DOI: 10.1016/j.febslet.2007.05.039. The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions

10.1016/j.febslet.2007.05.039

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The human heat shock protein 70 (Hsp70) family contains at least eight homologous chaperone proteins. Endoplasmatic reticulum and mitochondria have their specific Hsp70 proteins, whereas the remaining six family members reside mainly in the cytosol and nucleus. The requirement for multiple highly homologous although different Hsp70 proteins is still far from clear, but their individual and tissue‐specific expression suggests that they are assigned distinct biological tasks. This concept is supported by the fact that mice knockout for different Hsp70 genes display remarkably discrete phenotypes. Moreover, emerging data suggest that individual Hsp70 proteins can bring about non‐overlapping and chaperone‐independent functions essential for growth and survival of cancer cells. This review summarizes our present knowledge of the individual members of human Hsp70 family and elaborate on the functional differences between the cytosolic/nuclear representatives.

Bibliography

Daugaard, M., Rohde, M., & JÃ¤Ã¤ttelÃ¤, M. (2007). The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Letters, 581(19), 3702â3710. Portico.

Authors 3

Mads Daugaard (first)
Mikkel Rohde (additional)
Marja Jäättelä (additional)

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Dates

Type	When
Created	18 years, 3 months ago (May 26, 2007, 7:11 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 7:49 p.m.)
Indexed	5 days, 16 hours ago (Aug. 27, 2025, 11:53 a.m.)
Issued	18 years, 3 months ago (May 25, 2007)
Published	18 years, 3 months ago (May 25, 2007)
Published Online	18 years, 3 months ago (May 25, 2007)
Published Print	18 years, 1 month ago (July 31, 2007)

Funders 0

None

BibTeX

@article{Daugaard_2007, title={The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions}, volume={581}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2007.05.039}, DOI={10.1016/j.febslet.2007.05.039}, number={19}, journal={FEBS Letters}, publisher={Wiley}, author={Daugaard, Mads and Rohde, Mikkel and Jäättelä, Marja}, year={2007}, month=may, pages={3702–3710} }

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