DOI: 10.1016/j.cub.2004.10.027. Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

10.1016/j.cub.2004.10.027

Crossref journal-article

Elsevier BV

Current Biology (78)

Bibliography

Martinon, F., Agostini, L., Meylan, E., & Tschopp, J. (2004). Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome. Current Biology, 14(21), 1929â1934.

Authors 4

Fabio Martinon (first)
Laetitia Agostini (additional)
Etienne Meylan (additional)
Jürg Tschopp (additional)

References 32 Referenced 462

10.1016/j.cell.2004.05.004 / Cell / Inflammatory caspases by Martinon (2004)
10.1034/j.1600-065X.2003.00048.x / Immunol. Rev / Caspase-activation pathways in apoptosis and immunity by Creagh (2003)
10.1016/S1074-7613(04)00046-9 / Immunity / NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder by Agostini (2004)
10.1016/S1097-2765(02)00599-3 / Mol. Cell / The inflammasome by Martinon (2002)
10.1038/nature02664 / Nature / Differential activation of the inflammasome by caspase-1adaptors ASC and Ipaf by Mariathasan (2004)
10.1038/nrm1019 / Nat. Rev. Mol. Cell Biol / Nalps by Tschopp (2003)
10.1038/nri1086 / Nat. Rev. Immunol / Nods by Inohara (2003)
10.1016/S1369-5274(02)00289-8 / Curr. Opin. Microbiol / Nods by Inohara (2002)
10.1074/jbc.C100250200 / J. Biol. Chem / Identification of ipaf, a human caspase-1-activating protein related to Apaf-1 by Poyet (2001)
10.1006/bbrc.2001.4928 / Biochem. Biophys. Res. Commun / Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis by Geddes (2001)
10.1006/geno.2001.6579 / Genomics / CLAN, a novel human CED-4-like gene by Damiano (2001)
10.1146/annurev.immunol.20.083001.084359 / Annu. Rev. Immunol / Innate immune recognition by Janeway (2002)
10.1016/S1471-4906(03)00242-4 / Trends Immunol / Leucine-rich repeats and pathogen recognition in Toll-like receptors by Bell (2003)
10.1074/jbc.C200673200 / J. Biol. Chem / Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease by Inohara (2003)
10.1038/ni945 / Nat. Immunol / An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid by Chamaillard (2003)
10.1074/jbc.M307198200 / J. Biol. Chem / Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2 by Girardin (2003)
{'key': '10.1016/j.cub.2004.10.027_BIB17', 'first-page': '337', 'article-title': 'Enhancement of endotoxin activity by muramyldipeptide', 'volume': '8', 'author': 'Takada', 'year': '2002', 'journal-title': 'J. Endotoxin Res'} / J. Endotoxin Res / Enhancement of endotoxin activity by muramyldipeptide by Takada (2002)
10.1038/sj.embor.7400248 / EMBO Rep / Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition by Travassos (2004)
10.1016/S1097-2765(03)00051-0 / Mol. Cell / A unified model for apical caspase activation by Boatright (2003)
10.1038/ng756 / Nat. Genet / Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome by Hoffman (2001)
10.1002/art.10509 / Arthritis Rheum / Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis by Aganna (2002)
10.1086/340786 / Am. J. Hum. Genet / New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria by Dode (2002)
10.1086/341357 / Am. J. Hum. Genet / Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes by Feldmann (2002)
10.1016/S1471-4914(02)02425-5 / Trends Mol. Med / Genetic clues to understanding periodic fevers, and possible therapies by McDermott (2002)
10.1016/S0952-7915(02)00017-1 / Curr. Opin. Immunol / New insights into the mechanism of IL-1beta maturation by Burns (2003)
Dowds, T.A., Masumoto, J., Zhu, L., Inohara, N., and Nunez, G. (2004). Cryopyrin induced IL-1 secretion in monocytic cells: Enhanced activity of disease-associated mutants and requirement for ASC. J. Biol. Chem. (10.1074/jbc.M401178200)
10.4049/jimmunol.171.12.6329 / J. Immunol / Cutting edge by O'Connor (2003)
10.1074/jbc.C200651200 / J. Biol. Chem / Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection by Girardin (2003)
10.1016/0006-291X(74)90458-6 / Biochem. Biophys. Res. Commun / Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives by Ellouz (1974)
10.1159/000026384 / Neuroimmunomodulation / Effects of muramyl peptides on macrophages, monokines, and sleep by Pabst (1999)
10.1016/S0960-9822(99)80085-2 / Curr. Biol / Fever by Dinarello (1999)
10.1046/j.1523-1747.1998.00249.x / J. Invest. Dermatol / MDP(Lysyl)GDP, a nontoxic muramyl dipeptide derivative, inhibits cytokine production by activated macrophages and protects mice from phorbol ester- and oxazolone-induced inflammation by Zunic (1998)

Dates

Type	When
Created	20 years, 9 months ago (Nov. 9, 2004, 11:54 a.m.)
Deposited	1 year, 3 months ago (May 6, 2024, 12:07 p.m.)
Indexed	3 months, 2 weeks ago (May 13, 2025, 7:47 p.m.)
Issued	20 years, 9 months ago (Nov. 1, 2004)
Published	20 years, 9 months ago (Nov. 1, 2004)
Published Print	20 years, 9 months ago (Nov. 1, 2004)

Funders 0

None

BibTeX

@article{Martinon_2004, title={Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome}, volume={14}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/j.cub.2004.10.027}, DOI={10.1016/j.cub.2004.10.027}, number={21}, journal={Current Biology}, publisher={Elsevier BV}, author={Martinon, Fabio and Agostini, Laetitia and Meylan, Etienne and Tschopp, Jürg}, year={2004}, month=nov, pages={1929–1934} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        13
      ]
    ],
    "date-time": "2025-05-13T23:47:47Z",
    "timestamp": 1747180067531
  },
  "reference-count": 32,
  "publisher": "Elsevier BV",
  "issue": "21",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            11,
            1
          ]
        ],
        "date-time": "2004-11-01T00:00:00Z",
        "timestamp": 1099267200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            11,
            1
          ]
        ],
        "date-time": "2004-11-01T00:00:00Z",
        "timestamp": 1099267200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/legal/tdmrep-license"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            8,
            17
          ]
        ],
        "date-time": "2013-08-17T00:00:00Z",
        "timestamp": 1376697600000
      },
      "content-version": "vor",
      "delay-in-days": 3211,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            11,
            1
          ]
        ],
        "date-time": "2004-11-01T00:00:00Z",
        "timestamp": 1099267200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            11,
            1
          ]
        ],
        "date-time": "2004-11-01T00:00:00Z",
        "timestamp": 1099267200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            11,
            1
          ]
        ],
        "date-time": "2004-11-01T00:00:00Z",
        "timestamp": 1099267200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            11,
            1
          ]
        ],
        "date-time": "2004-11-01T00:00:00Z",
        "timestamp": 1099267200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            11,
            1
          ]
        ],
        "date-time": "2004-11-01T00:00:00Z",
        "timestamp": 1099267200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        11
      ]
    ]
  },
  "DOI": "10.1016/j.cub.2004.10.027",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        11,
        9
      ]
    ],
    "date-time": "2004-11-09T16:54:21Z",
    "timestamp": 1100019261000
  },
  "page": "1929-1934",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 462,
  "title": "Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome",
  "prefix": "10.1016",
  "volume": "14",
  "author": [
    {
      "given": "Fabio",
      "family": "Martinon",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Laetitia",
      "family": "Agostini",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Etienne",
      "family": "Meylan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J\u00fcrg",
      "family": "Tschopp",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.cub.2004.10.027_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "561",
      "DOI": "10.1016/j.cell.2004.05.004",
      "article-title": "Inflammatory caspases",
      "volume": "117",
      "author": "Martinon",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.1034/j.1600-065X.2003.00048.x",
      "article-title": "Caspase-activation pathways in apoptosis and immunity",
      "volume": "193",
      "author": "Creagh",
      "year": "2003",
      "journal-title": "Immunol. Rev"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "319",
      "DOI": "10.1016/S1074-7613(04)00046-9",
      "article-title": "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder",
      "volume": "20",
      "author": "Agostini",
      "year": "2004",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/S1097-2765(02)00599-3",
      "article-title": "The inflammasome",
      "volume": "10",
      "author": "Martinon",
      "year": "2002",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "213",
      "DOI": "10.1038/nature02664",
      "article-title": "Differential activation of the inflammasome by caspase-1adaptors ASC and Ipaf",
      "volume": "430",
      "author": "Mariathasan",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "95",
      "DOI": "10.1038/nrm1019",
      "article-title": "Nalps",
      "volume": "4",
      "author": "Tschopp",
      "year": "2003",
      "journal-title": "Nat. Rev. Mol. Cell Biol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "371",
      "DOI": "10.1038/nri1086",
      "article-title": "Nods",
      "volume": "3",
      "author": "Inohara",
      "year": "2003",
      "journal-title": "Nat. Rev. Immunol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "76",
      "DOI": "10.1016/S1369-5274(02)00289-8",
      "article-title": "Nods",
      "volume": "5",
      "author": "Inohara",
      "year": "2002",
      "journal-title": "Curr. Opin. Microbiol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "28309",
      "DOI": "10.1074/jbc.C100250200",
      "article-title": "Identification of ipaf, a human caspase-1-activating protein related to Apaf-1",
      "volume": "276",
      "author": "Poyet",
      "year": "2001",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1006/bbrc.2001.4928",
      "article-title": "Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis",
      "volume": "284",
      "author": "Geddes",
      "year": "2001",
      "journal-title": "Biochem. Biophys. Res. Commun"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1006/geno.2001.6579",
      "article-title": "CLAN, a novel human CED-4-like gene",
      "volume": "75",
      "author": "Damiano",
      "year": "2001",
      "journal-title": "Genomics"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1146/annurev.immunol.20.083001.084359",
      "article-title": "Innate immune recognition",
      "volume": "20",
      "author": "Janeway",
      "year": "2002",
      "journal-title": "Annu. Rev. Immunol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "528",
      "DOI": "10.1016/S1471-4906(03)00242-4",
      "article-title": "Leucine-rich repeats and pathogen recognition in Toll-like receptors",
      "volume": "24",
      "author": "Bell",
      "year": "2003",
      "journal-title": "Trends Immunol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "5509",
      "DOI": "10.1074/jbc.C200673200",
      "article-title": "Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease",
      "volume": "278",
      "author": "Inohara",
      "year": "2003",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "702",
      "DOI": "10.1038/ni945",
      "article-title": "An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid",
      "volume": "4",
      "author": "Chamaillard",
      "year": "2003",
      "journal-title": "Nat. Immunol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "41702",
      "DOI": "10.1074/jbc.M307198200",
      "article-title": "Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2",
      "volume": "278",
      "author": "Girardin",
      "year": "2003",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB17",
      "first-page": "337",
      "article-title": "Enhancement of endotoxin activity by muramyldipeptide",
      "volume": "8",
      "author": "Takada",
      "year": "2002",
      "journal-title": "J. Endotoxin Res"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1038/sj.embor.7400248",
      "article-title": "Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition",
      "volume": "5",
      "author": "Travassos",
      "year": "2004",
      "journal-title": "EMBO Rep"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "529",
      "DOI": "10.1016/S1097-2765(03)00051-0",
      "article-title": "A unified model for apical caspase activation",
      "volume": "11",
      "author": "Boatright",
      "year": "2003",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1038/ng756",
      "article-title": "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome",
      "volume": "29",
      "author": "Hoffman",
      "year": "2001",
      "journal-title": "Nat. Genet"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "2445",
      "DOI": "10.1002/art.10509",
      "article-title": "Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis",
      "volume": "46",
      "author": "Aganna",
      "year": "2002",
      "journal-title": "Arthritis Rheum"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "1498",
      "DOI": "10.1086/340786",
      "article-title": "New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria",
      "volume": "70",
      "author": "Dode",
      "year": "2002",
      "journal-title": "Am. J. Hum. Genet"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "198",
      "DOI": "10.1086/341357",
      "article-title": "Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes",
      "volume": "71",
      "author": "Feldmann",
      "year": "2002",
      "journal-title": "Am. J. Hum. Genet"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "550",
      "DOI": "10.1016/S1471-4914(02)02425-5",
      "article-title": "Genetic clues to understanding periodic fevers, and possible therapies",
      "volume": "8",
      "author": "McDermott",
      "year": "2002",
      "journal-title": "Trends Mol. Med"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "26",
      "DOI": "10.1016/S0952-7915(02)00017-1",
      "article-title": "New insights into the mechanism of IL-1beta maturation",
      "volume": "15",
      "author": "Burns",
      "year": "2003",
      "journal-title": "Curr. Opin. Immunol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB26",
      "doi-asserted-by": "crossref",
      "unstructured": "Dowds, T.A., Masumoto, J., Zhu, L., Inohara, N., and Nunez, G. (2004). Cryopyrin induced IL-1 secretion in monocytic cells: Enhanced activity of disease-associated mutants and requirement for ASC. J. Biol. Chem.",
      "DOI": "10.1074/jbc.M401178200"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "6329",
      "DOI": "10.4049/jimmunol.171.12.6329",
      "article-title": "Cutting edge",
      "volume": "171",
      "author": "O'Connor",
      "year": "2003",
      "journal-title": "J. Immunol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "8869",
      "DOI": "10.1074/jbc.C200651200",
      "article-title": "Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection",
      "volume": "278",
      "author": "Girardin",
      "year": "2003",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "1317",
      "DOI": "10.1016/0006-291X(74)90458-6",
      "article-title": "Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives",
      "volume": "59",
      "author": "Ellouz",
      "year": "1974",
      "journal-title": "Biochem. Biophys. Res. Commun"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1159/000026384",
      "article-title": "Effects of muramyl peptides on macrophages, monokines, and sleep",
      "volume": "6",
      "author": "Pabst",
      "year": "1999",
      "journal-title": "Neuroimmunomodulation"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "R147",
      "DOI": "10.1016/S0960-9822(99)80085-2",
      "article-title": "Fever",
      "volume": "9",
      "author": "Dinarello",
      "year": "1999",
      "journal-title": "Curr. Biol"
    },
    {
      "key": "10.1016/j.cub.2004.10.027_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1046/j.1523-1747.1998.00249.x",
      "article-title": "MDP(Lysyl)GDP, a nontoxic muramyl dipeptide derivative, inhibits cytokine production by activated macrophages and protects mice from phorbol ester- and oxazolone-induced inflammation",
      "volume": "111",
      "author": "Zunic",
      "year": "1998",
      "journal-title": "J. Invest. Dermatol"
    }
  ],
  "container-title": "Current Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982204008309?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982204008309?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        5,
        6
      ]
    ],
    "date-time": "2024-05-06T16:07:42Z",
    "timestamp": 1715011662000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0960982204008309"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        11
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "21",
    "published-print": {
      "date-parts": [
        [
          2004,
          11
        ]
      ]
    }
  },
  "alternative-id": [
    "S0960982204008309"
  ],
  "URL": "http://dx.doi.org/10.1016/j.cub.2004.10.027",
  "relation": {},
  "ISSN": [
    "0960-9822"
  ],
  "subject": [],
  "container-title-short": "Current Biology",
  "published": {
    "date-parts": [
      [
        2004,
        11
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Current Biology",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/j.cub.2004.10.027",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}