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References
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Referenced
60
{'key': '10.1016/j.ejmech.2017.05.041_bib1', 'series-title': 'Breast Cancer Facts & Figures\xa02015-2016', 'author': 'American Cancer Society', 'year': '2015'}
/ Breast Cancer Facts & Figures 2015-2016 by American Cancer Society (2015)-
T. Jha, N. Adhikari, A. K. Halder, A. Saha, Ligand- and structure-based drug design of non-steroidal aromatase inhibitors (NSAIs) in breast cancer, in: K. Roy (Ed.), Quantitative Structure-activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment, IGI Global, Hershey PA, USA, pp. 400–470.
(
10.4018/978-1-4666-8136-1.ch011
) {'key': '10.1016/j.ejmech.2017.05.041_bib3', 'first-page': '10', 'article-title': 'Cancer statistics, 2012, CA: a can', 'volume': '62', 'author': 'Siegel', 'year': '2012', 'journal-title': 'J.\xa0Clin.'}
/ J. Clin. / Cancer statistics, 2012, CA: a can by Siegel (2012)10.1186/1477-7827-12-66
/ Reprod. Biol. Endocrinol. / The role of hormones and aromatase inhibitors on breast tumor growth and general health in a postmenopausal mouse model by Arumugam (2014){'key': '10.1016/j.ejmech.2017.05.041_bib5', 'first-page': '1', 'article-title': 'US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status', 'volume': '106', 'author': 'Howlader', 'year': '2014', 'journal-title': 'J.\xa0Nat. Can. Inst.'}
/ J. Nat. Can. Inst. / US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status by Howlader (2014)10.1136/esmoopen-2016-000062
/ ESMO Open / Review of hormone-based treatments in postmenopausal patients with advanced breast cancer focusing on aromatase inhibitors and fulvestrant by Kumler (2016)10.1016/S0093-7754(03)00302-6
/ Semin. Oncol. / Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer by Miller (2003){'key': '10.1016/j.ejmech.2017.05.041_bib8', 'first-page': '101', 'article-title': 'On the treatment of inoperable cases of carcinoma of the mamma: suggestion for a new method of treatment, with illustrative cases', 'volume': '148', 'author': 'Beatson', 'year': '1896', 'journal-title': 'Lancet'}
/ Lancet / On the treatment of inoperable cases of carcinoma of the mamma: suggestion for a new method of treatment, with illustrative cases by Beatson (1896)10.2174/1568011043352669
/ Curr. Med. Chem. Anti-Can. Agents / Aromatase inhibitors: a new paradigm in breast cancer treatment by Murthy (2004)10.2174/156802606776173483
/ Curr. Top. Med. Chem. / Estrogen receptors as therapeutic targets in breast cancer by Ariazi (2006)10.1210/er.2004-0015
/ Endocrinol. Rev. / Aromatase inhibitors in the treatment of breast cancer by Brueggemeier (2005){'key': '10.1016/j.ejmech.2017.05.041_bib12', 'first-page': '123', 'article-title': 'The selective estrogen enzyme modulators in breast cancer: a review', 'volume': '1654', 'author': 'Pasqualini', 'year': '2004', 'journal-title': 'Biochimica Biophysica Acta'}
/ Biochimica Biophysica Acta / The selective estrogen enzyme modulators in breast cancer: a review by Pasqualini (2004)10.1016/S0968-0896(97)10053-0
/ Bioorg. Med. Chem. / Comparative molecular field analysis of non-steroidal aromatase inhibitors: an extended model for two different structural classes by Recanatini (1998)10.1016/j.jsbmb.2005.04.021
/ J. Steroid Biochem. Mol. Biol. / Aromatase inhibitors: future directions by Osborne (2005)10.1016/j.jsbmb.2006.09.002
/ J. Steroid Biochem. Mol. Biol. / Aromatase and breast cancer by Brodie (2006){'key': '10.1016/j.ejmech.2017.05.041_bib16', 'first-page': '34', 'article-title': 'Aromatase inhibitors in advanced breast cancer', 'volume': '99', 'author': 'Spinelli', 'year': '2008', 'journal-title': 'Recent. Prog. Med.'}
/ Recent. Prog. Med. / Aromatase inhibitors in advanced breast cancer by Spinelli (2008)10.1007/s12032-007-9019-x
/ Med. Oncol. / Aromatase inhibitors: Past, present and future in breast cancer therapy by Dutta (2008)10.2174/138955708784534472
/ Mini Rev. Med. Chem. / Aromatase inhibitors:A new reality for the adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women by Colozza (2008)10.2174/156802608784911590
/ Curr. Top. Med. Chem. / From non-steroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer by Gobbi (2008)10.1016/j.ejmech.2009.05.003
/ Eur. J. Med. Chem. / An efficient steroid pharmacophore based strategy to identify new aromatase inhibitors by Neves (2009)10.1002/med.10010
/ Med. Res. Rev. / Non-steroidal aromatase inhibitors: recent advances by Recanatini (2002)10.1126/science.1096361
/ Science / The many roles of computation in drug discovery by Jorgensen (2004)10.1007/978-1-61779-012-6_2
/ Methods Mol. Biol. / Computer-aided drug discovery and development by Zhang (2011)10.1038/nrd941
/ Nat. Rev. Drug Discov. / Integration of virtual and high-throughput screening by Bajorath (2002)10.1038/nchembio.1199
/ Nat. Chem. Biol. / Target identification and mechanism of action in chemical biology and drug discovery by Schenone (2013)10.1111/j.1476-5381.2010.01127.x
/ Br. J. Pharmacol. / Principles of early drug discovery by Hughes (2011)10.1021/jm8010096
/ J. Med. Chem. / Discovery of multi-target inhibitors by combining molecular docking with common pharmacophore matching by Wei (2008)10.1038/srep16924
/ Sci. Rep. / Large-scale computational screening identifies first in class multitarget inhibitor of EGFR kinase and BRD4 by allen (2015)10.1021/cr0780210
/ Chem. Rev. / Camptothecins: a SAR/QSAR study by Verma (2009)10.1021/ci6002043
/ J. Chem. Inf. Model / Parallel screening: a novel concept in pharmacophore modeling and virtual screening by Steindl (2006)10.1016/j.bmcl.2016.10.058
/ Bioorg. Med. Chem. Lett. / First molecular modeling report on novel arylpyrimidine kynurenine monooxygenase inhibitors through multi-QSAR analysis against Huntington's disease: a proposal to chemists! by Amin (2016){'key': '10.1016/j.ejmech.2017.05.041_bib32', 'first-page': '1', 'article-title': 'The history and development of quantitative structure-activity relationships', 'volume': '1', 'author': 'Dearden', 'year': '2016', 'journal-title': 'Int. J. Quant. Struct. Prop. Relat.'}
/ Int. J. Quant. Struct. Prop. Relat. / The history and development of quantitative structure-activity relationships by Dearden (2016)10.1016/S0968-0896(00)00203-0
/ Bioorg. Med. Chem. / Linking CoMFA and protein homology models of enzyme-inhibitor interactions: an application to non-steroidal aromatase inhibitors by Cavalli (2000)10.1021/ci050237k
/ J. Chem. Inf. Model / Pharmacophore modeling and in silico screening for new P450 19 (aromatase) inhibitors by Schuster (2006)10.1007/s11030-008-9077-9
/ Mol. Divers / Pharmacophore mapping of flavones derivatives for aromatase inhibition by Nagar (2008)10.1016/j.bmc.2008.08.046
/ Bioorg. Med. Chem. / CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors by Castellano (2008)10.1021/jm800945c
/ J. Med. Chem. / Fast three dimensional Pharmacophore virtual screening of new potent non-steroid aromatase inhibitors by Neves (2009)10.1016/j.ejmech.2010.06.033
/ Eur. J. Med. Chem. / Exploring benzcyclo derivatives as potent aromatase inhibitors using ligand based modeling studies by Nagar (2010)10.1002/jcc.21528
/ J. Comput. Chem. / Modeling of diarylalkyl-imidazole and diarylalkyl-triazole derivatives as potent aromatase inhibitors for treatment of hormone-dependent cancer by Nagar (2010)10.1016/j.bmcl.2010.03.113
/ Bioorg. Med. Chem. Lett. / Pharmacophore modeling strategies for the development of novel non-steroidal inhibitors of human aromatase (CYP19) by Muftuoglu (2010)10.1111/j.1747-0285.2011.01277.x
/ Chem. Biol. Drug Des. / Molecular modeling evaluation of non-steroidal aromatase inhibitors by Narayana (2012)10.1007/s11030-013-9462-x
/ Mol. Divers / Exploring the chemical space of aromatase inhibitors by Nantasenamat (2013)10.1016/j.ejmech.2013.08.015
/ Eur. J. Med. Chem. / QSAR modeling of aromatase inhibitory activity of 1-substituted 1, 2, 3-triazole analogs of letrozole by Nantasenamat (2013)10.1016/j.chemolab.2014.07.017
/ Chemom. Intell. Lab. Sys / Large-scale QSAR study of aromatase inhibitors using SMILES-based descriptors by Worachartcheewan (2014)10.1007/s00044-014-1257-9
/ Med. Chem. Res. / Pharmacophore modeling, virtual screening, and 3D-QSAR studies on a series of non-steroidal aromatase inhibitors by Xie (2015)10.1016/S0021-9258(19)36937-6
/ J. Biol. Chem. / Core glycosylation of cytochrome P-450(arom). Evidence for localization of N terminus of microsomal cytochrome P-450 in the lumen by Shimozawa (1993){'key': '10.1016/j.ejmech.2017.05.041_bib47', 'first-page': '1617', 'article-title': 'Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis', 'volume': '7', 'author': 'Amarneh', 'year': '1993', 'journal-title': 'Mol. Endocrinol. Baltim. Md.)'}
/ Mol. Endocrinol. Baltim. Md.) / Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis by Amarneh (1993)10.1038/nature07614
/ Nature / Structural basis for androgen specificity and oestrogen synthesis in human aromatase by Ghosh (2009)10.1016/j.jsbmb.2009.09.012
/ J. Steroid Biochem. Mol. Biol. / X-ray structure of human aromatase reveals an androgen-specific active site by Ghosh (2010)10.1016/S0960-0760(98)00022-3
/ J. Steroid Biochem. Mol. Biol. / Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications by Brodie (1998)10.1210/endo.142.11.8547
/ Endocrinol / Aromatase and the regulation of estrogen biosynthesis-some new perspectives by Simpson (2001)10.1016/S0021-9258(18)61364-X
/ J. Biol. Chem. / Purification and characterization of human placental aromatase cytochrome P450 by Kellis (1987){'key': '10.1016/j.ejmech.2017.05.041_bib53', 'first-page': '342', 'article-title': 'Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis', 'volume': '15', 'author': 'Simpson', 'year': '1994', 'journal-title': 'Endocr. Rev.'}
/ Endocr. Rev. / Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis by Simpson (1994){'key': '10.1016/j.ejmech.2017.05.041_bib54', 'first-page': '337', 'article-title': 'Detection of intratumoral aromatase in breast carcinomas, an immunohistochemical study with clinico-pathologic correlation', 'volume': '140', 'author': 'Esteban', 'year': '1992', 'journal-title': 'Am. J. Pathol.'}
/ Am. J. Pathol. / Detection of intratumoral aromatase in breast carcinomas, an immunohistochemical study with clinico-pathologic correlation by Esteban (1992){'key': '10.1016/j.ejmech.2017.05.041_bib55', 'article-title': 'Closing remarks to the conference, aromatase: new perspectives for breast cancer', 'volume': '42', 'author': 'Lipton', 'year': '1982', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Closing remarks to the conference, aromatase: new perspectives for breast cancer by Lipton (1982)10.3109/14756368809040728
/ J. Enz. Inhib. / Structure-activity relationships for non-steroidal inhibitors of aromatase by Banting (1988)10.1021/jm00173a001
/ J. Med. Chem. / Mechanism and inhibition of cytochrome P450 aromatase by Cole (1990)10.1007/BF00682739
/ Breast Cancer Res. Treat. / Aromatase inhibitors mechanisms of steroidal inhibitors by Brueggemeier (1994)10.1016/S0960-0760(99)00051-5
/ J. Steroid Biochem. Mol. Biol. / Aromatase and its inhibitors by Brodie (1999)10.1016/S0039-128X(99)00104-X
/ Steroids / Aromatase inhibitors and their application in breast cancer treatment by Brodie (2000)10.1634/theoncologist.11-6-553
/ Oncol. / Aromatase inhibitors in breast cancer: an overview by Altundag (2006)10.2174/157339407780126656
/ Curr. Cancer Ther. Rev. / Aromatase inhibitors for treatment of breast cancer by Benson (2007)10.1177/1060028014548416
/ Ann. Pharmacother. / Aromatase inhibitors in breast cancer prevention by Olin (2014)10.1586/14737140.2014.882233
/ Exp. Rev. Antican. Ther. / Advances in mechanisms of resistance to aromatase inhibitors by Chumsri (2014)10.1530/ERC-13-0269
/ Endocr. Relat. Cancer / Aromatase inhibitors in the breast cancer clinic: focus on exemestane by van Asten (2014){'key': '10.1016/j.ejmech.2017.05.041_bib66', 'first-page': '54', 'article-title': 'Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update, anticancer agent', 'volume': '14', 'author': 'Gobbi', 'year': '2014', 'journal-title': 'Med. Chem.'}
/ Med. Chem. / Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update, anticancer agent by Gobbi (2014)10.1016/j.tiv.2015.05.017
/ Tox. Vitro / Structural findings of phenylindoles as cytotoxic antimitotic agents in human breast cancer cell lines through multiple validated QSAR studies by Adhikari (2015)10.1139/cjc-2016-0050
/ Can. J. Chem. / Exploring structural requirements of unconventional Knoevenagel-type indole derivatives as anticancer agents through comparative QSAR modeling approaches by Amin (2016)10.1016/j.bmc.2016.07.023
/ Bioorg. Med. Chem. / Robust design of some selective matrix metalloproteinase-2 inhibitors over matrix metalloproteinase-9 through in silico/fragment-based lead identification and de novo lead modification: syntheses and biological assays by Adhikari (2016)- Tripos Inc., SYBYL-X 2.0, 1699 South Hanley Road. St Louis, MO. 63144. USA, 2012.
{'key': '10.1016/j.ejmech.2017.05.041_bib71', 'series-title': 'A.\xa0Exploring QSAR: Fundamentals and Applications in Chemistry and Biology', 'author': 'Hansch', 'year': '1995'}
/ A. Exploring QSAR: Fundamentals and Applications in Chemistry and Biology by Hansch (1995)10.1021/jm00158a007
/ J. Med. Chem. / Aromatase inhibitors. synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-dione by Hartmann (1986)10.1021/jm00392a004
/ J. Med. Chem. / Analogs of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents by Leung (1987)10.1021/jm00400a014
/ J. Med. Chem. / Analogs of aminoglutethimide based on 1-phenyl-3-azabicyclo[3.1.0]hexane-2,4-dione: selective inhibition of aromatase activity by Rowlands (1988)10.1021/jm00108a013
/ J. Med. Chem. / Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4-diones by Stanek (1991)10.1021/jm00098a016
/ J. Med. Chem. / Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives by McCague (1992)10.3109/14756369309020181
/ J. Enz. Inhib. / Some 1-, and 3-substituted 3-(4-aminophenyl)pyrrolidine-2,5-diones as selective inhibitors of aromatase by Whomsley (1993){'key': '10.1016/j.ejmech.2017.05.041_bib78', 'first-page': '279', 'article-title': 'Comparison of the in\xa0vitro aromatase inhibitory activity for 3- (azolylmethyl)-1H-indoles', 'volume': '3', 'author': 'Le Brogne', 'year': '1997', 'journal-title': 'Pharm. Sci.'}
/ Pharm. Sci. / Comparison of the in vitro aromatase inhibitory activity for 3- (azolylmethyl)-1H-indoles by Le Brogne (1997)10.1002/ardp.19973300506
/ Arch. Pharm. by Le Brogne (1997){'key': '10.1016/j.ejmech.2017.05.041_bib80', 'first-page': '211', 'article-title': '3-(Azolylmethyl)-1H-indoles as selective P450 aromatase inhibitors', 'volume': '4', 'author': 'Marchand', 'year': '1998', 'journal-title': 'Pharm. Pharmacol. Commun.'}
/ Pharm. Pharmacol. Commun. / 3-(Azolylmethyl)-1H-indoles as selective P450 aromatase inhibitors by Marchand (1998)10.1016/S0960-894X(98)00737-9
/ Bioorg. Med. Chem. Lett. / New selective non-steroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(α-azolylbenzyl)-1H-indoles by Le Brogne (1999)10.1016/S0960-894X(03)00182-3
/ Bioorg. Med. Chem. Lett. / Preparation and pharmacological profile of 7-(α-Azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors by Marchand (2003)10.1080/14756360701652658
/ J. Enz. Inhib. Med. Chem. / Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(alpha-azolylbenzyl)-1H-indoles as selective aromatase inhibitors by Le Brogne (2007)10.1016/j.bmc.2012.02.042
/ Bioorg. Med. Chem. Lett. / Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives by Bonfield (2012)10.1007/s00894-010-0667-y
/ J. Mol. Model / Docking and 3D-QSAR studies of diverse classes of human aromatase (CYP19) inhibitors by Roy (2010)10.1016/j.bmc.2010.05.042
/ Bioorg. Med. Chem. / Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer by Sun (2010)10.1080/14756360400004631
/ J. Enz. Inhib. Med. Chem. / 2- and 3-[(aryl)(azolyl)methyl]indoles as potential non-steroidal aromatase inhibitors by Leze (2004)10.1016/j.bmcl.2005.11.099
/ Bioorg. Med. Chem. Lett. / Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors by Leze (2006)10.1016/j.bmcl.2008.06.094
/ Bioorg. Med. Chem. Lett. / Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors by Leze (2008)10.1016/j.bmcl.2013.01.045
/ Bioorg. Med. Chem. Lett. / Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives by Wang (2013)10.1002/ardp.2503241008
/ Arch. Pharm. Weinh. / Pyridyl-substituted tetralone derivatives: a new class of non-steroidal aromatase inhibitors by Hartmann (1991)10.1002/ardp.2503241102
/ Arch. Pharm. Weinh. / New inhibitors of aromatase: synthesis and biological activity of pyridyl-substituted phenanthrenone derivatives by Hartmann (1991)10.1021/jm00113a004
/ J. Med. Chem. / New aromatase inhibitors. synthesis and biological activity of pyridyl-substituted tetralone derivatives by Bayer (1991)10.1021/jm00035a007
/ J. Med. Chem. / Aromatase inhibitors. syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins by Hartmann (1994)10.1021/jm00012a009
/ J. Med. Chem. / Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom by Hartmann (1995)10.1021/jm950377t
/ J. Med. Chem. / Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroidogenic enzymes P450 arom and P450 17 by Wachter (1996)10.1080/1475636042000196222
/ J. Enz. Inhib. Med. Chem. / CYP 17 and CYP 19 inhibitors. Evaluation of fluorine effects on the inhibiting activity of regioselectively fluorinated 1-(Naphthalene-2-ylmethyl)imidazoles by Hartmann (2004)10.1021/jm0492397
/ J. Med. Chem. / Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase by Ulmschneider (2005)10.1021/jm049600p
/ J. Med. Chem. / Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase by Ulmschneider (2005)10.1021/jm0503704
/ J. Med. Chem. / Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of cyp11b2 for the treatment of congestive heart failure and myocardial fibrosis by Voets (2005)10.1021/jm060055x
/ J. Med. Chem. / Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (cyp11b2) for the treatment of congestive heart failure and myocardial fibrosis by Voets (2006)10.1021/jm00173a022
/ J. Med. Chem. / Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid by McCague (1990)10.1021/jm00021a008
/ J. Med. Chem. / Esters of 3-pyridylacetic acid that combine potent inhibition of 17.alpha.-hydroxylase/c17,20-lyase (cytochrome p45017.alpha.) with resistance to esterase hydrolysis by Rowlands (1995)10.1016/S0304-3835(98)00211-0
/ Cancer Lett. / Aromatase and 17β-hydroxysteroid dehydrogenase inhibition by flavonoids by Le Bail (1998)10.1021/np010288l
/ J. Nat. Prod. / Aromatase inhibitors from Broussonetia papyrifera by Lee (2001)10.1016/S0024-3205(00)00974-7
/ Life Sci. / Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities by Le Bail (2001)10.1021/jm000955s
/ J. Med. Chem. / A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase by Recanatini (2001){'key': '10.1016/j.ejmech.2017.05.041_bib108', 'first-page': '286', 'article-title': 'Synthesis and aromatase inhibitory activity of flavanones', 'volume': '19', 'author': 'Pouget', 'year': '2002', 'journal-title': 'J.\xa0Pharm. Res.'}
/ J. Pharm. Res. / Synthesis and aromatase inhibitory activity of flavanones by Pouget (2002)10.1021/jm0306024
/ J. Med. Chem. / Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones by Kim (2004)10.1021/jm049535j
/ J. Med. Chem. / Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors by Leonetti (2004)10.1016/j.bmc.2005.03.050
/ Bioorg. Med. Chem. / Synthesis and characterization of azole isoflavone inhibitors of aromatase by Hackett (2005)-
B. Su, J. C. Hackett, E. S. Diaz-Cruz, Y. W. Kim, R. W. Brueggemeier, Lead optimization of 7-benzyloxy 2-(4'-pyridylmethyl)thio isoflavone aromatase inhibitors, Bioorg. Med. Chem. 13(23) 6571–6577.
(
10.1016/j.bmc.2005.07.038
) 10.1021/jm060186y
/ J. Med. Chem. / Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme by Gobbi (2006)10.1021/jm070109i
/ J. Med. Chem. / Synthesis and biological evaluation of (±)-abyssinone ii and its analogues as aromatase inhibitors for chemoprevention of breast cancer by Maiti (2007)10.1016/j.bmc.2007.10.057
/ Bioorg. Med. Chem. / New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation by Yahiaoui (2008)10.1021/jm801335z
/ J. Med. Chem. / Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities by Maiti (2009)10.1021/jm100319h
/ J. Med. Chem. / Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation by Gobbi (2010)10.1021/jm101120u
/ J. Med. Chem. / Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase by Stefanchi (2011)10.1021/jm301844q
/ J. Med. Chem. / Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition by Gobbi (2013)10.1016/j.bmc.2013.11.045
/ Bioorg. Med. Chem. / Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors by Amato (2014)10.1016/j.ejmech.2014.10.021
/ Eur. J. Med. Chem. / Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase by Stefanchi (2015)10.1016/j.tet.2015.06.058
/ Tetrahedron / Cytotoxic and cancer chemopreventive properties of prenylated stilbenoids from Macaranga siamensis by Pailee (2015)10.1021/jm991180u
/ J. Med. Chem. / 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase by Jacobs (2000)10.1021/jm3004637
/ J. Med. Chem. / Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer by Hu (2012)10.1021/jm301408t
/ J. Med. Chem. / Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks by Yin (2013)10.1021/jm400377z
/ J. Med. Chem. / Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as non-steroidal aromatase inhibitors by Ferlin (2013)10.1002/mnfr.201100122
/ Mol. Nutr. Food Res. / Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity by Kondratyuk (2011)10.1016/j.bmc.2011.09.031
/ Bioorg. Med. Chem. / Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets by Mayhoub (2012)10.1016/j.bmc.2012.01.047
/ Bioorg. Med. Chem. / Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol by Mayhoub (2012)10.1211/0022357991772637
/ J. Pharm. Pharmacol. / Inhibition of aromatase (P450Arom) by some 1-(benzofuran-2-ylmethyl)imidazoles by Owen (1999){'key': '10.1016/j.ejmech.2017.05.041_bib131', 'first-page': '217', 'article-title': '1-[(Benzofuran-2-yl)phenylmethyl]triazoles as steroidogenic inhibitors: synthesis and in\xa0vitro inhibition of human placental CYP19 aromatase', 'volume': '16', 'author': 'Vinh', 'year': '2001', 'journal-title': 'Anti-Can. Drug Des.'}
/ Anti-Can. Drug Des. / 1-[(Benzofuran-2-yl)phenylmethyl]triazoles as steroidogenic inhibitors: synthesis and in vitro inhibition of human placental CYP19 aromatase by Vinh (2001)10.1021/jm0508282
/ J. Med. Chem. / Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation by Saberi (2006)10.1002/cmdc.200700266
/ ChemMedChem / Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling by Jackson (2008)10.1021/jm901705h
/ J. Med. Chem. / Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template by Woo (2010)10.1021/jm100400a
/ J. Med. Chem. / Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors by Hu (2010)10.1021/jm100317b
/ J. Med. Chem. / Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer by Hu (2010)10.1021/jm051126f
/ J. Med. Chem. / Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition by Su (2006)10.1021/jm061133j
/ J. Med. Chem. / Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells by Su (2007)10.1021/jm701107h
/ J. Med. Chem. / Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification by Su (2008)10.1021/jm00391a016
/ J. Med. Chem. / Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines by Taylor (1987)10.1021/jm00163a065
/ J. Med. Chem. / Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups by Jones (1990)10.1039/b707768h
/ Org. Biomol. Chem. / Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity by Jackson (2007)10.1021/jm061462b
/ J. Med. Chem. / Dual aromatase-steroid sulfatase inhibitors by Woo (2007)10.1002/cmdc.200800164
/ ChemMedChem. / Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino) benzonitrile: SAR, crystal structures, in vitro and in vivo activities by Bubert (2008)10.1021/jm800168s
/ J. Med. Chem. / Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity by Wood (2008)10.1002/cmdc.201000203
/ ChemMedChem. / Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-Bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: synthesis, SAR, crystal structure, and in vitro and in vivo activities by Wood (2010)10.1021/ml100273k
/ ACS Med. Chem. Lett. / Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity by Woo (2011)10.1002/cmdc.201100145
/ ChemMedChem. / Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates by Wood (2011)10.1002/cmdc.201300015
/ ChemMedChem. / Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate by Woo (2011)10.1021/jm00106a038
/ J. Med. Chem. / Fadrozole hydrochloride: a potent, selective, non-steroidal inhibitor of aromatase for the treatment of estrogen-dependent disease by Browne (1991)10.1021/jm00062a012
/ J. Med. Chem. / Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds by Furet (1993)10.1016/S0928-0987(00)00074-9
/ Eur. J. Pharm. Sci. / Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons by Karjalainen (2000)10.1021/jm020557k
/ J. Med. Chem. / Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors by Nakamura (2003)10.1021/jm0702938
/ J. Med. Chem. / Imidazolylmethylbenzophenones as highly potent aromatase inhibitors by Gobbi (2007)10.1016/j.ejmech.2011.05.074
/ Eur. J. Med. Chem. / Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors by Doiron (2011)10.1021/jm2000689
/ J. Med. Chem. / Structure-based design of potent aromatase inhibitors by high-throughput docking by Caporuscio (2011)10.1021/jm950749y
/ J. Med. Chem. / 3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential non-steroidal agents for the treatment of prostatic cancer by Chan (1996)10.1016/j.bmcl.2012.01.076
/ Bioorg. Med. Chem. Lett. / New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series by Stauffer (2012)10.1016/j.ejmech.2015.04.013
/ Eur. J. Med. Chem. / Identification of 4-(4-nitro-2-phenethoxyphenyl) pyridine as a promising new lead for discovering inhibitors of both human and rat 11β-Hydroxylase by Hu (2015)10.1016/j.bmc.2015.04.036
/ Bioorg. Med. Chem. / Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors by Pingaew (2015)10.1021/jm501218e
/ J. Med. Chem. / Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities by Lv (2015)10.1016/j.bmc.2005.05.002
/ Bioorg. Med. Chem. / An approach toward the problem of outliers in QSAR by Verma (2005)10.1021/cr020464a
/ Chem. Rev. / Cyclooxygenase (COX) inhibitors: a comparative QSAR study by Garg (2003)10.1038/sj.bjp.0707305
/ Br. J. Pharmacol. / In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling by Ekins (2007)10.1021/ci050314b
/ J. Chem. Inf. Model / Modeling robust QSAR by Polanski (2006)
Funders
1
UGC
10.13039/501100001501
University Grants CommissionRegion: Asia
gov (Universities (academic only))
Labels
6
- UGC INDIA
- University Grants Commission (India)
- विश्वविद्यालय अनुदान आयोग
- University Grants Commission India
- UGC
- यूजीसी
Awards
1
- F1-17.1/2014-15/RGNF-2014-15-SC-WES-73725/SA-III/Website
@article{Adhikari_2017, title={Combating breast cancer with non-steroidal aromatase inhibitors (NSAIs): Understanding the chemico-biological interactions through comparative SAR/QSAR study}, volume={137}, ISSN={0223-5234}, url={http://dx.doi.org/10.1016/j.ejmech.2017.05.041}, DOI={10.1016/j.ejmech.2017.05.041}, journal={European Journal of Medicinal Chemistry}, publisher={Elsevier BV}, author={Adhikari, Nilanjan and Amin, Sk. Abdul and Saha, Achintya and Jha, Tarun}, year={2017}, month=sep, pages={365–438} }