DOI: 10.1016/j.febslet.2008.02.065. How do in vitro reconstituted actin‐based motility assays provide insight into in vivo behavior?

How do in vitro reconstituted actin‐based motility assays provide insight into in vivo behavior?

10.1016/j.febslet.2008.02.065

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Recent live cell image analysis of actin dynamics in lamellipodia of motile cells has shown that regulated treadmilling, which supports actin‐based propulsion of functionalized particles in biomimetic reconstituted motility assays, is also responsible for lamellipodia extension. In both cases, filaments are created by branching with Arp2/3 complex only at the membrane or particle surface, grow transiently and are capped; ADF/cofilin enhances the treadmilling but does not sever filaments in the body of the meshwork. Differences between the cellular and biomimetic systems suggest that additional regulatory mechanisms take place in lamellipodia.

Bibliography

Bugyi, B., Le Clainche, C., Romet-Lemonne, G., & Carlier, M.-F. (2008). How do in vitro reconstituted actinâbased motility assays provide insight into in vivo behavior? FEBS Letters, 582(14), 2086â2092. Portico.

Authors 4

Beáta Bugyi (first)
Christophe Le Clainche (additional)
Guillaume Romet-Lemonne (additional)
Marie-France Carlier (additional)

References 66 Referenced 14

Dates

Type	When
Created	17 years, 5 months ago (March 12, 2008, 10:40 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 11:25 p.m.)
Indexed	1 year ago (Aug. 12, 2024, 7:51 a.m.)
Issued	17 years, 5 months ago (March 5, 2008)
Published	17 years, 5 months ago (March 5, 2008)
Published Online	17 years, 5 months ago (March 5, 2008)
Published Print	17 years, 2 months ago (June 18, 2008)

Funders 0

None

BibTeX

@article{Bugyi_2008, title={How do in vitro reconstituted actin‐based motility assays provide insight into in vivo behavior?}, volume={582}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2008.02.065}, DOI={10.1016/j.febslet.2008.02.065}, number={14}, journal={FEBS Letters}, publisher={Wiley}, author={Bugyi, Beáta and Le Clainche, Christophe and Romet-Lemonne, Guillaume and Carlier, Marie-France}, year={2008}, month=mar, pages={2086–2092} }

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