DOI: 10.1016/j.immuni.2005.04.004. Dynamics and Function of Langerhans Cells In Vivo

Dynamics and Function of Langerhans Cells In Vivo

10.1016/j.immuni.2005.04.004

Crossref journal-article

Elsevier BV

Immunity (78)

Bibliography

Kissenpfennig, A., Henri, S., Dubois, B., Laplace-BuilhÃ©, C., Perrin, P., Romani, N., Tripp, C. H., Douillard, P., Leserman, L., Kaiserlian, D., Saeland, S., Davoust, J., & Malissen, B. (2005). Dynamics and Function of Langerhans Cells In Vivo. Immunity, 22(5), 643â654.

Authors 13

Adrien Kissenpfennig (first)
Sandrine Henri (additional)
Bertrand Dubois (additional)
Corinne Laplace-Builhé (additional)
Pierre Perrin (additional)
Nikolaus Romani (additional)
Christoph H. Tripp (additional)
Patrice Douillard (additional)
Lee Leserman (additional)
Dominique Kaiserlian (additional)
Sem Saeland (additional)
Jean Davoust (additional)
Bernard Malissen (additional)

References 43 Referenced 777

10.4049/jimmunol.168.6.3079 / J. Immunol. / Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis by Akiba (2002)
10.1126/science.1087576 / Science / Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells by Allan (2003)
10.1182/blood.V93.2.590 / Blood / Definition of dendritic cell subpopulations present in the spleen, Peyer’s patches, lymph nodes, and skin of the mouse by Anjuere (1999)
10.4049/jimmunol.171.12.6466 / J. Immunol. / Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody by Asselin-Paturel (2003)
10.1002/eji.1830270214 / Eur. J. Immunol. / High and low doses of haptens dictate whether dermal or epidermal antigen-presenting cells promote contact hypersensitivity by Bacci (1997)
10.4049/jimmunol.172.4.1996 / J. Immunol. / Cutting edge: conventional CD8alpha(+) dendritic cells are generally involved in priming CTL immunity to viruses by Belz (2004)
10.1002/eji.1830171105 / Eur. J. Immunol. / Dendritic cells of the mouse recognized by two monoclonal antibodies by Breel (1987)
10.1016/j.it.2004.09.013 / Trends Immunol. / Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity by Carbone (2004)
10.4049/jimmunol.172.2.1018 / J. Immunol. / Development of the dendritic cell system during mouse ontogeny by Dakic (2004)
10.1084/jem.192.12.1685 / J. Exp. Med. / CD8(+) but not CD8(−) dendritic cells cross-prime cytotoxic T cells in vivo by den Haan (2000)
10.1084/jem.192.10.1425 / J. Exp. Med. / Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex by Gretz (2000)
10.1038/ni0205-125 / Nat. Immunol. / No driving without a license by Heath (2005)
10.1093/intimm/13.5.695 / Int. Immunol. / Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells by Hemmi (2001)
10.4049/jimmunol.167.2.741 / J. Immunol. / The dendritic cell populations of mouse lymph nodes by Henri (2001)
10.1016/S0171-2985(82)80081-8 / Immunobiology / Relation between langerhans cells, veiled cells, and interdigitating cells by Hoefsmit (1982)
10.1038/ni957 / Nat. Immunol. / Antigen presentation to naive CD4 T cells in the lymph node by Itano (2003)
10.1016/S1074-7613(03)00175-4 / Immunity / Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity by Itano (2003)
10.1084/jem.20030737 / J. Exp. Med. / The importance of CD11b+ dendritic cells in CD4+ T cell activation in vivo: with help from interleukin 1 by Iwasaki (2003)
10.1016/S1074-7613(02)00365-5 / Immunity / In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens by Jung (2002)
10.1182/blood.V100.5.1734.h81702001734_1734_1741 / Blood / Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs by Kamath (2002)
10.1084/jem.189.5.779 / J. Exp. Med. / Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity by Kehren (1999)
10.1128/MCB.25.1.88-99.2005 / Mol. Cell. Biol. / Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function by Kissenpfennig (2005)
10.1038/ni1139 / Nat. Immunol. / Visualizing dendritic cell networks in vivo by Lindquist (2004)
10.1016/j.immuni.2004.07.019 / Immunity / Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state by Mayerova (2004)
10.1182/blood.V99.6.2084 / Blood / Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression by McLellan (2002)
10.1038/ni852 / Nat. Immunol. / Langerhans cells renew in the skin throughout life under steady-state conditions by Merad (2002)
10.1038/nm1038 / Nat. Med. / Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease by Merad (2004)
10.1016/S0190-9622(94)70059-1 / J. Am. Acad. Dermatol. / Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin by Nickoloff (1994)
10.1016/S1074-7613(03)00120-1 / Immunity / Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance by Probst (2003)
10.4049/jimmunol.168.9.4361 / J. Immunol. / Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin by Ratzinger (2002)
10.4049/jimmunol.165.9.4910 / J. Immunol. / Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes by Ruedl (2000)
10.1038/ni1162 / Nat. Immunol. / Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4(+) T cell populations lacking helper function by Sporri (2005)
10.1073/pnas.231606698 / Proc. Natl. Acad. Sci. USA / Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance by Steinman (2002)
10.1046/j.0022-202x.2001.01631.x / J. Invest. Dermatol. / A close-up view of migrating Langerhans cells in the skin by Stoitzner (2002)
10.1046/j.1523-1747.2003.12042.x / J. Invest. Dermatol. / Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207 by Stoitzner (2003)
10.4049/jimmunol.137.8.2460 / J. Immunol. / Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells by Sullivan (1986)
10.1093/intimm/14.5.433 / Int. Immunol. / Identification and expression of mouse Langerin (CD207) in dendritic cells by Takahara (2002)
10.4049/jimmunol.129.5.1898 / J. Immunol. / Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity by Tigelaar (1982)
10.1016/S1074-7613(00)80160-0 / Immunity / Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules by Valladeau (2000)
10.4049/jimmunol.168.2.782 / J. Immunol. / Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues by Valladeau (2002)
10.4049/jimmunol.164.6.2978 / J. Immunol. / CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen by Vremec (2000)
10.1182/blood-2003-02-0513 / Blood / Most lymphoid organ dendritic cell types are phenotypically and functionally immature by Wilson (2003)
10.1084/jem.20021109 / J. Exp. Med. / Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2 by Zhao (2003)

Dates

Type	When
Created	20 years, 3 months ago (May 18, 2005, 8:01 a.m.)
Deposited	1 year, 3 months ago (May 10, 2024, 7:16 a.m.)
Indexed	2 weeks, 5 days ago (Aug. 6, 2025, 9:50 a.m.)
Issued	20 years, 3 months ago (May 1, 2005)
Published	20 years, 3 months ago (May 1, 2005)
Published Print	20 years, 3 months ago (May 1, 2005)

Funders 0

None

BibTeX

@article{Kissenpfennig_2005, title={Dynamics and Function of Langerhans Cells In Vivo}, volume={22}, ISSN={1074-7613}, url={http://dx.doi.org/10.1016/j.immuni.2005.04.004}, DOI={10.1016/j.immuni.2005.04.004}, number={5}, journal={Immunity}, publisher={Elsevier BV}, author={Kissenpfennig, Adrien and Henri, Sandrine and Dubois, Bertrand and Laplace-Builhé, Corinne and Perrin, Pierre and Romani, Nikolaus and Tripp, Christoph H. and Douillard, Patrice and Leserman, Lee and Kaiserlian, Dominique and Saeland, Sem and Davoust, Jean and Malissen, Bernard}, year={2005}, month=may, pages={643–654} }

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      "journal-title": "J. Immunol."
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    {
      "key": "10.1016/j.immuni.2005.04.004_bib2",
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      "first-page": "1925",
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      "article-title": "Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells",
      "volume": "301",
      "author": "Allan",
      "year": "2003",
      "journal-title": "Science"
    },
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      "key": "10.1016/j.immuni.2005.04.004_bib3",
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      "article-title": "Definition of dendritic cell subpopulations present in the spleen, Peyer\u2019s patches, lymph nodes, and skin of the mouse",
      "volume": "93",
      "author": "Anjuere",
      "year": "1999",
      "journal-title": "Blood"
    },
    {
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      "first-page": "6466",
      "DOI": "10.4049/jimmunol.171.12.6466",
      "article-title": "Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody",
      "volume": "171",
      "author": "Asselin-Paturel",
      "year": "2003",
      "journal-title": "J. Immunol."
    },
    {
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      "doi-asserted-by": "crossref",
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      "DOI": "10.1002/eji.1830270214",
      "article-title": "High and low doses of haptens dictate whether dermal or epidermal antigen-presenting cells promote contact hypersensitivity",
      "volume": "27",
      "author": "Bacci",
      "year": "1997",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "1996",
      "DOI": "10.4049/jimmunol.172.4.1996",
      "article-title": "Cutting edge: conventional CD8alpha(+) dendritic cells are generally involved in priming CTL immunity to viruses",
      "volume": "172",
      "author": "Belz",
      "year": "2004",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1555",
      "DOI": "10.1002/eji.1830171105",
      "article-title": "Dendritic cells of the mouse recognized by two monoclonal antibodies",
      "volume": "17",
      "author": "Breel",
      "year": "1987",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "655",
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      "article-title": "Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity",
      "volume": "25",
      "author": "Carbone",
      "year": "2004",
      "journal-title": "Trends Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "1018",
      "DOI": "10.4049/jimmunol.172.2.1018",
      "article-title": "Development of the dendritic cell system during mouse ontogeny",
      "volume": "172",
      "author": "Dakic",
      "year": "2004",
      "journal-title": "J. Immunol."
    },
    {
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      "article-title": "CD8(+) but not CD8(\u2212) dendritic cells cross-prime cytotoxic T cells in vivo",
      "volume": "192",
      "author": "den Haan",
      "year": "2000",
      "journal-title": "J. Exp. Med."
    },
    {
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      "volume": "192",
      "author": "Gretz",
      "year": "2000",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1038/ni0205-125",
      "article-title": "No driving without a license",
      "volume": "6",
      "author": "Heath",
      "year": "2005",
      "journal-title": "Nat. Immunol."
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      "first-page": "741",
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      "volume": "167",
      "author": "Henri",
      "year": "2001",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib15",
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      "volume": "161",
      "author": "Hoefsmit",
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    },
    {
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      "first-page": "733",
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      "author": "Itano",
      "year": "2003",
      "journal-title": "Nat. Immunol."
    },
    {
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      "first-page": "47",
      "DOI": "10.1016/S1074-7613(03)00175-4",
      "article-title": "Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity",
      "volume": "19",
      "author": "Itano",
      "year": "2003",
      "journal-title": "Immunity"
    },
    {
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      "first-page": "185",
      "DOI": "10.1084/jem.20030737",
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      "volume": "198",
      "author": "Iwasaki",
      "year": "2003",
      "journal-title": "J. Exp. Med."
    },
    {
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      "first-page": "211",
      "DOI": "10.1016/S1074-7613(02)00365-5",
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      "volume": "17",
      "author": "Jung",
      "year": "2002",
      "journal-title": "Immunity"
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      "first-page": "1734",
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      "article-title": "Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs",
      "volume": "100",
      "author": "Kamath",
      "year": "2002",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1084/jem.189.5.779",
      "article-title": "Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity",
      "volume": "189",
      "author": "Kehren",
      "year": "1999",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1128/MCB.25.1.88-99.2005",
      "article-title": "Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function",
      "volume": "25",
      "author": "Kissenpfennig",
      "year": "2005",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "1243",
      "DOI": "10.1038/ni1139",
      "article-title": "Visualizing dendritic cell networks in vivo",
      "volume": "5",
      "author": "Lindquist",
      "year": "2004",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1016/j.immuni.2004.07.019",
      "article-title": "Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state",
      "volume": "21",
      "author": "Mayerova",
      "year": "2004",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "2084",
      "DOI": "10.1182/blood.V99.6.2084",
      "article-title": "Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression",
      "volume": "99",
      "author": "McLellan",
      "year": "2002",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "1135",
      "DOI": "10.1038/ni852",
      "article-title": "Langerhans cells renew in the skin throughout life under steady-state conditions",
      "volume": "3",
      "author": "Merad",
      "year": "2002",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "510",
      "DOI": "10.1038/nm1038",
      "article-title": "Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease",
      "volume": "10",
      "author": "Merad",
      "year": "2004",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "535",
      "DOI": "10.1016/S0190-9622(94)70059-1",
      "article-title": "Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin",
      "volume": "30",
      "author": "Nickoloff",
      "year": "1994",
      "journal-title": "J. Am. Acad. Dermatol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1016/S1074-7613(03)00120-1",
      "article-title": "Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance",
      "volume": "18",
      "author": "Probst",
      "year": "2003",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "4361",
      "DOI": "10.4049/jimmunol.168.9.4361",
      "article-title": "Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin",
      "volume": "168",
      "author": "Ratzinger",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "4910",
      "DOI": "10.4049/jimmunol.165.9.4910",
      "article-title": "Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes",
      "volume": "165",
      "author": "Ruedl",
      "year": "2000",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "163",
      "DOI": "10.1038/ni1162",
      "article-title": "Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4(+) T cell populations lacking helper function",
      "volume": "6",
      "author": "Sporri",
      "year": "2005",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1073/pnas.231606698",
      "article-title": "Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance",
      "volume": "99",
      "author": "Steinman",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "117",
      "DOI": "10.1046/j.0022-202x.2001.01631.x",
      "article-title": "A close-up view of migrating Langerhans cells in the skin",
      "volume": "118",
      "author": "Stoitzner",
      "year": "2002",
      "journal-title": "J. Invest. Dermatol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1046/j.1523-1747.2003.12042.x",
      "article-title": "Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207",
      "volume": "120",
      "author": "Stoitzner",
      "year": "2003",
      "journal-title": "J. Invest. Dermatol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "2460",
      "DOI": "10.4049/jimmunol.137.8.2460",
      "article-title": "Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells",
      "volume": "137",
      "author": "Sullivan",
      "year": "1986",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "433",
      "DOI": "10.1093/intimm/14.5.433",
      "article-title": "Identification and expression of mouse Langerin (CD207) in dendritic cells",
      "volume": "14",
      "author": "Takahara",
      "year": "2002",
      "journal-title": "Int. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "1898",
      "DOI": "10.4049/jimmunol.129.5.1898",
      "article-title": "Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity",
      "volume": "129",
      "author": "Tigelaar",
      "year": "1982",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "71",
      "DOI": "10.1016/S1074-7613(00)80160-0",
      "article-title": "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules",
      "volume": "12",
      "author": "Valladeau",
      "year": "2000",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "782",
      "DOI": "10.4049/jimmunol.168.2.782",
      "article-title": "Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues",
      "volume": "168",
      "author": "Valladeau",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "2978",
      "DOI": "10.4049/jimmunol.164.6.2978",
      "article-title": "CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen",
      "volume": "164",
      "author": "Vremec",
      "year": "2000",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "2187",
      "DOI": "10.1182/blood-2003-02-0513",
      "article-title": "Most lymphoid organ dendritic cell types are phenotypically and functionally immature",
      "volume": "102",
      "author": "Wilson",
      "year": "2003",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.immuni.2005.04.004_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "153",
      "DOI": "10.1084/jem.20021109",
      "article-title": "Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2",
      "volume": "197",
      "author": "Zhao",
      "year": "2003",
      "journal-title": "J. Exp. Med."
    }
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