10.1016/j.febslet.2007.04.075
Crossref journal-article
Wiley
FEBS Letters (311)
Abstract

Yeast self‐perpetuating amyloids (prions) provide a convenient model for studying the cellular control of highly ordered aggregates involved in mammalian protein assembly disorders. The very ability of an amyloid to propagate a prion state in yeast is determined by its interactions with the stress‐inducible chaperone Hsp104. Prion formation and propagation are also influenced by other stress‐related chaperones (Hsp70 and Hsp40), and by alterations of the protein trafficking and degradation networks. Some stress conditions induce prion formation or loss. It is proposed that prions arise as byproducts of the reversible assembly of highly ordered complexes, protecting certain proteins during unfavorable conditions.

Bibliography

Chernoff, Y. O. (2007). Stress and prions: Lessons from the yeast model. FEBS Letters, 581(19), 3695–3701. Portico.

Authors 1
  1. Yury O. Chernoff (first)
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Dates
Type When
Created 18 years, 3 months ago (May 9, 2007, 7:04 a.m.)
Deposited 1 year, 11 months ago (Sept. 17, 2023, 7:48 p.m.)
Indexed 1 year, 1 month ago (Aug. 4, 2024, 2:33 p.m.)
Issued 18 years, 3 months ago (May 8, 2007)
Published 18 years, 3 months ago (May 8, 2007)
Published Online 18 years, 3 months ago (May 8, 2007)
Published Print 18 years, 1 month ago (July 31, 2007)
Funders 0

None

@article{Chernoff_2007, title={Stress and prions: Lessons from the yeast model}, volume={581}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2007.04.075}, DOI={10.1016/j.febslet.2007.04.075}, number={19}, journal={FEBS Letters}, publisher={Wiley}, author={Chernoff, Yury O.}, year={2007}, month=may, pages={3695–3701} }