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Cell Metabolism (78)
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Shah, Y. M., Matsubara, T., Ito, S., Yim, S.-H., & Gonzalez, F. J. (2009). Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency. Cell Metabolism, 9(2), 152–164.

Authors 5
  1. Yatrik M. Shah (first)
  2. Tsutomu Matsubara (additional)
  3. Shinji Ito (additional)
  4. Sun-Hee Yim (additional)
  5. Frank J. Gonzalez (additional)
References 65 Referenced 359
  1. 10.1074/jbc.M000713200 / J. Biol. Chem. / A novel mammalian iron-regulated protein involved in intracellular iron metabolism by Abboud (2000)
  2. 10.1093/ajcn/81.1.130 / Am. J. Clin. Nutr. / Duodenal ascorbate and ferric reductase in human iron deficiency by Atanasova (2005)
  3. 10.1038/ng1777 / Nat. Genet. / Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression by Babitt (2006)
  4. 10.1172/JCI31342 / J. Clin. Invest. / Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance by Babitt (2007)
  5. 10.1182/blood-2002-06-1747 / Blood / The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis by Beutler (2003)
  6. 10.1016/j.cell.2008.02.038 / Cell / Epidermal sensing of oxygen is essential for systemic hypoxic response by Boutin (2008)
  7. 10.1158/0008-5472.CAN-05-2519 / Cancer Res. / Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway by Carroll (2006)
  8. 10.1074/jbc.M202653200 / J. Biol. Chem. / C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism by Courselaud (2002)
  9. 10.1038/35001596 / Nature / Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter by Donovan (2000)
  10. 10.1016/j.cmet.2005.01.003 / Cell Metab. / The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis by Donovan (2005)
  11. 10.1093/jn/133.5.1510S / J. Nutr. / Novel roles for iron regulatory proteins in the adaptive response to iron deficiency by Eisenstein (2003)
  12. 10.1126/science.7732381 / Science / Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor by Fernandez-Salguero (1995)
  13. 10.1073/pnas.95.3.1148 / Proc. Natl. Acad. Sci. USA / Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport by Fleming (1998)
  14. 10.1038/ng0897-383 / Nat. Genet. / Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene by Fleming (1997)
  15. 10.1073/pnas.162360699 / Proc. Natl. Acad. Sci. USA / Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis by Fleming (2002)
  16. 10.1182/blood-2008-04-150953 / Blood / Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2 by Foot (2008)
  17. 10.1053/gast.2002.35353 / Gastroenterology / Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats by Frazer (2002)
  18. 10.1016/j.cmet.2007.10.006 / Cell Metab. / Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum by Galy (2008)
  19. 10.1038/41343 / Nature / Cloning and characterization of a mammalian proton-coupled metal-ion transporter by Gunshin (1997)
  20. 10.1016/S0014-5793(01)03189-1 / FEBS Lett. / Iron-dependent regulation of the divalent metal ion transporter by Gunshin (2001)
  21. 10.1172/JCI24356 / J. Clin. Invest. / Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver by Gunshin (2005)
  22. 10.1182/blood-2005-02-0716 / Blood / Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice by Gunshin (2005)
  23. 10.1016/j.semcdb.2005.03.006 / Semin. Cell Dev. Biol. / The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting by Haase (2005)
  24. 10.1073/pnas.98.4.1583 / Proc. Natl. Acad. Sci. USA / Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor by Haase (2001)
  25. 10.1128/MCB.23.24.9361-9374.2003 / Mol. Cell. Biol. / Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation by Hu (2003)
  26. 10.1073/pnas.192423399 / Proc. Natl. Acad. Sci. USA / Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function by Hubert (2002)
  27. 10.1172/JCI31647 / J. Clin. Invest. / Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut by Ito (2007)
  28. 10.1126/science.1059817 / Science / HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing by Ivan (2001)
  29. 10.1126/science.1059796 / Science / Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation by Jaakkola (2001)
  30. 10.1038/sj.cdd.4402313 / Cell Death Differ. / The VHL tumor suppressor and HIF: insights from genetic studies in mice by Kapitsinou (2008)
  31. 10.1093/jn/138.6.991 / J. Nutr. / Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells by Latunde-Dada (2008)
  32. 10.2174/156652406779010849 / Curr. Mol. Med. / Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders by Lee (2006)
  33. 10.1172/JCI9635 / J. Clin. Invest. / Genes that modify the hemochromatosis phenotype in mice by Levy (2000)
  34. 10.1152/ajpgi.00363.2005 / Am. J. Physiol. Gastrointest. Liver Physiol. / Iron Imports. II. Iron uptake at the apical membrane in the intestine by Mackenzie (2005)
  35. 10.1016/S1097-2765(00)80425-6 / Mol. Cell / A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation by McKie (2000)
  36. 10.1126/science.1057206 / Science / An iron-regulated ferric reductase associated with the absorption of dietary iron by McKie (2001)
  37. 10.1182/blood.V18.6.727.727 / Blood / Studies on iron absorption. I. The relationships between the rate of erythropoiesis, hypoxia and iron absorption by Mendel (1961)
  38. 10.1126/science.1104742 / Science / Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization by Nemeth (2004)
  39. 10.1073/pnas.151179498 / Proc. Natl. Acad. Sci. USA / Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice by Nicolas (2001)
  40. 10.1073/pnas.072632499 / Proc. Natl. Acad. Sci. USA / Severe iron deficiency anemia in transgenic mice expressing liver hepcidin by Nicolas (2002)
  41. 10.1172/JCI0215686 / J. Clin. Invest. / The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation by Nicolas (2002)
  42. 10.1196/annals.1306.001 / Ann. N Y Acad. Sci. / Iron metabolism and the IRE/IRP regulatory system: an update by Pantopoulos (2004)
  43. 10.1172/JCI31370 / J. Clin. Invest. / Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs) by Peyssonnaux (2007)
  44. 10.4161/cc.7.1.5145 / Cell Cycle / Role of the hypoxia inducible factors HIF in iron metabolism by Peyssonnaux (2008)
  45. 10.1074/jbc.M008923200 / J. Biol. Chem. / A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload by Pigeon (2001)
  46. 10.1074/jbc.274.1.305 / J. Biol. Chem. / Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase by Postic (1999)
  47. 10.1038/nm0603-677 / Nat. Med. / Regulation of angiogenesis by hypoxia: role of the HIF system by Pugh (2003)
  48. 10.1172/JCI30117 / J. Clin. Invest. / Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo by Rankin (2007)
  49. {'key': '10.1016/j.cmet.2008.12.012_bib49', 'first-page': '848', 'article-title': 'Influence of altitude changes on intestinal iron absorption', 'volume': '57', 'author': 'Reynafarje', 'year': '1961', 'journal-title': 'J. Lab. Clin. Med.'} / J. Lab. Clin. Med. / Influence of altitude changes on intestinal iron absorption by Reynafarje (1961)
  50. 10.1038/nchembio807 / Nat. Chem. Biol. / The role of iron regulatory proteins in mammalian iron homeostasis and disease by Rouault (2006)
  51. 10.1038/nrc1187 / Nat. Rev. Cancer / Targeting HIF-1 for cancer therapy by Semenza (2003)
  52. 10.1128/MCB.12.12.5447 / Mol. Cell. Biol. / A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation by Semenza (1992)
  53. 10.1053/j.gastro.2008.03.009 / Gastroenterology / Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade by Shah (2008)
  54. 10.1042/0264-6021:3630449 / Biochem. J. / Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element by Tchernitchko (2002)
  55. 10.1101/gad.11.1.72 / Genes Dev. / Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells by Tian (1997)
  56. {'key': '10.1016/j.cmet.2008.12.012_bib56', 'first-page': '1674', 'article-title': 'Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha', 'volume': '14', 'author': 'Tomita', 'year': '2000', 'journal-title': 'Mol. Endocrinol.'} / Mol. Endocrinol. / Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha by Tomita (2000)
  57. 10.1128/MCB.23.19.6739-6749.2003 / Mol. Cell. Biol. / Defective brain development in mice lacking the Hif-1alpha gene in neural cells by Tomita (2003)
  58. 10.1182/blood-2006-07-033969 / Blood / STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation by Verga Falzacappa (2007)
  59. 10.1016/S0021-9258(20)80571-7 / J. Biol. Chem. / Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia by Wang (1993)
  60. 10.1073/pnas.92.12.5510 / Proc. Natl. Acad. Sci. USA / Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension by Wang (1995)
  61. 10.1016/j.cmet.2005.10.010 / Cell Metab. / A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression by Wang (2005)
  62. 10.1301/00296640260385900 / Nutr. Rev. / A possible link between hepcidin and regulation of dietary iron absorption by Wessling-Resnick (2002)
  63. 10.1182/blood-2007-09-111567 / Blood / Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin by Xia (2008)
  64. 10.1073/pnas.95.5.2492 / Proc. Natl. Acad. Sci. USA / HFE gene knockout produces mouse model of hereditary hemochromatosis by Zhou (1998)
  65. 10.1006/bcmd.2002.0587 / Blood Cells Mol. Dis. / Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1 by Zoller (2002)
Dates
Type When
Created 16 years, 7 months ago (Jan. 16, 2009, 4:29 a.m.)
Deposited 3 years, 10 months ago (Sept. 29, 2021, 11:01 p.m.)
Indexed 56 minutes ago (Aug. 28, 2025, 5:17 p.m.)
Issued 16 years, 6 months ago (Feb. 1, 2009)
Published 16 years, 6 months ago (Feb. 1, 2009)
Published Print 16 years, 6 months ago (Feb. 1, 2009)
Funders 0

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@article{Shah_2009, title={Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency}, volume={9}, ISSN={1550-4131}, url={http://dx.doi.org/10.1016/j.cmet.2008.12.012}, DOI={10.1016/j.cmet.2008.12.012}, number={2}, journal={Cell Metabolism}, publisher={Elsevier BV}, author={Shah, Yatrik M. and Matsubara, Tsutomu and Ito, Shinji and Yim, Sun-Hee and Gonzalez, Frank J.}, year={2009}, month=feb, pages={152–164} }