DOI: 10.1016/j.febslet.2006.03.003. Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks

Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks

10.1016/j.febslet.2006.03.003

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

We investigate the structural properties of hubs that enable them to interact with several partners in protein–protein interaction networks. We find that hubs have more observed and predicted disordered residues with fewer loops/coils, and more charged residues on the surface as compared to non‐hubs. Smaller hubs have fewer disordered residues and more charged residues on the surface than larger hubs. We conclude that the global flexibility provided by disordered domains, and high surface charge are complementary factors that play a significant role in the binding ability of hubs.

Bibliography

Patil, A., & Nakamura, H. (2006). Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks. FEBS Letters, 580(8), 2041â2045. Portico.

Authors 2

Ashwini Patil (first)
Haruki Nakamura (additional)

References 31 Referenced 238

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Dates

Type	When
Created	19 years, 5 months ago (March 14, 2006, 8:45 a.m.)
Deposited	1 year, 10 months ago (Oct. 12, 2023, 6:56 p.m.)
Indexed	3 weeks ago (Aug. 5, 2025, 8:19 a.m.)
Issued	19 years, 5 months ago (March 10, 2006)
Published	19 years, 5 months ago (March 10, 2006)
Published Online	19 years, 5 months ago (March 10, 2006)
Published Print	19 years, 4 months ago (April 3, 2006)

Funders 0

None

BibTeX

@article{Patil_2006, title={Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks}, volume={580}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2006.03.003}, DOI={10.1016/j.febslet.2006.03.003}, number={8}, journal={FEBS Letters}, publisher={Wiley}, author={Patil, Ashwini and Nakamura, Haruki}, year={2006}, month=mar, pages={2041–2045} }

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