DOI: 10.1016/j.febslet.2004.03.065. Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide‐bond formation, chirality discrimination and antibiotics synergism

Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide‐bond formation, chirality discrimination and antibiotics synergism

10.1016/j.febslet.2004.03.065

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The linkage between internal ribosomal symmetry and transfer RNA (tRNA) positioning confirmed positional catalysis of amino‐acid polymerization. Peptide bonds are formed concurrently with tRNA‐3′end rotatory motion, in conjunction with the overall messenger RNA (mRNA)/tRNA translocation. Accurate substrate alignment, mandatory for the processivity of protein biosynthesis, is governed by remote interactions. Inherent flexibility of a conserved nucleotide, anchoring the rotatory motion, facilitates chirality discrimination and antibiotics synergism. Potential tRNA interactions explain the universality of the tRNA CCA‐end and P‐site preference of initial tRNA. The interactions of protein L2 tail with the symmetry‐related region periphery explain its conservation and its contributions to nascent chain elongation.

Bibliography

Agmon, I., Amit, M., Auerbach, T., Bashan, A., Baram, D., Bartels, H., Berisio, R., Greenberg, I., Harms, J., Hansen, H. A. S., Kessler, M., Pyetan, E., Schluenzen, F., Sittner, A., Yonath, A., & Zarivach, R. (2004). Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptideâbond formation, chirality discrimination and antibiotics synergism. FEBS Letters, 567(1), 20â26. Portico.

Authors 16

Ilana Agmon (first)
Maya Amit (additional)
Tamar Auerbach (additional)
Anat Bashan (additional)
David Baram (additional)
Heike Bartels (additional)
Rita Berisio (additional)
Inbal Greenberg (additional)
Joerg Harms (additional)
Harly A.S. Hansen (additional)
Maggie Kessler (additional)
Erez Pyetan (additional)
Frank Schluenzen (additional)
Assa Sittner (additional)
Ada Yonath (additional)
Raz Zarivach (additional)

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Dates

Type	When
Created	21 years, 4 months ago (April 9, 2004, 5:21 a.m.)
Deposited	1 year, 11 months ago (Sept. 11, 2023, 5:22 p.m.)
Indexed	1 year ago (Aug. 3, 2024, 10:21 p.m.)
Issued	21 years, 4 months ago (April 8, 2004)
Published	21 years, 4 months ago (April 8, 2004)
Published Online	21 years, 4 months ago (April 8, 2004)
Published Print	21 years, 3 months ago (June 1, 2004)

Funders 0

None

BibTeX

@article{Agmon_2004, title={Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide‐bond formation, chirality discrimination and antibiotics synergism}, volume={567}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/j.febslet.2004.03.065}, DOI={10.1016/j.febslet.2004.03.065}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Agmon, Ilana and Amit, Maya and Auerbach, Tamar and Bashan, Anat and Baram, David and Bartels, Heike and Berisio, Rita and Greenberg, Inbal and Harms, Joerg and Hansen, Harly A.S. and Kessler, Maggie and Pyetan, Erez and Schluenzen, Frank and Sittner, Assa and Yonath, Ada and Zarivach, Raz}, year={2004}, month=apr, pages={20–26} }

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