DOI: 10.1016/j.ejcb.2007.03.003. Dissecting the molecular function of reggie/flotillin proteins

Dissecting the molecular function of reggie/flotillin proteins

10.1016/j.ejcb.2007.03.003

Crossref journal-article

Elsevier BV

European Journal of Cell Biology (78)

Bibliography

Babuke, T., & Tikkanen, R. (2007). Dissecting the molecular function of reggie/flotillin proteins. European Journal of Cell Biology, 86(9), 525â532.

Authors 2

Tanja Babuke (first)
Ritva Tikkanen (additional)

References 49 Referenced 138

10.1016/j.febslet.2006.08.077 / FEBS Lett. / A new paradigm for membrane-organizing and -shaping scaffolds by Bauer (2006)
10.1038/35025089 / Nature / CAP defines a second signalling pathway required for insulin-stimulated glucose transport by Baumann (2000)
10.1074/jbc.272.21.13793 / J. Biol. Chem. / Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins by Bickel (1997)
10.1104/pp.104.053041 / Plant Physiol. / Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts by Borner (2005)
10.1182/blood-2003-03-0871 / Blood / Lipid raft-associated protein sorting in exosomes by de Gassart (2003)
10.1016/S1044-7431(03)00028-9 / Mol. Cell. Neurosci. / Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons by Deininger (2003)
10.1074/jbc.M101113200 / J. Biol. Chem. / Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes by Dermine (2001)
10.1016/S1357-2725(00)00069-8 / Int. J. Biochem. Cell Biol. / Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals by Edgar (2001)
10.1016/S0378-1119(98)00064-X / Gene / Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster by Galbiati (1998)
10.1091/mbc.12.6.1819 / Mol. Biol. Cell / Sphingomyelin-enriched microdomains at the Golgi complex by Gkantiragas (2001)
10.1038/ncb1342 / Nat. Cell Biol. / Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells by Glebov (2006)
10.1242/jcs.01148 / J. Cell Sci. / Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites by Haglund (2004)
10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D / J. Cell. Biochem. / Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation by Hazarika (1999)
10.1158/0008-5472.CAN-04-0823 / Cancer Res. / Up-regulation of flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1 by Hazarika (2004)
10.1111/j.1365-2443.2005.00909.x / Genes Cells / Role of Src family tyrosine kinases in the down-regulation of epidermal growth factor signaling in PC12 cells by Kasai (2005)
10.1073/pnas.151252898 / Proc. Natl. Acad. Sci. USA / The sorbin homology domain: a motif for the targeting of proteins to lipid rafts by Kimura (2001)
10.1247/csf.27.1 / Cell Struct. Funct. / Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction by Kioka (2002)
10.1002/(SICI)1097-4695(199812)37:4<502::AID-NEU2>3.0.CO;2-S / J. Neurobiol. / Identification of reggie-1 and reggie-2 as plasma membrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons by Lang (1998)
10.1007/s00018-005-5166-4 / Cell. Mol. Life Sci. / Scaffolding microdomains and beyond: the function of reggie/flotillin proteins by Langhorst (2005)
10.1074/jbc.M500940200 / J. Biol. Chem. / The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes by Liu (2005)
10.1182/blood.V100.3.897 / Blood / Stomatin is a major lipid-raft component of platelet alpha granules by Mairhofer (2002)
10.1083/jcb.144.5.1001 / J. Cell Biol. / Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell–cell and cell–matrix adherens junctions by Mandai (1999)
10.1074/jbc.C400180200 / J. Biol. Chem. / RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin by Mitra (2004)
10.1111/j.1600-0854.2005.00318.x / Traffic / Flotillins and the PHB domain protein family: rafts, worms and anaesthetics by Morrow (2005)
10.1074/jbc.M209082200 / J. Biol. Chem. / Flotillin-1/reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation by Morrow (2002)
10.1042/bj20031100 / Biochem. J. / Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression by Neumann-Giesen (2004)
10.1242/jcs.03336 / J. Cell Sci. / Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton by Neumann-Giesen (2007)
10.1002/dvdy.20191 / Dev. Dyn. / Xenopus flotillin 1, a novel gene highly expressed in the dorsal nervous system by Pandur (2004)
10.1091/mbc.e04-07-0596 / Mol. Biol. Cell / Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains by Puri (2005)
10.1073/pnas.1331629100 / Proc. Natl. Acad. Sci. USA / Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells by Rajendran (2003)
10.1007/s00018-004-4193-x / Cell. Mol. Life Sci. / PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells by Reuter (2004)
10.1074/jbc.273.7.4073 / J. Biol. Chem. / A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions by Ribon (1998)
10.1007/s00018-005-5434-3 / Cell. Mol. Life Sci. / Ancient origin of reggie (flotillin), reggie-like, and other lipid-raft proteins: convergent evolution of the SPFH domain by Rivera-Milla (2006)
10.1042/BJ20050645 / Biochem. J. / A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia by Roitbak (2005)
10.1016/S0002-9440(10)64357-X / Am. J. Pathol. / Podocin localizes in the kidney to the slit diaphragm area by Roselli (2002)
10.1016/S0002-9440(10)63885-0 / Am. J. Pathol. / PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle by Santamaria (2003)
10.1016/S0021-9258(17)32117-8 / J. Biol. Chem. / Cloning and characterization of a novel epidermal cell surface antigen (ESA) by Schroeder (1994)
10.1242/dev.124.2.577 / Development / Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration by Schulte (1997)
10.1073/pnas.95.11.5857 / Proc. Natl. Acad. Sci. USA / SMART, a simple modular architecture research tool: identification of signaling domains by Schultz (1998)
10.1074/jbc.273.27.17221 / J. Biol. Chem. / Oligomeric nature of the integral membrane protein stomatin by Snyers (1998)
Solis, G.P., Hoegg, M., Munderloh, C., Schrock, Y., Malaga-Trillo, E., Rivera-Milla, E., Stuermer, C.A., 2007. Reggie/flotillin proteins are organized into stable tetramers in membrane-microdomains. Biochem. J. [E-pub ahead of print, manuscript BJ20061686]. (10.1042/BJ20061686)
Stuermer, C.A., Plattner, H., 2005. The ‘lipid raft’ microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling. In: Biochemistry Society Symposium, pp. 109–118. (10.1042/bss0720109)
10.1091/mbc.12.10.3031 / Mol. Biol. Cell / Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2 by Stuermer (2001)
10.1096/fj.04-2150fje / FASEB J. / PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction by Stuermer (2004)
Sugawara, Y., Nishii, H., Takahashi, T., Yamauchi, J., Mizuno, N., Tago, K., Itoh, H., 2007. The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. Cell. Signal. [E-pub ahead of print, doi:10.1016/j.cellsig.2007.01.012]. (10.1016/j.cellsig.2007.01.012)
10.1016/S0968-0004(99)01467-X / Trends Biochem. Sci. / The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins by Tavernarakis (1999)
10.1074/jbc.M513720200 / J. Biol. Chem. / Characterization of the stomatin domain involved in homo-oligomerization and lipid raft association by Umlauf (2006)
10.1074/jbc.274.18.12702 / J. Biol. Chem. / Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe by Volonte (1999)
10.1002/cne.20423 / J. Comp. Neurol. / Restricted expression of reggie genes and proteins during early zebrafish development by von Philipsborn (2005)

Dates

Type	When
Created	18 years, 3 months ago (May 7, 2007, 10:23 a.m.)
Deposited	1 year, 5 months ago (April 6, 2024, 12:07 a.m.)
Indexed	1 month, 3 weeks ago (July 12, 2025, 6:48 p.m.)
Issued	18 years ago (Sept. 1, 2007)
Published	18 years ago (Sept. 1, 2007)
Published Print	18 years ago (Sept. 1, 2007)

Funders 0

None

BibTeX

@article{Babuke_2007, title={Dissecting the molecular function of reggie/flotillin proteins}, volume={86}, ISSN={0171-9335}, url={http://dx.doi.org/10.1016/j.ejcb.2007.03.003}, DOI={10.1016/j.ejcb.2007.03.003}, number={9}, journal={European Journal of Cell Biology}, publisher={Elsevier BV}, author={Babuke, Tanja and Tikkanen, Ritva}, year={2007}, month=sep, pages={525–532} }

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      "author": "Baumann",
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      "article-title": "Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts",
      "volume": "137",
      "author": "Borner",
      "year": "2005",
      "journal-title": "Plant Physiol."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "4336",
      "DOI": "10.1182/blood-2003-03-0871",
      "article-title": "Lipid raft-associated protein sorting in exosomes",
      "volume": "102",
      "author": "de Gassart",
      "year": "2003",
      "journal-title": "Blood"
    },
    {
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      "article-title": "Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons",
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      "author": "Deininger",
      "year": "2003",
      "journal-title": "Mol. Cell. Neurosci."
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    {
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      "article-title": "Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes",
      "volume": "276",
      "author": "Dermine",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
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      "author": "Edgar",
      "year": "2001",
      "journal-title": "Int. J. Biochem. Cell Biol."
    },
    {
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      "volume": "8",
      "author": "Glebov",
      "year": "2006",
      "journal-title": "Nat. Cell Biol."
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      "volume": "117",
      "author": "Haglund",
      "year": "2004",
      "journal-title": "J. Cell Sci."
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    {
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      "article-title": "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation",
      "volume": "75",
      "author": "Hazarika",
      "year": "1999",
      "journal-title": "J. Cell. Biochem."
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      "volume": "98",
      "author": "Kimura",
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      "author": "Kioka",
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      "volume": "37",
      "author": "Lang",
      "year": "1998",
      "journal-title": "J. Neurobiol."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "2228",
      "DOI": "10.1007/s00018-005-5166-4",
      "article-title": "Scaffolding microdomains and beyond: the function of reggie/flotillin proteins",
      "volume": "62",
      "author": "Langhorst",
      "year": "2005",
      "journal-title": "Cell. Mol. Life Sci."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "16125",
      "DOI": "10.1074/jbc.M500940200",
      "article-title": "The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes",
      "volume": "280",
      "author": "Liu",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "897",
      "DOI": "10.1182/blood.V100.3.897",
      "article-title": "Stomatin is a major lipid-raft component of platelet alpha granules",
      "volume": "100",
      "author": "Mairhofer",
      "year": "2002",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1001",
      "DOI": "10.1083/jcb.144.5.1001",
      "article-title": "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell\u2013cell and cell\u2013matrix adherens junctions",
      "volume": "144",
      "author": "Mandai",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "37431",
      "DOI": "10.1074/jbc.C400180200",
      "article-title": "RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin",
      "volume": "279",
      "author": "Mitra",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "725",
      "DOI": "10.1111/j.1600-0854.2005.00318.x",
      "article-title": "Flotillins and the PHB domain protein family: rafts, worms and anaesthetics",
      "volume": "6",
      "author": "Morrow",
      "year": "2005",
      "journal-title": "Traffic"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "48834",
      "DOI": "10.1074/jbc.M209082200",
      "article-title": "Flotillin-1/reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation",
      "volume": "277",
      "author": "Morrow",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1042/bj20031100",
      "article-title": "Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression",
      "volume": "378",
      "author": "Neumann-Giesen",
      "year": "2004",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "395",
      "DOI": "10.1242/jcs.03336",
      "article-title": "Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton",
      "volume": "120",
      "author": "Neumann-Giesen",
      "year": "2007",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "881",
      "DOI": "10.1002/dvdy.20191",
      "article-title": "Xenopus flotillin 1, a novel gene highly expressed in the dorsal nervous system",
      "volume": "231",
      "author": "Pandur",
      "year": "2004",
      "journal-title": "Dev. Dyn."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "2704",
      "DOI": "10.1091/mbc.e04-07-0596",
      "article-title": "Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains",
      "volume": "16",
      "author": "Puri",
      "year": "2005",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "8241",
      "DOI": "10.1073/pnas.1331629100",
      "article-title": "Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells",
      "volume": "100",
      "author": "Rajendran",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "2092",
      "DOI": "10.1007/s00018-004-4193-x",
      "article-title": "PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells",
      "volume": "61",
      "author": "Reuter",
      "year": "2004",
      "journal-title": "Cell. Mol. Life Sci."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "4073",
      "DOI": "10.1074/jbc.273.7.4073",
      "article-title": "A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions",
      "volume": "273",
      "author": "Ribon",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "343",
      "DOI": "10.1007/s00018-005-5434-3",
      "article-title": "Ancient origin of reggie (flotillin), reggie-like, and other lipid-raft proteins: convergent evolution of the SPFH domain",
      "volume": "63",
      "author": "Rivera-Milla",
      "year": "2006",
      "journal-title": "Cell. Mol. Life Sci."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "29",
      "DOI": "10.1042/BJ20050645",
      "article-title": "A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia",
      "volume": "392",
      "author": "Roitbak",
      "year": "2005",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1016/S0002-9440(10)64357-X",
      "article-title": "Podocin localizes in the kidney to the slit diaphragm area",
      "volume": "160",
      "author": "Roselli",
      "year": "2002",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "897",
      "DOI": "10.1016/S0002-9440(10)63885-0",
      "article-title": "PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle",
      "volume": "162",
      "author": "Santamaria",
      "year": "2003",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "19983",
      "DOI": "10.1016/S0021-9258(17)32117-8",
      "article-title": "Cloning and characterization of a novel epidermal cell surface antigen (ESA)",
      "volume": "269",
      "author": "Schroeder",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1242/dev.124.2.577",
      "article-title": "Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration",
      "volume": "124",
      "author": "Schulte",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "5857",
      "DOI": "10.1073/pnas.95.11.5857",
      "article-title": "SMART, a simple modular architecture research tool: identification of signaling domains",
      "volume": "95",
      "author": "Schultz",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "17221",
      "DOI": "10.1074/jbc.273.27.17221",
      "article-title": "Oligomeric nature of the integral membrane protein stomatin",
      "volume": "273",
      "author": "Snyers",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib41",
      "doi-asserted-by": "crossref",
      "unstructured": "Solis, G.P., Hoegg, M., Munderloh, C., Schrock, Y., Malaga-Trillo, E., Rivera-Milla, E., Stuermer, C.A., 2007. Reggie/flotillin proteins are organized into stable tetramers in membrane-microdomains. Biochem. J. [E-pub ahead of print, manuscript BJ20061686].",
      "DOI": "10.1042/BJ20061686"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib42",
      "doi-asserted-by": "crossref",
      "unstructured": "Stuermer, C.A., Plattner, H., 2005. The \u2018lipid raft\u2019 microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling. In: Biochemistry Society Symposium, pp. 109\u2013118.",
      "DOI": "10.1042/bss0720109"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "3031",
      "DOI": "10.1091/mbc.12.10.3031",
      "article-title": "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2",
      "volume": "12",
      "author": "Stuermer",
      "year": "2001",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "1731",
      "DOI": "10.1096/fj.04-2150fje",
      "article-title": "PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction",
      "volume": "18",
      "author": "Stuermer",
      "year": "2004",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib45",
      "doi-asserted-by": "crossref",
      "unstructured": "Sugawara, Y., Nishii, H., Takahashi, T., Yamauchi, J., Mizuno, N., Tago, K., Itoh, H., 2007. The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. Cell. Signal. [E-pub ahead of print, doi:10.1016/j.cellsig.2007.01.012].",
      "DOI": "10.1016/j.cellsig.2007.01.012"
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "425",
      "DOI": "10.1016/S0968-0004(99)01467-X",
      "article-title": "The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins",
      "volume": "24",
      "author": "Tavernarakis",
      "year": "1999",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "23349",
      "DOI": "10.1074/jbc.M513720200",
      "article-title": "Characterization of the stomatin domain involved in homo-oligomerization and lipid raft association",
      "volume": "281",
      "author": "Umlauf",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "12702",
      "DOI": "10.1074/jbc.274.18.12702",
      "article-title": "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe",
      "volume": "274",
      "author": "Volonte",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ejcb.2007.03.003_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1002/cne.20423",
      "article-title": "Restricted expression of reggie genes and proteins during early zebrafish development",
      "volume": "482",
      "author": "von Philipsborn",
      "year": "2005",
      "journal-title": "J. Comp. Neurol."
    }
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