DOI: 10.1016/j.immuni.2013.05.004. Immune Sensing of DNA

Immune Sensing of DNA

10.1016/j.immuni.2013.05.004

Crossref journal-article

Elsevier BV

Immunity (78)

Bibliography

Paludan, S. R., & Bowie, A. G. (2013). Immune Sensing of DNA. Immunity, 38(5), 870â880.

Authors 2

Søren R. Paludan (first)
Andrew G. Bowie (additional)

References 113 Referenced 668

10.1016/j.molcel.2013.01.039 / Mol. Cell / STING recognition of cytoplasmic DNA instigates cellular defense by Abe (2013)
10.1038/ni.1779 / Nat. Immunol. / RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate by Ablasser (2009)
10.1038/sj.onc.1207057 / Oncogene / A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway by Aglipay (2003)
10.4049/jimmunol.0803872 / J. Immunol. / Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease by Agrawal (2009)
10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO;2-U / Eur. J. Immunol. / Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments by Ahmad-Nejad (2002)
10.1073/pnas.1215006109 / Proc. Natl. Acad. Sci. USA / STING manifests self DNA-dependent inflammatory disease by Ahn (2012)
10.1073/pnas.0337679100 / Proc. Natl. Acad. Sci. USA / Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus by Baechler (2003)
10.4049/jimmunol.177.6.3515 / J. Immunol. / Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection by Bafica (2006)
10.1084/jem.20021553 / J. Exp. Med. / Interferon and granulopoiesis signatures in systemic lupus erythematosus blood by Bennett (2003)
10.1371/journal.pone.0029291 / PLoS ONE / Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA by Berg (2012)
10.4049/jimmunol.1100040 / J. Immunol. / The DNA damage response induces IFN by Brzostek-Racine (2011)
10.1038/ni.1702 / Nat. Immunol. / An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome by Bürckstümmer (2009)
10.1038/ni.2491 / Nat. Immunol. / STING and the innate immune response to nucleic acids in the cytosol by Burdette (2013)
10.1038/nature10429 / Nature / STING is a direct innate immune sensor of cyclic di-GMP by Burdette (2011)
10.1016/j.chom.2008.11.002 / Cell Host Microbe / TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA by Charrel-Dennis (2008)
10.1016/j.cell.2011.09.022 / Cell / Activation of STAT6 by STING is critical for antiviral innate immunity by Chen (2011)
10.1016/j.cell.2009.06.015 / Cell / RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway by Chiu (2009)
10.1016/j.immuni.2006.07.013 / Immunity / Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus by Christensen (2006)
10.1016/j.molcel.2010.09.019 / Mol. Cell / The DNA damage response: making it safe to play with knives by Ciccia (2010)
10.1186/1471-2148-12-140 / BMC Evol. Biol. / The mammalian PYHIN gene family: phylogeny, evolution and expression by Cridland (2012)
10.1038/ng1845 / Nat. Genet. / Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus by Crow (2006)
10.1128/JVI.01748-09 / J. Virol. / Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1 by DeFilippis (2010)
10.1016/j.cell.2010.11.001 / Cell / Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue by Doitsh (2010)
10.1038/nature07405 / Nature / The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor by Ewald (2008)
10.7554/eLife.00047 / eLIFE / DNA-PK is a DNA sensor for IRF-3-dependent innate immunity by Ferguson (2012)
10.1038/nature07710 / Nature / AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA by Fernandes-Alnemri (2009)
10.1038/ni.1859 / Nat. Immunol. / The AIM2 inflammasome is critical for innate immunity to Francisella tularensis by Fernandes-Alnemri (2010)
10.1073/pnas.0809742106 / Proc. Natl. Acad. Sci. USA / Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function by Franklin (2009)
10.1016/j.immuni.2011.11.018 / Immunity / Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease by Gall (2012)
10.1038/ni1110-984 / Nat. Immunol. / PYHIN proteins: center stage in DNA sensing by Goubau (2010)
10.1038/35047123 / Nature / A Toll-like receptor recognizes bacterial DNA by Hemmi (2000)
10.4049/jimmunol.1202749 / J. Immunol. / Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors by Horan (2013)
10.1038/nature07725 / Nature / AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC by Hornung (2009)
10.1038/nsmb.2333 / Nat. Struct. Mol. Biol. / The structural basis for the sensing and binding of cyclic di-GMP by STING by Huang (2012)
10.1016/S0140-6736(63)92585-6 / Lancet / Foreign nucleic acids as the stimulus to make interferon by Isaacs (1963)
10.1038/ni1282 / Nat. Immunol. / A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA by Ishii (2006)
10.1038/nature06537 / Nature / TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines by Ishii (2008)
10.1038/nature07317 / Nature / STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling by Ishikawa (2008)
10.1038/nature08476 / Nature / STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity by Ishikawa (2009)
10.1128/MCB.00640-08 / Mol. Cell. Biol. / MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals by Jin (2008)
10.4049/jimmunol.1100088 / J. Immunol. / MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP by Jin (2011)
10.1016/j.immuni.2012.02.014 / Immunity / Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor by Jin (2012)
10.1084/jem.194.6.863 / J. Exp. Med. / Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens by Kadowaki (2001)
10.1016/j.cell.2012.11.011 / Cell / Signaling organelles of the innate immune system by Kagan (2012)
10.4049/jimmunol.181.9.6427 / J. Immunol. / Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors by Kaiser (2008)
10.1111/j.1600-065X.2011.01052.x / Immunol. Rev. / RIG-I-like receptors: cytoplasmic sensors for non-self RNA by Kato (2011)
10.1126/science.292.5521.1546 / Science / Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver by Kawane (2001)
10.1016/j.it.2011.08.004 / Trends Immunol. / Cytosolic DNA sensors regulating type I interferon induction by Keating (2011)
10.1016/j.chom.2011.04.008 / Cell Host Microbe / IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection by Kerur (2011)
10.1073/pnas.1006539107 / Proc. Natl. Acad. Sci. USA / Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells by Kim (2010)
10.4049/jimmunol.1100469 / J. Immunol. / Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response by Kis-Toth (2011)
10.1073/pnas.1222694110 / Proc. Natl. Acad. Sci. USA / DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking by Kondo (2013)
10.4049/jimmunol.1004143 / J. Immunol. / Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs by Koppe (2012)
10.1016/j.cell.2011.09.039 / Cell / Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA by Kowalinski (2011)
10.1038/ni1028 / Nat. Immunol. / TLR9 signals after translocating from the ER to CpG DNA in the lysosome by Latz (2004)
10.1038/ni1479 / Nat. Immunol. / Ligand-induced conformational changes allosterically activate Toll-like receptor 9 by Latz (2007)
10.1038/416603a / Nature / Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors by Leadbetter (2002)
10.1016/S0092-8674(00)80172-5 / Cell / The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults by Lemaitre (1996)
10.1073/pnas.1203447109 / Proc. Natl. Acad. Sci. USA / Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16 by Li (2012)
10.1084/jem.20030162 / J. Exp. Med. / Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells by Lund (2003)
10.1016/j.cell.2011.09.023 / Cell / Structural insights into RNA recognition by RIG-I by Luo (2011)
10.1016/j.chom.2012.03.007 / Cell Host Microbe / Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages by Manzanillo (2012)
10.1128/JVI.02435-10 / J. Virol. / Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1 by McFarlane (2011)
10.1084/jem.20082874 / J. Exp. Med. / A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP by McWhirter (2009)
10.1038/41131 / Nature / A human homologue of the Drosophila Toll protein signals activation of adaptive immunity by Medzhitov (1997)
10.4049/jimmunol.176.12.7589 / J. Immunol. / TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondii by Minns (2006)
10.1128/MCB.01368-10 / Mol. Cell. Biol. / DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling by Miyashita (2011)
10.3109/08916930903510922 / Autoimmunity / The interferon-inducible HIN-200 gene family in apoptosis and inflammation: implication for autoimmunity by Mondini (2010)
10.1111/j.1462-5822.2010.01478.x / Cell. Microbiol. / Induction of type I interferons by bacteria by Monroe (2010)
10.1038/nature06664 / Nature / The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response by Muruve (2008)
10.1084/jem.20051654 / J. Exp. Med. / Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation by Okabe (2005)
10.1073/pnas.1211302109 / Proc. Natl. Acad. Sci. USA / Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation if IFI16 by the viral ICP0 protein by Orzalli (2012)
10.1016/j.immuni.2012.03.019 / Immunity / Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding by Ouyang (2012)
10.1038/nri2937 / Nat. Rev. Immunol. / Recognition of herpesviruses by the innate immune system by Paludan (2011)
10.1007/s10495-012-0775-5 / Apoptosis / PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway by Park (2012)
10.1038/ni.2460 / Nat. Immunol. / The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response by Parvatiyar (2012)
10.4049/jimmunol.172.8.4926 / J. Immunol. / Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway by Pichyangkul (2004)
10.4049/jimmunol.1100949 / J. Immunol. / Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes by Rasmussen (2011)
10.1038/embor.2009.109 / EMBO Rep. / DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB by Rebsamen (2009)
10.1126/science.1169841 / Science / HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA by Roberts (2009)
10.1038/197564a0 / Nature / Inhibition of virus multiplication by foreign nucleic acid by Rotem (1963)
10.1016/j.jaut.2009.11.001 / J. Autoimmun. / Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice by Santiago-Raber (2010)
10.1038/emboj.2008.143 / EMBO J. / Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation by Schröder (2008)
10.1038/nsmb.2332 / Nat. Struct. Mol. Biol. / Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP by Shang (2012)
10.1016/j.immuni.2011.05.016 / Immunity / Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome by Sharma (2011)
10.1038/nsmb.2331 / Nat. Struct. Mol. Biol. / Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system by Shu (2012)
10.1128/JVI.01635-10 / J. Virol. / RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I by Solis (2011)
10.1016/j.immuni.2005.12.003 / Immunity / Recognition of cytosolic DNA activates an IRF3-dependent innate immune response by Stetson (2006)
10.1016/j.cell.2008.06.032 / Cell / Trex1 prevents cell-intrinsic initiation of autoimmunity by Stetson (2008)
10.1073/pnas.0900850106 / Proc. Natl. Acad. Sci. USA / ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization by Sun (2009)
10.1126/science.1232458 / Science / Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway by Sun (2013)
10.1038/nature06013 / Nature / DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response by Takaoka (2007)
10.1126/scisignal.2002521 / Sci. Signal. / STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway by Tanaka (2012)
10.1038/ni.1932 / Nat. Immunol. / IFI16 is an innate immune sensor for intracellular DNA by Unterholzner (2010)
10.1016/j.chom.2010.03.006 / Cell Host Microbe / Virus inhibition of RIP3-dependent necrosis by Upton (2010)
10.1016/j.chom.2012.01.016 / Cell Host Microbe / DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA by Upton (2012)
10.1016/j.cell.2012.06.040 / Cell / Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway by Watson (2012)
10.4049/jimmunol.1100523 / J. Immunol. / Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III by Wenzel (2012)
10.1016/j.cell.2012.11.048 / Cell / Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5 by Wu (2013)
10.1126/science.1229963 / Science / Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA by Wu (2013)
10.1128/jvi.76.5.2043-2053.2002 / J. Virol. / Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors by Yan (2002)
10.1038/ni.1941 / Nat. Immunol. / The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1 by Yan (2010)
10.1016/j.cell.2007.10.017 / Cell / Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease by Yang (2007)
10.4049/jimmunol.0900399 / J. Immunol. / Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes by Yasuda (2009)
10.1016/j.molcel.2012.05.029 / Mol. Cell / Cyclic di-GMP sensing via the innate immune signaling protein STING by Yin (2012)
10.1038/ni1087 / Nat. Immunol. / The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses by Yoneyama (2004)
10.1038/ni1146 / Nat. Immunol. / Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA by Yoshida (2005)
10.1093/intimm/dxl067 / Int. Immunol. / Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE by Yu (2006)
10.4049/jimmunol.1003389 / J. Immunol. / Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN by Zhang (2011)
10.1038/ni.2091 / Nat. Immunol. / The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells by Zhang (2011)
10.4049/jimmunol.1101307 / J. Immunol. / DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells by Zhang (2011)
10.1038/ni.2492 / Nat. Immunol. / The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA by Zhang (2013)
10.1016/j.immuni.2008.09.003 / Immunity / The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation by Zhong (2008)

Dates

Type	When
Created	12 years, 3 months ago (May 23, 2013, 11:21 a.m.)
Deposited	3 years, 1 month ago (July 9, 2022, 2:33 p.m.)
Indexed	3 days, 9 hours ago (Aug. 30, 2025, 1:18 p.m.)
Issued	12 years, 4 months ago (May 1, 2013)
Published	12 years, 4 months ago (May 1, 2013)
Published Print	12 years, 4 months ago (May 1, 2013)

Funders 7

National Institutes of Health 10.13039/100000002
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH
Awards1
1. AI093752
Novo Nordisk Fonden 10.13039/501100009708
Region: Europe
pri (Trusts, charities, foundations (both public and private))
Labels3
1. Novo Nordisk Foundation
2. Novo Nordic Foundation
3. NNF
Sundhed og Sygdom, Det Frie Forskningsråd 10.13039/100008392
Region: Europe
gov (National government)
Labels7
1. Det Frie Forskningsråd, Sundhed og Sygdom
2. DFF, Sundhed og Sygdom
3. Medical Sciences, Danish Council for Independent Research
4. Danish Council for Independent Research, Medical Sciences
5. Danish Health Sciences Research Council
6. Danish Medical Research Council
7. FSS, DFF
Awards2
1. 09-072636
2. 12-124330
Science Foundation Ireland 10.13039/501100001602
Region: Europe
gov (National government)
Labels1
1. SFI
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1. 11/PI/1056
Aarhus Universitets Forskningsfond 10.13039/501100002739
Region: Europe
pri (Trusts, charities, foundations (both public and private))
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1. Aarhus University Research Foundation
Aase og Ejnar Danielsens Fond 10.13039/501100003035
Region: Europe
pri (Trusts, charities, foundations (both public and private))
Labels1
1. Aase and Ejnar Danielsen Foundation
Lundbeckfonden 10.13039/501100003554 Lundbeck Foundation
Region: Europe
pri (Other non-profit organizations)
Labels1
1. Lundbeckfonden
Awards1
1. R83-A7598

BibTeX

@article{Paludan_2013, title={Immune Sensing of DNA}, volume={38}, ISSN={1074-7613}, url={http://dx.doi.org/10.1016/j.immuni.2013.05.004}, DOI={10.1016/j.immuni.2013.05.004}, number={5}, journal={Immunity}, publisher={Elsevier BV}, author={Paludan, Søren R. and Bowie, Andrew G.}, year={2013}, month=may, pages={870–880} }

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      "author": "Ablasser",
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      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "8931",
      "DOI": "10.1038/sj.onc.1207057",
      "article-title": "A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway",
      "volume": "22",
      "author": "Aglipay",
      "year": "2003",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "6021",
      "DOI": "10.4049/jimmunol.0803872",
      "article-title": "Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease",
      "volume": "183",
      "author": "Agrawal",
      "year": "2009",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "1958",
      "DOI": "10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO;2-U",
      "article-title": "Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments",
      "volume": "32",
      "author": "Ahmad-Nejad",
      "year": "2002",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "19386",
      "DOI": "10.1073/pnas.1215006109",
      "article-title": "STING manifests self DNA-dependent inflammatory disease",
      "volume": "109",
      "author": "Ahn",
      "year": "2012",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "2610",
      "DOI": "10.1073/pnas.0337679100",
      "article-title": "Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus",
      "volume": "100",
      "author": "Baechler",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "3515",
      "DOI": "10.4049/jimmunol.177.6.3515",
      "article-title": "Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection",
      "volume": "177",
      "author": "Bafica",
      "year": "2006",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "711",
      "DOI": "10.1084/jem.20021553",
      "article-title": "Interferon and granulopoiesis signatures in systemic lupus erythematosus blood",
      "volume": "197",
      "author": "Bennett",
      "year": "2003",
      "journal-title": "J.\u00a0Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "e29291",
      "DOI": "10.1371/journal.pone.0029291",
      "article-title": "Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA",
      "volume": "7",
      "author": "Berg",
      "year": "2012",
      "journal-title": "PLoS ONE"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "5336",
      "DOI": "10.4049/jimmunol.1100040",
      "article-title": "The DNA damage response induces IFN",
      "volume": "187",
      "author": "Brzostek-Racine",
      "year": "2011",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1038/ni.1702",
      "article-title": "An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome",
      "volume": "10",
      "author": "B\u00fcrckst\u00fcmmer",
      "year": "2009",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1038/ni.2491",
      "article-title": "STING and the innate immune response to nucleic acids in the cytosol",
      "volume": "14",
      "author": "Burdette",
      "year": "2013",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "515",
      "DOI": "10.1038/nature10429",
      "article-title": "STING is a direct innate immune sensor of cyclic di-GMP",
      "volume": "478",
      "author": "Burdette",
      "year": "2011",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "543",
      "DOI": "10.1016/j.chom.2008.11.002",
      "article-title": "TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA",
      "volume": "4",
      "author": "Charrel-Dennis",
      "year": "2008",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "436",
      "DOI": "10.1016/j.cell.2011.09.022",
      "article-title": "Activation of STAT6 by STING is critical for antiviral innate immunity",
      "volume": "147",
      "author": "Chen",
      "year": "2011",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "576",
      "DOI": "10.1016/j.cell.2009.06.015",
      "article-title": "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway",
      "volume": "138",
      "author": "Chiu",
      "year": "2009",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/j.immuni.2006.07.013",
      "article-title": "Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus",
      "volume": "25",
      "author": "Christensen",
      "year": "2006",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1016/j.molcel.2010.09.019",
      "article-title": "The DNA damage response: making it safe to play with knives",
      "volume": "40",
      "author": "Ciccia",
      "year": "2010",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "140",
      "DOI": "10.1186/1471-2148-12-140",
      "article-title": "The mammalian PYHIN gene family: phylogeny, evolution and expression",
      "volume": "12",
      "author": "Cridland",
      "year": "2012",
      "journal-title": "BMC Evol. Biol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "917",
      "DOI": "10.1038/ng1845",
      "article-title": "Mutations in the gene encoding the 3\u2032-5\u2032 DNA exonuclease TREX1 cause Aicardi-Gouti\u00e8res syndrome at the AGS1 locus",
      "volume": "38",
      "author": "Crow",
      "year": "2006",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "585",
      "DOI": "10.1128/JVI.01748-09",
      "article-title": "Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1",
      "volume": "84",
      "author": "DeFilippis",
      "year": "2010",
      "journal-title": "J.\u00a0Virol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "789",
      "DOI": "10.1016/j.cell.2010.11.001",
      "article-title": "Abortive HIV infection mediates CD4 T\u00a0cell depletion and inflammation in human lymphoid tissue",
      "volume": "143",
      "author": "Doitsh",
      "year": "2010",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "658",
      "DOI": "10.1038/nature07405",
      "article-title": "The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor",
      "volume": "456",
      "author": "Ewald",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "e00047",
      "DOI": "10.7554/eLife.00047",
      "article-title": "DNA-PK is a DNA sensor for IRF-3-dependent innate immunity",
      "volume": "1",
      "author": "Ferguson",
      "year": "2012",
      "journal-title": "eLIFE"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1038/nature07710",
      "article-title": "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA",
      "volume": "458",
      "author": "Fernandes-Alnemri",
      "year": "2009",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1038/ni.1859",
      "article-title": "The AIM2 inflammasome is critical for innate immunity to Francisella tularensis",
      "volume": "11",
      "author": "Fernandes-Alnemri",
      "year": "2010",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "5789",
      "DOI": "10.1073/pnas.0809742106",
      "article-title": "Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function",
      "volume": "106",
      "author": "Franklin",
      "year": "2009",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "120",
      "DOI": "10.1016/j.immuni.2011.11.018",
      "article-title": "Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease",
      "volume": "36",
      "author": "Gall",
      "year": "2012",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "984",
      "DOI": "10.1038/ni1110-984",
      "article-title": "PYHIN proteins: center stage in DNA sensing",
      "volume": "11",
      "author": "Goubau",
      "year": "2010",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "740",
      "DOI": "10.1038/35047123",
      "article-title": "A Toll-like receptor recognizes bacterial DNA",
      "volume": "408",
      "author": "Hemmi",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "2311",
      "DOI": "10.4049/jimmunol.1202749",
      "article-title": "Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors",
      "volume": "190",
      "author": "Horan",
      "year": "2013",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "514",
      "DOI": "10.1038/nature07725",
      "article-title": "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC",
      "volume": "458",
      "author": "Hornung",
      "year": "2009",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "728",
      "DOI": "10.1038/nsmb.2333",
      "article-title": "The structural basis for the sensing and binding of cyclic di-GMP by STING",
      "volume": "19",
      "author": "Huang",
      "year": "2012",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1016/S0140-6736(63)92585-6",
      "article-title": "Foreign nucleic acids as the stimulus to make interferon",
      "volume": "2",
      "author": "Isaacs",
      "year": "1963",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "40",
      "DOI": "10.1038/ni1282",
      "article-title": "A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA",
      "volume": "7",
      "author": "Ishii",
      "year": "2006",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "725",
      "DOI": "10.1038/nature06537",
      "article-title": "TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines",
      "volume": "451",
      "author": "Ishii",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "674",
      "DOI": "10.1038/nature07317",
      "article-title": "STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling",
      "volume": "455",
      "author": "Ishikawa",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "788",
      "DOI": "10.1038/nature08476",
      "article-title": "STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity",
      "volume": "461",
      "author": "Ishikawa",
      "year": "2009",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "5014",
      "DOI": "10.1128/MCB.00640-08",
      "article-title": "MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals",
      "volume": "28",
      "author": "Jin",
      "year": "2008",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "2595",
      "DOI": "10.4049/jimmunol.1100088",
      "article-title": "MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP",
      "volume": "187",
      "author": "Jin",
      "year": "2011",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "561",
      "DOI": "10.1016/j.immuni.2012.02.014",
      "article-title": "Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor",
      "volume": "36",
      "author": "Jin",
      "year": "2012",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "863",
      "DOI": "10.1084/jem.194.6.863",
      "article-title": "Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens",
      "volume": "194",
      "author": "Kadowaki",
      "year": "2001",
      "journal-title": "J.\u00a0Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "1168",
      "DOI": "10.1016/j.cell.2012.11.011",
      "article-title": "Signaling organelles of the innate immune system",
      "volume": "151",
      "author": "Kagan",
      "year": "2012",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "6427",
      "DOI": "10.4049/jimmunol.181.9.6427",
      "article-title": "Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors",
      "volume": "181",
      "author": "Kaiser",
      "year": "2008",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "91",
      "DOI": "10.1111/j.1600-065X.2011.01052.x",
      "article-title": "RIG-I-like receptors: cytoplasmic sensors for non-self RNA",
      "volume": "243",
      "author": "Kato",
      "year": "2011",
      "journal-title": "Immunol. Rev."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "1546",
      "DOI": "10.1126/science.292.5521.1546",
      "article-title": "Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver",
      "volume": "292",
      "author": "Kawane",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "574",
      "DOI": "10.1016/j.it.2011.08.004",
      "article-title": "Cytosolic DNA sensors regulating type I interferon induction",
      "volume": "32",
      "author": "Keating",
      "year": "2011",
      "journal-title": "Trends Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "363",
      "DOI": "10.1016/j.chom.2011.04.008",
      "article-title": "IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection",
      "volume": "9",
      "author": "Kerur",
      "year": "2011",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "15181",
      "DOI": "10.1073/pnas.1006539107",
      "article-title": "Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells",
      "volume": "107",
      "author": "Kim",
      "year": "2010",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "1222",
      "DOI": "10.4049/jimmunol.1100469",
      "article-title": "Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response",
      "volume": "187",
      "author": "Kis-Toth",
      "year": "2011",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "2969",
      "DOI": "10.1073/pnas.1222694110",
      "article-title": "DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking",
      "volume": "110",
      "author": "Kondo",
      "year": "2013",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "811",
      "DOI": "10.4049/jimmunol.1004143",
      "article-title": "Streptococcus\u00a0pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs",
      "volume": "188",
      "author": "Koppe",
      "year": "2012",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "423",
      "DOI": "10.1016/j.cell.2011.09.039",
      "article-title": "Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA",
      "volume": "147",
      "author": "Kowalinski",
      "year": "2011",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "190",
      "DOI": "10.1038/ni1028",
      "article-title": "TLR9 signals after translocating from the ER to CpG DNA in the lysosome",
      "volume": "5",
      "author": "Latz",
      "year": "2004",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "772",
      "DOI": "10.1038/ni1479",
      "article-title": "Ligand-induced conformational changes allosterically activate Toll-like receptor 9",
      "volume": "8",
      "author": "Latz",
      "year": "2007",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "603",
      "DOI": "10.1038/416603a",
      "article-title": "Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors",
      "volume": "416",
      "author": "Leadbetter",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "973",
      "DOI": "10.1016/S0092-8674(00)80172-5",
      "article-title": "The dorsoventral regulatory gene cassette sp\u00e4tzle/Toll/cactus controls the potent antifungal response in Drosophila adults",
      "volume": "86",
      "author": "Lemaitre",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "10558",
      "DOI": "10.1073/pnas.1203447109",
      "article-title": "Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16",
      "volume": "109",
      "author": "Li",
      "year": "2012",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "513",
      "DOI": "10.1084/jem.20030162",
      "article-title": "Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells",
      "volume": "198",
      "author": "Lund",
      "year": "2003",
      "journal-title": "J.\u00a0Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "409",
      "DOI": "10.1016/j.cell.2011.09.023",
      "article-title": "Structural insights into RNA recognition by RIG-I",
      "volume": "147",
      "author": "Luo",
      "year": "2011",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1016/j.chom.2012.03.007",
      "article-title": "Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages",
      "volume": "11",
      "author": "Manzanillo",
      "year": "2012",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "4212",
      "DOI": "10.1128/JVI.02435-10",
      "article-title": "Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1",
      "volume": "85",
      "author": "McFarlane",
      "year": "2011",
      "journal-title": "J.\u00a0Virol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "1899",
      "DOI": "10.1084/jem.20082874",
      "article-title": "A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP",
      "volume": "206",
      "author": "McWhirter",
      "year": "2009",
      "journal-title": "J.\u00a0Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "394",
      "DOI": "10.1038/41131",
      "article-title": "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity",
      "volume": "388",
      "author": "Medzhitov",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "7589",
      "DOI": "10.4049/jimmunol.176.12.7589",
      "article-title": "TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondii",
      "volume": "176",
      "author": "Minns",
      "year": "2006",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "3802",
      "DOI": "10.1128/MCB.01368-10",
      "article-title": "DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling",
      "volume": "31",
      "author": "Miyashita",
      "year": "2011",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.3109/08916930903510922",
      "article-title": "The interferon-inducible HIN-200 gene family in apoptosis and inflammation: implication for autoimmunity",
      "volume": "43",
      "author": "Mondini",
      "year": "2010",
      "journal-title": "Autoimmunity"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "881",
      "DOI": "10.1111/j.1462-5822.2010.01478.x",
      "article-title": "Induction of type I interferons by bacteria",
      "volume": "12",
      "author": "Monroe",
      "year": "2010",
      "journal-title": "Cell. Microbiol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1038/nature06664",
      "article-title": "The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response",
      "volume": "452",
      "author": "Muruve",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "1333",
      "DOI": "10.1084/jem.20051654",
      "article-title": "Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation",
      "volume": "202",
      "author": "Okabe",
      "year": "2005",
      "journal-title": "J.\u00a0Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "E3008",
      "DOI": "10.1073/pnas.1211302109",
      "article-title": "Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation if IFI16 by the viral ICP0 protein",
      "volume": "109",
      "author": "Orzalli",
      "year": "2012",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "1073",
      "DOI": "10.1016/j.immuni.2012.03.019",
      "article-title": "Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding",
      "volume": "36",
      "author": "Ouyang",
      "year": "2012",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1038/nri2937",
      "article-title": "Recognition of herpesviruses by the innate immune system",
      "volume": "11",
      "author": "Paludan",
      "year": "2011",
      "journal-title": "Nat. Rev. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "1247",
      "DOI": "10.1007/s10495-012-0775-5",
      "article-title": "PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway",
      "volume": "17",
      "author": "Park",
      "year": "2012",
      "journal-title": "Apoptosis"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "1155",
      "DOI": "10.1038/ni.2460",
      "article-title": "The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response",
      "volume": "13",
      "author": "Parvatiyar",
      "year": "2012",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "4926",
      "DOI": "10.4049/jimmunol.172.8.4926",
      "article-title": "Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway",
      "volume": "172",
      "author": "Pichyangkul",
      "year": "2004",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "5268",
      "DOI": "10.4049/jimmunol.1100949",
      "article-title": "Activation of autophagy by \u03b1-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes",
      "volume": "187",
      "author": "Rasmussen",
      "year": "2011",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "916",
      "DOI": "10.1038/embor.2009.109",
      "article-title": "DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB",
      "volume": "10",
      "author": "Rebsamen",
      "year": "2009",
      "journal-title": "EMBO Rep."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "1057",
      "DOI": "10.1126/science.1169841",
      "article-title": "HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA",
      "volume": "323",
      "author": "Roberts",
      "year": "2009",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib81",
      "doi-asserted-by": "crossref",
      "first-page": "564",
      "DOI": "10.1038/197564a0",
      "article-title": "Inhibition of virus multiplication by foreign nucleic acid",
      "volume": "197",
      "author": "Rotem",
      "year": "1963",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "339",
      "DOI": "10.1016/j.jaut.2009.11.001",
      "article-title": "Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice",
      "volume": "34",
      "author": "Santiago-Raber",
      "year": "2010",
      "journal-title": "J.\u00a0Autoimmun."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib83",
      "doi-asserted-by": "crossref",
      "first-page": "2147",
      "DOI": "10.1038/emboj.2008.143",
      "article-title": "Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation",
      "volume": "27",
      "author": "Schr\u00f6der",
      "year": "2008",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib84",
      "doi-asserted-by": "crossref",
      "first-page": "725",
      "DOI": "10.1038/nsmb.2332",
      "article-title": "Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP",
      "volume": "19",
      "author": "Shang",
      "year": "2012",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib85",
      "doi-asserted-by": "crossref",
      "first-page": "194",
      "DOI": "10.1016/j.immuni.2011.05.016",
      "article-title": "Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome",
      "volume": "35",
      "author": "Sharma",
      "year": "2011",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib86",
      "doi-asserted-by": "crossref",
      "first-page": "722",
      "DOI": "10.1038/nsmb.2331",
      "article-title": "Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system",
      "volume": "19",
      "author": "Shu",
      "year": "2012",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib87",
      "doi-asserted-by": "crossref",
      "first-page": "1224",
      "DOI": "10.1128/JVI.01635-10",
      "article-title": "RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I",
      "volume": "85",
      "author": "Solis",
      "year": "2011",
      "journal-title": "J.\u00a0Virol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib88",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/j.immuni.2005.12.003",
      "article-title": "Recognition of cytosolic DNA activates an IRF3-dependent innate immune response",
      "volume": "24",
      "author": "Stetson",
      "year": "2006",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib89",
      "doi-asserted-by": "crossref",
      "first-page": "587",
      "DOI": "10.1016/j.cell.2008.06.032",
      "article-title": "Trex1 prevents cell-intrinsic initiation of autoimmunity",
      "volume": "134",
      "author": "Stetson",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib90",
      "doi-asserted-by": "crossref",
      "first-page": "8653",
      "DOI": "10.1073/pnas.0900850106",
      "article-title": "ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization",
      "volume": "106",
      "author": "Sun",
      "year": "2009",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib91",
      "doi-asserted-by": "crossref",
      "first-page": "786",
      "DOI": "10.1126/science.1232458",
      "article-title": "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway",
      "volume": "339",
      "author": "Sun",
      "year": "2013",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib92",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1038/nature06013",
      "article-title": "DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response",
      "volume": "448",
      "author": "Takaoka",
      "year": "2007",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib93",
      "doi-asserted-by": "crossref",
      "first-page": "ra20",
      "DOI": "10.1126/scisignal.2002521",
      "article-title": "STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway",
      "volume": "5",
      "author": "Tanaka",
      "year": "2012",
      "journal-title": "Sci. Signal."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib94",
      "doi-asserted-by": "crossref",
      "first-page": "997",
      "DOI": "10.1038/ni.1932",
      "article-title": "IFI16 is an innate immune sensor for intracellular DNA",
      "volume": "11",
      "author": "Unterholzner",
      "year": "2010",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib95",
      "doi-asserted-by": "crossref",
      "first-page": "302",
      "DOI": "10.1016/j.chom.2010.03.006",
      "article-title": "Virus inhibition of RIP3-dependent necrosis",
      "volume": "7",
      "author": "Upton",
      "year": "2010",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib96",
      "doi-asserted-by": "crossref",
      "first-page": "290",
      "DOI": "10.1016/j.chom.2012.01.016",
      "article-title": "DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA",
      "volume": "11",
      "author": "Upton",
      "year": "2012",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib97",
      "doi-asserted-by": "crossref",
      "first-page": "803",
      "DOI": "10.1016/j.cell.2012.06.040",
      "article-title": "Extracellular M.\u00a0tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway",
      "volume": "150",
      "author": "Watson",
      "year": "2012",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib98",
      "doi-asserted-by": "crossref",
      "first-page": "394",
      "DOI": "10.4049/jimmunol.1100523",
      "article-title": "Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III",
      "volume": "188",
      "author": "Wenzel",
      "year": "2012",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib99",
      "doi-asserted-by": "crossref",
      "first-page": "276",
      "DOI": "10.1016/j.cell.2012.11.048",
      "article-title": "Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5",
      "volume": "152",
      "author": "Wu",
      "year": "2013",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib100",
      "doi-asserted-by": "crossref",
      "first-page": "826",
      "DOI": "10.1126/science.1229963",
      "article-title": "Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA",
      "volume": "339",
      "author": "Wu",
      "year": "2013",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib101",
      "doi-asserted-by": "crossref",
      "first-page": "2043",
      "DOI": "10.1128/jvi.76.5.2043-2053.2002",
      "article-title": "Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors",
      "volume": "76",
      "author": "Yan",
      "year": "2002",
      "journal-title": "J.\u00a0Virol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib102",
      "doi-asserted-by": "crossref",
      "first-page": "1005",
      "DOI": "10.1038/ni.1941",
      "article-title": "The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1",
      "volume": "11",
      "author": "Yan",
      "year": "2010",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib103",
      "doi-asserted-by": "crossref",
      "first-page": "873",
      "DOI": "10.1016/j.cell.2007.10.017",
      "article-title": "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease",
      "volume": "131",
      "author": "Yang",
      "year": "2007",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib104",
      "doi-asserted-by": "crossref",
      "first-page": "3109",
      "DOI": "10.4049/jimmunol.0900399",
      "article-title": "Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes",
      "volume": "183",
      "author": "Yasuda",
      "year": "2009",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib105",
      "doi-asserted-by": "crossref",
      "first-page": "735",
      "DOI": "10.1016/j.molcel.2012.05.029",
      "article-title": "Cyclic di-GMP sensing via the innate immune signaling protein STING",
      "volume": "46",
      "author": "Yin",
      "year": "2012",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib106",
      "doi-asserted-by": "crossref",
      "first-page": "730",
      "DOI": "10.1038/ni1087",
      "article-title": "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses",
      "volume": "5",
      "author": "Yoneyama",
      "year": "2004",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib107",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1038/ni1146",
      "article-title": "Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA",
      "volume": "6",
      "author": "Yoshida",
      "year": "2005",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib108",
      "doi-asserted-by": "crossref",
      "first-page": "1211",
      "DOI": "10.1093/intimm/dxl067",
      "article-title": "Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE",
      "volume": "18",
      "author": "Yu",
      "year": "2006",
      "journal-title": "Int. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2013.05.004_bib109",
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