DOI: 10.1016/j.ejphar.2004.02.042. Signaling by insulin-like growth factor 1 in brain

Signaling by insulin-like growth factor 1 in brain

10.1016/j.ejphar.2004.02.042

Crossref journal-article

Elsevier BV

European Journal of Pharmacology (78)

Bibliography

Bondy, C. A., & Cheng, C. M. (2004). Signaling by insulin-like growth factor 1 in brain. European Journal of Pharmacology, 490(1â3), 25â31.

Authors 2

Carolyn A. Bondy (first)
Clara M. Cheng (additional)

References 40 Referenced 267

10.1016/S0021-9258(18)70226-3 / J. Biol. Chem. / Phosphorus assay in column chromatography by Bartlett (1959)
10.1016/0896-6273(95)90216-3 / Neuron / Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons by Beck (1995)
10.1016/0006-8993(88)90931-6 / Brain Res. / Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography by Bohannon (1988)
10.1523/JNEUROSCI.11-11-03442.1991 / J. Neurosci. / Transient IGF-I gene expression during the maturation of functionally related central projection neurons by Bondy (1991)
10.1016/1058-6741(92)90034-U / NeuroProtocols / Mapping of brain insulin and insulin-like growth factor receptor gene expression by in situ hybridization by Bondy (1992)
10.1016/0306-4522(92)90193-6 / Neuroscience / Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II by Bondy (1992)
10.1016/0165-3806(84)90032-4 / Brain Res. / Glycogen, its transient occurrence in neurons of the rat CNS during normal postnatal development by Borke (1984)
10.1203/00006450-200102000-00011 / Pediatr. Res. / Nutritional regulation of IGF-I expression during brain development in mice by Calikoglu (2001)
10.1523/JNEUROSCI.18-15-05673.1998 / J. Neurosci. / Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition by Cheng (1998)
10.1002/jnr.1084 / J. Neurosci. Res. / Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus by Cheng (2001)
10.1073/pnas.170008497 / Proc. Natl. Acad. Sci. U. S. A. / Insulin-like growth factor 1 regulates developing brain glucose metabolism by Cheng (2000)
10.1210/en.2002-0057 / Endocrinology / A ketogenic diet increases brain insulin-like growth factor receptor and glucose transporter gene expression by Cheng (2003)
10.1002/jnr.10634 / J. Neurosci. Res. / Insulin-like growth factor 1 is essential for normal dendritic growth by Cheng (2003)
10.1016/0169-328X(90)90052-F / Brain Res. Mol. Brain Res. / Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues by Coker (1990)
10.1074/jbc.M006160200 / J. Biol. Chem. / Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal by Crowder (2000)
10.1677/joe.0.1750041 / J. Endocrinol. / Specifying the cellular responses to IGF signals: roles of IGF-binding proteins by Duan (2002)
10.1042/0264-6021:3590001 / Biochem. J. / GSK3 takes centre stage more than 20 years after its discovery by Frame (2001)
10.1006/exnr.1994.1128 / Exp. Neurol. / Expression of insulin-like growth factor-I and related peptides during motoneuron regeneration by Gehrmann (1994)
10.1523/JNEUROSCI.20-07-02567.2000 / J. Neurosci. / Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal by Hetman (2000)
10.1016/0306-4522(86)90082-5 / Neuroscience / Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas by Hill (1986)
10.1074/jbc.272.31.19547 / J. Biol. Chem. / Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons by Hong (1997)
10.1074/jbc.271.49.31372 / J. Biol. Chem. / Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation by Kohn (1996)
10.1073/pnas.89.5.1894 / Proc. Natl. Acad. Sci. U. S. A. / Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination by Komoly (1992)
10.1016/1044-7431(92)90006-N / Mol. Cell. Neurosci. / Insulin-like growth factors in the response to cerebral ischemia by Lee (1992)
10.1210/en.133.6.2540 / Endocrinology / Ischemic injury induces brain glucose transporter gene expression by Lee (1993)
10.1016/0306-4522(93)90303-W / Neuroscience / Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: correlation with insulin-like growth factors I and II by Lee (1993)
10.1016/S0950-351X(96)80298-9 / Bailliere's Clin. Endocrinol. Metab. / Insulin-like growth factor receptors and binding proteins by LeRoith (1996)
10.1016/S0306-4522(00)00200-1 / Neuroscience / Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons by Lesort (2000)
10.1016/S0169-328X(98)00075-8 / Brain Res. Mol. Brain Res. / Induction of IGF-1 mRNA expression following traumatic injury to the postnatal brain by Li (1998)
10.1128/MCB.20.24.9356-9363.2000 / Mol. Cell. Biol. / Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta by Li (2000)
10.1093/emboj/20.1.27 / EMBO J. / Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice by Lucas (2001)
10.1523/JNEUROSCI.20-11-04165.2000 / J. Neurosci. / Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex by Niblock (2000)
10.1210/en.135.5.1753 / Endocrinology / Insulin-like growth factors cross the blood–brain barrier by Reinhardt (1994)
10.1042/bst0250981 / Biochem. Soc. Trans. / A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake by Summers (1997)
10.1074/jbc.274.25.17934 / J. Biol. Chem. / The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism by Summers (1999)
10.1016/S0065-3101(24)00055-0 / Adv. Pediatr. / The ketogenic diet: 1997 by Swink (1997)
{'key': '10.1016/j.ejphar.2004.02.042_BIB37', 'first-page': '80', 'article-title': 'Nutritional regulation of the insulin-like growth factors', 'volume': '15', 'author': 'Thissen', 'year': '1994', 'journal-title': 'Endocr. Rev.'} / Endocr. Rev. / Nutritional regulation of the insulin-like growth factors by Thissen (1994)
10.1046/j.0953-816x.2001.01572.x / Eur. J. Neurosci. / Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons by Tong (2001)
10.1210/en.140.7.3391 / Endocrinology / Effects of Igf1 gene deletion on postnatal growth patterns by Wang (1999)
10.1016/0143-4179(86)90035-1 / Neuropeptides / Periventricular hypothalamic cells in rat brain contain insulin mRNA by Young (1986)

Dates

Type	When
Created	21 years, 4 months ago (April 14, 2004, 5:27 a.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 5:32 p.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 9:17 p.m.)
Issued	21 years, 4 months ago (April 1, 2004)
Published	21 years, 4 months ago (April 1, 2004)
Published Print	21 years, 4 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Bondy_2004, title={Signaling by insulin-like growth factor 1 in brain}, volume={490}, ISSN={0014-2999}, url={http://dx.doi.org/10.1016/j.ejphar.2004.02.042}, DOI={10.1016/j.ejphar.2004.02.042}, number={1–3}, journal={European Journal of Pharmacology}, publisher={Elsevier BV}, author={Bondy, Carolyn A. and Cheng, Clara M.}, year={2004}, month=apr, pages={25–31} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        12
      ]
    ],
    "date-time": "2025-07-12T01:17:44Z",
    "timestamp": 1752283064191
  },
  "reference-count": 40,
  "publisher": "Elsevier BV",
  "issue": "1-3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            4,
            1
          ]
        ],
        "date-time": "2004-04-01T00:00:00Z",
        "timestamp": 1080777600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        4
      ]
    ]
  },
  "DOI": "10.1016/j.ejphar.2004.02.042",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        14
      ]
    ],
    "date-time": "2004-04-14T09:27:06Z",
    "timestamp": 1081934826000
  },
  "page": "25-31",
  "source": "Crossref",
  "is-referenced-by-count": 267,
  "title": "Signaling by insulin-like growth factor 1 in brain",
  "prefix": "10.1016",
  "volume": "490",
  "author": [
    {
      "given": "Carolyn A.",
      "family": "Bondy",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Clara M.",
      "family": "Cheng",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "466",
      "DOI": "10.1016/S0021-9258(18)70226-3",
      "article-title": "Phosphorus assay in column chromatography",
      "volume": "234",
      "author": "Bartlett",
      "year": "1959",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1016/0896-6273(95)90216-3",
      "article-title": "Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons",
      "volume": "14",
      "author": "Beck",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "205",
      "DOI": "10.1016/0006-8993(88)90931-6",
      "article-title": "Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography",
      "volume": "444",
      "author": "Bohannon",
      "year": "1988",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "3442",
      "DOI": "10.1523/JNEUROSCI.11-11-03442.1991",
      "article-title": "Transient IGF-I gene expression during the maturation of functionally related central projection neurons",
      "volume": "11",
      "author": "Bondy",
      "year": "1991",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "240",
      "DOI": "10.1016/1058-6741(92)90034-U",
      "article-title": "Mapping of brain insulin and insulin-like growth factor receptor gene expression by in situ hybridization",
      "volume": "1",
      "author": "Bondy",
      "year": "1992",
      "journal-title": "NeuroProtocols"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "909",
      "DOI": "10.1016/0306-4522(92)90193-6",
      "article-title": "Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II",
      "volume": "46",
      "author": "Bondy",
      "year": "1992",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1016/0165-3806(84)90032-4",
      "article-title": "Glycogen, its transient occurrence in neurons of the rat CNS during normal postnatal development",
      "volume": "318",
      "author": "Borke",
      "year": "1984",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1203/00006450-200102000-00011",
      "article-title": "Nutritional regulation of IGF-I expression during brain development in mice",
      "volume": "49",
      "author": "Calikoglu",
      "year": "2001",
      "journal-title": "Pediatr. Res."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "5673",
      "DOI": "10.1523/JNEUROSCI.18-15-05673.1998",
      "article-title": "Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition",
      "volume": "18",
      "author": "Cheng",
      "year": "1998",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "341",
      "DOI": "10.1002/jnr.1084",
      "article-title": "Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus",
      "volume": "64",
      "author": "Cheng",
      "year": "2001",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "10236",
      "DOI": "10.1073/pnas.170008497",
      "article-title": "Insulin-like growth factor 1 regulates developing brain glucose metabolism",
      "volume": "97",
      "author": "Cheng",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "2676",
      "DOI": "10.1210/en.2002-0057",
      "article-title": "A ketogenic diet increases brain insulin-like growth factor receptor and glucose transporter gene expression",
      "volume": "144",
      "author": "Cheng",
      "year": "2003",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1002/jnr.10634",
      "article-title": "Insulin-like growth factor 1 is essential for normal dendritic growth",
      "volume": "73",
      "author": "Cheng",
      "year": "2003",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/0169-328X(90)90052-F",
      "article-title": "Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues",
      "volume": "8",
      "author": "Coker",
      "year": "1990",
      "journal-title": "Brain Res. Mol. Brain Res."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "34266",
      "DOI": "10.1074/jbc.M006160200",
      "article-title": "Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal",
      "volume": "275",
      "author": "Crowder",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1677/joe.0.1750041",
      "article-title": "Specifying the cellular responses to IGF signals: roles of IGF-binding proteins",
      "volume": "175",
      "author": "Duan",
      "year": "2002",
      "journal-title": "J. Endocrinol."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1042/0264-6021:3590001",
      "article-title": "GSK3 takes centre stage more than 20 years after its discovery",
      "volume": "359",
      "author": "Frame",
      "year": "2001",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "202",
      "DOI": "10.1006/exnr.1994.1128",
      "article-title": "Expression of insulin-like growth factor-I and related peptides during motoneuron regeneration",
      "volume": "128",
      "author": "Gehrmann",
      "year": "1994",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "2567",
      "DOI": "10.1523/JNEUROSCI.20-07-02567.2000",
      "article-title": "Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal",
      "volume": "20",
      "author": "Hetman",
      "year": "2000",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "1127",
      "DOI": "10.1016/0306-4522(86)90082-5",
      "article-title": "Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas",
      "volume": "17",
      "author": "Hill",
      "year": "1986",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "19547",
      "DOI": "10.1074/jbc.272.31.19547",
      "article-title": "Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons",
      "volume": "272",
      "author": "Hong",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "31372",
      "DOI": "10.1074/jbc.271.49.31372",
      "article-title": "Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation",
      "volume": "271",
      "author": "Kohn",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1894",
      "DOI": "10.1073/pnas.89.5.1894",
      "article-title": "Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination",
      "volume": "89",
      "author": "Komoly",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "36",
      "DOI": "10.1016/1044-7431(92)90006-N",
      "article-title": "Insulin-like growth factors in the response to cerebral ischemia",
      "volume": "3",
      "author": "Lee",
      "year": "1992",
      "journal-title": "Mol. Cell. Neurosci."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "2540",
      "DOI": "10.1210/en.133.6.2540",
      "article-title": "Ischemic injury induces brain glucose transporter gene expression",
      "volume": "133",
      "author": "Lee",
      "year": "1993",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1016/0306-4522(93)90303-W",
      "article-title": "Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: correlation with insulin-like growth factors I and II",
      "volume": "53",
      "author": "Lee",
      "year": "1993",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1016/S0950-351X(96)80298-9",
      "article-title": "Insulin-like growth factor receptors and binding proteins",
      "volume": "10",
      "author": "LeRoith",
      "year": "1996",
      "journal-title": "Bailliere's Clin. Endocrinol. Metab."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1016/S0306-4522(00)00200-1",
      "article-title": "Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons",
      "volume": "99",
      "author": "Lesort",
      "year": "2000",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "92",
      "DOI": "10.1016/S0169-328X(98)00075-8",
      "article-title": "Induction of IGF-1 mRNA expression following traumatic injury to the postnatal brain",
      "volume": "57",
      "author": "Li",
      "year": "1998",
      "journal-title": "Brain Res. Mol. Brain Res."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "9356",
      "DOI": "10.1128/MCB.20.24.9356-9363.2000",
      "article-title": "Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta",
      "volume": "20",
      "author": "Li",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1093/emboj/20.1.27",
      "article-title": "Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice",
      "volume": "20",
      "author": "Lucas",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "4165",
      "DOI": "10.1523/JNEUROSCI.20-11-04165.2000",
      "article-title": "Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex",
      "volume": "20",
      "author": "Niblock",
      "year": "2000",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1753",
      "DOI": "10.1210/en.135.5.1753",
      "article-title": "Insulin-like growth factors cross the blood\u2013brain barrier",
      "volume": "135",
      "author": "Reinhardt",
      "year": "1994",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "981",
      "DOI": "10.1042/bst0250981",
      "article-title": "A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake",
      "volume": "25",
      "author": "Summers",
      "year": "1997",
      "journal-title": "Biochem. Soc. Trans."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "17934",
      "DOI": "10.1074/jbc.274.25.17934",
      "article-title": "The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism",
      "volume": "274",
      "author": "Summers",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1016/S0065-3101(24)00055-0",
      "article-title": "The ketogenic diet: 1997",
      "volume": "44",
      "author": "Swink",
      "year": "1997",
      "journal-title": "Adv. Pediatr."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB37",
      "first-page": "80",
      "article-title": "Nutritional regulation of the insulin-like growth factors",
      "volume": "15",
      "author": "Thissen",
      "year": "1994",
      "journal-title": "Endocr. Rev."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1913",
      "DOI": "10.1046/j.0953-816x.2001.01572.x",
      "article-title": "Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons",
      "volume": "13",
      "author": "Tong",
      "year": "2001",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "3391",
      "DOI": "10.1210/en.140.7.3391",
      "article-title": "Effects of Igf1 gene deletion on postnatal growth patterns",
      "volume": "140",
      "author": "Wang",
      "year": "1999",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/j.ejphar.2004.02.042_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/0143-4179(86)90035-1",
      "article-title": "Periventricular hypothalamic cells in rat brain contain insulin mRNA",
      "volume": "8",
      "author": "Young",
      "year": "1986",
      "journal-title": "Neuropeptides"
    }
  ],
  "container-title": "European Journal of Pharmacology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0014299904001992?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0014299904001992?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        12
      ]
    ],
    "date-time": "2024-01-12T22:32:01Z",
    "timestamp": 1705098721000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0014299904001992"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        4
      ]
    ]
  },
  "references-count": 40,
  "journal-issue": {
    "issue": "1-3",
    "published-print": {
      "date-parts": [
        [
          2004,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "S0014299904001992"
  ],
  "URL": "http://dx.doi.org/10.1016/j.ejphar.2004.02.042",
  "relation": {},
  "ISSN": [
    "0014-2999"
  ],
  "subject": [],
  "container-title-short": "European Journal of Pharmacology",
  "published": {
    "date-parts": [
      [
        2004,
        4
      ]
    ]
  }
}