Authors
11
- Frauke Christ (first)
- Wannes Thys (additional)
- Jan De Rijck (additional)
- Rik Gijsbers (additional)
- Alberto Albanese (additional)
- Daniele Arosio (additional)
- Stephane Emiliani (additional)
- Jean-Christophe Rain (additional)
- Richard Benarous (additional)
- Anna Cereseto (additional)
- Zeger Debyser (additional)
References
46
Referenced
211
10.1084/jem.174.6.1477
/ J. Exp. Med. / Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes by Weinberg (1991)10.1101/gad.12.2.175
/ Genes Dev. / HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection by Vodicka (1998)10.1002/j.1460-2075.1992.tb05376.x
/ EMBO J. / Human immunodeficiency virus infection of cells arrested in the cell cycle by Lewis (1992)10.1038/nrmicro1579
/ Nat. Rev. Microbiol. / The road to chromatin - nuclear entry of retroviruses by Suzuki (2007)10.1002/bies.20561
/ Bioessays / Lentiviral nuclear import: A complex interplay between virus and host by De Rijck (2007)10.1073/pnas.94.18.9825
/ Proc. Natl. Acad. Sci. USA / HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway by Gallay (1997)10.1016/j.jmb.2003.11.057
/ J. Mol. Biol. / A synthetic peptide bearing the HIV-1 integrase 161–173 amino acid residues mediates active nuclear import and binding to importin alpha: Characterization of a functional nuclear localization signal by Armon-Omer (2004)10.1074/jbc.M009029200
/ J. Biol. Chem. / Characterization of the nuclear import pathway for HIV-1 integrase by Depienne (2001)10.1042/BJ20060466
/ Biochem. J. / HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism by Hearps (2006)10.1093/emboj/cdg357
/ EMBO J. / Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7 by Fassati (2003)10.1128/JVI.79.17.11541-11546.2005
/ J. Virol. / Importin 7 may be dispensable for human immunodeficiency virus type 1 and simian immunodeficiency virus infection of primary macrophages by Zielske (2005)10.1074/jbc.M610546200
/ J. Biol. Chem. / Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication by Ao (2007)10.1083/jcb.145.6.1145
/ J. Cell Biol. / Transportin-SR, a nuclear import receptor for SR proteins by Kataoka (1999)10.1074/jbc.275.11.7950
/ J. Biol. Chem. / A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins by Lai (2000)10.1073/pnas.181354098
/ Proc. Natl. Acad. Sci. USA / Transportin-SR2 mediates nuclear import of phosphorylated SR proteins by Lai (2001)10.1074/jbc.M211714200
/ J. Biol. Chem. / Phosphorylation-dependent and -independent nuclear import of RS domain-containing splicing factors and regulators by Yun (2003)10.1093/emboj/cdg126
/ EMBO J. / A novel splicing regulator shares a nuclear import pathway with SR proteins by Lai (2003)- Legrain P., Rain, J.C., Benarouse, R., Emiliani, S., Berlioz-Torrent, C., and Blot, G. (2003). Protein-protein interactions in human immunodeficiency virus. World Intellectual Property Organization: WO 03/04176 A04172.
10.1074/jbc.M209278200
/ J. Biol. Chem. / HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells by Cherepanov (2003)10.1128/JVI.80.4.1886-1896.2006
/ J. Virol. / Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus by Vandekerckhove (2006)10.1128/JVI.00801-06
/ J. Virol. / Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication by De Rijck (2006)10.1371/journal.ppat.0030047
/ PLoS Pathog. / Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV by Hombrouck (2007)10.1126/science.1132319
/ Science / An essential role for LEDGF/p75 in HIV integration by Llano (2006)10.1101/gad.1565107
/ Genes Dev. / LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration by Shun (2007)10.1128/AAC.00210-08
/ Antimicrob. Agents Chemother. / Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors by Hombrouck (2008)10.1073/pnas.0308698100
/ Proc. Natl. Acad. Sci. USA / Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells by Scacheri (2004)10.1128/JVI.78.12.6517-6526.2004
/ J. Virol. / A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression by Caputi (2004)10.1186/1742-4690-2-33
/ Retrovirology / Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production by Jacquenet (2005){'year': '1997', 'series-title': 'Retroviruses', 'author': 'Coffin', 'key': '10.1016/j.cub.2008.07.079_bib29'}
/ Retroviruses by Coffin (1997)10.1371/journal.pone.0002413
/ PloS One / HIV-1 pre-integration complexes selectively target decondennsed chromatin in the nuclear periphery by Albanese (2008)10.1128/jvi.69.6.3389-3398.1995
/ J. Virol. / Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx by Wu (1995)10.1074/jbc.M406307200
/ J. Biol. Chem. / Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase by Cherepanov (2004)10.1073/pnas.0506924102
/ Proc. Natl. Acad. Sci. USA / Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator by Cherepanov (2005)10.1038/nm1329
/ Nat. Med. / A role for LEDGF/p75 in targeting HIV DNA integration by Ciuffi (2005)10.1074/jbc.M501378200
/ J. Biol. Chem. / Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication by Emiliani (2005)10.1074/jbc.M408508200
/ J. Biol. Chem. / Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase by Llano (2004)10.1074/jbc.M303594200
/ J. Biol. Chem. / LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells by Maertens (2003)10.1128/JVI.02470-05
/ J. Virol. / Modest but reproducible inhibition of human immunodeficiency virus type 1 infection in macrophages following LEDGFp75 silencing by Zielske (2006)10.1128/jvi.66.11.6361-6369.1992
/ J. Virol. / Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro by Engelman (1992)10.1006/meth.1999.0876
/ Methods / Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking by Liu (1999)10.1371/journal.ppat.0010018
/ PLoS Pathog. / The cell cycle independence of HIV Infections is not determined by known karyophilic viral elements by Yamashita (2005)10.1128/JVI.78.11.5670-5678.2004
/ J. Virol. / Capsid is a dominant determinant of retrovirus infectivity in nondividing cells by Yamashita (2004)10.1126/science.1152725
/ Science / Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen by Brass (2008)10.1038/nrd2336
/ Nat. Rev. Drug Discov. / HIV drug development: The next 25 years by Flexner (2007)10.1074/jbc.M411681200
/ J. Biol. Chem. / The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding by Busschots (2005)10.1038/nm725
/ Nat. Med. / siRNA-directed inhibition of HIV-1 infection by Novina (2002)
Dates
Type | When |
---|---|
Created | 17 years ago (Aug. 22, 2008, 6:34 a.m.) |
Deposited | 1 year, 3 months ago (May 6, 2024, 1:16 p.m.) |
Indexed | 1 month, 4 weeks ago (July 2, 2025, 10:19 a.m.) |
Issued | 17 years, 1 month ago (Aug. 1, 2008) |
Published | 17 years, 1 month ago (Aug. 1, 2008) |
Published Print | 17 years, 1 month ago (Aug. 1, 2008) |
Funders
3
Seventh Framework Programme
10.13039/100011102
Region: Europe
gov (National government)
Labels
13
- EC Seventh Framework Programm
- European Commission Seventh Framework Programme
- EU Seventh Framework Programme
- European Union Seventh Framework Programme
- EU 7th Framework Programme
- European Union 7th Framework Programme
- Siebten Rahmenprogramm
- Séptimo Programa Marco
- Septième programme-cadre
- Settimo programma quadro
- 7th Framework Programme
- Seventh EU Framework Programme
- FP7
Awards
1
- Health-2007-2.3.2-1
Sixth Framework Programme
10.13039/100011103
Region: Europe
gov (National government)
Labels
14
- EC Sixth Framework Programme
- European Commission Sixth Framework Programme
- EU Sixth Framework Programme
- European Union Sixth Framework Programme
- EU 6th Framework Programme
- European Union 6th Framework Programme
- 6th EU Research Framework Programme
- European Union's Sixth Framework Programme
- The 6th EU Research Framework Programme
- 6th FP
- EUROPEAN UNION'S 6TH FRAMEWORK PROGRAMME
- 6th Framework Programme
- EC Framework Programme 6
- FP6
Awards
1
- LSHB-CT-2003-503480
Agentschap voor Innovatie door Wetenschap en Technologie
10.13039/501100003132
Region: Europe
gov (Local government)
Labels
2
- Agency for Innovation by Science and Technology, Flanders
- IWT
@article{Christ_2008, title={Transportin-SR2 Imports HIV into the Nucleus}, volume={18}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/j.cub.2008.07.079}, DOI={10.1016/j.cub.2008.07.079}, number={16}, journal={Current Biology}, publisher={Elsevier BV}, author={Christ, Frauke and Thys, Wannes and De Rijck, Jan and Gijsbers, Rik and Albanese, Alberto and Arosio, Daniele and Emiliani, Stephane and Rain, Jean-Christophe and Benarous, Richard and Cereseto, Anna and Debyser, Zeger}, year={2008}, month=aug, pages={1192–1202} }