DOI: 10.1016/j.febslet.2006.05.008. The neural cell adhesion molecule binds to fibroblast growth factor receptor 2

The neural cell adhesion molecule binds to fibroblast growth factor receptor 2

10.1016/j.febslet.2006.05.008

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The neural cell adhesion molecule (NCAM) can bind to and activate fibroblast growth factor receptor 1 (FGFR1). However, there are four major FGFR isoforms (FGFR1–FGFR4), and it is not known whether NCAM also interacts directly with the other three FGFR isoforms. In this study, we show by surface plasmon resonance analysis that NCAM can bind to FGFR2 with an affinity similar to that for the NCAM–FGFR1 interaction. However, the kinetic parameters for the NCAM–FGFR2 binding are different from those of the NCAM–FGFR1 binding. Both receptors were shown to cycle relatively fast between the NCAM bound and unbound states, although FGFR2 cycling was clearly faster (13 times) than the FGFR1 cycling. Moreover, ATP was more effective in inhibiting the binding of NCAM to FGFR1 than to FGFR2, indicating that the binding sites in NCAM for the two receptors are similar, but not identical.

Bibliography

Christensen, C., Lauridsen, J. B., Berezin, V., Bock, E., & Kiselyov, V. V. (2006). The neural cell adhesion molecule binds to fibroblast growth factor receptor 2. FEBS Letters, 580(14), 3386â3390. Portico.

Authors 5

Claus Christensen (first)
Jes B. Lauridsen (additional)
Vladimir Berezin (additional)
Elisabeth Bock (additional)
Vladislav V. Kiselyov (additional)

References 11 Referenced 58

{'key': 'e_1_2_6_2_1', 'first-page': '605', 'article-title': 'The neural cell adhesion molecule', 'volume': '3', 'author': 'Berezin V.', 'year': '2000', 'journal-title': 'Curr. Opin. Drug. Disc. Dev.'} / Curr. Opin. Drug. Disc. Dev. / The neural cell adhesion molecule by Berezin V. (2000)
10.1152/ajpcell.1993.265.3.C577
10.1093/hmg/ddh235
10.1021/bi0352320
10.1016/S0065-230X(08)60821-0
10.1016/S0969-2126(03)00096-0
10.1111/j.1471-4159.2005.03284.x
10.1111/j.1471-4159.2004.02779.x
10.1111/j.1460-9568.2005.04345.x
10.1093/protein/3.4.245
10.1007/s11064-004-6875-z

Dates

Type	When
Created	19 years, 3 months ago (May 12, 2006, 11:16 a.m.)
Deposited	1 year, 10 months ago (Oct. 12, 2023, 7:12 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 16, 2024, 5:11 a.m.)
Issued	19 years, 3 months ago (May 11, 2006)
Published	19 years, 3 months ago (May 11, 2006)
Published Online	19 years, 3 months ago (May 11, 2006)
Published Print	19 years, 2 months ago (June 12, 2006)

Funders 0

None

BibTeX

@article{Christensen_2006, title={The neural cell adhesion molecule binds to fibroblast growth factor receptor 2}, volume={580}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2006.05.008}, DOI={10.1016/j.febslet.2006.05.008}, number={14}, journal={FEBS Letters}, publisher={Wiley}, author={Christensen, Claus and Lauridsen, Jes B. and Berezin, Vladimir and Bock, Elisabeth and Kiselyov, Vladislav V.}, year={2006}, month=may, pages={3386–3390} }

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