DOI: 10.1016/j.cmet.2007.11.014. Hfe Acts in Hepatocytes to Prevent Hemochromatosis

Hfe Acts in Hepatocytes to Prevent Hemochromatosis

10.1016/j.cmet.2007.11.014

Crossref journal-article

Elsevier BV

Cell Metabolism (78)

Bibliography

VujiÄ SpasiÄ, M., Kiss, J., Herrmann, T., Galy, B., Martinache, S., Stolte, J., GrÃ¶ne, H.-J., Stremmel, W., Hentze, M. W., & Muckenthaler, M. U. (2008). Hfe Acts in Hepatocytes to Prevent Hemochromatosis. Cell Metabolism, 7(2), 173â178.

Authors 10

Maja Vujić Spasić (first)
Judit Kiss (additional)
Thomas Herrmann (additional)
Bruno Galy (additional)
Stefanie Martinache (additional)
Jens Stolte (additional)
Hermann-Josef Gröne (additional)
Wolfgang Stremmel (additional)
Matthias W. Hentze (additional)
Martina U. Muckenthaler (additional)

References 30 Referenced 125

10.1136/gut.52.3.318 / Gut / Lessons from liver transplantation: flip, flop, and why? by Adams (2003)
10.1056/NEJM199912233412607 / N. Engl. J. Med. / Disorders of iron metabolism by Andrews (1999)
10.1038/35042073 / Nat. Rev. Genet. / Iron homeostasis: insights from genetics and animal models by Andrews (2000)
10.1038/ng1777 / Nat. Genet. / Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression by Babitt (2006)
10.1016/S0140-6736(03)12602-5 / Lancet / Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis by Bridle (2003)
10.1023/A:1008942828960 / Transgenic Res. / Conditional gene targeting in macrophages and granulocytes using LysMcre mice by Clausen (1999)
10.1002/hep.20242 / Hepatology / Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis by Crawford (2004)
10.1038/ng0896-399 / Nat. Genet. / A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis by Feder (1996)
10.1146/annurev.physiol.64.081501.155838 / Annu. Rev. Physiol. / Mechanisms of iron accumulation in hereditary hemochromatosis by Fleming (2002)
10.1073/pnas.96.6.3143 / Proc. Natl. Acad. Sci. USA / Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1 by Fleming (1999)
10.1073/pnas.051630898 / Proc. Natl. Acad. Sci. USA / Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis by Fleming (2001)
10.1074/jbc.C600197200 / J. Biol. Chem. / Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing by Goswami (2006)
10.1007/s00109-003-0508-x / J. Mol. Med. / Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin by Herrmann (2004)
10.1002/(SICI)1526-968X(200002)26:2<151::AID-GENE17>3.0.CO;2-E / Genesis / Hepatocyte-specific expression of Cre recombinase by Kellendonk (2000)
10.1016/S0014-5793(00)01920-7 / FEBS Lett. / LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity by Krause (2000)
10.1182/blood.V94.1.9.413a43_9_11 / Blood / The C282Y mutation causing hereditary hemochromatosis does not produce a null allele by Levy (1999)
{'key': '10.1016/j.cmet.2007.11.014_bib17', 'first-page': 'G39', 'article-title': 'LPS receptor CD14 participates in release of TNF-alpha in RAW 264.7 and peritoneal cells but not in kupffer cells', 'volume': '275', 'author': 'Lichtman', 'year': '1998', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / LPS receptor CD14 participates in release of TNF-alpha in RAW 264.7 and peritoneal cells but not in kupffer cells by Lichtman (1998)
10.1002/hep.20663 / Hepatology / Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo by Lou (2005)
10.1182/blood-2005-02-0629 / Blood / Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading by Makui (2005)
10.1002/hep.20620 / Hepatology / Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload by Montosi (2005)
10.1038/ng1152 / Nat. Genet. / Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis by Muckenthaler (2003)
10.1126/science.1104742 / Science / Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization by Nemeth (2004)
10.1073/pnas.151179498 / Proc. Natl. Acad. Sci. USA / Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice by Nicolas (2001)
10.1038/ng1150 / Nat. Genet. / Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis by Nicolas (2003)
10.1074/jbc.M008922200 / J. Biol. Chem. / Hepcidin, a urinary antimicrobial peptide synthesized in the liver by Park (2001)
{'key': '10.1016/j.cmet.2007.11.014_bib26', 'first-page': '9', 'article-title': 'A simple technique for measuring storage iron concentrations in formalinised liver samples', 'volume': '33', 'author': 'Torrance', 'year': '1968', 'journal-title': 'S. Afr. J. Med. Sci.'} / S. Afr. J. Med. Sci. / A simple technique for measuring storage iron concentrations in formalinised liver samples by Torrance (1968)
10.1182/blood-2004-12-4608 / Blood / Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice by Viatte (2005)
10.1182/blood-2006-07-036186 / Blood / Physiological systemic iron metabolism in mice deficient for duodenal Hfe by Vujic Spasic (2007)
10.1136/gut.52.3.433 / Gut / Heterozygous recipient and donor HFE mutations associated with a hereditary haemochromatosis phenotype after liver transplantation by Wigg (2003)
10.1073/pnas.95.5.2492 / Proc. Natl. Acad. Sci. USA / HFE gene knockout produces mouse model of hereditary hemochromatosis by Zhou (1998)

Dates

Type	When
Created	17 years, 6 months ago (Feb. 7, 2008, 7:36 a.m.)
Deposited	5 years, 4 months ago (May 1, 2020, 4:21 p.m.)
Indexed	2 months ago (July 2, 2025, 6:01 p.m.)
Issued	17 years, 7 months ago (Feb. 1, 2008)
Published	17 years, 7 months ago (Feb. 1, 2008)
Published Print	17 years, 7 months ago (Feb. 1, 2008)

Funders 0

None

BibTeX

@article{Vuji_Spasi__2008, title={Hfe Acts in Hepatocytes to Prevent Hemochromatosis}, volume={7}, ISSN={1550-4131}, url={http://dx.doi.org/10.1016/j.cmet.2007.11.014}, DOI={10.1016/j.cmet.2007.11.014}, number={2}, journal={Cell Metabolism}, publisher={Elsevier BV}, author={Vujić Spasić, Maja and Kiss, Judit and Herrmann, Thomas and Galy, Bruno and Martinache, Stefanie and Stolte, Jens and Gröne, Hermann-Josef and Stremmel, Wolfgang and Hentze, Matthias W. and Muckenthaler, Martina U.}, year={2008}, month=feb, pages={173–178} }

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      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1550413107003713"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
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    ]
  },
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  "URL": "http://dx.doi.org/10.1016/j.cmet.2007.11.014",
  "relation": {},
  "ISSN": [
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  "subject": [],
  "container-title-short": "Cell Metabolism",
  "published": {
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        2008,
        2
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    ]
  }
}