DOI: 10.1016/j.jconrel.2003.12.011. Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice

Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice

10.1016/j.jconrel.2003.12.011

Crossref journal-article

Elsevier BV

Journal of Controlled Release (78)

Bibliography

Ishida, T., Ichikawa, T., Ichihara, M., Sadzuka, Y., & Kiwada, H. (2004). Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice. Journal of Controlled Release, 95(3), 403â412.

Authors 5

Tatsuhiro Ishida (first)
Takako Ichikawa (additional)
Masako Ichihara (additional)
Yasuyuki Sadzuka (additional)
Hiroshi Kiwada (additional)

References 44 Referenced 97

10.1016/0005-2736(91)90201-I / Biochim. Biophys. Acta / Pharmacokinetics of stealth versus conventional liposomes: effect of dose by Allen (1991)
10.1016/0165-6147(94)90314-X / Trends Pharmacol. Sci. / Long-circulating (sterically stabilized) liposomes for targeted drug delivery by Allen (1994)
10.1016/S0168-3659(02)00462-5 / J. Control. Release / Accelerated clearance of PEGylated liposomes in rat after repeated injection by Ishida (2003)
10.1016/S0378-5173(03)00085-1 / Int. J. Pharm. / Accelerated clearance of a second injection of PEGylated liposomes in mice by Ishida (2003)
{'key': '10.1016/j.jconrel.2003.12.011_BIB5', 'first-page': '1071', 'article-title': 'Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes', 'volume': '292', 'author': 'Dams', 'year': '2000', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes by Dams (2000)
{'key': '10.1016/j.jconrel.2003.12.011_BIB6', 'first-page': '607', 'article-title': 'Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection', 'volume': '298', 'author': 'Laverman', 'year': '2001', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection by Laverman (2001)
10.3109/08982109809035531 / J. Liposome Res. / Repeat injection studies of technetium-99m-labeled PEG-liposomes in the same animal by Goins (1998)
10.3109/08982109909018655 / J. Liposome Res. / Effect of repeated intravenous administration on the circulation kinetics of poly(ethyleneglycol)-liposomes in rats by Oussoren (1999)
10.1093/jac/35.4.509 / J. Antimicrob. Chemother. / Biodistribution of liposomal amphotericin B (ambisome) and amphotericin B desoxycholate (fungizone) in uninfected immunocompetent mice and leucopenic mice infected with Candida albicans by Vanetten (1995)
10.1016/0168-3659(95)00071-F / J. Control. Release / Sterically stabilized amphotericin B liposomes: toxicity and biodistribution in mice by Vanetten (1995)
10.3109/08982109709035506 / J. Liposome Res. / Liposome targeting in animal models: problems and opportunities by Allen (1997)
{'key': '10.1016/j.jconrel.2003.12.011_BIB12', 'first-page': '123', 'article-title': 'Fate and behaviour of liposomes in vivo: a review of controlling factors', 'volume': '3', 'author': 'Senior', 'year': '1987', 'journal-title': 'Crit. Rev. Ther. Drug Carr. Syst.'} / Crit. Rev. Ther. Drug Carr. Syst. / Fate and behaviour of liposomes in vivo: a review of controlling factors by Senior (1987)
10.1016/0169-409X(95)00029-7 / Adv. Drug Deliv. Rev. / Pharmacokinetics of long circulating liposomes by Allen (1995)
10.1016/0024-3205(82)90455-6 / Life Sci. / Stability of small unilamellar liposomes in serum and clearance from the circulation by Senior (1982)
{'key': '10.1016/j.jconrel.2003.12.011_BIB15', 'first-page': '123', 'article-title': 'Fate and behavior of liposomes in vivo: a review of controlling factors', 'volume': '3', 'author': 'Senior', 'year': '1987', 'journal-title': 'Crit. Rev. Ther. Drug Carr. Syst.'} / Crit. Rev. Ther. Drug Carr. Syst. / Fate and behavior of liposomes in vivo: a review of controlling factors by Senior (1987)
10.1073/pnas.88.24.11460 / Proc. Natl. Acad. Sci. U. S. A. / Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy by Papahadjopoulos (1991)
10.1016/0005-2736(91)90385-L / Biochim. Biophys. Acta / Activity of amphipathic poly(ethyleneglycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target by Klibanov (1991)
{'key': '10.1016/j.jconrel.2003.12.011_BIB18', 'first-page': '3320', 'article-title': 'In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma', 'volume': '58', 'author': 'Lopes de Menezes', 'year': '1998', 'journal-title': 'Cancer Res.'} / Cancer Res. / In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma by Lopes de Menezes (1998)
10.1016/S0021-9258(18)70226-3 / J. Biol. Chem. / Phosphorus assay in column chromatography by Bartlett (1959)
{'key': '10.1016/j.jconrel.2003.12.011_BIB20', 'series-title': 'Liposomes in the Therapy of Infectious Disease and Cancer', 'first-page': '205', 'volume': 'vol. 3', 'author': 'Allen', 'year': '1984'} / Liposomes in the Therapy of Infectious Disease and Cancer by Allen (1984)
10.1007/BF01059781 / Eur. J. Pharm. Biopharm. / Kinetic analysis of AUC-dependent saturable clearance of liposomes: mathematical description of AUC dependency by Harashima (1993)
10.2165/00003495-199856050-00001 / Drugs / Liposomal drug formulations. Rationale for development and what we can expect for the future by Allen (1998)
10.2165/00003495-200262140-00012 / Drugs / Polyethylene glycol-liposomal doxorubicin: a review of its use in the management of solid and haematological malignancies and AIDS-related Kaposi's sarcoma by Sharpe (2002)
10.1046/j.1472-8206.2003.00168.x / Fundam. Clin. Pharmacol. / Liposomal amphotericin B in the treatment of visceral leishmaniasis immunocompetent patients by Minodier (2003)
10.1093/jac/49.suppl_1.31 / J. Antimicrob. Chemother. / Overview of the lipid formulations of amphotericin B by Dupont (2002)
{'key': '10.1016/j.jconrel.2003.12.011_BIB26', 'first-page': '1739', 'article-title': 'Myocet (liposome-encapsulated doxorubicin citrate): a new approach in breast cancer therapy', 'volume': '2002', 'author': 'Batist', 'year': '2003', 'journal-title': 'Expert Opin. Pharmacother.'} / Expert Opin. Pharmacother. / Myocet (liposome-encapsulated doxorubicin citrate): a new approach in breast cancer therapy by Batist (2003)
10.1038/bjc.1996.193 / Br. J. Cancer / Efficacy and safety of stealth liposomal doxorubicin in AIDS-related Kaposi's sarcoma by Goebel (1996)
10.1023/A:1008386822906 / Ann. Oncol. / A phase II study of PEGylated liposomal doxorubicin for treatment of advanced hepatocellular carcinoma by Halm (2000)
10.1200/JCO.1995.13.4.914 / J. Clin. Oncol. / Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma by Harrison (1995)
10.1097/00001813-200002000-00009 / Anticancer Drugs / Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer by Hubert (2000)
10.1016/S0006-3495(95)80369-3 / Biophys. J. / Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol) by Kenworthy (1995)
10.1016/0005-2736(92)90112-Y / Biochim. Biophys. Acta / Repulsive interactions and mechanical stability of polymer-grafted lipid membranes by Needham (1992)
10.1016/0304-4157(92)90038-C / Biochim. Biophys. Acta / Sterically stabilized liposomes by Woodle (1992)
10.1016/S0005-2760(96)00112-9 / Biochim. Biophys. Acta / Effect of grafted PEG-2000 on the size and permeability of vesicles by Nikolova (1996)
10.1016/S0005-2736(99)00192-3 / Biochim. Biophys. Acta / Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency and permeability of vesicles by Nicholas (2000)
10.1016/S0005-2736(97)00027-8 / Biochim. Biophys. Acta / Grafted poly-(ethylene glycol) on lipid surfaces inhibits protein adsorption and cell adhesion by Du (1997)
10.3109/08982109209010213 / J. Liposome Res. / On the molecular mechanism of steric stabilization of liposomes in biological fluids by Lasic (1992)
10.1016/S0169-409X(97)00131-2 / Adv. Drug Deliv. Rev. / Serum mediated recognition of liposomes by phagocytic cells of the reticuloendotherial system: the concept of tissue specificity by Moghimi (1998)
10.1023/A:1020134521778 / Biosci. Rep. / Liposome clearance by Ishida (2002)
10.1615/CritRevTherDrugCarrierSyst.v14.i2.10 / Crit. Rev. Ther. Drug Carr. Syst. / The role of immunoproteins in the survival of liposomes in the circulation by Devine (1997)
10.1016/S0168-3659(01)00481-3 / J. Control. Release / Modulation of murine liver macrophage clearance of liposomes by diethylstilbestrol. The effect of vesicle surface charge and a role for the complement receptor Mac-1 (CD11b/CD18) of newly recruited macrophages in liposome recognition by Moghimi (2002)
10.1002/ijc.2910610520 / Int. J. Cancer / Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages by Daemen (1995)
10.1002/ijc.2910610520 / Int. J. Cancer / Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages by Daemen (1995)
10.1200/JCO.2000.18.17.3093 / J. Clin. Oncol. / Phase II study of liposomal doxorubicin in platinum- and paclitaxel-refractory epithelial ovarian cancer by Gordon (2000)

Dates

Type	When
Created	21 years, 6 months ago (Feb. 5, 2004, 5:35 a.m.)
Deposited	4 years, 2 months ago (June 14, 2021, 11:54 a.m.)
Indexed	3 days, 3 hours ago (Aug. 30, 2025, 1:03 p.m.)
Issued	21 years, 6 months ago (March 1, 2004)
Published	21 years, 6 months ago (March 1, 2004)
Published Print	21 years, 6 months ago (March 1, 2004)

Funders 0

None

BibTeX

@article{Ishida_2004, title={Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice}, volume={95}, ISSN={0168-3659}, url={http://dx.doi.org/10.1016/j.jconrel.2003.12.011}, DOI={10.1016/j.jconrel.2003.12.011}, number={3}, journal={Journal of Controlled Release}, publisher={Elsevier BV}, author={Ishida, Tatsuhiro and Ichikawa, Takako and Ichihara, Masako and Sadzuka, Yasuyuki and Kiwada, Hiroshi}, year={2004}, month=mar, pages={403–412} }

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      "author": "Oussoren",
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      "journal-title": "J. Liposome Res."
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      "author": "Vanetten",
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      "volume": "2002",
      "author": "Batist",
      "year": "2003",
      "journal-title": "Expert Opin. Pharmacother."
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      "author": "Halm",
      "year": "2000",
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      "article-title": "Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma",
      "volume": "13",
      "author": "Harrison",
      "year": "1995",
      "journal-title": "J. Clin. Oncol."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1097/00001813-200002000-00009",
      "article-title": "Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer",
      "volume": "11",
      "author": "Hubert",
      "year": "2000",
      "journal-title": "Anticancer Drugs"
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB31",
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      "first-page": "1921",
      "DOI": "10.1016/S0006-3495(95)80369-3",
      "article-title": "Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol)",
      "volume": "68",
      "author": "Kenworthy",
      "year": "1995",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "40",
      "DOI": "10.1016/0005-2736(92)90112-Y",
      "article-title": "Repulsive interactions and mechanical stability of polymer-grafted lipid membranes",
      "volume": "1108",
      "author": "Needham",
      "year": "1992",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1016/0304-4157(92)90038-C",
      "article-title": "Sterically stabilized liposomes",
      "volume": "1113",
      "author": "Woodle",
      "year": "1992",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "120",
      "DOI": "10.1016/S0005-2760(96)00112-9",
      "article-title": "Effect of grafted PEG-2000 on the size and permeability of vesicles",
      "volume": "1304",
      "author": "Nikolova",
      "year": "1996",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1016/S0005-2736(99)00192-3",
      "article-title": "Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency and permeability of vesicles",
      "volume": "1463",
      "author": "Nicholas",
      "year": "2000",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "236",
      "DOI": "10.1016/S0005-2736(97)00027-8",
      "article-title": "Grafted poly-(ethylene glycol) on lipid surfaces inhibits protein adsorption and cell adhesion",
      "volume": "1326",
      "author": "Du",
      "year": "1997",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.3109/08982109209010213",
      "article-title": "On the molecular mechanism of steric stabilization of liposomes in biological fluids",
      "volume": "2",
      "author": "Lasic",
      "year": "1992",
      "journal-title": "J. Liposome Res."
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1016/S0169-409X(97)00131-2",
      "article-title": "Serum mediated recognition of liposomes by phagocytic cells of the reticuloendotherial system: the concept of tissue specificity",
      "volume": "32",
      "author": "Moghimi",
      "year": "1998",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1023/A:1020134521778",
      "article-title": "Liposome clearance",
      "volume": "22",
      "author": "Ishida",
      "year": "2002",
      "journal-title": "Biosci. Rep."
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1615/CritRevTherDrugCarrierSyst.v14.i2.10",
      "article-title": "The role of immunoproteins in the survival of liposomes in the circulation",
      "volume": "14",
      "author": "Devine",
      "year": "1997",
      "journal-title": "Crit. Rev. Ther. Drug Carr. Syst."
    },
    {
      "key": "10.1016/j.jconrel.2003.12.011_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/S0168-3659(01)00481-3",
      "article-title": "Modulation of murine liver macrophage clearance of liposomes by diethylstilbestrol. The effect of vesicle surface charge and a role for the complement receptor Mac-1 (CD11b/CD18) of newly recruited macrophages in liposome recognition",
      "volume": "78",
      "author": "Moghimi",
      "year": "2002",
      "journal-title": "J. Control. Release"
    },
    {
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      "first-page": "716",
      "DOI": "10.1002/ijc.2910610520",
      "article-title": "Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages",
      "volume": "61",
      "author": "Daemen",
      "year": "1995",
      "journal-title": "Int. J. Cancer"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "666",
      "DOI": "10.1002/ijc.2910610520",
      "article-title": "Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages",
      "volume": "61",
      "author": "Daemen",
      "year": "1995",
      "journal-title": "Int. J. Cancer"
    },
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      "first-page": "3093",
      "DOI": "10.1200/JCO.2000.18.17.3093",
      "article-title": "Phase II study of liposomal doxorubicin in platinum- and paclitaxel-refractory epithelial ovarian cancer",
      "volume": "18",
      "author": "Gordon",
      "year": "2000",
      "journal-title": "J. Clin. Oncol."
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