Abstract
The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30–40 nm diameter with a scaffold‐like arrangement of protein subunits at the surface. The ‘PspA‐scaffold’ is the basic structure that is common to all particles. The PspA‐scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
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Dates
Type | When |
---|---|
Created | 16 years, 10 months ago (Oct. 13, 2008, 1:19 a.m.) |
Deposited | 1 year, 10 months ago (Oct. 12, 2023, 8:10 p.m.) |
Indexed | 2 weeks, 2 days ago (Aug. 5, 2025, 8:45 a.m.) |
Issued | 16 years, 10 months ago (Oct. 10, 2008) |
Published | 16 years, 10 months ago (Oct. 10, 2008) |
Published Online | 16 years, 10 months ago (Oct. 10, 2008) |
Published Print | 16 years, 9 months ago (Oct. 29, 2008) |
@article{Standar_2008, title={PspA can form large scaffolds in Escherichia coli}, volume={582}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2008.09.002}, DOI={10.1016/j.febslet.2008.09.002}, number={25–26}, journal={FEBS Letters}, publisher={Wiley}, author={Standar, Kerstin and Mehner, Denise and Osadnik, Hendrik and Berthelmann, Felix and Hause, Gerd and Lünsdorf, Heinrich and Brüser, Thomas}, year={2008}, month=oct, pages={3585–3589} }