Cancer Ther. / P-glycoprotein modulates ceramide-mediated sensitivity of human breast cancer cells to tubulin-binding anticancer drugs by Shabbits (2002)
{'key': '10.1016/j.jconrel.2005.03.007_bib33', 'first-page': '5922', 'article-title': 'Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice', 'volume': '49', 'author': 'Mayer', 'year': '1989', 'journal-title': 'Cancer Res.'} / Cancer Res. / Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice by Mayer (1989)
10.1007/BF00686017 / Cancer Chemother. Pharmacol. / Identification of vesicle properties that enhance the antitumour activity of liposomal vincristine against murine L1210 leukemia by Mayer (1993)
10.1038/bjc.1995.430 / Br. J. Cancer / Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models by Webb (1995)
{'key': '10.1016/j.jconrel.2005.03.007_bib36', 'first-page': '337', 'article-title': 'Role of drug release and liposome-mediated drug delivery in governing the therapeutic activity of liposomal mitoxantrone used to treat human A431 and LS180 solid tumors', 'volume': '292', 'author': 'Lim', 'year': '2000', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Role of drug release and liposome-mediated drug delivery in governing the therapeutic activity of liposomal mitoxantrone used to treat human A431 and LS180 solid tumors by Lim (2000)
10.1248/cpb.51.815 / Chem. Pharm. Bull. (Tokyo) / Effects of poly(ethylene glycol) (PEG) chain length of PEG-lipid on the permeability of liposomal bilayer membranes by Hashizaki (2003)
10.1016/S0005-2736(99)00192-3 / Biochim. Biophys. Acta / Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency and permeability of vesicles by Nicholas (2000)
10.1016/S0006-3495(97)78066-4 / Biophys. J. / Effect of polyethyleneglycol-phospholipids on aggregate structure in preparations of small unilamellar liposomes by Edwards (1997)
10.1023/A:1020186505848 / Biosci. Rep. / Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol) by Allen (2002)
10.1021/bc990135y / Bioconjug. Chem. / Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles by Sou (2000)
10.1016/0014-5793(96)00452-8 / FEBS Lett. / Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time by Uster (1996)
{'key': '10.1016/j.jconrel.2005.03.007_bib43', 'first-page': '365', 'article-title': 'Comparative evaluation of the intracellular accumulation and DNA binding of idarubicin and daunorubicin in sensitive and multidrug-resistant human leukaemia K562 cells', 'volume': '16', 'author': 'Bogush', 'year': '1996', 'journal-title': 'Anticancer Res.'} / Anticancer Res. / Comparative evaluation of the intracellular accumulation and DNA binding of idarubicin and daunorubicin in sensitive and multidrug-resistant human leukaemia K562 cells by Bogush (1996)
10.1097/00001813-199707000-00009 / Anticancer Drugs / Cellular pharmacology of lipophilic anthracyclines in human tumor cells in culture selected for resistance to doxorubicin by Bennis (1997)
{'key': '10.1016/j.jconrel.2005.03.007_bib45', 'first-page': '3595', 'article-title': 'Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and-resistant P388 leukemia', 'volume': '48', 'author': 'Deffie', 'year': '1988', 'journal-title': 'Cancer Res.'} / Cancer Res. / Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and-resistant P388 leukemia by Deffie (1988)
{'key': '10.1016/j.jconrel.2005.03.007_bib46', 'first-page': '4243', 'article-title': 'Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha', 'volume': '17', 'author': 'McPherson', 'year': '1997', 'journal-title': 'Anticancer Res.'} / Anticancer Res. / Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha by McPherson (1997)
10.1016/S0005-2736(02)00507-2 / Biochim. Biophys. Acta / Formation of transition metal-doxorubicin complexes inside liposomes by Abraham (2002)

Dates

Type	When
Created	20 years, 3 months ago (May 6, 2005, 6:48 p.m.)
Deposited	5 years, 4 months ago (April 7, 2020, 3:39 a.m.)
Indexed	5 months, 1 week ago (March 19, 2025, 11:51 a.m.)
Issued	20 years, 2 months ago (June 1, 2005)
Published	20 years, 2 months ago (June 1, 2005)
Published Print	20 years, 2 months ago (June 1, 2005)

Funders 0

None

BibTeX

@article{Dos_Santos_2005, title={Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity}, volume={105}, ISSN={0168-3659}, url={http://dx.doi.org/10.1016/j.jconrel.2005.03.007}, DOI={10.1016/j.jconrel.2005.03.007}, number={1–2}, journal={Journal of Controlled Release}, publisher={Elsevier BV}, author={Dos Santos, Nancy and Waterhouse, Dawn and Masin, Dana and Tardi, Paul G. and Karlsson, Göran and Edwards, Katarina and Bally, Marcel B.}, year={2005}, month=jun, pages={89–105} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        3,
        19
      ]
    ],
    "date-time": "2025-03-19T15:51:34Z",
    "timestamp": 1742399494994
  },
  "reference-count": 47,
  "publisher": "Elsevier BV",
  "issue": "1-2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            6,
            1
          ]
        ],
        "date-time": "2005-06-01T00:00:00Z",
        "timestamp": 1117584000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2005,
        6
      ]
    ]
  },
  "DOI": "10.1016/j.jconrel.2005.03.007",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        5,
        6
      ]
    ],
    "date-time": "2005-05-06T22:48:52Z",
    "timestamp": 1115419732000
  },
  "page": "89-105",
  "source": "Crossref",
  "is-referenced-by-count": 39,
  "title": "Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity",
  "prefix": "10.1016",
  "volume": "105",
  "author": [
    {
      "given": "Nancy",
      "family": "Dos Santos",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Dawn",
      "family": "Waterhouse",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dana",
      "family": "Masin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Paul G.",
      "family": "Tardi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "G\u00f6ran",
      "family": "Karlsson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Katarina",
      "family": "Edwards",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marcel B.",
      "family": "Bally",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib1",
      "first-page": "891",
      "article-title": "Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes",
      "volume": "52",
      "author": "Gabizon",
      "year": "1992",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1002/j.1552-4604.1996.tb04152.x",
      "article-title": "Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma",
      "volume": "36",
      "author": "Northfelt",
      "year": "1996",
      "journal-title": "J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "2353",
      "DOI": "10.1200/JCO.1996.14.8.2353",
      "article-title": "Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma",
      "volume": "14",
      "author": "Gill",
      "year": "1996",
      "journal-title": "J. Clin. Oncol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib4",
      "series-title": "Anthracyclines: Current Status and New Developments",
      "first-page": "403",
      "article-title": "Effects of modifications in position 4 of the chromophore or in position 4\u2032 of the aminosugar, on the antitumor acitivity and toxicity of daunorubicin and doxorubicin",
      "author": "Casazza",
      "year": "1980"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib5",
      "first-page": "829",
      "article-title": "Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7,9-diepidaunorubicin, and their beta anomers",
      "volume": "60",
      "author": "Arcamone",
      "year": "1976",
      "journal-title": "Cancer Treat. Rep."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib6",
      "first-page": "70",
      "article-title": "Selected pharmacologic characteristics of idarubicin and idarubicinol",
      "volume": "6",
      "author": "Ames",
      "year": "1992",
      "journal-title": "Leukemia"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib7",
      "first-page": "835",
      "article-title": "Experimental evaluation of anthracycline analogs",
      "volume": "63",
      "author": "Casazza",
      "year": "1979",
      "journal-title": "Cancer Treat. Rep."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "1807",
      "DOI": "10.1016/S0006-2952(02)00920-6",
      "article-title": "Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells",
      "volume": "63",
      "author": "Willmore",
      "year": "2002",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "340",
      "DOI": "10.1007/BF02897289",
      "article-title": "Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells",
      "volume": "26",
      "author": "Limonta",
      "year": "1990",
      "journal-title": "Cancer Chemother. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "1673",
      "DOI": "10.1016/0006-2952(95)02069-1",
      "article-title": "Susceptibility of idarubicin, daunorubicin, and their C-13 alcohol metabolites to transport-mediated multidrug resistance",
      "volume": "50",
      "author": "Ross",
      "year": "1995",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "51",
      "DOI": "10.1007/BF00686485",
      "article-title": "Anthracyclines and their C-13 alcohol metabolites: growth inhibition and DNA damage following incubation with human tumor cells in culture",
      "volume": "30",
      "author": "Kuffel",
      "year": "1992",
      "journal-title": "Cancer Chemother. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "539",
      "DOI": "10.1016/S0145-2126(99)00041-7",
      "article-title": "Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines",
      "volume": "23",
      "author": "Roovers",
      "year": "1999",
      "journal-title": "Leuk. Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1016/0145-2126(94)00157-6",
      "article-title": "Evaluation of resistance index of several anticancer agents on parental and resistant P-388 cell lines",
      "volume": "19",
      "author": "Testi",
      "year": "1995",
      "journal-title": "Leuk. Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "3267",
      "DOI": "10.1182/blood.V79.12.3267.3267",
      "article-title": "Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells",
      "volume": "79",
      "author": "Berman",
      "year": "1992",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "313",
      "DOI": "10.1182/blood.V79.2.313.313",
      "article-title": "Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia",
      "volume": "79",
      "author": "Wiernik",
      "year": "1992",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "1666",
      "DOI": "10.1182/blood.V77.8.1666.1666",
      "article-title": "Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia",
      "volume": "77",
      "author": "Berman",
      "year": "1991",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "427",
      "DOI": "10.1159/000226863",
      "article-title": "Comparative phase II study of idarubicin versus doxorubicin in advanced breast cancer",
      "volume": "47",
      "author": "Martoni",
      "year": "1990",
      "journal-title": "Oncology"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib18",
      "first-page": "739",
      "article-title": "Activity and distribution of iv and oral 4-demethoxydaunorubicin in murine experimental tumors",
      "volume": "68",
      "author": "Broggini",
      "year": "1984",
      "journal-title": "Cancer Treat. Rep."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib19",
      "first-page": "665",
      "article-title": "Synthesis, antitumor activity, and cardiac toxicity of new 4-demethoxyanthracyclines",
      "volume": "67",
      "author": "Penco",
      "year": "1983",
      "journal-title": "Cancer Treat. Rep."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "879",
      "DOI": "10.1111/j.1432-1033.1996.00879.x",
      "article-title": "The overall partitioning of anthracyclines into phosphatidyl-containing model membranes depends neither on the drug charge nor the presence of anionic phospholipids",
      "volume": "241",
      "author": "Gallois",
      "year": "1996",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "967",
      "DOI": "10.1016/0006-2952(95)00221-K",
      "article-title": "The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity",
      "volume": "50",
      "author": "Mulder",
      "year": "1995",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1016/S0005-2736(02)00345-0",
      "article-title": "Improved retention of idarubicin after intravenous injection obtained for cholesterol-free liposomes",
      "volume": "1561",
      "author": "Dos Santos",
      "year": "2002",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1016/0005-2736(79)90085-3",
      "article-title": "Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes",
      "volume": "557",
      "author": "Olson",
      "year": "1979",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1016/0167-4889(87)90047-4",
      "article-title": "Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages",
      "volume": "931",
      "author": "Derksen",
      "year": "1987",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1016/0005-2736(86)90105-7",
      "article-title": "Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient",
      "volume": "857",
      "author": "Mayer",
      "year": "1986",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1016/S0006-3495(89)82684-0",
      "article-title": "Proton flux in large unilamellar vesicles in response to membrane potentials and pH gradients",
      "volume": "56",
      "author": "Redelmeier",
      "year": "1989",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "270",
      "DOI": "10.1016/S1359-0294(96)80015-X",
      "article-title": "Cryo-transmission electron microscopy of thin vitrified samples",
      "volume": "1",
      "author": "Almgren",
      "year": "1996",
      "journal-title": "Curr. Opin. Colloid Interface Sci."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1016/0005-2736(90)90018-J",
      "article-title": "Liposomes with entrapped doxorubicin exhibit extended blood residence times",
      "volume": "1023",
      "author": "Bally",
      "year": "1990",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/0022-1759(83)90303-4",
      "article-title": "Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays",
      "volume": "65",
      "author": "Mosmann",
      "year": "1983",
      "journal-title": "J. Immunol. Methods"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib30",
      "first-page": "589",
      "article-title": "Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay",
      "volume": "48",
      "author": "Alley",
      "year": "1988",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1016/S0006-3495(93)81385-7",
      "article-title": "Osmotic properties of large unilamellar vesicles prepared by extrusion",
      "volume": "64",
      "author": "Mui",
      "year": "1993",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib32",
      "first-page": "205",
      "article-title": "P-glycoprotein modulates ceramide-mediated sensitivity of human breast cancer cells to tubulin-binding anticancer drugs",
      "volume": "1",
      "author": "Shabbits",
      "year": "2002",
      "journal-title": "Mol. Cancer Ther."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib33",
      "first-page": "5922",
      "article-title": "Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice",
      "volume": "49",
      "author": "Mayer",
      "year": "1989",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.1007/BF00686017",
      "article-title": "Identification of vesicle properties that enhance the antitumour activity of liposomal vincristine against murine L1210 leukemia",
      "volume": "33",
      "author": "Mayer",
      "year": "1993",
      "journal-title": "Cancer Chemother. Pharmacol."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "896",
      "DOI": "10.1038/bjc.1995.430",
      "article-title": "Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models",
      "volume": "72",
      "author": "Webb",
      "year": "1995",
      "journal-title": "Br. J. Cancer"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib36",
      "first-page": "337",
      "article-title": "Role of drug release and liposome-mediated drug delivery in governing the therapeutic activity of liposomal mitoxantrone used to treat human A431 and LS180 solid tumors",
      "volume": "292",
      "author": "Lim",
      "year": "2000",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "815",
      "DOI": "10.1248/cpb.51.815",
      "article-title": "Effects of poly(ethylene glycol) (PEG) chain length of PEG-lipid on the permeability of liposomal bilayer membranes",
      "volume": "51",
      "author": "Hashizaki",
      "year": "2003",
      "journal-title": "Chem. Pharm. Bull. (Tokyo)"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1016/S0005-2736(99)00192-3",
      "article-title": "Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency and permeability of vesicles",
      "volume": "1463",
      "author": "Nicholas",
      "year": "2000",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "258",
      "DOI": "10.1016/S0006-3495(97)78066-4",
      "article-title": "Effect of polyethyleneglycol-phospholipids on aggregate structure in preparations of small unilamellar liposomes",
      "volume": "73",
      "author": "Edwards",
      "year": "1997",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1023/A:1020186505848",
      "article-title": "Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol)",
      "volume": "22",
      "author": "Allen",
      "year": "2002",
      "journal-title": "Biosci. Rep."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "372",
      "DOI": "10.1021/bc990135y",
      "article-title": "Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles",
      "volume": "11",
      "author": "Sou",
      "year": "2000",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1016/0014-5793(96)00452-8",
      "article-title": "Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time",
      "volume": "386",
      "author": "Uster",
      "year": "1996",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib43",
      "first-page": "365",
      "article-title": "Comparative evaluation of the intracellular accumulation and DNA binding of idarubicin and daunorubicin in sensitive and multidrug-resistant human leukaemia K562 cells",
      "volume": "16",
      "author": "Bogush",
      "year": "1996",
      "journal-title": "Anticancer Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "610",
      "DOI": "10.1097/00001813-199707000-00009",
      "article-title": "Cellular pharmacology of lipophilic anthracyclines in human tumor cells in culture selected for resistance to doxorubicin",
      "volume": "8",
      "author": "Bennis",
      "year": "1997",
      "journal-title": "Anticancer Drugs"
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib45",
      "first-page": "3595",
      "article-title": "Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and-resistant P388 leukemia",
      "volume": "48",
      "author": "Deffie",
      "year": "1988",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib46",
      "first-page": "4243",
      "article-title": "Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha",
      "volume": "17",
      "author": "McPherson",
      "year": "1997",
      "journal-title": "Anticancer Res."
    },
    {
      "key": "10.1016/j.jconrel.2005.03.007_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1016/S0005-2736(02)00507-2",
      "article-title": "Formation of transition metal-doxorubicin complexes inside liposomes",
      "volume": "1565",
      "author": "Abraham",
      "year": "2002",
      "journal-title": "Biochim. Biophys. Acta"
    }
  ],
  "container-title": "Journal of Controlled Release",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0168365905001197?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0168365905001197?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        4,
        7
      ]
    ],
    "date-time": "2020-04-07T07:39:58Z",
    "timestamp": 1586245198000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0168365905001197"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2005,
        6
      ]
    ]
  },
  "references-count": 47,
  "journal-issue": {
    "issue": "1-2",
    "published-print": {
      "date-parts": [
        [
          2005,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0168365905001197"
  ],
  "URL": "http://dx.doi.org/10.1016/j.jconrel.2005.03.007",
  "relation": {},
  "ISSN": [
    "0168-3659"
  ],
  "subject": [],
  "container-title-short": "Journal of Controlled Release",
  "published": {
    "date-parts": [
      [
        2005,
        6
      ]
    ]
  }
}