Abstract
Only a small portion of the total RNA transcribed in human cells becomes mature mRNA and constitutes the human transcriptome, which is context‐dependent and varies with development, physiology and pathology. A small fraction of different repetitive sequences, which make up more than half of the human genome, is retained in mature transcripts and shapes their function. Among them are short interspersed elements (SINEs), of which Alu sequences are most frequent, and simple sequence repeats, which come in many varieties. In this review, we have focused on the structural and functional role of Alu elements and trinucleotide repeats in transcripts.
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Dates
Type | When |
---|---|
Created | 21 years, 4 months ago (April 23, 2004, 5:53 a.m.) |
Deposited | 1 year, 11 months ago (Sept. 11, 2023, 5:22 p.m.) |
Indexed | 2 months, 1 week ago (June 27, 2025, 12:24 a.m.) |
Issued | 21 years, 4 months ago (April 22, 2004) |
Published | 21 years, 4 months ago (April 22, 2004) |
Published Online | 21 years, 4 months ago (April 22, 2004) |
Published Print | 21 years, 3 months ago (June 1, 2004) |
@article{Jasinska_2004, title={Repetitive sequences that shape the human transcriptome}, volume={567}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2004.03.109}, DOI={10.1016/j.febslet.2004.03.109}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Jasinska, Anna and Krzyzosiak, Wlodzimierz J.}, year={2004}, month=apr, pages={136–141} }