DOI: 10.1016/j.febslet.2008.04.029. Nuclear functions in space and time: Gene expression in a dynamic, constrained environment

Nuclear functions in space and time: Gene expression in a dynamic, constrained environment

10.1016/j.febslet.2008.04.029

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

All eukaryotic cells enclose their genome within a dedicated, membrane‐bound organelle termed the nucleus, which functions to partition gene transcription from sites of protein translation in the cytoplasm. Despite a great deal of research effort, basic questions about chromosome structure and gene expression mechanisms remain to be answered, including the relationship between the spatial organization of the genome and the transcription machinery. Powerful in vivo approaches are allowing researchers to test established in vitro concepts within the dynamic cellular environment, while genome‐wide screens have enabled rapid high throughput analyses of both structural and functional parameters. In several cases, as highlighted here, this has turned up surprising results and has forced a re‐evaluation of models for nuclear structure and gene regulation.

Bibliography

Trinkle-Mulcahy, L., & Lamond, A. I. (2008). Nuclear functions in space and time: Gene expression in a dynamic, constrained environment. FEBS Letters, 582(14), 1960â1970. Portico.

Authors 2

Laura Trinkle-Mulcahy (first)
Angus I. Lamond (additional)

References 85 Referenced 20

Dates

Type	When
Created	17 years, 3 months ago (April 29, 2008, 12:02 p.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 11:25 p.m.)
Indexed	1 year ago (July 23, 2024, 7:56 a.m.)
Issued	17 years, 3 months ago (April 28, 2008)
Published	17 years, 3 months ago (April 28, 2008)
Published Online	17 years, 3 months ago (April 28, 2008)
Published Print	17 years, 2 months ago (June 18, 2008)

Funders 0

None

BibTeX

@article{Trinkle_Mulcahy_2008, title={Nuclear functions in space and time: Gene expression in a dynamic, constrained environment}, volume={582}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2008.04.029}, DOI={10.1016/j.febslet.2008.04.029}, number={14}, journal={FEBS Letters}, publisher={Wiley}, author={Trinkle-Mulcahy, Laura and Lamond, Angus I.}, year={2008}, month=apr, pages={1960–1970} }

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