DOI: 10.1016/j.febslet.2004.11.063. From peptide‐bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects

From peptide‐bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects

10.1016/j.febslet.2004.11.063

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Ribosomes are ribozymes exerting substrate positioning and promoting substrate‐mediated catalysis. Peptide‐bonds are formed within a symmetrical region, thus suggesting that ribosomes evolved by gene‐fusion. Remote interactions dominate substrate positioning at stereochemistry suitable for peptide‐bond formation and elaborate architectural‐design guides the processivity of the reaction by rotatory motion. Nascent proteins are directed into the exit tunnel at extended conformation, complying with the tunnel's narrow entrance. Tunnel dynamics facilitate its interactive participation in elongation, discrimination, cellular signaling and nascent‐protein trafficking into the chaperon‐aided folding site. Conformational alterations, induced by ribosomal‐recycling factor, facilitate subunit dissociation. Remarkably, although antibiotics discrimination is determined by the identity of a single nucleotide, involved also in resistance, additional nucleotides dictate antibiotics effectiveness.

Bibliography

Baram, D., & Yonath, A. (2004). From peptideâbond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects. FEBS Letters, 579(4), 948â954. Portico.

Authors 2

David Baram (first)
Ada Yonath (additional)

References 51 Referenced 41

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{'key': 'e_1_2_9_48_1', 'first-page': '213', 'volume-title': 'Supramolecular Structure and Function', 'author': 'Eisenstein M.', 'year': '1994'} / Supramolecular Structure and Function by Eisenstein M. (1994)
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Dates

Type	When
Created	20 years, 8 months ago (Dec. 8, 2004, 4:43 p.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 11:16 p.m.)
Indexed	1 year ago (Aug. 24, 2024, 9:01 a.m.)
Issued	20 years, 8 months ago (Dec. 2, 2004)
Published	20 years, 8 months ago (Dec. 2, 2004)
Published Online	20 years, 8 months ago (Dec. 2, 2004)
Published Print	20 years, 6 months ago (Feb. 7, 2005)

Funders 0

None

BibTeX

@article{Baram_2004, title={From peptide‐bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects}, volume={579}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2004.11.063}, DOI={10.1016/j.febslet.2004.11.063}, number={4}, journal={FEBS Letters}, publisher={Wiley}, author={Baram, David and Yonath, Ada}, year={2004}, month=dec, pages={948–954} }

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