DOI: 10.1016/j.febslet.2004.03.091. Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase <i>GPX2</i> by oxidative stress is mediated by Yap1 and Skn7

Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7

10.1016/j.febslet.2004.03.091

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The GPX2 gene encodes a homologue of phospholipid hydroperoxide glutathione peroxidase in Saccharomyces cerevisiae. The GPX2 promoter contains three elements the sequence of which is completely consistent with the optimal sequence for the Yap1 response element (YRE). Here, we identify the intrinsic YRE that functions in the oxidative stress response of GPX2. In addition, we discovered a cis‐acting element (5′‐GGCCGGC‐3′) within the GPX2 promoter proximal to the functional YRE that is necessary for H2O2‐induced expression of GPX2. We present evidence showing that Skn7 is necessary for the oxidative stress response of GPX2 and is able to bind to this sequence. We determine the optimal sequence for Skn7 to regulate GPX2 under conditions of oxidative stress to be 5′‐GGC(C/T)GGC‐3′, and we designate this sequence the oxidative stress‐responsive Skn7 response element.

Bibliography

Tsuzi, D., Maeta, K., Takatsume, Y., Izawa, S., & Inoue, Y. (2004). Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7. FEBS Letters, 565(1â3), 148â154. Portico.

Authors 5

Daisuke Tsuzi (first)
Kazuhiro Maeta (additional)
Yoshifumi Takatsume (additional)
Shingo Izawa (additional)
Yoshiharu Inoue (additional)

References 25 Referenced 40

Dates

Type	When
Created	21 years, 4 months ago (April 18, 2004, 7:33 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 12:52 a.m.)
Indexed	1 year ago (Aug. 7, 2024, 1:13 p.m.)
Issued	21 years, 4 months ago (April 15, 2004)
Published	21 years, 4 months ago (April 15, 2004)
Published Online	21 years, 4 months ago (April 15, 2004)
Published Print	21 years, 3 months ago (May 7, 2004)

Funders 0

None

BibTeX

@article{Tsuzi_2004, title={Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7}, volume={565}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2004.03.091}, DOI={10.1016/j.febslet.2004.03.091}, number={1–3}, journal={FEBS Letters}, publisher={Wiley}, author={Tsuzi, Daisuke and Maeta, Kazuhiro and Takatsume, Yoshifumi and Izawa, Shingo and Inoue, Yoshiharu}, year={2004}, month=apr, pages={148–154} }

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