DOI: 10.1016/j.cell.2009.03.007. Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

10.1016/j.cell.2009.03.007

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S., & Dikic, I. (2009). Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-ÎºB Activation. Cell, 136(6), 1098â1109.

Authors 13

Simin Rahighi (first)
Fumiyo Ikeda (additional)
Masato Kawasaki (additional)
Masato Akutsu (additional)
Nobuhiro Suzuki (additional)
Ryuichi Kato (additional)
Tobias Kensche (additional)
Tamami Uejima (additional)
Stuart Bloor (additional)
David Komander (additional)
Felix Randow (additional)
Soichi Wakatsuki (additional)
Ivan Dikic (additional)

References 35 Referenced 658

10.1016/j.molcel.2008.04.029 / Mol. Cell / Crystal structure of a vFlip-IKKγ complex: insights into viral activation of the IKK signalosome by Bagnéris (2008)
10.1126/science.1120615 / Science / Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis by Bienko (2005)
10.1042/BJ20081885 / Biochem. J. / Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1) by Blankenship (2009)
10.1073/pnas.0706552105 / Proc. Natl. Acad. Sci. USA / Signal processing by its coil zipper domain activates IKKγ by Bloor (2008)
10.1038/sj.emboj.7601210 / EMBO J. / HDAC6-p97/VCP controlled polyubiquitin chain turnover by Boyault (2006)
10.1016/j.cell.2006.01.021 / Cell / The E3 ubiquitin ligase itch couples JNK activation to TNF-α induced cell death by inducing c-FLIPL turnover by Chang (2006)
10.1016/j.jmb.2008.01.048 / J. Mol. Biol. / Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation by Cordier (2008)
10.1016/S0092-8674(00)00126-4 / Cell / Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain by Deng (2000)
10.1038/85837 / Nat. Genet. / X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-кB signaling by Döffinger (2001)
10.1016/j.molcel.2006.03.026 / Mol. Cell / Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO by Ea (2006)
10.1084/jem.20060085 / J. Exp. Med. / X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production by Filipe-Santos (2006)
10.1038/ncb1789 / Nat. Cell Biol. / IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis by Gyrd-Hansen (2008)
10.1126/stke.3572006re13 / Sci. STKE / Regulation and function of IKK and IKK-related kinases by Häcker (2006)
10.1016/j.cell.2008.01.020 / Cell / Shared principles in NF-kappaB signaling by Hayden (2008)
10.1042/BJ20061138 / Biochem. J. / Ubiquitin-binding domains by Hurley (2006)
10.1038/embor.2008.93 / EMBO Rep. / Atypical ubiquitin chains: new molecular signals by Ikeda (2008)
10.1016/j.molcel.2004.08.008 / Mol. Cell / TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains by Kanayama (2004)
10.1038/sj.emboj.7601360 / EMBO J. / A ubiquitin ligase complex assembles linear polyubiquitin chains by Kirisako (2006)
10.1016/j.molcel.2007.12.018 / Mol. Cell / The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module by Komander (2008)
10.1016/j.molcel.2009.01.012 / Mol. Cell / Structural basis for recognition of diubiquitins by NEMO by Lo (2009)
10.1126/science.1157340 / Science / Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex by Matsuzawa (2008)
10.1016/j.cell.2008.07.039 / Cell / Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies by Newton (2008)
10.1038/nature07575 / Nature / ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development by Oshima (2009)
10.1042/BJ20071365 / Biochem. J. / The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 by Ordureau (2008)
10.1016/j.coi.2003.11.013 / Curr. Opin. Immunol. / Inherited disorders of NF-кB-mediated immunity in man by Puel (2004)
10.1016/j.str.2008.02.012 / Structure / Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site by Rushe (2008)
10.1016/S1097-2765(00)80263-4 / Mol. Cell / NEMO/IKKγ-deficient mice model incontinentia pigmenti by Schmidt-Supprian (2000)
10.1101/gad.1360605 / Genes Dev. / TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo by Shim (2005)
10.1038/ncb1821 / Nat. Cell Biol. / Involvement of linear polyubiquitylation of NEMO in NF-κB activation by Tokunaga (2009)
10.1074/jbc.C800128200 / J. Biol. Chem. / c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation by Varfolomeev (2008)
10.1038/sj.onc.1211042 / Oncogene / Ubiquitin binding mediates the NF-кB inhibitory potential of ABIN proteins by Wagner (2008)
10.1038/35085597 / Nature / TAK1 is a ubiquitin-dependent kinase of MKK and IKK by Wang (2001)
10.1038/ncb1384 / Nat. Cell Biol. / Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation by Wu (2006)
10.1038/ni1367 / Nat. Immunol. / Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling by Yamamoto (2006)
10.1016/j.cub.2007.07.041 / Curr. Biol. / Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP by Zhu (2007)

Dates

Type	When
Created	16 years, 5 months ago (March 20, 2009, 4:43 a.m.)
Deposited	2 years, 6 months ago (Jan. 28, 2023, 6:44 a.m.)
Indexed	4 days, 7 hours ago (Aug. 19, 2025, 6:11 a.m.)
Issued	16 years, 5 months ago (March 1, 2009)
Published	16 years, 5 months ago (March 1, 2009)
Published Print	16 years, 5 months ago (March 1, 2009)

Funders 3

Ministry of Education, Culture, Sports, Science and Technology 10.13039/501100001700
Region: Asia
gov (National government)
Labels3
1. Monbu-kagaku-shō
2. 文部科学省
3. MEXT
Goethe-Universität Frankfurt am Main 10.13039/501100005687
Region: Europe
gov (Local government)
Labels3
1. Goethe University Frankfurt am Main
2. Goethe-Universität
3. Goethe-Universität Frankfurt
Awards1
1. EXC115
Deutsche Forschungsgemeinschaft 10.13039/501100001659
Region: Europe
gov (National government)
Labels3
1. German Research Association
2. German Research Foundation
3. DFG

BibTeX

@article{Rahighi_2009, title={Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation}, volume={136}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2009.03.007}, DOI={10.1016/j.cell.2009.03.007}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Rahighi, Simin and Ikeda, Fumiyo and Kawasaki, Masato and Akutsu, Masato and Suzuki, Nobuhiro and Kato, Ryuichi and Kensche, Tobias and Uejima, Tamami and Bloor, Stuart and Komander, David and Randow, Felix and Wakatsuki, Soichi and Dikic, Ivan}, year={2009}, month=mar, pages={1098–1109} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        19
      ]
    ],
    "date-time": "2025-08-19T10:11:24Z",
    "timestamp": 1755598284575,
    "version": "3.37.3"
  },
  "reference-count": 35,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2009,
            3,
            1
          ]
        ],
        "date-time": "2009-03-01T00:00:00Z",
        "timestamp": 1235865600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            8,
            22
          ]
        ],
        "date-time": "2013-08-22T00:00:00Z",
        "timestamp": 1377129600000
      },
      "content-version": "vor",
      "delay-in-days": 1635,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2009,
            3,
            1
          ]
        ],
        "date-time": "2009-03-01T00:00:00Z",
        "timestamp": 1235865600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2009,
            3,
            1
          ]
        ],
        "date-time": "2009-03-01T00:00:00Z",
        "timestamp": 1235865600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2009,
            3,
            1
          ]
        ],
        "date-time": "2009-03-01T00:00:00Z",
        "timestamp": 1235865600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2009,
            3,
            1
          ]
        ],
        "date-time": "2009-03-01T00:00:00Z",
        "timestamp": 1235865600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2009,
            3,
            1
          ]
        ],
        "date-time": "2009-03-01T00:00:00Z",
        "timestamp": 1235865600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "funder": [
    {
      "DOI": "10.13039/501100001700",
      "name": "Ministry of Education, Culture, Sports, Science and Technology",
      "doi-asserted-by": "publisher",
      "id": [
        {
          "id": "10.13039/501100001700",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    },
    {
      "DOI": "10.13039/501100005687",
      "name": "Goethe-Universit\u00e4t Frankfurt am Main",
      "doi-asserted-by": "publisher",
      "award": [
        "EXC115"
      ],
      "id": [
        {
          "id": "10.13039/501100005687",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    },
    {
      "DOI": "10.13039/501100001659",
      "name": "Deutsche Forschungsgemeinschaft",
      "doi-asserted-by": "publisher",
      "id": [
        {
          "id": "10.13039/501100001659",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2009,
        3
      ]
    ]
  },
  "DOI": "10.1016/j.cell.2009.03.007",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2009,
        3,
        20
      ]
    ],
    "date-time": "2009-03-20T08:43:55Z",
    "timestamp": 1237538635000
  },
  "page": "1098-1109",
  "update-policy": "https://doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 658,
  "title": "Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-\u03baB Activation",
  "prefix": "10.1016",
  "volume": "136",
  "author": [
    {
      "given": "Simin",
      "family": "Rahighi",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Fumiyo",
      "family": "Ikeda",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Masato",
      "family": "Kawasaki",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Masato",
      "family": "Akutsu",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Nobuhiro",
      "family": "Suzuki",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ryuichi",
      "family": "Kato",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Tobias",
      "family": "Kensche",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Tamami",
      "family": "Uejima",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stuart",
      "family": "Bloor",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David",
      "family": "Komander",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Felix",
      "family": "Randow",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Soichi",
      "family": "Wakatsuki",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ivan",
      "family": "Dikic",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.cell.2009.03.007_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "620",
      "DOI": "10.1016/j.molcel.2008.04.029",
      "article-title": "Crystal structure of a vFlip-IKK\u03b3 complex: insights into viral activation of the IKK signalosome",
      "volume": "30",
      "author": "Bagn\u00e9ris",
      "year": "2008",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "1821",
      "DOI": "10.1126/science.1120615",
      "article-title": "Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis",
      "volume": "310",
      "author": "Bienko",
      "year": "2005",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "149",
      "DOI": "10.1042/BJ20081885",
      "article-title": "Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)",
      "volume": "417",
      "author": "Blankenship",
      "year": "2009",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "1279",
      "DOI": "10.1073/pnas.0706552105",
      "article-title": "Signal processing by its coil zipper domain activates IKK\u03b3",
      "volume": "105",
      "author": "Bloor",
      "year": "2008",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "3357",
      "DOI": "10.1038/sj.emboj.7601210",
      "article-title": "HDAC6-p97/VCP controlled polyubiquitin chain turnover",
      "volume": "25",
      "author": "Boyault",
      "year": "2006",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "601",
      "DOI": "10.1016/j.cell.2006.01.021",
      "article-title": "The E3 ubiquitin ligase itch couples JNK activation to TNF-\u03b1 induced cell death by inducing c-FLIPL turnover",
      "volume": "124",
      "author": "Chang",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1419",
      "DOI": "10.1016/j.jmb.2008.01.048",
      "article-title": "Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation",
      "volume": "377",
      "author": "Cordier",
      "year": "2008",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1016/S0092-8674(00)00126-4",
      "article-title": "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain",
      "volume": "103",
      "author": "Deng",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1038/85837",
      "article-title": "X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-\u043aB signaling",
      "volume": "27",
      "author": "D\u00f6ffinger",
      "year": "2001",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "245",
      "DOI": "10.1016/j.molcel.2006.03.026",
      "article-title": "Activation of IKK by TNF\u03b1 requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO",
      "volume": "22",
      "author": "Ea",
      "year": "2006",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "1745",
      "DOI": "10.1084/jem.20060085",
      "article-title": "X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production",
      "volume": "203",
      "author": "Filipe-Santos",
      "year": "2006",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "1309",
      "DOI": "10.1038/ncb1789",
      "article-title": "IAPs\u00a0contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis",
      "volume": "10",
      "author": "Gyrd-Hansen",
      "year": "2008",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "re13",
      "DOI": "10.1126/stke.3572006re13",
      "article-title": "Regulation and function of IKK and IKK-related kinases",
      "volume": "2006",
      "author": "H\u00e4cker",
      "year": "2006",
      "journal-title": "Sci. STKE"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "344",
      "DOI": "10.1016/j.cell.2008.01.020",
      "article-title": "Shared principles in NF-kappaB signaling",
      "volume": "132",
      "author": "Hayden",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "361",
      "DOI": "10.1042/BJ20061138",
      "article-title": "Ubiquitin-binding domains",
      "volume": "399",
      "author": "Hurley",
      "year": "2006",
      "journal-title": "Biochem.\u00a0J."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "536",
      "DOI": "10.1038/embor.2008.93",
      "article-title": "Atypical ubiquitin chains: new molecular signals",
      "volume": "9",
      "author": "Ikeda",
      "year": "2008",
      "journal-title": "EMBO Rep."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "535",
      "DOI": "10.1016/j.molcel.2004.08.008",
      "article-title": "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains",
      "volume": "15",
      "author": "Kanayama",
      "year": "2004",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "4877",
      "DOI": "10.1038/sj.emboj.7601360",
      "article-title": "A ubiquitin ligase complex assembles linear polyubiquitin chains",
      "volume": "25",
      "author": "Kirisako",
      "year": "2006",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1016/j.molcel.2007.12.018",
      "article-title": "The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module",
      "volume": "29",
      "author": "Komander",
      "year": "2008",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib20",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/j.molcel.2009.01.012",
      "article-title": "Structural basis for recognition of diubiquitins by NEMO",
      "author": "Lo",
      "year": "2009",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "663",
      "DOI": "10.1126/science.1157340",
      "article-title": "Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex",
      "volume": "321",
      "author": "Matsuzawa",
      "year": "2008",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "668",
      "DOI": "10.1016/j.cell.2008.07.039",
      "article-title": "Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies",
      "volume": "134",
      "author": "Newton",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "906",
      "DOI": "10.1038/nature07575",
      "article-title": "ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development",
      "volume": "457",
      "author": "Oshima",
      "year": "2009",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1042/BJ20071365",
      "article-title": "The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1",
      "volume": "409",
      "author": "Ordureau",
      "year": "2008",
      "journal-title": "Biochem.\u00a0J."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "34",
      "DOI": "10.1016/j.coi.2003.11.013",
      "article-title": "Inherited disorders of NF-\u043aB-mediated immunity in man",
      "volume": "16",
      "author": "Puel",
      "year": "2004",
      "journal-title": "Curr. Opin. Immunol."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "798",
      "DOI": "10.1016/j.str.2008.02.012",
      "article-title": "Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site",
      "volume": "16",
      "author": "Rushe",
      "year": "2008",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "981",
      "DOI": "10.1016/S1097-2765(00)80263-4",
      "article-title": "NEMO/IKK\u03b3-deficient mice model incontinentia pigmenti",
      "volume": "5",
      "author": "Schmidt-Supprian",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "2668",
      "DOI": "10.1101/gad.1360605",
      "article-title": "TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in\u00a0vivo",
      "volume": "19",
      "author": "Shim",
      "year": "2005",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1038/ncb1821",
      "article-title": "Involvement of linear polyubiquitylation of NEMO in NF-\u03baB activation",
      "volume": "11",
      "author": "Tokunaga",
      "year": "2009",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "24295",
      "DOI": "10.1074/jbc.C800128200",
      "article-title": "c-IAP1 and c-IAP2 are\u00a0critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation",
      "volume": "283",
      "author": "Varfolomeev",
      "year": "2008",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "3739",
      "DOI": "10.1038/sj.onc.1211042",
      "article-title": "Ubiquitin binding mediates the NF-\u043aB inhibitory potential of ABIN proteins",
      "volume": "27",
      "author": "Wagner",
      "year": "2008",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "346",
      "DOI": "10.1038/35085597",
      "article-title": "TAK1 is a ubiquitin-dependent kinase of MKK and IKK",
      "volume": "412",
      "author": "Wang",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "398",
      "DOI": "10.1038/ncb1384",
      "article-title": "Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-\u03baB activation",
      "volume": "8",
      "author": "Wu",
      "year": "2006",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "962",
      "DOI": "10.1038/ni1367",
      "article-title": "Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling",
      "volume": "7",
      "author": "Yamamoto",
      "year": "2006",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.cell.2009.03.007_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "1438",
      "DOI": "10.1016/j.cub.2007.07.041",
      "article-title": "Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP",
      "volume": "17",
      "author": "Zhu",
      "year": "2007",
      "journal-title": "Curr. Biol."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867409002645?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867409002645?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        1,
        28
      ]
    ],
    "date-time": "2023-01-28T11:44:29Z",
    "timestamp": 1674906269000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867409002645"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2009,
        3
      ]
    ]
  },
  "references-count": 35,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2009,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867409002645"
  ],
  "URL": "http://dx.doi.org/10.1016/j.cell.2009.03.007",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2009,
        3
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-\u03baB Activation",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Cell",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/j.cell.2009.03.007",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2009 Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}