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Insall, R. H., & Machesky, L. M. (2009). Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks. Developmental Cell, 17(3), 310–322.

Authors 2
  1. Robert H. Insall (first)
  2. Laura M. Machesky (additional)
References 123 Referenced 353
  1. 10.1038/ncb1536 / Nat. Cell Biol. / Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions by Andrew (2007)
  2. 10.1016/j.molcel.2006.08.006 / Mol. Cell / Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin by Andrianantoandro (2006)
  3. 10.1126/science.1140324 / Science / Quantitative morphological signatures define local signaling networks regulating cell morphology by Bakal (2007)
  4. 10.1242/jcs.038125 / J. Cell Sci. / Ena/VASP: towards resolving a pointed controversy at the barbed end by Bear (2009)
  5. 10.1083/jcb.142.5.1325 / J. Cell Biol. / SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development by Bear (1998)
  6. 10.1038/ncb1745 / Nat. Cell Biol. / WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2 by Beli (2008)
  7. 10.1074/jbc.M705894200 / J. Biol. Chem. / Pathway of actin filament branch formation by Arp2/3 complex by Beltzner (2008)
  8. 10.1016/S0960-9822(03)00580-3 / Curr. Biol. / PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium by Blagg (2003)
  9. 10.1016/j.str.2008.02.013 / Structure / X-ray scattering study of activated Arp2/3 complex with bound actin-WCA by Boczkowska (2008)
  10. 10.1016/j.molcel.2007.10.033 / Mol. Cell / Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding by Boeda (2007)
  11. 10.1126/science.3277283 / Science / Cortical flow in animal cells by Bray (1988)
  12. 10.1038/emboj.2008.211 / EMBO J. / Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation by Breitsprecher (2008)
  13. 10.1016/j.cell.2007.01.031 / Cell / Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge by Cai (2007)
  14. 10.1016/j.cell.2008.06.054 / Cell / Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia by Cai (2008)
  15. 10.1016/j.cell.2008.05.032 / Cell / WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport by Campellone (2008)
  16. 10.1016/j.cub.2009.02.060 / Curr. Biol. / Cofilin Dissociates Arp2/3 Complex and Branches from Actin Filaments by Chan (2009)
  17. 10.1016/j.cub.2009.02.060 / Curr. Biol. / Cofilin dissociates Arp2/3 complex and branches from actin filaments by Chan (2009)
  18. 10.1111/j.1365-2818.2008.02059.x / J. Microsc. / A short history of blebbing by Charras (2008)
  19. 10.1038/nrm2453 / Nat. Rev. Mol. Cell Biol. / Blebs lead the way: how to migrate without lamellipodia by Charras (2008)
  20. 10.1038/nature03550 / Nature / Non-equilibration of hydrostatic pressure in blebbing cells by Charras (2005)
  21. 10.1016/j.devcel.2007.03.005 / Dev. Cell / PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis by Chen (2007)
  22. 10.1073/pnas.0507021102 / Proc. Natl. Acad. Sci. USA / Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly by Chereau (2005)
  23. 10.1038/ncb1007-1110 / Nat. Cell Biol. / The many faces of actin: matching assembly factors with cellular structures by Chhabra (2007)
  24. 10.1016/j.cell.2006.12.049 / Cell / Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains by Co (2007)
  25. 10.1128/MCB.18.1.152 / Mol. Cell. Biol. / Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled by Comer (1998)
  26. 10.1002/cm.20342 / Cell Motil. Cytoskeleton / The Wave complex is intrinsically inactive by Derivery (2009)
  27. 10.1242/jcs.01211 / J. Cell Sci. / Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension by DesMarais (2004)
  28. 10.1038/ncb1199 / Nat. Cell Biol. / Eps8 controls actin-based motility by capping the barbed ends of actin filaments by Disanza (2004)
  29. 10.1038/nature00859 / Nature / Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck by Eden (2002)
  30. 10.1016/j.febslet.2006.11.031 / FEBS Lett. / Time-resolved responses to chemoattractant, characteristic of the front and tail of Dictyostelium cells by Etzrodt (2006)
  31. 10.1083/jcb.200802081 / J. Cell Biol. / Cell motility through plasma membrane blebbing by Fackler (2008)
  32. 10.1038/ncb1517 / Nat. Cell Biol. / PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis by Ferguson (2007)
  33. 10.1042/bss0700277 / Biochem. Soc. Symp. / Proteolytic and non-proteolytic migration of tumour cells and leucocytes by Friedl (2003)
  34. 10.1016/j.jmb.2007.12.007 / J. Mol. Biol. / Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament by Galkin (2008)
  35. 10.1016/j.molcel.2009.02.029 / Mol. Cell / Coronin switches roles in actin disassembly depending on the nucleotide state of actin by Gandhi (2009)
  36. 10.1088/1367-2630/10/3/033022 / N. J. Phys. / Velocity oscillations in actin-based motility by Gholami (2008)
  37. 10.1007/s10585-008-9225-8 / Clin. Exp. Metastasis / Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo by Goswami (2009)
  38. 10.1038/nrm2476 / Nat. Rev. Mol. Cell Biol. / Mammalian Rho GTPases: new insights into their functions from in vivo studies by Heasman (2008)
  39. 10.1016/j.cub.2007.04.004 / Curr. Biol. / Chemotaxis in the absence of PIP3 gradients by Hoeller (2007)
  40. 10.1083/jcb.200206113 / J. Cell Biol. / Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin by Humphries (2002)
  41. 10.1016/j.cub.2006.02.068 / Curr. Biol. / Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways by Ibarra (2006)
  42. 10.1038/ncb1105 / Nat. Cell Biol. / Abi1 is essential for the formation and activation of a WAVE2 signalling complex by Innocenti (2004)
  43. 10.1038/ncb1304 / Nat. Cell Biol. / Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes by Innocenti (2005)
  44. 10.1038/nsmb.1587 / Nat. Struct. Mol. Biol. / The WAVE regulatory complex is inhibited by Ismail (2009)
  45. 10.1186/1471-2121-9-65 / BMC Cell Biol. / Arp2/3 complex activity in filopodia of spreading cells by Johnston (2008)
  46. 10.1016/j.cub.2008.06.068 / Curr. Biol. / PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis by Kamimura (2008)
  47. 10.1038/nature06952 / Nature / Mechanism of shape determination in motile cells by Keren (2008)
  48. 10.1038/nature04976 / Nature / Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology by Kim (2006)
  49. 10.1073/pnas.0605380104 / Proc. Natl. Acad. Sci. USA / Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry by Kiselar (2007)
  50. 10.1074/jbc.273.1.291 / J. Biol. Chem. / p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase by Kobayashi (1998)
  51. 10.1038/ncb1692 / Nat. Cell Biol. / Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front by Koestler (2008)
  52. 10.1073/pnas.0405902101 / Proc. Natl. Acad. Sci. USA / Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces by Kovar (2004)
  53. 10.1083/jcb.200801027 / J. Cell Biol. / Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers by Kueh (2008)
  54. 10.1016/j.cub.2003.10.005 / Curr. Biol. / Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions by Kunda (2003)
  55. 10.1371/journal.pbio.0050233 / PLoS Biol. / Emergence of large-scale cell morphology and movement from local actin filament growth dynamics by Lacayo (2007)
  56. 10.1038/emboj.2008.34 / EMBO J. / Arp2/3 complex interactions and actin network turnover in lamellipodia by Lai (2008)
  57. 10.1038/nature06887 / Nature / Rapid leukocyte migration by integrin-independent flowing and squeezing by Lammermann (2008)
  58. 10.1083/jcb.200802145 / J. Cell Biol. / Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments by LeClaire (2008)
  59. 10.1016/j.str.2006.12.005 / Structure / Structural basis for the actin-binding function of missing-in-metastasis by Lee (2007)
  60. 10.1091/mbc.e06-06-0569 / Mol. Biol. Cell / N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts by Legg (2007)
  61. 10.1371/journal.pgen.0030237 / PLoS Genet. / Human subtelomeric WASH genes encode a new subclass of the WASP family by Linardopoulou (2007)
  62. 10.1038/44183 / Nature / Reconstitution of actin-based motility of Listeria and Shigella using pure proteins by Loisel (1999)
  63. 10.1073/pnas.95.26.15362 / Proc. Natl. Acad. Sci. USA / The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42 by Ma (1998)
  64. 10.1016/S0960-9822(98)00015-3 / Curr. Biol. / Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex by Machesky (1998)
  65. 10.1016/S0955-0674(99)80014-3 / Curr. Opin. Cell Biol. / The Arp2/3 complex: a multifunctional actin organizer by Machesky (1999)
  66. 10.1083/jcb.138.4.771 / J. Cell Biol. / Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function by McGough (1997)
  67. 10.1093/emboj/17.23.6932 / EMBO J. / WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac by Miki (1998)
  68. 10.1016/j.cub.2008.12.044 / Curr. Biol. / Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion by Millius (2009)
  69. 10.1016/S0092-8674(00)81281-7 / Cell / Actin-based cell motility and cell locomotion by Mitchison (1996)
  70. 10.1016/j.semcdb.2008.01.008 / Semin. Cell Dev. Biol. / Implications of a poroelastic cytoplasm for the dynamics of animal cell shape by Mitchison (2008)
  71. 10.1007/s00285-008-0182-2 / J. Math. Biol. / Mathematics of cell motility: have we got its number? by Mogilner (2009)
  72. 10.1016/S0006-3495(96)79496-1 / Biophys. J. / Cell motility driven by actin polymerization by Mogilner (1996)
  73. 10.1074/jbc.M804201200 / J. Biol. Chem. / Formin differentially utilizes profilin isoforms to rapidly assemble actin filaments by Neidt (2009)
  74. 10.1101/gad.12.21.3337 / Genes Dev. / Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes by Nolan (1998)
  75. 10.1016/j.molcel.2007.04.017 / Mol. Cell / Insights into the influence of nucleotides on actin family proteins from seven structures of Arp2/3 complex by Nolen (2007)
  76. 10.1074/jbc.M802607200 / J. Biol. Chem. / Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit by Nolen (2008)
  77. 10.1016/j.jaci.2006.02.005 / J. Allergy Clin. Immunol. / The Wiskott-Aldrich syndrome by Ochs (2006)
  78. 10.1016/j.molcel.2008.10.012 / Mol. Cell / Hierarchical regulation of WASP/WAVE proteins by Padrick (2008)
  79. 10.1074/jbc.M402357200 / J. Biol. Chem. / ARPC1/Arc40 mediates the interaction of the actin-related protein 2 and 3 complex with Wiskott-Aldrich syndrome protein family activators by Pan (2004)
  80. 10.1002/cm.20379 / Cell Motil. Cytoskeleton / Review of the mechanism of processive actin filament elongation by formins by Paul (2009)
  81. 10.1016/j.jmb.2006.10.102 / J. Mol. Biol. / Actin filament severing by cofilin by Pavlov (2007)
  82. 10.1016/S0006-3495(93)81035-X / Biophys. J. / Cellular motions and thermal fluctuations: the Brownian ratchet by Peskin (1993)
  83. 10.1016/j.devcel.2008.09.003 / Dev. Cell / A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis by Philippar (2008)
  84. 10.1111/j.1365-2818.2008.02056.x / J. Microsc. / Imaging amoeboid cancer cell motility in vivo by Pinner (2008)
  85. 10.1038/ncb1675 / Nat. Cell Biol. / PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE by Pinner (2008)
  86. 10.1146/annurev.biophys.35.040405.101936 / Annu. Rev. Biophys. Biomol. Struct. / Regulation of actin filament assembly by Arp2/3 complex and formins by Pollard (2007)
  87. 10.1016/j.cub.2008.01.026 / Curr. Biol. / Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE complex in cytokinesis by Pollitt (2008)
  88. 10.1073/pnas.0801650105 / Proc. Natl. Acad. Sci. USA / X-ray scattering study of actin polymerization nuclei assembled by tandem W domains by Rebowski (2008)
  89. 10.1038/35004000 / Nat. Cell Biol. / CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans by Reddien (2000)
  90. 10.1016/S1047-8477(02)00005-9 / J. Struct. Biol. / Pure F-actin networks are distorted and branched by steps in the critical-point drying method by Resch (2002)
  91. 10.1126/science.1066333 / Science / Crystal structure of Arp2/3 complex by Robinson (2001)
  92. 10.1038/nsmb870 / Nat. Struct. Mol. Biol. / Conformational changes in the Arp2/3 complex leading to actin nucleation by Rodal (2005)
  93. 10.1186/1471-2121-6-36 / BMC Cell Biol. / Regulation of actin cytoskeleton architecture by Eps8 and Abi1 by Roffers-Agarwal (2005)
  94. 10.1016/j.cell.2004.09.039 / Cell / Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis by Romero (2004)
  95. 10.1083/jcb.200709092 / J. Cell Biol. / The structural basis of actin filament branching by the Arp2/3 complex by Rouiller (2008)
  96. 10.1128/MCB.01483-08 / Mol. Cell Biol. / Regulation of cell-cell adhesion by Abi/Diaphanous complexes by Ryu (2009)
  97. 10.1016/j.cell.2008.09.043 / Cell / Rac activation and inactivation control plasticity of tumor cell movement by Sanz-Moreno (2008)
  98. 10.1083/jcb.200708123 / J. Cell Biol. / WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells by Sarmiento (2008)
  99. 10.1242/dev.016816 / Development / The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1 by Schmidt (2009)
  100. 10.4161/cc.5.11.2770 / Cell Cycle / Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulation by Schneider (2006)
  101. 10.1016/S1097-2765(04)00059-0 / Mol. Cell / The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization by Shimada (2004)
  102. 10.1083/jcb.200707009 / J. Cell Biol. / Cofilin determines the migration behavior and turning frequency of metastatic cancer cells by Sidani (2007)
  103. 10.1111/j.1365-2818.2008.02060.x / J. Microsc. / Unravelling the structure of the lamellipodium by Small (2008)
  104. 10.1091/mbc.e05-11-1088 / Mol. Biol. Cell / Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes by Steffen (2006)
  105. 10.1016/S0960-9822(01)00239-1 / Curr. Biol. / The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia by Stradal (2001)
  106. 10.1016/S1534-5807(03)00297-1 / Dev. Cell / Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration by Suetsugu (2003)
  107. 10.1083/jcb.200210174 / J. Cell Biol. / Mechanism of filopodia initiation by reorganization of a dendritic network by Svitkina (2003)
  108. 10.1074/jbc.M301447200 / J. Biol. Chem. / Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase by Tani (2003)
  109. 10.1021/bi062152y / Biochemistry / Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2 by Tomasevic (2007)
  110. 10.1529/biophysj.106.091884 / Biophys. J. / VASP governs actin dynamics by modulating filament anchoring by Trichet (2007)
  111. 10.1083/jcb.200710168 / J. Cell Biol. / Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP by Trichet (2008)
  112. 10.1242/dev.02792 / Development / The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis by Uhrig (2007)
  113. 10.1242/jcs.031146 / J. Cell Sci. / A common cofilin activity cycle in invasive tumor cells and inflammatory cells by van Rheenen (2009)
  114. 10.1083/jcb.200709180 / J. Cell Biol. / Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum by Veltman (2008)
  115. 10.1016/S0960-9822(02)01035-7 / Curr. Biol. / Interaction of cortactin and N-WASp with Arp2/3 complex by Weaver (2002)
  116. 10.1371/journal.pbio.0040038 / PLoS Biol. / Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis by Weiner (2006)
  117. 10.1371/journal.pbio.0050221 / PLoS Biol. / An actin-based wave generator organizes cell motility by Weiner (2007)
  118. 10.1038/nature07773 / Nature / The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility by Weisswange (2009)
  119. 10.1111/j.1365-2133.2006.07231.x / Br. J. Dermatol. / Molecular mechanisms of cancer cell invasion and plasticity by Wolf (2006)
  120. 10.1016/S0092-8674(04)00210-7 / Cell / Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture by Xu (2004)
  121. 10.1371/journal.pbio.0050317 / PLoS Biol. / Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells by Yang (2007)
  122. 10.1016/j.cub.2008.08.069 / Curr. Biol. / Spatiotemporal regulation of Ras activity provides directional sensing by Zhang (2008)
  123. 10.1038/ncb1852 / Nat. Cell Biol. / p53-cofactor JMY is a multifunctional actin nucleation factor by Zuchero (2009)
Dates
Type When
Created 15 years, 11 months ago (Sept. 15, 2009, 4:54 a.m.)
Deposited 1 year, 3 months ago (May 22, 2024, 9:33 a.m.)
Indexed 11 hours, 28 minutes ago (Sept. 3, 2025, 6:54 a.m.)
Issued 16 years ago (Sept. 1, 2009)
Published 16 years ago (Sept. 1, 2009)
Published Print 16 years ago (Sept. 1, 2009)
Funders 0

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@article{Insall_2009, title={Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks}, volume={17}, ISSN={1534-5807}, url={http://dx.doi.org/10.1016/j.devcel.2009.08.012}, DOI={10.1016/j.devcel.2009.08.012}, number={3}, journal={Developmental Cell}, publisher={Elsevier BV}, author={Insall, Robert H. and Machesky, Laura M.}, year={2009}, month=sep, pages={310–322} }