DOI: 10.1016/j.febslet.2004.03.122. Of flies and men; p53, a tumour suppressor

Of flies and men; p53, a tumour suppressor

10.1016/j.febslet.2004.03.122

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The completion of the Drosophila genome sequencing project [Science 287 (2000) 2185] has reconfirmed the fruit fly as a model organism to study human disease. Comparison studies have shown that two thirds of genes implicated in human cancers have counterparts in the fly [Curr. Opin. Genet. Dev. 11 (2001) 274; J. Cell Biol. 150 (2000) F23], including the tumour suppressor, p53. The suitability of the fruit fly to study the function of the tumour suppressor p53 is further exemplified by the lack of p53 family members within the fly genome, i.e., no homologues to p63 and p73 have been identified. Hence, there is no redundancy between family members greatly facilitating the analysis of p53 function. In addition, studying p53 in Drosophila provides an opportunity to learn about the evolution of tumour suppressors. Here, we will discuss what is known about Drosophila p53 in relation to human p53.

Bibliography

Sutcliffe, J. E., & Brehm, A. (2004). Of flies and men; p53, a tumour suppressor. FEBS Letters, 567(1), 86â91. Portico.

Authors 2

Josephine E. Sutcliffe (first)
Alexander Brehm (additional)

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{'key': 'e_1_2_5_7_1', 'article-title': 'Activation of p53 tumour suppressor protein', 'volume': '1602', 'author': 'Vousden K.H.', 'year': '2002', 'journal-title': 'Biochemia et Biophysica Acta'} / Biochemia et Biophysica Acta / Activation of p53 tumour suppressor protein by Vousden K.H. (2002)
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Dates

Type	When
Created	21 years, 3 months ago (May 11, 2004, 6:36 a.m.)
Deposited	1 year, 11 months ago (Sept. 11, 2023, 5:22 p.m.)
Indexed	3 months, 4 weeks ago (April 24, 2025, 2:44 a.m.)
Issued	21 years, 3 months ago (May 10, 2004)
Published	21 years, 3 months ago (May 10, 2004)
Published Online	21 years, 3 months ago (May 10, 2004)
Published Print	21 years, 2 months ago (June 1, 2004)

Funders 0

None

BibTeX

@article{Sutcliffe_2004, title={Of flies and men; p53, a tumour suppressor}, volume={567}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2004.03.122}, DOI={10.1016/j.febslet.2004.03.122}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Sutcliffe, Josephine E. and Brehm, Alexander}, year={2004}, month=may, pages={86–91} }

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