DOI: 10.1016/j.dnarep.2004.03.021. Role of DNA–PK in the cellular response to DNA double-strand breaks

Role of DNA–PK in the cellular response to DNA double-strand breaks

10.1016/j.dnarep.2004.03.021

Crossref journal-article

Elsevier BV

DNA Repair (78)

Bibliography

Burma, S., & Chen, D. J. (2004). Role of DNAâPK in the cellular response to DNA double-strand breaks. DNA Repair, 3(8â9), 909â918.

Authors 2

Sandeep Burma (first)
David J. Chen (additional)

References 98 Referenced 174

10.1038/85798 / Nat. Genet. / DNA double-strand breaks: signaling, repair and the cancer connection by Khanna (2001)
10.1101/gad.13.8.916 / Genes Dev. / The DNA-dependent protein kinase by Smith (1999)
10.1038/nrc1011 / Nat. Rev. Cancer / ATM and related protein kinases: safeguarding genome integrity by Shiloh (2003)
10.1016/S0960-9822(01)00555-3 / Curr. Biol. / DNA repair: how Ku makes ends meet? by Doherty (2001)
10.1016/S0921-8777(99)00006-3 / Mutat. Res. / A DNA repair protein with multiple cellular functions? by Featherstone (1999)
10.1006/jmbi.1998.2212 / J. Mol. Biol. / Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase by Chiu (1998)
10.1093/emboj/18.5.1114 / Embo. J. / Structure of DNA-dependent protein kinase: implications for its regulation by DNA by Leuther (1999)
10.1038/35088000 / Nature / Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair by Walker (2001)
10.1093/nar/27.17.3494 / Nucleic Acids Res. / Mapping of protein-protein interactions within the DNA-dependent protein kinase complex by Gell (1999)
10.1128/MCB.19.5.3267 / Mol. Cell Biol. / The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit by Singleton (1999)
10.1073/pnas.95.2.525 / Proc. Natl. Acad. Sci. U.S.A. / DNA-dependent protein kinase: DNA binding and activation in the absence of Ku by Hammarsten (1998)
10.1093/nar/27.24.4679 / Nucleic Acids Res. / Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA–PKcs induces inward translocation of Ku protein by Yoo (1999)
10.1073/pnas.94.9.4267 / Proc. Natl. Acad. Sci. U.S.A. / DNA looping by Ku and the DNA-dependent protein kinase by Cary (1997)
10.1093/emboj/cdf299 / Embo. J. / Synapsis of DNA ends by DNA-dependent protein kinase by DeFazio (2002)
10.1016/S1568-7864(01)00018-0 / DNA Repair (Amst.) / Defining interactions between DNA–PK and ligase IV/XRCC4 by Hsu (2002)
10.1016/S0022-2836(02)01328-1 / J. Mol. Biol. / Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment by Calsou (2003)
10.1074/jbc.M000491200 / J. Biol. Chem. / Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase by Chen (2000)
{'key': '10.1016/j.dnarep.2004.03.021_BIB18', 'first-page': '22', 'article-title': 'Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro', 'volume': '63', 'author': 'Lee', 'year': '2003', 'journal-title': 'Cancer Res.'} / Cancer Res. / Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro by Lee (2003)
10.1074/jbc.273.3.1794 / J. Biol. Chem. / The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase by Leber (1998)
10.1016/S0014-5793(00)01800-7 / FEBS Lett. / Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation by Matsumoto (2000)
10.1073/pnas.96.4.1403 / Proc. Natl. Acad. Sci. U.S.A. / Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis by Kurimasa (1999)
10.1084/jem.186.6.921 / J. Exp. Med. / Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo by Ouyang (1997)
10.1038/382551a0 / Nature / Requirement for Ku80 in growth and immunoglobulin V(D)J recombination by Nussenzweig (1996)
10.1016/S0092-8674(00)81714-6 / Cell / A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis by Gao (1998)
10.1038/24172 / Nature / Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV by Frank (1998)
10.1038/nrm1202 / Nat. Rev. Mol. Cell Biol. / Mechanism and regulation of human non-homologous DNA end-joining by Lieber (2003)
10.1074/jbc.M101913200 / J. Biol. Chem. / Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase by Yannone (2001)
10.1074/jbc.M111523200 / J. Biol. Chem. / Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation by Karmakar (2002)
10.1016/S0092-8674(02)00671-2 / Cell / Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination by Ma (2002)
M. Lieber, The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination, DNA Repair 3 (2004) 817–826. (10.1016/j.dnarep.2004.03.015)
10.1128/MCB.19.5.3877 / Mol. Cell Biol. / Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining by Kurimasa (1999)
{'key': '10.1016/j.dnarep.2004.03.021_BIB32', 'first-page': '283', 'article-title': 'The nuclear serine/threonine protein kinase DNA–PK', 'volume': '2', 'author': 'Anderson', 'year': '1992', 'journal-title': 'Crit. Rev. Eukaryot. Gene Expr.'} / Crit. Rev. Eukaryot. Gene Expr. / The nuclear serine/threonine protein kinase DNA–PK by Anderson (1992)
10.1074/jbc.271.15.8936 / J. Biol. Chem. / The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit by Chan (1996)
10.1101/gad.1015202 / Genes Dev. / Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks by Chan (2002)
10.1042/bj20020973 / Biochem. J. / Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase by Douglas (2002)
{'key': '10.1016/j.dnarep.2004.03.021_BIB36', 'first-page': '1198', 'article-title': 'Threonines 2638/2647 in DNA–PK are essential for cellular resistance to ionizing radiation', 'volume': '63', 'author': 'Soubeyrand', 'year': '2003', 'journal-title': 'Cancer Res.'} / Cancer Res. / Threonines 2638/2647 in DNA–PK are essential for cellular resistance to ionizing radiation by Soubeyrand (2003)
10.1074/jbc.274.53.37538 / J. Biol. Chem. / Substrate specificities and identification of putative substrates of ATM kinase family members by Kim (1999)
10.1128/MCB.23.16.5836-5848.2003 / Mol. Cell Biol. / Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair by Ding (2003)
10.1073/pnas.95.9.5172 / Proc. Natl. Acad. Sci. U.S.A. / Homology-directed repair is a major double-strand break repair pathway in mammalian cells by Liang (1998)
10.1128/MCB.17.3.1425 / Mol. Cell Biol. / Evidence for DNA–PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle by Lee (1997)
10.1073/pnas.052545899 / Proc. Natl. Acad. Sci. U.S.A. / DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination by Allen (2002)
10.1074/jbc.M106295200 / J. Biol. Chem. / Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S/G2 phase DNA double-strand break repair by Fukushima (2001)
10.1074/jbc.M300198200 / J. Biol. Chem. / Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes by Furuta (2003)
10.1093/emboj/18.5.1397 / Embo. J. / Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA–PK complexes by Shao (1999)
{'key': '10.1016/j.dnarep.2004.03.021_BIB45', 'first-page': '8554', 'article-title': 'Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase', 'volume': '61', 'author': 'Wang', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase by Wang (2001)
10.1074/jbc.M011703200 / J. Biol. Chem. / Protein phosphatases regulate DNA-dependent protein kinase activity by Douglas (2001)
10.1073/pnas.0307765100 / Proc. Natl. Acad. Sci. U.S.A. / DNA–PKcs function regulated specifically by protein phosphatases 5 by Wechsler (2004)
10.1021/bi0263558 / Biochemistry / The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation by Merkle (2002)
10.1126/science.1088877 / Science / BRCT repeats as phosphopeptide-binding modules involved in protein targeting by Manke (2003)
10.1074/jbc.C300407200 / J. Biol. Chem. / Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains by Rodriguez (2003)
10.1126/science.1088753 / Science / The BRCT domain is a phospho-protein binding domain by Yu (2003)
10.1038/35040500 / Nature / Telomere states and cell fates by Blackburn (2000)
10.1126/science.280.5364.741 / Science / Yeast Ku as a regulator of chromosomal DNA end structure by Gravel (1998)
10.1093/emboj/17.6.1819 / Embo. J. / Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing by Boulton (1998)
10.1074/jbc.274.30.21223 / J. Biol. Chem. / Ku binds telomeric DNA in vitro by Bianchi (1999)
10.1073/pnas.96.22.12454 / Proc. Natl. Acad. Sci. U.S.A. / Ku is associated with the telomere in mammals by Hsu (1999)
10.1016/S0960-9822(01)00328-1 / Curr. Biol. / Effects of DNA non-homologous end-joining factors on telomere length and chromosomal stability in mammalian cells by d’Adda di Fagagna (2001)
10.1101/gad.844000 / Genes Dev. / Ku acts in a unique way at the mammalian telomere to prevent end joining by Hsu (2000)
10.1073/pnas.96.26.14899 / Proc. Natl. Acad. Sci. U.S.A. / DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes by Bailey (1999)
10.1093/embo-reports/kvd051 / EMBO Rep. / Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang by Samper (2000)
10.1073/pnas.261574698 / Proc. Natl. Acad. Sci. U.S.A. / DNA–PKcs is critical for telomere capping by Gilley (2001)
10.1073/pnas.022649699 / Proc. Natl. Acad. Sci. U.S.A. / Ku86 is essential in human somatic cells by Li (2002)
10.1128/MCB.21.11.3642-3651.2001 / Mol. Cell Biol. / The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang by Goytisolo (2001)
10.1093/emboj/cdf593 / Embo. J. / Functional interaction between DNA–PKcs and telomerase in telomere length maintenance by Espejel (2002)
10.1093/emboj/21.9.2207 / Embo. J. / Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres by Espejel (2002)
10.1101/gad.10.9.1054 / Genes. Dev. / p53: puzzle and paradigm by Ko (1996)
10.1126/science.281.5383.1677 / Science / Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 by Canman (1998)
10.1126/science.281.5383.1674 / Science / Enhanced phosphorylation of p53 by ATM in response to DNA damage by Banin (1998)
10.1073/pnas.89.10.4231 / Proc. Natl. Acad. Sci. U.S.A. / Phosphorylation sites in the amino-terminal region of mouse p53 by Wang (1992)
10.1128/MCB.12.11.5041 / Mol. Cell Biol. / Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53 by Lees-Miller (1992)
10.1101/gad.10.16.2038 / Genes Dev. / V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors by Guidos (1996)
10.1093/carcin/17.12.2537 / Carcinogenesis / p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice by Gurley (1996)
{'key': '10.1016/j.dnarep.2004.03.021_BIB73', 'first-page': '2940', 'article-title': 'p53-Dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts', 'volume': '56', 'author': 'Huang', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / p53-Dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts by Huang (1996)
{'key': '10.1016/j.dnarep.2004.03.021_BIB74', 'first-page': '68', 'article-title': 'DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage', 'volume': '57', 'author': 'Rathmell', 'year': '1997', 'journal-title': 'Cancer Res.'} / Cancer Res. / DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage by Rathmell (1997)
10.1038/29343 / Nature / DNA-dependent protein kinase acts upstream of p53 in response to DNA damage by Woo (1998)
10.1074/jbc.274.19.13111 / J. Biol. Chem. / The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase by Kachnic (1999)
{'key': '10.1016/j.dnarep.2004.03.021_BIB77', 'first-page': '3543', 'article-title': 'Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells', 'volume': '59', 'author': 'Araki', 'year': '1999', 'journal-title': 'Cancer Res.'} / Cancer Res. / Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells by Araki (1999)
10.1074/jbc.274.24.17139 / J. Biol. Chem. / DNA-dependent protein kinase-independent activation of p53 in response to DNA damage by Burma (1999)
10.1038/21913 / Nature / DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage by Jimenez (1999)
10.1016/S1383-5742(02)00009-1 / Mutat. Res. / DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis by Bernstein (2002)
10.1128/MCB.18.11.6719 / Mol. Cell Biol. / Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis by Bharti (1998)
10.1073/pnas.97.4.1584 / Proc. Natl. Acad. Sci. U.S.A. / The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest by Wang (2000)
10.1093/emboj/cdf307 / Embo. J. / DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53 by Woo (2002)
10.1016/0092-8674(94)90071-X / Cell / Transcriptional activation by p53 correlates with suppression of growth but not transformation by Crook (1994)
10.1038/33345 / Nature / Essential role of mouse telomerase in highly proliferative organs by Lee (1998)
10.1128/MCB.20.11.4075-4083.2000 / Mol. Cell Biol. / The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase by Jhappan (2000)
10.1002/j.1460-2075.1996.tb00688.x / Embo. J. / DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis by Song (1996)
10.4049/jimmunol.158.5.2083 / J. Immunol. / The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells by McConnell (1997)
10.1016/S0092-8674(00)80412-2 / Cell / Innate immunity: the virtues of a non-clonal system of recognition by Medzhitov (1997)
10.1016/S0952-7915(97)80152-5 / Curr. Opin. Immunol. / Innate immunity: impact on the adaptive immune response by Medzhitov (1997)
10.1073/pnas.93.7.2879 / Proc. Natl. Acad. Sci. U.S.A. / CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma by Klinman (1996)
10.1016/S0065-2776(08)60790-7 / Adv. Immunol. / Bacterial CpG DNA activates immune cells to signal infectious danger by Wagner (1999)
10.1016/S0092-8674(00)00194-X / Cell / DNA–PKcs is required for activation of innate immunity by immunostimulatory DNA by Chu (2000)
10.1084/jem.20020773 / J. Exp. Med. / Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation by Ishii (2002)
10.1073/pnas.052713899 / Proc. Natl. Acad. Sci. U.S.A. / Interferon regulatory factor-3 is an in vivo target of DNA–PK by Karpova (2002)
10.1016/S1097-2765(00)80051-9 / Mol. Cell / Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo by Wathelet (1998)
10.1083/jcb.146.5.905 / J. Cell Biol. / Megabase chromatin domains involved in DNA double-strand breaks in vivo by Rogakou (1999)
10.1083/jcb.153.3.613 / J. Cell Biol. / Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways by Rappold (2001)

Dates

Type	When
Created	21 years, 4 months ago (April 10, 2004, 5:40 a.m.)
Deposited	2 years, 4 months ago (April 28, 2023, 3:15 a.m.)
Indexed	4 days, 5 hours ago (Aug. 30, 2025, 12:32 p.m.)
Issued	21 years, 1 month ago (Aug. 1, 2004)
Published	21 years, 1 month ago (Aug. 1, 2004)
Published Print	21 years, 1 month ago (Aug. 1, 2004)

Funders 0

None

BibTeX

@article{Burma_2004, title={Role of DNA–PK in the cellular response to DNA double-strand breaks}, volume={3}, ISSN={1568-7864}, url={http://dx.doi.org/10.1016/j.dnarep.2004.03.021}, DOI={10.1016/j.dnarep.2004.03.021}, number={8–9}, journal={DNA Repair}, publisher={Elsevier BV}, author={Burma, Sandeep and Chen, David J.}, year={2004}, month=aug, pages={909–918} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        30
      ]
    ],
    "date-time": "2025-08-30T16:32:50Z",
    "timestamp": 1756571570881
  },
  "reference-count": 98,
  "publisher": "Elsevier BV",
  "issue": "8-9",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            8,
            1
          ]
        ],
        "date-time": "2004-08-01T00:00:00Z",
        "timestamp": 1091318400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        8
      ]
    ]
  },
  "DOI": "10.1016/j.dnarep.2004.03.021",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        10
      ]
    ],
    "date-time": "2004-04-10T09:40:04Z",
    "timestamp": 1081590004000
  },
  "page": "909-918",
  "source": "Crossref",
  "is-referenced-by-count": 174,
  "title": "Role of DNA\u2013PK in the cellular response to DNA double-strand breaks",
  "prefix": "10.1016",
  "volume": "3",
  "author": [
    {
      "given": "Sandeep",
      "family": "Burma",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "David J.",
      "family": "Chen",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "247",
      "DOI": "10.1038/85798",
      "article-title": "DNA double-strand breaks: signaling, repair and the cancer connection",
      "volume": "27",
      "author": "Khanna",
      "year": "2001",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "916",
      "DOI": "10.1101/gad.13.8.916",
      "article-title": "The DNA-dependent protein kinase",
      "volume": "13",
      "author": "Smith",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "155",
      "DOI": "10.1038/nrc1011",
      "article-title": "ATM and related protein kinases: safeguarding genome integrity",
      "volume": "3",
      "author": "Shiloh",
      "year": "2003",
      "journal-title": "Nat. Rev. Cancer"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "R920",
      "DOI": "10.1016/S0960-9822(01)00555-3",
      "article-title": "DNA repair: how Ku makes ends meet?",
      "volume": "11",
      "author": "Doherty",
      "year": "2001",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/S0921-8777(99)00006-3",
      "article-title": "A DNA repair protein with multiple cellular functions?",
      "volume": "434",
      "author": "Featherstone",
      "year": "1999",
      "journal-title": "Mutat. Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1075",
      "DOI": "10.1006/jmbi.1998.2212",
      "article-title": "Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase",
      "volume": "284",
      "author": "Chiu",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1114",
      "DOI": "10.1093/emboj/18.5.1114",
      "article-title": "Structure of DNA-dependent protein kinase: implications for its regulation by DNA",
      "volume": "18",
      "author": "Leuther",
      "year": "1999",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "607",
      "DOI": "10.1038/35088000",
      "article-title": "Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair",
      "volume": "412",
      "author": "Walker",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "3494",
      "DOI": "10.1093/nar/27.17.3494",
      "article-title": "Mapping of protein-protein interactions within the DNA-dependent protein kinase complex",
      "volume": "27",
      "author": "Gell",
      "year": "1999",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "3267",
      "DOI": "10.1128/MCB.19.5.3267",
      "article-title": "The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit",
      "volume": "19",
      "author": "Singleton",
      "year": "1999",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "525",
      "DOI": "10.1073/pnas.95.2.525",
      "article-title": "DNA-dependent protein kinase: DNA binding and activation in the absence of Ku",
      "volume": "95",
      "author": "Hammarsten",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "4679",
      "DOI": "10.1093/nar/27.24.4679",
      "article-title": "Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA\u2013PKcs induces inward translocation of Ku protein",
      "volume": "27",
      "author": "Yoo",
      "year": "1999",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "4267",
      "DOI": "10.1073/pnas.94.9.4267",
      "article-title": "DNA looping by Ku and the DNA-dependent protein kinase",
      "volume": "94",
      "author": "Cary",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "3192",
      "DOI": "10.1093/emboj/cdf299",
      "article-title": "Synapsis of DNA ends by DNA-dependent protein kinase",
      "volume": "21",
      "author": "DeFazio",
      "year": "2002",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1016/S1568-7864(01)00018-0",
      "article-title": "Defining interactions between DNA\u2013PK and ligase IV/XRCC4",
      "volume": "1",
      "author": "Hsu",
      "year": "2002",
      "journal-title": "DNA Repair (Amst.)"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/S0022-2836(02)01328-1",
      "article-title": "Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment",
      "volume": "326",
      "author": "Calsou",
      "year": "2003",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "26196",
      "DOI": "10.1074/jbc.M000491200",
      "article-title": "Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase",
      "volume": "275",
      "author": "Chen",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB18",
      "first-page": "22",
      "article-title": "Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro",
      "volume": "63",
      "author": "Lee",
      "year": "2003",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "1794",
      "DOI": "10.1074/jbc.273.3.1794",
      "article-title": "The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase",
      "volume": "273",
      "author": "Leber",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1016/S0014-5793(00)01800-7",
      "article-title": "Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation",
      "volume": "478",
      "author": "Matsumoto",
      "year": "2000",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "1403",
      "DOI": "10.1073/pnas.96.4.1403",
      "article-title": "Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis",
      "volume": "96",
      "author": "Kurimasa",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1084/jem.186.6.921",
      "article-title": "Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo",
      "volume": "186",
      "author": "Ouyang",
      "year": "1997",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1038/382551a0",
      "article-title": "Requirement for Ku80 in growth and immunoglobulin V(D)J recombination",
      "volume": "382",
      "author": "Nussenzweig",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "891",
      "DOI": "10.1016/S0092-8674(00)81714-6",
      "article-title": "A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis",
      "volume": "95",
      "author": "Gao",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1038/24172",
      "article-title": "Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV",
      "volume": "396",
      "author": "Frank",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "712",
      "DOI": "10.1038/nrm1202",
      "article-title": "Mechanism and regulation of human non-homologous DNA end-joining",
      "volume": "4",
      "author": "Lieber",
      "year": "2003",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "38242",
      "DOI": "10.1074/jbc.M101913200",
      "article-title": "Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase",
      "volume": "276",
      "author": "Yannone",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "18291",
      "DOI": "10.1074/jbc.M111523200",
      "article-title": "Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation",
      "volume": "277",
      "author": "Karmakar",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "781",
      "DOI": "10.1016/S0092-8674(02)00671-2",
      "article-title": "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination",
      "volume": "108",
      "author": "Ma",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB30",
      "doi-asserted-by": "crossref",
      "unstructured": "M. Lieber, The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination, DNA Repair 3 (2004) 817\u2013826.",
      "DOI": "10.1016/j.dnarep.2004.03.015"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "3877",
      "DOI": "10.1128/MCB.19.5.3877",
      "article-title": "Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining",
      "volume": "19",
      "author": "Kurimasa",
      "year": "1999",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB32",
      "first-page": "283",
      "article-title": "The nuclear serine/threonine protein kinase DNA\u2013PK",
      "volume": "2",
      "author": "Anderson",
      "year": "1992",
      "journal-title": "Crit. Rev. Eukaryot. Gene Expr."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "8936",
      "DOI": "10.1074/jbc.271.15.8936",
      "article-title": "The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit",
      "volume": "271",
      "author": "Chan",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "2333",
      "DOI": "10.1101/gad.1015202",
      "article-title": "Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks",
      "volume": "16",
      "author": "Chan",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1042/bj20020973",
      "article-title": "Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase",
      "volume": "368",
      "author": "Douglas",
      "year": "2002",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB36",
      "first-page": "1198",
      "article-title": "Threonines 2638/2647 in DNA\u2013PK are essential for cellular resistance to ionizing radiation",
      "volume": "63",
      "author": "Soubeyrand",
      "year": "2003",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "37538",
      "DOI": "10.1074/jbc.274.53.37538",
      "article-title": "Substrate specificities and identification of putative substrates of ATM kinase family members",
      "volume": "274",
      "author": "Kim",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "5836",
      "DOI": "10.1128/MCB.23.16.5836-5848.2003",
      "article-title": "Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair",
      "volume": "23",
      "author": "Ding",
      "year": "2003",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "5172",
      "DOI": "10.1073/pnas.95.9.5172",
      "article-title": "Homology-directed repair is a major double-strand break repair pathway in mammalian cells",
      "volume": "95",
      "author": "Liang",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1425",
      "DOI": "10.1128/MCB.17.3.1425",
      "article-title": "Evidence for DNA\u2013PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle",
      "volume": "17",
      "author": "Lee",
      "year": "1997",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "3758",
      "DOI": "10.1073/pnas.052545899",
      "article-title": "DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination",
      "volume": "99",
      "author": "Allen",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "44413",
      "DOI": "10.1074/jbc.M106295200",
      "article-title": "Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S/G2 phase DNA double-strand break repair",
      "volume": "276",
      "author": "Fukushima",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "20303",
      "DOI": "10.1074/jbc.M300198200",
      "article-title": "Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes",
      "volume": "278",
      "author": "Furuta",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "1397",
      "DOI": "10.1093/emboj/18.5.1397",
      "article-title": "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA\u2013PK complexes",
      "volume": "18",
      "author": "Shao",
      "year": "1999",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB45",
      "first-page": "8554",
      "article-title": "Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase",
      "volume": "61",
      "author": "Wang",
      "year": "2001",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "18992",
      "DOI": "10.1074/jbc.M011703200",
      "article-title": "Protein phosphatases regulate DNA-dependent protein kinase activity",
      "volume": "276",
      "author": "Douglas",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "1247",
      "DOI": "10.1073/pnas.0307765100",
      "article-title": "DNA\u2013PKcs function regulated specifically by protein phosphatases 5",
      "volume": "101",
      "author": "Wechsler",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "12706",
      "DOI": "10.1021/bi0263558",
      "article-title": "The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation",
      "volume": "41",
      "author": "Merkle",
      "year": "2002",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "636",
      "DOI": "10.1126/science.1088877",
      "article-title": "BRCT repeats as phosphopeptide-binding modules involved in protein targeting",
      "volume": "302",
      "author": "Manke",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "52914",
      "DOI": "10.1074/jbc.C300407200",
      "article-title": "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains",
      "volume": "278",
      "author": "Rodriguez",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "639",
      "DOI": "10.1126/science.1088753",
      "article-title": "The BRCT domain is a phospho-protein binding domain",
      "volume": "302",
      "author": "Yu",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1038/35040500",
      "article-title": "Telomere states and cell fates",
      "volume": "408",
      "author": "Blackburn",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "741",
      "DOI": "10.1126/science.280.5364.741",
      "article-title": "Yeast Ku as a regulator of chromosomal DNA end structure",
      "volume": "280",
      "author": "Gravel",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "1819",
      "DOI": "10.1093/emboj/17.6.1819",
      "article-title": "Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing",
      "volume": "17",
      "author": "Boulton",
      "year": "1998",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "21223",
      "DOI": "10.1074/jbc.274.30.21223",
      "article-title": "Ku binds telomeric DNA in vitro",
      "volume": "274",
      "author": "Bianchi",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "12454",
      "DOI": "10.1073/pnas.96.22.12454",
      "article-title": "Ku is associated with the telomere in mammals",
      "volume": "96",
      "author": "Hsu",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "1192",
      "DOI": "10.1016/S0960-9822(01)00328-1",
      "article-title": "Effects of DNA non-homologous end-joining factors on telomere length and chromosomal stability in mammalian cells",
      "volume": "11",
      "author": "d\u2019Adda di Fagagna",
      "year": "2001",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "2807",
      "DOI": "10.1101/gad.844000",
      "article-title": "Ku acts in a unique way at the mammalian telomere to prevent end joining",
      "volume": "14",
      "author": "Hsu",
      "year": "2000",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "14899",
      "DOI": "10.1073/pnas.96.26.14899",
      "article-title": "DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes",
      "volume": "96",
      "author": "Bailey",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "244",
      "DOI": "10.1093/embo-reports/kvd051",
      "article-title": "Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang",
      "volume": "1",
      "author": "Samper",
      "year": "2000",
      "journal-title": "EMBO Rep."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "15084",
      "DOI": "10.1073/pnas.261574698",
      "article-title": "DNA\u2013PKcs is critical for telomere capping",
      "volume": "98",
      "author": "Gilley",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "832",
      "DOI": "10.1073/pnas.022649699",
      "article-title": "Ku86 is essential in human somatic cells",
      "volume": "99",
      "author": "Li",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "3642",
      "DOI": "10.1128/MCB.21.11.3642-3651.2001",
      "article-title": "The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang",
      "volume": "21",
      "author": "Goytisolo",
      "year": "2001",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "6275",
      "DOI": "10.1093/emboj/cdf593",
      "article-title": "Functional interaction between DNA\u2013PKcs and telomerase in telomere length maintenance",
      "volume": "21",
      "author": "Espejel",
      "year": "2002",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "2207",
      "DOI": "10.1093/emboj/21.9.2207",
      "article-title": "Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres",
      "volume": "21",
      "author": "Espejel",
      "year": "2002",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "1054",
      "DOI": "10.1101/gad.10.9.1054",
      "article-title": "p53: puzzle and paradigm",
      "volume": "10",
      "author": "Ko",
      "year": "1996",
      "journal-title": "Genes. Dev."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB67",
      "doi-asserted-by": "crossref",
      "first-page": "1677",
      "DOI": "10.1126/science.281.5383.1677",
      "article-title": "Activation of the ATM kinase by ionizing radiation and phosphorylation of p53",
      "volume": "281",
      "author": "Canman",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB68",
      "doi-asserted-by": "crossref",
      "first-page": "1674",
      "DOI": "10.1126/science.281.5383.1674",
      "article-title": "Enhanced phosphorylation of p53 by ATM in response to DNA damage",
      "volume": "281",
      "author": "Banin",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "4231",
      "DOI": "10.1073/pnas.89.10.4231",
      "article-title": "Phosphorylation sites in the amino-terminal region of mouse p53",
      "volume": "89",
      "author": "Wang",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "5041",
      "DOI": "10.1128/MCB.12.11.5041",
      "article-title": "Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53",
      "volume": "12",
      "author": "Lees-Miller",
      "year": "1992",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "2038",
      "DOI": "10.1101/gad.10.16.2038",
      "article-title": "V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors",
      "volume": "10",
      "author": "Guidos",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB72",
      "doi-asserted-by": "crossref",
      "first-page": "2537",
      "DOI": "10.1093/carcin/17.12.2537",
      "article-title": "p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice",
      "volume": "17",
      "author": "Gurley",
      "year": "1996",
      "journal-title": "Carcinogenesis"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB73",
      "first-page": "2940",
      "article-title": "p53-Dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts",
      "volume": "56",
      "author": "Huang",
      "year": "1996",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB74",
      "first-page": "68",
      "article-title": "DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage",
      "volume": "57",
      "author": "Rathmell",
      "year": "1997",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB75",
      "doi-asserted-by": "crossref",
      "first-page": "700",
      "DOI": "10.1038/29343",
      "article-title": "DNA-dependent protein kinase acts upstream of p53 in response to DNA damage",
      "volume": "394",
      "author": "Woo",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB76",
      "doi-asserted-by": "crossref",
      "first-page": "13111",
      "DOI": "10.1074/jbc.274.19.13111",
      "article-title": "The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase",
      "volume": "274",
      "author": "Kachnic",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB77",
      "first-page": "3543",
      "article-title": "Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells",
      "volume": "59",
      "author": "Araki",
      "year": "1999",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB78",
      "doi-asserted-by": "crossref",
      "first-page": "17139",
      "DOI": "10.1074/jbc.274.24.17139",
      "article-title": "DNA-dependent protein kinase-independent activation of p53 in response to DNA damage",
      "volume": "274",
      "author": "Burma",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB79",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1038/21913",
      "article-title": "DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage",
      "volume": "400",
      "author": "Jimenez",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB80",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1016/S1383-5742(02)00009-1",
      "article-title": "DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis",
      "volume": "511",
      "author": "Bernstein",
      "year": "2002",
      "journal-title": "Mutat. Res."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB81",
      "doi-asserted-by": "crossref",
      "first-page": "6719",
      "DOI": "10.1128/MCB.18.11.6719",
      "article-title": "Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis",
      "volume": "18",
      "author": "Bharti",
      "year": "1998",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB82",
      "doi-asserted-by": "crossref",
      "first-page": "1584",
      "DOI": "10.1073/pnas.97.4.1584",
      "article-title": "The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest",
      "volume": "97",
      "author": "Wang",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB83",
      "doi-asserted-by": "crossref",
      "first-page": "3000",
      "DOI": "10.1093/emboj/cdf307",
      "article-title": "DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53",
      "volume": "21",
      "author": "Woo",
      "year": "2002",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB84",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1016/0092-8674(94)90071-X",
      "article-title": "Transcriptional activation by p53 correlates with suppression of growth but not transformation",
      "volume": "79",
      "author": "Crook",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB85",
      "doi-asserted-by": "crossref",
      "first-page": "569",
      "DOI": "10.1038/33345",
      "article-title": "Essential role of mouse telomerase in highly proliferative organs",
      "volume": "392",
      "author": "Lee",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB86",
      "doi-asserted-by": "crossref",
      "first-page": "4075",
      "DOI": "10.1128/MCB.20.11.4075-4083.2000",
      "article-title": "The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase",
      "volume": "20",
      "author": "Jhappan",
      "year": "2000",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB87",
      "doi-asserted-by": "crossref",
      "first-page": "3238",
      "DOI": "10.1002/j.1460-2075.1996.tb00688.x",
      "article-title": "DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis",
      "volume": "15",
      "author": "Song",
      "year": "1996",
      "journal-title": "Embo. J."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB88",
      "doi-asserted-by": "crossref",
      "first-page": "2083",
      "DOI": "10.4049/jimmunol.158.5.2083",
      "article-title": "The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells",
      "volume": "158",
      "author": "McConnell",
      "year": "1997",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB89",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1016/S0092-8674(00)80412-2",
      "article-title": "Innate immunity: the virtues of a non-clonal system of recognition",
      "volume": "91",
      "author": "Medzhitov",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB90",
      "doi-asserted-by": "crossref",
      "first-page": "4",
      "DOI": "10.1016/S0952-7915(97)80152-5",
      "article-title": "Innate immunity: impact on the adaptive immune response",
      "volume": "9",
      "author": "Medzhitov",
      "year": "1997",
      "journal-title": "Curr. Opin. Immunol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB91",
      "doi-asserted-by": "crossref",
      "first-page": "2879",
      "DOI": "10.1073/pnas.93.7.2879",
      "article-title": "CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma",
      "volume": "93",
      "author": "Klinman",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB92",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1016/S0065-2776(08)60790-7",
      "article-title": "Bacterial CpG DNA activates immune cells to signal infectious danger",
      "volume": "73",
      "author": "Wagner",
      "year": "1999",
      "journal-title": "Adv. Immunol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB93",
      "doi-asserted-by": "crossref",
      "first-page": "909",
      "DOI": "10.1016/S0092-8674(00)00194-X",
      "article-title": "DNA\u2013PKcs is required for activation of innate immunity by immunostimulatory DNA",
      "volume": "103",
      "author": "Chu",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB94",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1084/jem.20020773",
      "article-title": "Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation",
      "volume": "196",
      "author": "Ishii",
      "year": "2002",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB95",
      "doi-asserted-by": "crossref",
      "first-page": "2818",
      "DOI": "10.1073/pnas.052713899",
      "article-title": "Interferon regulatory factor-3 is an in vivo target of DNA\u2013PK",
      "volume": "99",
      "author": "Karpova",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB96",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1016/S1097-2765(00)80051-9",
      "article-title": "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo",
      "volume": "1",
      "author": "Wathelet",
      "year": "1998",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB97",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1083/jcb.146.5.905",
      "article-title": "Megabase chromatin domains involved in DNA double-strand breaks in vivo",
      "volume": "146",
      "author": "Rogakou",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.dnarep.2004.03.021_BIB98",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1083/jcb.153.3.613",
      "article-title": "Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways",
      "volume": "153",
      "author": "Rappold",
      "year": "2001",
      "journal-title": "J. Cell Biol."
    }
  ],
  "container-title": "DNA Repair",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1568786404000801?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1568786404000801?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        28
      ]
    ],
    "date-time": "2023-04-28T07:15:17Z",
    "timestamp": 1682666117000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1568786404000801"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        8
      ]
    ]
  },
  "references-count": 98,
  "journal-issue": {
    "issue": "8-9",
    "published-print": {
      "date-parts": [
        [
          2004,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S1568786404000801"
  ],
  "URL": "http://dx.doi.org/10.1016/j.dnarep.2004.03.021",
  "relation": {},
  "ISSN": [
    "1568-7864"
  ],
  "subject": [],
  "container-title-short": "DNA Repair",
  "published": {
    "date-parts": [
      [
        2004,
        8
      ]
    ]
  }
}