DOI: 10.1016/j.cell.2010.11.050. Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

10.1016/j.cell.2010.11.050

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Olzscha, H., Schermann, S. M., Woerner, A. C., Pinkert, S., Hecht, M. H., Tartaglia, G. G., Vendruscolo, M., Hayer-Hartl, M., Hartl, F. U., & Vabulas, R. M. (2011). Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions. Cell, 144(1), 67â78.

Authors 10

Heidi Olzscha (first)
Sonya M. Schermann (additional)
Andreas C. Woerner (additional)
Stefan Pinkert (additional)
Michael H. Hecht (additional)
Gian G. Tartaglia (additional)
Michele Vendruscolo (additional)
Manajit Hayer-Hartl (additional)
F. Ulrich Hartl (additional)
R. Martin Vabulas (additional)

References 49 Referenced 609

10.1126/science.1141448 / Science / Adapting proteostasis for disease intervention by Balch (2008)
10.1126/science.292.5521.1552 / Science / Impairment of the ubiquitin-proteasome system by protein aggregation by Bence (2001)
10.1021/cb1001203 / ACS Chem. Biol. / ANS Binding Reveals Common Features of Cytotoxic Amyloid Species by Bolognesi (2010)
10.1038/nchembio.283 / Nat. Chem. Biol. / A causative link between the structure of aberrant protein oligomers and their toxicity by Campioni (2010)
10.1146/annurev.biochem.75.101304.123901 / Annu. Rev. Biochem. / Protein misfolding, functional amyloid, and human disease by Chiti (2006)
10.1126/science.1129462 / Science / Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models by Cooper (2006)
10.1038/nbt.1511 / Nat. Biotechnol. / MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification by Cox (2008)
10.1093/bioinformatics/bti541 / Bioinformatics / IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content by Dosztanyi (2005)
10.1016/j.sbi.2008.10.002 / Curr. Opin. Struct. Biol. / Function and structure of inherently disordered proteins by Dunker (2008)
10.1093/nar/gkp1130 / Nucleic Acids Res. / Functional interplay between chromatin remodeling complexes RSC, SWI/SNF and ISWI in regulation of yeast heat shock genes by Erkina (2010)
10.1146/annurev.biochem.70.1.603 / Annu. Rev. Biochem. / Folding of newly translated proteins in vivo: The role of molecular chaperones by Frydman (2001)
10.1126/science.1124514 / Science / Progressive disruption of cellular protein folding in models of polyglutamine diseases by Gidalevitz (2006)
10.1073/pnas.0915166107 / Proc. Natl. Acad. Sci. USA / Identifying the amylome, proteins capable of forming amyloid-like fibrils by Goldschmidt (2010)
10.1126/science.1068408 / Science / Molecular chaperones in the cytosol: from nascent chain to folded protein by Hartl (2002)
10.1371/journal.pcbi.0020100 / PLoS Comput. Biol. / Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes by Haynes (2006)
10.1016/j.abb.2007.05.015 / Arch. Biochem. Biophys. / Folding versus aggregation: Polypeptide conformations on competing pathways by Jahn (2008)
10.1038/35075138 / Nature / Lethality and centrality in protein networks by Jeong (2001)
10.1126/science.1079469 / Science / Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis by Kayed (2003)
10.1093/nar/gkn892 / Nucleic Acids Res. / Human Protein Reference Database–2009 update by Keshava Prasad (2009)
10.1021/cb600135w / ACS Chem. Biol. / A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide by Kim (2006)
10.1016/0022-2836(82)90515-0 / J. Mol. Biol. / A simple method for displaying the hydropathic character of a protein by Kyte (1982)
10.1016/j.cell.2006.11.038 / Cell / ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology by Lam (2006)
10.1017/S0033583506004422 / Q. Rev. Biophys. / Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? by Lashuel (2006)
10.1016/j.bbrc.2006.03.166 / Biochem. Biophys. Res. Commun. / Cytosolic amyloid-beta peptide 42 escaping from degradation induces cell death by Lee (2006)
10.1016/j.str.2003.10.002 / Structure / Protein disorder prediction: implications for structural proteomics by Linding (2003)
10.1101/gad.1657108 / Genes Dev. / Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging by Morimoto (2008)
10.1016/j.jmb.2010.07.005 / J. Mol. Biol. / The Non-Core Regions of Human Lysozyme Amyloid Fibrils Give Rise to Cytotoxicity by Mossuto (2010)
10.1002/anie.200500845 / Angew. Chem. Int. Ed. / In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers by Nesterov (2005)
10.1038/nn0901-887 / Nat. Neurosci. / The ‘Arctic’ APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation by Nilsberth (2001)
10.1038/nprot.2006.427 / Nat. Protoc. / A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC) by Ong (2006)
10.1002/prot.22504 / Proteins / Modularity of intrinsic disorder in the human proteome by Pentony (2009)
10.1371/journal.pone.0005566 / PLoS ONE / The role of intrinsically unstructured proteins in neurodegenerative diseases by Raychaudhuri (2009)
10.1016/S0076-6879(99)09047-3 / Methods Enzymol. / Toxicity of protein aggregates in PC12 cells: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay by Shearman (1999)
10.1007/s00109-003-0464-5 / J. Mol. Med. / Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution by Stefani (2003)
10.1073/pnas.012025199 / Proc. Natl. Acad. Sci. USA / Large-scale analysis of the human and mouse transcriptomes by Su (2002)
10.1128/MCB.21.17.5826-5837.2001 / Mol. Cell. Biol. / Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF by Sullivan (2001)
10.1016/j.jmb.2008.05.013 / J. Mol. Biol. / Prediction of aggregation-prone regions in structured proteins by Tartaglia (2008)
10.1073/pnas.92.7.2944 / Proc. Natl. Acad. Sci. USA / Scrapie prions selectively modify the stress response in neuroblastoma cells by Tatzelt (1995)
10.1110/ps.0228003 / Protein Sci. / Stably folded de novo proteins from a designed combinatorial library by Wei (2003)
10.1073/pnas.96.20.11211 / Proc. Natl. Acad. Sci. USA / De novo amyloid proteins from designed combinatorial libraries by West (1999)
{'key': '10.1016/j.cell.2010.11.050_bib41', 'first-page': '2574', 'article-title': 'E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex', 'volume': '9', 'author': 'Williams', 'year': '1989', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex by Williams (1989)
10.1038/sj.emboj.7601930 / EMBO J. / The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases by Winklhofer (2008)
10.1016/S0092-8674(02)01250-3 / Cell / Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70 by Young (2003)
Bult, C.J., Eppig, J.T., Kadin, J.A., Richardson, J.E., and Blake, J.A. (2008). The Mouse Genome Database (MGD): mouse biology and model systems. Nucleic Acids Res. 36, D724–D728. (10.1093/nar/gkm961)
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., and Bauer, S. (2004). Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526–1529. (10.1126/science.1093620)
Heinz, C., Engelhardt, H., Niederweis, M., Heinz, C., Engelhardt, H., and Niederweis, M. (2003). The core of the tetrameric mycobacterial porin MspA is an extremely stable beta-sheet domain. J. Biol. Chem. 278, 8678–8685. (10.1074/jbc.M212280200)
Tartaglia, G.G., Cavalli, A., and Vendruscolo, M. (2007). Prediction of local structural stabilities of proteins from their amino acid sequences. Structure 15, 139–143. (10.1016/j.str.2006.12.007)
Wurth, C., Guimard, N.K., and Hecht, M.H. (2002). Mutations that reduce aggregation of the Alzheimer's A beta 42 peptide: an unbiased search for the sequence determinants of A beta amyloidogenesis. J. Mol. Biol. 319, 1279–1290. (10.1016/S0022-2836(02)00399-6)
Zandomeneghi, G., Krebs, M.R., McCammon, M.G., Fandrich, M. (2004). FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci. 13, 3314–3321. (10.1110/ps.041024904)

Dates

Type	When
Created	14 years, 7 months ago (Jan. 7, 2011, 4:14 a.m.)
Deposited	3 years, 9 months ago (Oct. 29, 2021, 8:54 p.m.)
Indexed	4 weeks ago (July 26, 2025, 5:04 a.m.)
Issued	14 years, 7 months ago (Jan. 1, 2011)
Published	14 years, 7 months ago (Jan. 1, 2011)
Published Print	14 years, 7 months ago (Jan. 1, 2011)

Funders 0

None

BibTeX

@article{Olzscha_2011, title={Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions}, volume={144}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2010.11.050}, DOI={10.1016/j.cell.2010.11.050}, number={1}, journal={Cell}, publisher={Elsevier BV}, author={Olzscha, Heidi and Schermann, Sonya M. and Woerner, Andreas C. and Pinkert, Stefan and Hecht, Michael H. and Tartaglia, Gian G. and Vendruscolo, Michele and Hayer-Hartl, Manajit and Hartl, F. Ulrich and Vabulas, R. Martin}, year={2011}, month=jan, pages={67–78} }

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      "article-title": "Impairment of the ubiquitin-proteasome system by protein aggregation",
      "volume": "292",
      "author": "Bence",
      "year": "2001",
      "journal-title": "Science"
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      "first-page": "735",
      "DOI": "10.1021/cb1001203",
      "article-title": "ANS Binding Reveals Common Features of Cytotoxic Amyloid Species",
      "volume": "5",
      "author": "Bolognesi",
      "year": "2010",
      "journal-title": "ACS Chem. Biol."
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      "first-page": "140",
      "DOI": "10.1038/nchembio.283",
      "article-title": "A causative link between the structure of aberrant protein oligomers and their toxicity",
      "volume": "6",
      "author": "Campioni",
      "year": "2010",
      "journal-title": "Nat. Chem. Biol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1146/annurev.biochem.75.101304.123901",
      "article-title": "Protein misfolding, functional amyloid, and human disease",
      "volume": "75",
      "author": "Chiti",
      "year": "2006",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "324",
      "DOI": "10.1126/science.1129462",
      "article-title": "Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models",
      "volume": "313",
      "author": "Cooper",
      "year": "2006",
      "journal-title": "Science"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "1367",
      "DOI": "10.1038/nbt.1511",
      "article-title": "MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification",
      "volume": "26",
      "author": "Cox",
      "year": "2008",
      "journal-title": "Nat. Biotechnol."
    },
    {
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      "doi-asserted-by": "crossref",
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      "volume": "21",
      "author": "Dosztanyi",
      "year": "2005",
      "journal-title": "Bioinformatics"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "756",
      "DOI": "10.1016/j.sbi.2008.10.002",
      "article-title": "Function and\u00a0structure of inherently disordered proteins",
      "volume": "18",
      "author": "Dunker",
      "year": "2008",
      "journal-title": "Curr. Opin. Struct. Biol."
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      "volume": "38",
      "author": "Erkina",
      "year": "2010",
      "journal-title": "Nucleic Acids Res."
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      "volume": "70",
      "author": "Frydman",
      "year": "2001",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
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      "first-page": "1471",
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      "author": "Gidalevitz",
      "year": "2006",
      "journal-title": "Science"
    },
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      "doi-asserted-by": "crossref",
      "first-page": "3487",
      "DOI": "10.1073/pnas.0915166107",
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      "volume": "107",
      "author": "Goldschmidt",
      "year": "2010",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib14",
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      "first-page": "1852",
      "DOI": "10.1126/science.1068408",
      "article-title": "Molecular chaperones in the cytosol: from nascent chain to folded protein",
      "volume": "295",
      "author": "Hartl",
      "year": "2002",
      "journal-title": "Science"
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      "volume": "2",
      "author": "Haynes",
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      "first-page": "100",
      "DOI": "10.1016/j.abb.2007.05.015",
      "article-title": "Folding versus aggregation: Polypeptide conformations on competing pathways",
      "volume": "469",
      "author": "Jahn",
      "year": "2008",
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      "author": "Jeong",
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      "author": "Kayed",
      "year": "2003",
      "journal-title": "Science"
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      "first-page": "D767",
      "DOI": "10.1093/nar/gkn892",
      "article-title": "Human Protein Reference Database\u20132009 update",
      "volume": "37",
      "author": "Keshava Prasad",
      "year": "2009",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "461",
      "DOI": "10.1021/cb600135w",
      "article-title": "A\u00a0high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide",
      "volume": "1",
      "author": "Kim",
      "year": "2006",
      "journal-title": "ACS Chem. Biol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1016/0022-2836(82)90515-0",
      "article-title": "A simple method for displaying the hydropathic character of a protein",
      "volume": "157",
      "author": "Kyte",
      "year": "1982",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1335",
      "DOI": "10.1016/j.cell.2006.11.038",
      "article-title": "ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology",
      "volume": "127",
      "author": "Lam",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1017/S0033583506004422",
      "article-title": "Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?",
      "volume": "39",
      "author": "Lashuel",
      "year": "2006",
      "journal-title": "Q. Rev. Biophys."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "471",
      "DOI": "10.1016/j.bbrc.2006.03.166",
      "article-title": "Cytosolic amyloid-beta peptide 42 escaping from degradation induces cell death",
      "volume": "344",
      "author": "Lee",
      "year": "2006",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "1453",
      "DOI": "10.1016/j.str.2003.10.002",
      "article-title": "Protein disorder prediction: implications for structural proteomics",
      "volume": "11",
      "author": "Linding",
      "year": "2003",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib26",
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      "first-page": "1427",
      "DOI": "10.1101/gad.1657108",
      "article-title": "Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging",
      "volume": "22",
      "author": "Morimoto",
      "year": "2008",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "783",
      "DOI": "10.1016/j.jmb.2010.07.005",
      "article-title": "The Non-Core Regions of Human Lysozyme Amyloid Fibrils Give Rise to Cytotoxicity",
      "volume": "402",
      "author": "Mossuto",
      "year": "2010",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "5452",
      "DOI": "10.1002/anie.200500845",
      "article-title": "In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers",
      "volume": "44",
      "author": "Nesterov",
      "year": "2005",
      "journal-title": "Angew. Chem. Int. Ed."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "887",
      "DOI": "10.1038/nn0901-887",
      "article-title": "The \u2018Arctic\u2019 APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation",
      "volume": "4",
      "author": "Nilsberth",
      "year": "2001",
      "journal-title": "Nat. Neurosci."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "2650",
      "DOI": "10.1038/nprot.2006.427",
      "article-title": "A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)",
      "volume": "1",
      "author": "Ong",
      "year": "2006",
      "journal-title": "Nat. Protoc."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "212",
      "DOI": "10.1002/prot.22504",
      "article-title": "Modularity of intrinsic disorder in the human proteome",
      "volume": "78",
      "author": "Pentony",
      "year": "2009",
      "journal-title": "Proteins"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "e5566",
      "DOI": "10.1371/journal.pone.0005566",
      "article-title": "The role of intrinsically unstructured proteins in neurodegenerative diseases",
      "volume": "4",
      "author": "Raychaudhuri",
      "year": "2009",
      "journal-title": "PLoS ONE"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "716",
      "DOI": "10.1016/S0076-6879(99)09047-3",
      "article-title": "Toxicity of protein aggregates in PC12 cells: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay",
      "volume": "309",
      "author": "Shearman",
      "year": "1999",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "678",
      "DOI": "10.1007/s00109-003-0464-5",
      "article-title": "Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution",
      "volume": "81",
      "author": "Stefani",
      "year": "2003",
      "journal-title": "J. Mol. Med."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "4465",
      "DOI": "10.1073/pnas.012025199",
      "article-title": "Large-scale analysis of the human and mouse transcriptomes",
      "volume": "99",
      "author": "Su",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "5826",
      "DOI": "10.1128/MCB.21.17.5826-5837.2001",
      "article-title": "Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF",
      "volume": "21",
      "author": "Sullivan",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "425",
      "DOI": "10.1016/j.jmb.2008.05.013",
      "article-title": "Prediction of aggregation-prone regions in structured proteins",
      "volume": "380",
      "author": "Tartaglia",
      "year": "2008",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "2944",
      "DOI": "10.1073/pnas.92.7.2944",
      "article-title": "Scrapie prions selectively modify the stress response in neuroblastoma cells",
      "volume": "92",
      "author": "Tatzelt",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "92",
      "DOI": "10.1110/ps.0228003",
      "article-title": "Stably folded de novo proteins from a designed combinatorial library",
      "volume": "12",
      "author": "Wei",
      "year": "2003",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "11211",
      "DOI": "10.1073/pnas.96.20.11211",
      "article-title": "De novo amyloid proteins from designed combinatorial libraries",
      "volume": "96",
      "author": "West",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib41",
      "first-page": "2574",
      "article-title": "E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex",
      "volume": "9",
      "author": "Williams",
      "year": "1989",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "336",
      "DOI": "10.1038/sj.emboj.7601930",
      "article-title": "The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases",
      "volume": "27",
      "author": "Winklhofer",
      "year": "2008",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1016/S0092-8674(02)01250-3",
      "article-title": "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70",
      "volume": "112",
      "author": "Young",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib44",
      "doi-asserted-by": "crossref",
      "unstructured": "Bult, C.J., Eppig, J.T., Kadin, J.A., Richardson, J.E., and Blake, J.A. (2008). The Mouse Genome Database (MGD): mouse biology and model systems. Nucleic Acids Res. 36, D724\u2013D728.",
      "DOI": "10.1093/nar/gkm961"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib45",
      "doi-asserted-by": "crossref",
      "unstructured": "Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., and Bauer, S. (2004). Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526\u20131529.",
      "DOI": "10.1126/science.1093620"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib46",
      "doi-asserted-by": "crossref",
      "unstructured": "Heinz, C., Engelhardt, H., Niederweis, M., Heinz, C., Engelhardt, H., and Niederweis, M. (2003). The core of the tetrameric mycobacterial porin MspA is an extremely stable beta-sheet domain. J. Biol. Chem. 278, 8678\u20138685.",
      "DOI": "10.1074/jbc.M212280200"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib47",
      "doi-asserted-by": "crossref",
      "unstructured": "Tartaglia, G.G., Cavalli, A., and Vendruscolo, M. (2007). Prediction of local structural stabilities of proteins from their amino acid sequences. Structure 15, 139\u2013143.",
      "DOI": "10.1016/j.str.2006.12.007"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib48",
      "doi-asserted-by": "crossref",
      "unstructured": "Wurth, C., Guimard, N.K., and Hecht, M.H. (2002). Mutations that reduce aggregation of the Alzheimer's A beta 42 peptide: an unbiased search for the sequence determinants of A beta amyloidogenesis. J. Mol. Biol. 319, 1279\u20131290.",
      "DOI": "10.1016/S0022-2836(02)00399-6"
    },
    {
      "key": "10.1016/j.cell.2010.11.050_bib49",
      "doi-asserted-by": "crossref",
      "unstructured": "Zandomeneghi, G., Krebs, M.R., McCammon, M.G., Fandrich, M. (2004). FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci. 13, 3314\u20133321.",
      "DOI": "10.1110/ps.041024904"
    }
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