DOI: 10.1016/j.immuni.2008.05.008. Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin

Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin

10.1016/j.immuni.2008.05.008

Crossref journal-article

Elsevier BV

Immunity (78)

Bibliography

Shinohara, M. L., Kim, J.-H., Garcia, V. A., & Cantor, H. (2008). Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin. Immunity, 29(1), 68â78.

Authors 4

Mari L. Shinohara (first)
June-Ho Kim (additional)
Virgilio A. Garcia (additional)
Harvey Cantor (additional)

References 48 Referenced 211

10.4049/jimmunol.171.9.4479 / J. Immunol. / Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent by Al Alwan (2003)
10.1126/science.287.5454.860 / Science / Eta-1 (osteopontin): an early component of Type 1(cell-mediated) immunity by Ashkar (2000)
10.1038/ni1541 / Nat. Immunol. / A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells by Awasthi (2007)
10.1038/ni1375 / Nat. Immunol. / Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells by Batten (2006)
10.1126/science.1099159 / Science / Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming by Benvenuti (2004)
10.4049/jimmunol.172.1.292 / J. Immunol. / Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes by Benvenuti (2004)
10.1084/jem.20021603 / J. Exp. Med. / Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis by Bettelli (2003)
10.1038/nature04753 / Nature / Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells by Bettelli (2006)
10.1128/IAI.71.6.3437-3442.2003 / Infect. Immun. / Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi by Burchill (2003)
10.4049/jimmunol.180.2.922 / J. Immunol. / IL-27 induces a Th1 immune response and susceptibility to experimental arthritis by Cao (2008)
10.1126/science.1062960 / Science / The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease by Chabas (2001)
10.4049/jimmunol.168.10.4854 / J. Immunol. / Immunostimulatory CpG-DNA activates murine microglia by Dalpke (2002)
10.1038/ni1540 / Nat. Immunol. / Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells by Fitzgerald (2007)
10.1084/jem.20011603 / J. Exp. Med. / Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells by Gilliet (2002)
10.4049/jimmunol.178.3.1341 / J. Immunol. / T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity by Gocke (2007)
10.1038/nm1197 / Nat. Med. / Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis by Greter (2005)
10.1111/j.0105-2896.2005.00240.x / Immunol. Rev. / Multiple sclerosis by Hafler (2005)
10.1038/ni1254 / Nat. Immunol. / Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages by Harrington (2005)
10.1038/nm1177 / Nat. Med. / Experimental autoimmune encephalomyelitis repressed by microglial paralysis by Heppner (2005)
10.1093/intimm/dxm139 / Int. Immunol. / IL-27 inhibits the development of regulatory T cells via STAT3 by Huber (2008)
10.1038/ni1415 / Nat. Immunol. / Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells by Hur (2007)
10.1016/j.cell.2006.07.035 / Cell / The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells by Ivanov (2006)
10.4049/jimmunol.168.5.2096 / J. Immunol. / Attenuated experimental autoimmune encephalomyelitis in Eta-1/osteopontin-deficient mice by Jansson (2002)
10.1146/annurev.immunol.22.012703.104758 / Annu. Rev. Immunol. / Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation by Kastelein (2007)
10.1084/jem.20031064 / J. Exp. Med. / The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis by Kawakami (2004)
10.1038/ni1449 / Nat. Immunol. / IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge by Khader (2007)
10.1084/jem.20041257 / J. Exp. Med. / IL-23 drives a pathogenic T cell population that induces autoimmune inflammation by Langrish (2005)
10.1038/ni1460 / Nat. Immunol. / Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 by Leibundgut-Landmann (2007)
10.1038/nature02916 / Nature / A role for the immunological synapse in lineage commitment of CD4 lymphocytes by Maldonado (2004)
10.1016/S0167-5699(00)01715-1 / Immunol. Today / Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks by O'Regan (2000)
10.1038/ni1261 / Nat. Immunol. / A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 by Park (2005)
10.1212/WNL.43.4.662 / Neurology / Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial by Paty (1993)
10.1016/S1074-7613(02)00324-2 / Immunity / IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells by Pflanz (2002)
10.1182/blood-2004-08-3228 / Blood / Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype by Renkl (2005)
10.1359/jbmr.1998.13.7.1101 / J. Bone Miner. Res. / Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro by Rittling (1998)
10.1136/gut.2004.048298 / Gut / Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response by Sato (2005)
10.1016/j.jneuroim.2003.08.002 / J. Neuroimmunol. / The “immunological-synapse” at its APC side in relapsing and secondary-progressive multiple sclerosis: modulation by interferon-beta by Shapiro (2003)
10.1073/pnas.0508666102 / Proc. Natl. Acad. Sci. USA / T-bet-dependent expression of osteopontin contributes to T cell polarization by Shinohara (2005)
10.1038/ni1327 / Nat. Immunol. / Osteopontin expression is essential for IFN-α production by plasmacytoid dendritic cells by Shinohara (2006)
10.1073/pnas.0802301105 / Proc. Natl. Acad. Sci. USA / Alternative translation of Osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells by Shinohara (2008)
10.1038/nri1108 / Nat. Rev. Immunol. / Transcriptional analysis of targets in multiple sclerosis by Steinman (2003)
10.1038/ni1376 / Nat. Immunol. / Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system by Stumhofer (2006)
10.1038/35073080 / Nat. Rev. Mol. Cell Biol. / A weak signal for strong responses: interferon-alpha/beta revisited by Taniguchi (2001)
10.4049/jimmunol.168.8.4173 / J. Immunol. / De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis by Tompkins (2002)
10.4049/jimmunol.178.6.3786 / J. Immunol. / IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection by Umemura (2007)
10.1016/j.immuni.2006.01.001 / Immunity / TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells by Veldhoen (2006)
10.1126/science.1099153 / Science / Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling by West (2004)
10.1016/0165-5728(95)00160-3 / J. Neuroimmunol. / Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis by Yu (1996)

Dates

Type	When
Created	17 years, 1 month ago (July 11, 2008, 7:15 a.m.)
Deposited	6 years, 8 months ago (Dec. 27, 2018, 3:53 a.m.)
Indexed	3 days, 2 hours ago (Sept. 3, 2025, 6:14 a.m.)
Issued	17 years, 2 months ago (July 1, 2008)
Published	17 years, 2 months ago (July 1, 2008)
Published Print	17 years, 2 months ago (July 1, 2008)

Funders 0

None

BibTeX

@article{Shinohara_2008, title={Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin}, volume={29}, ISSN={1074-7613}, url={http://dx.doi.org/10.1016/j.immuni.2008.05.008}, DOI={10.1016/j.immuni.2008.05.008}, number={1}, journal={Immunity}, publisher={Elsevier BV}, author={Shinohara, Mari L. and Kim, June-Ho and Garcia, Virgilio A. and Cantor, Harvey}, year={2008}, month=jul, pages={68–78} }

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      "author": "Ashkar",
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      "article-title": "A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells",
      "volume": "8",
      "author": "Awasthi",
      "year": "2007",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "929",
      "DOI": "10.1038/ni1375",
      "article-title": "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells",
      "volume": "7",
      "author": "Batten",
      "year": "2006",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "1150",
      "DOI": "10.1126/science.1099159",
      "article-title": "Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming",
      "volume": "305",
      "author": "Benvenuti",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib6",
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      "first-page": "292",
      "DOI": "10.4049/jimmunol.172.1.292",
      "article-title": "Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes",
      "volume": "172",
      "author": "Benvenuti",
      "year": "2004",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1073",
      "DOI": "10.1084/jem.20021603",
      "article-title": "Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis",
      "volume": "197",
      "author": "Bettelli",
      "year": "2003",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1038/nature04753",
      "article-title": "Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells",
      "volume": "441",
      "author": "Bettelli",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "3437",
      "DOI": "10.1128/IAI.71.6.3437-3442.2003",
      "article-title": "Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi",
      "volume": "71",
      "author": "Burchill",
      "year": "2003",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "922",
      "DOI": "10.4049/jimmunol.180.2.922",
      "article-title": "IL-27 induces a Th1 immune response and susceptibility to experimental arthritis",
      "volume": "180",
      "author": "Cao",
      "year": "2008",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "1731",
      "DOI": "10.1126/science.1062960",
      "article-title": "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease",
      "volume": "294",
      "author": "Chabas",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "4854",
      "DOI": "10.4049/jimmunol.168.10.4854",
      "article-title": "Immunostimulatory CpG-DNA activates murine microglia",
      "volume": "168",
      "author": "Dalpke",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "1372",
      "DOI": "10.1038/ni1540",
      "article-title": "Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells",
      "volume": "8",
      "author": "Fitzgerald",
      "year": "2007",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "695",
      "DOI": "10.1084/jem.20011603",
      "article-title": "Generation of human CD8 T regulatory cells by\u00a0CD40 ligand-activated plasmacytoid dendritic cells",
      "volume": "195",
      "author": "Gilliet",
      "year": "2002",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "1341",
      "DOI": "10.4049/jimmunol.178.3.1341",
      "article-title": "T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity",
      "volume": "178",
      "author": "Gocke",
      "year": "2007",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "328",
      "DOI": "10.1038/nm1197",
      "article-title": "Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis",
      "volume": "11",
      "author": "Greter",
      "year": "2005",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "208",
      "DOI": "10.1111/j.0105-2896.2005.00240.x",
      "article-title": "Multiple sclerosis",
      "volume": "204",
      "author": "Hafler",
      "year": "2005",
      "journal-title": "Immunol. Rev."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1123",
      "DOI": "10.1038/ni1254",
      "article-title": "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages",
      "volume": "6",
      "author": "Harrington",
      "year": "2005",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "146",
      "DOI": "10.1038/nm1177",
      "article-title": "Experimental autoimmune encephalomyelitis repressed by microglial paralysis",
      "volume": "11",
      "author": "Heppner",
      "year": "2005",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1093/intimm/dxm139",
      "article-title": "IL-27 inhibits the development of regulatory T cells via STAT3",
      "volume": "20",
      "author": "Huber",
      "year": "2008",
      "journal-title": "Int. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "74",
      "DOI": "10.1038/ni1415",
      "article-title": "Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells",
      "volume": "8",
      "author": "Hur",
      "year": "2007",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1121",
      "DOI": "10.1016/j.cell.2006.07.035",
      "article-title": "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells",
      "volume": "126",
      "author": "Ivanov",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "2096",
      "DOI": "10.4049/jimmunol.168.5.2096",
      "article-title": "Attenuated experimental autoimmune encephalomyelitis in Eta-1/osteopontin-deficient mice",
      "volume": "168",
      "author": "Jansson",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.1146/annurev.immunol.22.012703.104758",
      "article-title": "Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation",
      "volume": "25",
      "author": "Kastelein",
      "year": "2007",
      "journal-title": "Annu. Rev. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "185",
      "DOI": "10.1084/jem.20031064",
      "article-title": "The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis",
      "volume": "199",
      "author": "Kawakami",
      "year": "2004",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1038/ni1449",
      "article-title": "IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge",
      "volume": "8",
      "author": "Khader",
      "year": "2007",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1084/jem.20041257",
      "article-title": "IL-23 drives a pathogenic T cell population that induces autoimmune inflammation",
      "volume": "201",
      "author": "Langrish",
      "year": "2005",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "630",
      "DOI": "10.1038/ni1460",
      "article-title": "Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17",
      "volume": "8",
      "author": "Leibundgut-Landmann",
      "year": "2007",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "527",
      "DOI": "10.1038/nature02916",
      "article-title": "A role for the immunological synapse in lineage commitment of CD4 lymphocytes",
      "volume": "431",
      "author": "Maldonado",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "475",
      "DOI": "10.1016/S0167-5699(00)01715-1",
      "article-title": "Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks",
      "volume": "21",
      "author": "O'Regan",
      "year": "2000",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "1133",
      "DOI": "10.1038/ni1261",
      "article-title": "A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17",
      "volume": "6",
      "author": "Park",
      "year": "2005",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "662",
      "DOI": "10.1212/WNL.43.4.662",
      "article-title": "Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial",
      "volume": "43",
      "author": "Paty",
      "year": "1993",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1016/S1074-7613(02)00324-2",
      "article-title": "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells",
      "volume": "16",
      "author": "Pflanz",
      "year": "2002",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "946",
      "DOI": "10.1182/blood-2004-08-3228",
      "article-title": "Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype",
      "volume": "106",
      "author": "Renkl",
      "year": "2005",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "1101",
      "DOI": "10.1359/jbmr.1998.13.7.1101",
      "article-title": "Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro",
      "volume": "13",
      "author": "Rittling",
      "year": "1998",
      "journal-title": "J. Bone Miner. Res."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1254",
      "DOI": "10.1136/gut.2004.048298",
      "article-title": "Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response",
      "volume": "54",
      "author": "Sato",
      "year": "2005",
      "journal-title": "Gut"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "116",
      "DOI": "10.1016/j.jneuroim.2003.08.002",
      "article-title": "The \u201cimmunological-synapse\u201d at its APC side in relapsing and secondary-progressive multiple sclerosis: modulation by interferon-beta",
      "volume": "144",
      "author": "Shapiro",
      "year": "2003",
      "journal-title": "J. Neuroimmunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "17101",
      "DOI": "10.1073/pnas.0508666102",
      "article-title": "T-bet-dependent expression of osteopontin contributes to T cell polarization",
      "volume": "102",
      "author": "Shinohara",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "498",
      "DOI": "10.1038/ni1327",
      "article-title": "Osteopontin expression is essential for IFN-\u03b1 production by plasmacytoid dendritic cells",
      "volume": "7",
      "author": "Shinohara",
      "year": "2006",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "7235",
      "DOI": "10.1073/pnas.0802301105",
      "article-title": "Alternative translation of Osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells",
      "volume": "105",
      "author": "Shinohara",
      "year": "2008",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1038/nri1108",
      "article-title": "Transcriptional analysis of targets in multiple sclerosis",
      "volume": "3",
      "author": "Steinman",
      "year": "2003",
      "journal-title": "Nat. Rev. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "937",
      "DOI": "10.1038/ni1376",
      "article-title": "Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system",
      "volume": "7",
      "author": "Stumhofer",
      "year": "2006",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "378",
      "DOI": "10.1038/35073080",
      "article-title": "A weak signal for strong responses: interferon-alpha/beta revisited",
      "volume": "2",
      "author": "Taniguchi",
      "year": "2001",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "4173",
      "DOI": "10.4049/jimmunol.168.8.4173",
      "article-title": "De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis",
      "volume": "168",
      "author": "Tompkins",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "3786",
      "DOI": "10.4049/jimmunol.178.6.3786",
      "article-title": "IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection",
      "volume": "178",
      "author": "Umemura",
      "year": "2007",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1016/j.immuni.2006.01.001",
      "article-title": "TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells",
      "volume": "24",
      "author": "Veldhoen",
      "year": "2006",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "1153",
      "DOI": "10.1126/science.1099153",
      "article-title": "Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling",
      "volume": "305",
      "author": "West",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.immuni.2008.05.008_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "91",
      "DOI": "10.1016/0165-5728(95)00160-3",
      "article-title": "Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis",
      "volume": "64",
      "author": "Yu",
      "year": "1996",
      "journal-title": "J. Neuroimmunol."
    }
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