DOI: 10.1016/j.cell.2009.01.042. Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

10.1016/j.cell.2009.01.042

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Sonenberg, N., & Hinnebusch, A. G. (2009). Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets. Cell, 136(4), 731â745.

Authors 2

Nahum Sonenberg (first)
Alan G. Hinnebusch (additional)

References 143 Referenced 2,791

10.1074/jbc.M600210200 / J. Biol. Chem. / Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining by Acker (2006)
10.1016/j.molcel.2005.09.008 / Mol. Cell / Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation by Algire (2005)
10.1038/nature06974 / Nature / Translation factors promote the formation of two states of the closed-loop mRNP by Amrani (2008)
10.1016/j.tibs.2007.12.003 / Trends Biochem. Sci. / Stress granules: the Tao of RNA triage by Anderson (2008)
10.1016/j.molcel.2006.05.030 / Mol. Cell / How initiation factors maximize the accuracy of tRNA selection in initiation of bacterial protein synthesis by Antoun (2006)
10.1371/journal.ppat.1000334 / PLoS Pathog. / Activation of host translational control pathways by a viral developmental switch by Arias (2009)
10.1158/0008-5472.CAN-07-0881 / Cancer Res. / 4E-binding protein 1: a key molecular “funnel factor” in human cancer with clinical implications by Armengol (2007)
10.1038/nature07242 / Nature / The impact of microRNAs on protein output by Baek (2008)
10.1523/JNEUROSCI.2423-05.2005 / J. Neurosci. / The translation repressor 4E–BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus by Banko (2005)
10.1016/S0092-8674(02)00657-8 / Cell / Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture by Barco (2002)
10.1038/nature07449 / Nature / Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency by Barna (2008)
10.1016/j.cell.2005.06.011 / Cell / A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila by Beckmann (2005)
10.1242/dev.126.4.659 / Development / Role for mRNA localization in translational activation but not spatial restriction of nanos RNA by Bergsten (1999)
10.1016/j.chembiol.2006.10.005 / Chem. Biol. / RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation by Bordeleau (2006)
10.1016/j.molcel.2007.10.019 / Mol. Cell / A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer by Braunstein (2007)
10.1038/nrmicro1855 / Nat. Rev. Microbiol. / The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway by Buchkovich (2008)
10.1016/S1097-2765(00)80414-1 / Mol. Cell / VASA mediates translation through interaction with a Drosophila yIF2 homolog by Carrera (2000)
10.1016/j.cell.2006.01.031 / Cell / Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles by Chekulaeva (2006)
10.1101/gad.1528307 / Genes Dev. / Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo by Cheung (2007)
10.1016/j.devcel.2007.10.002 / Dev. Cell / Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression by Chicoine (2007)
10.1016/j.cell.2005.02.024 / Cell / A new paradigm for translational control: inhibition via 5′-3′ mRNA tethering by Bicoid and the eIF4E cognate 4EHP by Cho (2005)
10.1016/j.cub.2006.08.093 / Curr. Biol. / Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos by Cho (2006)
10.1016/j.ydbio.2007.11.008 / Dev. Biol. / Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila by Clouse (2008)
10.1038/nature03897 / Nature / Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2 by Costa-Mattioli (2005)
10.1016/j.cell.2007.01.050 / Cell / eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory by Costa-Mattioli (2007)
10.1016/j.neuron.2008.10.055 / Neuron / Translational control of long-lasting synaptic plasticity and memory by Costa-Mattioli (2009)
10.1038/nsmb1351 / Nat. Struct. Mol. Biol. / tRNA-mRNA mimicry drives translation initiation from a viral IRES by Costantino (2008)
10.1371/journal.pgen.0030056 / PLoS Genet. / Lifespan regulation by evolutionarily conserved genes essential for viability by Curran (2007)
10.1016/j.cell.2005.06.044 / Cell / Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR by Dar (2005)
10.1101/gad.1184404 / Genes Dev. / Specificity of microRNA target selection in translational repression by Doench (2004)
10.1101/gad.1696608 / Genes Dev. / Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection by Dong (2008)
10.1126/science.1130276 / Science / S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth by Dorrello (2006)
{'key': '10.1016/j.cell.2009.01.042_bib32', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '129', 'article-title': 'Translation initiation by viral internal ribosome entry sites', 'author': 'Doudna', 'year': '2007'} / Translational Control in Biology and Medicine / Translation initiation by viral internal ribosome entry sites by Doudna (2007)
10.1038/nsmb1031 / Nat. Struct. Mol. Biol. / An mRNA-rRNA base-pairing mechanism for translation initiation in eukaryotes by Dresios (2006)
{'key': '10.1016/j.cell.2009.01.042_bib34', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '155', 'article-title': 'Translation initiation via celluar internal ribosome entry sites', 'author': 'Elroy-Stein', 'year': '2007'} / Translational Control in Biology and Medicine / Translation initiation via celluar internal ribosome entry sites by Elroy-Stein (2007)
10.1038/nsmb.1405 / Nat. Struct. Mol. Biol. / GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay by Eulalio (2008)
10.1038/sj.emboj.7601613 / EMBO J. / N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection by Fekete (2007)
10.1038/nrg2290 / Nat. Rev. Genet. / Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? by Filipowicz (2008)
{'key': '10.1016/j.cell.2009.01.042_bib38', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '804', 'article-title': 'Noncanonical functions of aminoacyl-tRNA synthetases in translational control', 'author': 'Fox', 'year': '2007'} / Translational Control in Biology and Medicine / Noncanonical functions of aminoacyl-tRNA synthetases in translational control by Fox (2007)
10.1016/j.molcel.2007.05.019 / Mol. Cell / eIF3j is located in the decoding center of the human 40S ribosomal subunit by Fraser (2007)
10.1128/MCB.02254-06 / Mol. Cell. Biol. / Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining by Fringer (2007)
10.1016/j.molcel.2005.09.019 / Mol. Cell / Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay by Gaba (2005)
10.1038/nature07267 / Nature / Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation by Gandin (2008)
10.1371/journal.pbio.0020079 / PLoS Biol. / Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast by Gerber (2004)
10.1126/science.1144467 / Science / Cap-independent translation is required for starvation-induced differentiation in yeast by Gilbert (2007)
10.1093/emboj/cdf515 / EMBO J. / Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation by Gomez (2002)
10.1172/JCI32044 / J. Clin. Invest. / Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity by Graff (2007)
10.1016/S0092-8674(03)00975-9 / Cell / Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E by Gross (2003)
10.1126/science.1064023 / Science / Argonaute2, a link between genetic and biochemical analyses of RNAi by Hammond (2001)
10.1111/j.1474-9726.2006.00267.x / Aging Cell / Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans by Hansen (2007)
10.1093/gerona/61.5.444 / J. Gerontol. A Biol. Sci. Med. Sci. / daf-16 protects the nematode Caenorhabditis elegans during food deprivation by Henderson (2006)
{'key': '10.1016/j.cell.2009.01.042_bib51', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '269', 'article-title': 'cis-regulatory sequences and trans-acting factors in translational control', 'author': 'Hentze', 'year': '2007'} / Translational Control in Biology and Medicine / cis-regulatory sequences and trans-acting factors in translational control by Hentze (2007)
{'key': '10.1016/j.cell.2009.01.042_bib52', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '225', 'article-title': 'Mechanism of translation initiation in the yeast Saccharomyces cerevisiae', 'author': 'Hinnebusch', 'year': '2007'} / Translational Control in Biology and Medicine / Mechanism of translation initiation in the yeast Saccharomyces cerevisiae by Hinnebusch (2007)
10.1016/j.cell.2005.10.024 / Cell / mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events by Holz (2005)
10.1038/nature04115 / Nature / Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1 by Huttelmaier (2005)
10.1126/science.1073827 / Science / A microRNA in a multiple-turnover RNAi enzyme complex by Hutvagner (2002)
10.1073/pnas.2535183100 / Proc. Natl. Acad. Sci. USA / Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis by Jan (2003)
10.1128/MCB.22.24.8562-8570.2002 / Mol. Cell. Biol. / Inhibition of translation termination mediated by an interaction of eukaryotic release factor 1 with a nascent peptidyl-tRNA by Janzen (2002)
10.1242/dev.01286 / Development / Interaction with eIF5B is essential for Vasa function during development by Johnstone (2004)
10.1242/dev.002212 / Development / Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline by Kadyrova (2007)
10.1101/gad.1262905 / Genes Dev. / Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms by Kahvejian (2005)
10.1016/j.molcel.2006.11.028 / Mol. Cell / L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control by Kapasi (2007)
10.1016/j.chom.2007.08.005 / Cell Host Microbe / Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions by Katsafanas (2007)
10.1038/nrg2111 / Nat. Rev. Genet. / RNA regulons: coordination of post-transcriptional events by Keene (2007)
10.1016/S0092-8674(04)00115-1 / Cell / Translational control by MAPK signaling in long-term synaptic plasticity and memory by Kelleher (2004)
10.1016/j.tibs.2008.04.007 / Trends Biochem. Sci. / Viral IRES RNA structures and ribosome interactions by Kieft (2008)
10.1016/j.molcel.2006.08.016 / Mol. Cell / Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation by Kim (2006)
10.1105/tpc.104.026880 / Plant Cell / Translational regulation via 5′ mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h by Kim (2004)
10.1016/j.cell.2007.05.016 / Cell / An mRNA m7G cap binding-like motif within human Ago2 represses translation by Kiriakidou (2007)
{'key': '10.1016/j.cell.2009.01.042_bib69', 'series-title': 'Translational Control in Bioloy and Medicine', 'first-page': '485', 'article-title': 'Translational control of synaotic plasticity and learning and memory', 'author': 'Klann', 'year': '2007'} / Translational Control in Bioloy and Medicine / Translational control of synaotic plasticity and learning and memory by Klann (2007)
10.1158/0008-5472.CAN-07-0752 / Cancer Res. / Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors by Larsson (2007)
10.1172/JCI29528 / J. Clin. Invest. / Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E–BP1 and 4E–BP2 by Le Bacquer (2007)
10.1073/pnas.0608845103 / Proc. Natl. Acad. Sci. USA / Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules by Leung (2006)
10.1038/sj.emboj.7601549 / EMBO J. / HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly by Locker (2007)
10.1038/sj.emboj.7600904 / EMBO J. / The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH by Lomakin (2006)
10.1016/j.molcel.2004.11.051 / Mol. Cell / A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon by Maag (2005)
10.1371/journal.pone.0000242 / PLoS ONE / Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation by Mamane (2007)
10.1016/S1097-2765(01)80003-4 / Mol. Cell / Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G by Marcotrigiano (1999)
10.1016/j.cell.2009.01.014 / Cell / Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation by Marintchev (2009)
10.1016/S0092-8674(02)00908-X / Cell / Single-stranded antisense siRNAs guide target RNA cleavage in RNAi by Martinez (2002)
10.1126/science.1146067 / Science / MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F by Mathonnet (2007)
10.1016/j.molcel.2008.04.014 / Mol. Cell / Kinetic checkpoint at a late step in translation initiation by Milon (2008)
10.1074/jbc.M704629200 / J. Biol. Chem. / CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes by Minshall (2007)
10.1101/gad.339105 / Genes Dev. / Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry by Mitchell (2005)
10.1016/j.cell.2006.11.046 / Cell / Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G by Moerke (2007)
{'key': '10.1016/j.cell.2009.01.042_bib85', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '545', 'article-title': 'Protein synthesis and translational control during viral infection', 'author': 'Mohr', 'year': '2007'} / Translational Control in Biology and Medicine / Protein synthesis and translational control during viral infection by Mohr (2007)
10.1016/j.molcel.2008.09.019 / Mol. Cell / DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression by Mukhopadhyay (2008)
10.1016/S1534-5807(03)00400-3 / Dev. Cell / Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis by Nakamura (2004)
10.1016/j.cell.2008.07.031 / Cell / The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP by Napoli (2008)
10.1038/sj.emboj.7600026 / EMBO J. / Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression by Nelson (2004)
10.1016/0531-5565(96)00011-3 / Exp. Gerontol. / Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in vitro by Norsgaard (1996)
10.1016/S0092-8674(01)00212-4 / Cell / Lipoxygenase mRNA silencing in erythroid differentiation: The 3′UTR regulatory complex controls 60S ribosomal subunit joining by Ostareck (2001)
10.1111/j.1474-9726.2006.00266.x / Aging Cell / Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans by Pan (2007)
10.1016/S0092-8674(01)00487-1 / Cell / A plant viral “reinitiation” factor interacts with the host translational machinery by Park (2001)
10.1016/j.molcel.2007.02.011 / Mol. Cell / P bodies and the control of mRNA translation and degradation by Parker (2007)
10.1016/j.molcel.2007.03.018 / Mol. Cell / The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome by Passmore (2007)
{'key': '10.1016/j.cell.2009.01.042_bib96', 'series-title': 'Translation Control in Biology and Medicine', 'first-page': '830', 'article-title': 'Therapeutic opportunities in translation', 'author': 'Pelletier', 'year': '2007'} / Translation Control in Biology and Medicine / Therapeutic opportunities in translation by Pelletier (2007)
10.1101/gad.1020902 / Genes Dev. / The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection by Pestova (2002)
{'key': '10.1016/j.cell.2009.01.042_bib98', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '87', 'article-title': 'The mechanism of translation initiation in eukaryotes', 'author': 'Pestova', 'year': '2007'} / Translational Control in Biology and Medicine / The mechanism of translation initiation in eukaryotes by Pestova (2007)
10.1038/emboj.2008.49 / EMBO J. / eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II by Pestova (2008)
10.1016/j.cell.2007.08.041 / Cell / Recycling of eukaryotic posttermination ribosomal complexes by Pisarev (2007)
10.1038/emboj.2008.90 / EMBO J. / Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes by Pisarev (2008)
10.1016/j.cell.2008.10.037 / Cell / Translation initiation on mammalian mRNAs with structured 5′UTRs requires DExH-box protein DHX29 by Pisareva (2008)
10.1101/gad.439507 / Genes Dev. / The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation by Poyry (2007)
{'key': '10.1016/j.cell.2009.01.042_bib104', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '369', 'article-title': 'Signaling to translation initiation', 'author': 'Raught', 'year': '2007'} / Translational Control in Biology and Medicine / Signaling to translation initiation by Raught (2007)
{'key': '10.1016/j.cell.2009.01.042_bib105', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '345', 'article-title': 'eIF2α phosphorylation in celluar stress responses and disease', 'author': 'Ron', 'year': '2007'} / Translational Control in Biology and Medicine / eIF2α phosphorylation in celluar stress responses and disease by Ron (2007)
10.1016/j.stem.2008.03.013 / Cell Stem Cell / A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation by Sampath (2008)
{'key': '10.1016/j.cell.2009.01.042_bib107', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '401', 'article-title': 'Translational control in cancer development and progression', 'author': 'Schneider', 'year': '2007'} / Translational Control in Biology and Medicine / Translational control in cancer development and progression by Schneider (2007)
10.1038/nsmb1177 / Nat. Struct. Mol. Biol. / Structure of the ribosome-bound cricket paralysis virus IRES RNA by Schuler (2006)
10.1073/pnas.0800418105 / Proc. Natl. Acad. Sci. USA / Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions by Schutz (2008)
10.1128/MCB.21.15.4900-4908.2001 / Mol. Cell. Biol. / Linking the 3′ poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p by Searfoss (2001)
10.1038/nature07228 / Nature / Widespread changes in protein synthesis induced by microRNAs by Selbach (2008)
10.1126/science.1131127 / Science / Structure of the 70S ribosome complexed with mRNA and tRNA by Selmer (2006)
10.1016/j.cub.2005.01.048 / Curr. Biol. / Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo by Semotok (2005)
10.1016/S0092-8674(02)01171-6 / Cell / Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity by Shin (2002)
10.1038/nature07192 / Nature / Structure of the 30S translation initiation complex by Simonetti (2008)
10.1126/science.1118977 / Science / Structural roles for human translation factor eIF3 in initiation of protein synthesis by Siridechadilok (2005)
10.1016/j.molcel.2007.11.018 / Mol. Cell / New modes of translational control in development, behavior, and disease by Sonenberg (2007)
10.1038/sj.emboj.7600102 / EMBO J. / Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation by Spahn (2004)
10.1016/S1097-2765(00)80230-0 / Mol. Cell / Maskin is a CPEB-associated factor that transiently interacts with elF-4E by Stebbins-Boaz (1999)
10.1016/j.molcel.2005.09.012 / Mol. Cell / MicroRNAs and viral infection by Sullivan (2005)
10.1016/j.cell.2006.09.014 / Cell / Dendritic protein synthesis, synaptic plasticity, and memory by Sutton (2006)
10.1128/MCB.25.23.10556-10565.2005 / Mol. Cell. Biol. / Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation by Svitkin (2005)
10.1038/nature05603 / Nature / eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans by Syntichaki (2007)
10.1101/gad.480508 / Genes Dev. / eIF3a cooperates with sequences 5′ of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA by Szamecz (2008)
10.1038/nsmb.1445 / Nat. Struct. Mol. Biol. / Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2 by Terenin (2008)
10.1038/nature05878 / Nature / Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation by Thermann (2007)
{'key': '10.1016/j.cell.2009.01.042_bib127', 'series-title': 'Translational Control in Biology and Medicine', 'first-page': '486', 'article-title': 'Translational control in development', 'author': 'Thompson', 'year': '2007'} / Translational Control in Biology and Medicine / Translational control in development by Thompson (2007)
10.1158/0008-5472.CAN-04-2677 / Cancer Res. / Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities by Topisirovic (2004)
10.1038/nature02866 / Nature / Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity by Um (2004)
10.1101/gad.1065403 / Genes Dev. / The yeast eIF3 subunits TIF32/a and NIP1/c and eIF5 make critical connections with the 40S ribosome in vivo by Valášek (2003)
10.1126/science.1149460 / Science / Switching from repression to activation: microRNAs can up-regulate translation by Vasudevan (2007)
10.1073/pnas.0400541101 / Proc. Natl. Acad. Sci. USA / Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells by Vattem (2004)
10.1101/gad.1566707 / Genes Dev. / Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system by Wakiyama (2007)
10.1101/gad.1375006 / Genes Dev. / Assembly of an active translation initiation factor complex by a viral protein by Walsh (2006)
10.1128/MCB.01631-07 / Mol. Cell. Biol. / Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells by Walsh (2008)
10.1038/nature06716 / Nature / Following translation by single ribosomes one codon at a time by Wen (2008)
10.1101/gad.1604407 / Genes Dev. / Dissecting eIF4E action in tumorigenesis by Wendel (2007)
10.1038/nature05584 / Nature / 14–3-3sigma controls mitotic translation to facilitate cytokinesis by Wilker (2007)
10.1128/MCB.23.1.26-37.2003 / Mol. Cell. Biol. / The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation by Yang (2003)
10.1038/nature05281 / Nature / Structural basis for messenger RNA movement on the ribosome by Yusupova (2006)
10.1242/dev.02649 / Development / Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4 by Zaessinger (2006)
10.1016/j.cell.2008.06.053 / Cell / In vivo imaging of oskar mRNA transport reveals the mechanism of posterior localization by Zimyanin (2008)

Dates

Type	When
Created	16 years, 6 months ago (Feb. 22, 2009, 5:49 a.m.)
Deposited	3 years, 10 months ago (Oct. 2, 2021, 1:44 a.m.)
Indexed	8 minutes ago (Aug. 31, 2025, 2:08 p.m.)
Issued	16 years, 6 months ago (Feb. 1, 2009)
Published	16 years, 6 months ago (Feb. 1, 2009)
Published Print	16 years, 6 months ago (Feb. 1, 2009)

Funders 0

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BibTeX

@article{Sonenberg_2009, title={Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets}, volume={136}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2009.01.042}, DOI={10.1016/j.cell.2009.01.042}, number={4}, journal={Cell}, publisher={Elsevier BV}, author={Sonenberg, Nahum and Hinnebusch, Alan G.}, year={2009}, month=feb, pages={731–745} }

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  "source": "Crossref",
  "is-referenced-by-count": 2791,
  "title": "Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets",
  "prefix": "10.1016",
  "volume": "136",
  "author": [
    {
      "given": "Nahum",
      "family": "Sonenberg",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Alan G.",
      "family": "Hinnebusch",
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      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.cell.2009.01.042_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "8469",
      "DOI": "10.1074/jbc.M600210200",
      "article-title": "Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining",
      "volume": "281",
      "author": "Acker",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1016/j.molcel.2005.09.008",
      "article-title": "Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation",
      "volume": "20",
      "author": "Algire",
      "year": "2005",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "1276",
      "DOI": "10.1038/nature06974",
      "article-title": "Translation factors promote the formation of two states of the closed-loop mRNP",
      "volume": "453",
      "author": "Amrani",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1016/j.tibs.2007.12.003",
      "article-title": "Stress granules: the Tao of RNA triage",
      "volume": "33",
      "author": "Anderson",
      "year": "2008",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "183",
      "DOI": "10.1016/j.molcel.2006.05.030",
      "article-title": "How initiation factors maximize the accuracy of tRNA selection in initiation of bacterial protein synthesis",
      "volume": "23",
      "author": "Antoun",
      "year": "2006",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib143",
      "doi-asserted-by": "crossref",
      "DOI": "10.1371/journal.ppat.1000334",
      "article-title": "Activation of host translational control pathways by a viral developmental switch",
      "author": "Arias",
      "year": "2009",
      "journal-title": "PLoS Pathog."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "7551",
      "DOI": "10.1158/0008-5472.CAN-07-0881",
      "article-title": "4E-binding protein 1: a key molecular \u201cfunnel factor\u201d in human cancer with clinical implications",
      "volume": "67",
      "author": "Armengol",
      "year": "2007",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "64",
      "DOI": "10.1038/nature07242",
      "article-title": "The impact of microRNAs on protein output",
      "volume": "455",
      "author": "Baek",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "9581",
      "DOI": "10.1523/JNEUROSCI.2423-05.2005",
      "article-title": "The translation repressor 4E\u2013BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus",
      "volume": "25",
      "author": "Banko",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "689",
      "DOI": "10.1016/S0092-8674(02)00657-8",
      "article-title": "Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture",
      "volume": "108",
      "author": "Barco",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "971",
      "DOI": "10.1038/nature07449",
      "article-title": "Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency",
      "volume": "456",
      "author": "Barna",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "529",
      "DOI": "10.1016/j.cell.2005.06.011",
      "article-title": "A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila",
      "volume": "122",
      "author": "Beckmann",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "659",
      "DOI": "10.1242/dev.126.4.659",
      "article-title": "Role for mRNA localization in translational activation but not spatial restriction of nanos RNA",
      "volume": "126",
      "author": "Bergsten",
      "year": "1999",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "1287",
      "DOI": "10.1016/j.chembiol.2006.10.005",
      "article-title": "RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation",
      "volume": "13",
      "author": "Bordeleau",
      "year": "2006",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1016/j.molcel.2007.10.019",
      "article-title": "A\u00a0hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer",
      "volume": "28",
      "author": "Braunstein",
      "year": "2007",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1038/nrmicro1855",
      "article-title": "The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway",
      "volume": "6",
      "author": "Buchkovich",
      "year": "2008",
      "journal-title": "Nat. Rev. Microbiol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1016/S1097-2765(00)80414-1",
      "article-title": "VASA mediates translation through interaction with a Drosophila yIF2 homolog",
      "volume": "5",
      "author": "Carrera",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1016/j.cell.2006.01.031",
      "article-title": "Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles",
      "volume": "124",
      "author": "Chekulaeva",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1217",
      "DOI": "10.1101/gad.1528307",
      "article-title": "Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in\u00a0vivo",
      "volume": "21",
      "author": "Cheung",
      "year": "2007",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "691",
      "DOI": "10.1016/j.devcel.2007.10.002",
      "article-title": "Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression",
      "volume": "13",
      "author": "Chicoine",
      "year": "2007",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1016/j.cell.2005.02.024",
      "article-title": "A new paradigm for translational control: inhibition via 5\u2032-3\u2032 mRNA tethering by Bicoid and the eIF4E cognate 4EHP",
      "volume": "121",
      "author": "Cho",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "2035",
      "DOI": "10.1016/j.cub.2006.08.093",
      "article-title": "Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos",
      "volume": "16",
      "author": "Cho",
      "year": "2006",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1016/j.ydbio.2007.11.008",
      "article-title": "Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila",
      "volume": "313",
      "author": "Clouse",
      "year": "2008",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "1166",
      "DOI": "10.1038/nature03897",
      "article-title": "Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2",
      "volume": "436",
      "author": "Costa-Mattioli",
      "year": "2005",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1016/j.cell.2007.01.050",
      "article-title": "eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory",
      "volume": "129",
      "author": "Costa-Mattioli",
      "year": "2007",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.1016/j.neuron.2008.10.055",
      "article-title": "Translational control of long-lasting synaptic plasticity and memory",
      "volume": "61",
      "author": "Costa-Mattioli",
      "year": "2009",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1038/nsmb1351",
      "article-title": "tRNA-mRNA mimicry drives translation initiation from a viral IRES",
      "volume": "15",
      "author": "Costantino",
      "year": "2008",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "e56",
      "DOI": "10.1371/journal.pgen.0030056",
      "article-title": "Lifespan regulation by evolutionarily conserved genes essential for viability",
      "volume": "3",
      "author": "Curran",
      "year": "2007",
      "journal-title": "PLoS Genet."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "887",
      "DOI": "10.1016/j.cell.2005.06.044",
      "article-title": "Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR",
      "volume": "122",
      "author": "Dar",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "504",
      "DOI": "10.1101/gad.1184404",
      "article-title": "Specificity of microRNA target selection in translational repression",
      "volume": "18",
      "author": "Doench",
      "year": "2004",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "2242",
      "DOI": "10.1101/gad.1696608",
      "article-title": "Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection",
      "volume": "22",
      "author": "Dong",
      "year": "2008",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "467",
      "DOI": "10.1126/science.1130276",
      "article-title": "S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth",
      "volume": "314",
      "author": "Dorrello",
      "year": "2006",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib32",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "129",
      "article-title": "Translation initiation by viral internal ribosome entry sites",
      "author": "Doudna",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "30",
      "DOI": "10.1038/nsmb1031",
      "article-title": "An mRNA-rRNA base-pairing mechanism for translation initiation in eukaryotes",
      "volume": "13",
      "author": "Dresios",
      "year": "2006",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib34",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "155",
      "article-title": "Translation initiation via celluar internal ribosome entry sites",
      "author": "Elroy-Stein",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "346",
      "DOI": "10.1038/nsmb.1405",
      "article-title": "GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay",
      "volume": "15",
      "author": "Eulalio",
      "year": "2008",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1602",
      "DOI": "10.1038/sj.emboj.7601613",
      "article-title": "N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection",
      "volume": "26",
      "author": "Fekete",
      "year": "2007",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1038/nrg2290",
      "article-title": "Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?",
      "volume": "9",
      "author": "Filipowicz",
      "year": "2008",
      "journal-title": "Nat.\u00a0Rev. Genet."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib38",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "804",
      "article-title": "Noncanonical functions of aminoacyl-tRNA synthetases in translational control",
      "author": "Fox",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "811",
      "DOI": "10.1016/j.molcel.2007.05.019",
      "article-title": "eIF3j is located in the decoding center of the human 40S ribosomal subunit",
      "volume": "26",
      "author": "Fraser",
      "year": "2007",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "2384",
      "DOI": "10.1128/MCB.02254-06",
      "article-title": "Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining",
      "volume": "27",
      "author": "Fringer",
      "year": "2007",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1016/j.molcel.2005.09.019",
      "article-title": "Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay",
      "volume": "20",
      "author": "Gaba",
      "year": "2005",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "684",
      "DOI": "10.1038/nature07267",
      "article-title": "Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation",
      "volume": "455",
      "author": "Gandin",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "E79",
      "DOI": "10.1371/journal.pbio.0020079",
      "article-title": "Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast",
      "volume": "2",
      "author": "Gerber",
      "year": "2004",
      "journal-title": "PLoS Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "1224",
      "DOI": "10.1126/science.1144467",
      "article-title": "Cap-independent translation is required for starvation-induced differentiation in yeast",
      "volume": "317",
      "author": "Gilbert",
      "year": "2007",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "5292",
      "DOI": "10.1093/emboj/cdf515",
      "article-title": "Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation",
      "volume": "21",
      "author": "Gomez",
      "year": "2002",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "2638",
      "DOI": "10.1172/JCI32044",
      "article-title": "Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity",
      "volume": "117",
      "author": "Graff",
      "year": "2007",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "739",
      "DOI": "10.1016/S0092-8674(03)00975-9",
      "article-title": "Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E",
      "volume": "115",
      "author": "Gross",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "1146",
      "DOI": "10.1126/science.1064023",
      "article-title": "Argonaute2, a link between genetic and biochemical analyses of RNAi",
      "volume": "293",
      "author": "Hammond",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "95",
      "DOI": "10.1111/j.1474-9726.2006.00267.x",
      "article-title": "Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans",
      "volume": "6",
      "author": "Hansen",
      "year": "2007",
      "journal-title": "Aging Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "444",
      "DOI": "10.1093/gerona/61.5.444",
      "article-title": "daf-16 protects the nematode Caenorhabditis elegans during food deprivation",
      "volume": "61",
      "author": "Henderson",
      "year": "2006",
      "journal-title": "J. Gerontol. A\u00a0Biol. Sci. Med. Sci."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib51",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "269",
      "article-title": "cis-regulatory sequences and trans-acting factors in translational control",
      "author": "Hentze",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib52",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "225",
      "article-title": "Mechanism of translation initiation in the yeast Saccharomyces cerevisiae",
      "author": "Hinnebusch",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "569",
      "DOI": "10.1016/j.cell.2005.10.024",
      "article-title": "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events",
      "volume": "123",
      "author": "Holz",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "512",
      "DOI": "10.1038/nature04115",
      "article-title": "Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1",
      "volume": "438",
      "author": "Huttelmaier",
      "year": "2005",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "2056",
      "DOI": "10.1126/science.1073827",
      "article-title": "A microRNA in a multiple-turnover RNAi enzyme complex",
      "volume": "297",
      "author": "Hutvagner",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "15410",
      "DOI": "10.1073/pnas.2535183100",
      "article-title": "Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis",
      "volume": "100",
      "author": "Jan",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "8562",
      "DOI": "10.1128/MCB.22.24.8562-8570.2002",
      "article-title": "Inhibition of translation termination mediated by an interaction of eukaryotic release factor 1 with a nascent peptidyl-tRNA",
      "volume": "22",
      "author": "Janzen",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "4167",
      "DOI": "10.1242/dev.01286",
      "article-title": "Interaction with eIF5B is essential for Vasa function during development",
      "volume": "131",
      "author": "Johnstone",
      "year": "2004",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "1519",
      "DOI": "10.1242/dev.002212",
      "article-title": "Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline",
      "volume": "134",
      "author": "Kadyrova",
      "year": "2007",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "104",
      "DOI": "10.1101/gad.1262905",
      "article-title": "Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms",
      "volume": "19",
      "author": "Kahvejian",
      "year": "2005",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1016/j.molcel.2006.11.028",
      "article-title": "L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control",
      "volume": "25",
      "author": "Kapasi",
      "year": "2007",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.1016/j.chom.2007.08.005",
      "article-title": "Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions",
      "volume": "2",
      "author": "Katsafanas",
      "year": "2007",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1038/nrg2111",
      "article-title": "RNA regulons: coordination of post-transcriptional events",
      "volume": "8",
      "author": "Keene",
      "year": "2007",
      "journal-title": "Nat. Rev. Genet."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "467",
      "DOI": "10.1016/S0092-8674(04)00115-1",
      "article-title": "Translational control by MAPK signaling in long-term synaptic plasticity and memory",
      "volume": "116",
      "author": "Kelleher",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "274",
      "DOI": "10.1016/j.tibs.2008.04.007",
      "article-title": "Viral IRES RNA structures and ribosome interactions",
      "volume": "33",
      "author": "Kieft",
      "year": "2008",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/j.molcel.2006.08.016",
      "article-title": "Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation",
      "volume": "24",
      "author": "Kim",
      "year": "2006",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "3341",
      "DOI": "10.1105/tpc.104.026880",
      "article-title": "Translational regulation via 5\u2032 mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h",
      "volume": "16",
      "author": "Kim",
      "year": "2004",
      "journal-title": "Plant Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "1141",
      "DOI": "10.1016/j.cell.2007.05.016",
      "article-title": "An mRNA m7G cap binding-like motif within human Ago2 represses translation",
      "volume": "129",
      "author": "Kiriakidou",
      "year": "2007",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib69",
      "series-title": "Translational Control in Bioloy and Medicine",
      "first-page": "485",
      "article-title": "Translational control of synaotic plasticity and learning and memory",
      "author": "Klann",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "6814",
      "DOI": "10.1158/0008-5472.CAN-07-0752",
      "article-title": "Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors",
      "volume": "67",
      "author": "Larsson",
      "year": "2007",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "387",
      "DOI": "10.1172/JCI29528",
      "article-title": "Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E\u2013BP1 and 4E\u2013BP2",
      "volume": "117",
      "author": "Le Bacquer",
      "year": "2007",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "18125",
      "DOI": "10.1073/pnas.0608845103",
      "article-title": "Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules",
      "volume": "103",
      "author": "Leung",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "795",
      "DOI": "10.1038/sj.emboj.7601549",
      "article-title": "HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly",
      "volume": "26",
      "author": "Locker",
      "year": "2007",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "196",
      "DOI": "10.1038/sj.emboj.7600904",
      "article-title": "The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH",
      "volume": "25",
      "author": "Lomakin",
      "year": "2006",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1016/j.molcel.2004.11.051",
      "article-title": "A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon",
      "volume": "17",
      "author": "Maag",
      "year": "2005",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "e242",
      "DOI": "10.1371/journal.pone.0000242",
      "article-title": "Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation",
      "volume": "2",
      "author": "Mamane",
      "year": "2007",
      "journal-title": "PLoS ONE"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1016/S1097-2765(01)80003-4",
      "article-title": "Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G",
      "volume": "3",
      "author": "Marcotrigiano",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1016/j.cell.2009.01.014",
      "article-title": "Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation",
      "volume": "136",
      "author": "Marintchev",
      "year": "2009",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1016/S0092-8674(02)00908-X",
      "article-title": "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi",
      "volume": "110",
      "author": "Martinez",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "1764",
      "DOI": "10.1126/science.1146067",
      "article-title": "MicroRNA inhibition of translation initiation in\u00a0vitro by targeting the cap-binding complex eIF4F",
      "volume": "317",
      "author": "Mathonnet",
      "year": "2007",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib81",
      "doi-asserted-by": "crossref",
      "first-page": "712",
      "DOI": "10.1016/j.molcel.2008.04.014",
      "article-title": "Kinetic checkpoint at a late step in translation initiation",
      "volume": "30",
      "author": "Milon",
      "year": "2008",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "37389",
      "DOI": "10.1074/jbc.M704629200",
      "article-title": "CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes",
      "volume": "282",
      "author": "Minshall",
      "year": "2007",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib83",
      "doi-asserted-by": "crossref",
      "first-page": "1556",
      "DOI": "10.1101/gad.339105",
      "article-title": "Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry",
      "volume": "19",
      "author": "Mitchell",
      "year": "2005",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib84",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1016/j.cell.2006.11.046",
      "article-title": "Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G",
      "volume": "128",
      "author": "Moerke",
      "year": "2007",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib85",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "545",
      "article-title": "Protein synthesis and translational control during viral infection",
      "author": "Mohr",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib86",
      "doi-asserted-by": "crossref",
      "first-page": "371",
      "DOI": "10.1016/j.molcel.2008.09.019",
      "article-title": "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression",
      "volume": "32",
      "author": "Mukhopadhyay",
      "year": "2008",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib87",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1016/S1534-5807(03)00400-3",
      "article-title": "Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis",
      "volume": "6",
      "author": "Nakamura",
      "year": "2004",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib88",
      "doi-asserted-by": "crossref",
      "first-page": "1042",
      "DOI": "10.1016/j.cell.2008.07.031",
      "article-title": "The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP",
      "volume": "134",
      "author": "Napoli",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib89",
      "doi-asserted-by": "crossref",
      "first-page": "150",
      "DOI": "10.1038/sj.emboj.7600026",
      "article-title": "Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression",
      "volume": "23",
      "author": "Nelson",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib90",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1016/0531-5565(96)00011-3",
      "article-title": "Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in\u00a0vitro",
      "volume": "31",
      "author": "Norsgaard",
      "year": "1996",
      "journal-title": "Exp. Gerontol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib91",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1016/S0092-8674(01)00212-4",
      "article-title": "Lipoxygenase mRNA silencing in erythroid differentiation: The 3\u2032UTR regulatory complex controls 60S ribosomal subunit joining",
      "volume": "104",
      "author": "Ostareck",
      "year": "2001",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib92",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1111/j.1474-9726.2006.00266.x",
      "article-title": "Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans",
      "volume": "6",
      "author": "Pan",
      "year": "2007",
      "journal-title": "Aging Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib93",
      "doi-asserted-by": "crossref",
      "first-page": "723",
      "DOI": "10.1016/S0092-8674(01)00487-1",
      "article-title": "A plant viral \u201creinitiation\u201d factor interacts with the host translational machinery",
      "volume": "106",
      "author": "Park",
      "year": "2001",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib94",
      "doi-asserted-by": "crossref",
      "first-page": "635",
      "DOI": "10.1016/j.molcel.2007.02.011",
      "article-title": "P bodies and the control of mRNA translation and degradation",
      "volume": "25",
      "author": "Parker",
      "year": "2007",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib95",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1016/j.molcel.2007.03.018",
      "article-title": "The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome",
      "volume": "26",
      "author": "Passmore",
      "year": "2007",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib96",
      "series-title": "Translation Control in Biology and Medicine",
      "first-page": "830",
      "article-title": "Therapeutic opportunities in translation",
      "author": "Pelletier",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib97",
      "doi-asserted-by": "crossref",
      "first-page": "2906",
      "DOI": "10.1101/gad.1020902",
      "article-title": "The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection",
      "volume": "16",
      "author": "Pestova",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib98",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "87",
      "article-title": "The mechanism of translation initiation in eukaryotes",
      "author": "Pestova",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib99",
      "doi-asserted-by": "crossref",
      "first-page": "1060",
      "DOI": "10.1038/emboj.2008.49",
      "article-title": "eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II",
      "volume": "27",
      "author": "Pestova",
      "year": "2008",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib100",
      "doi-asserted-by": "crossref",
      "first-page": "286",
      "DOI": "10.1016/j.cell.2007.08.041",
      "article-title": "Recycling of eukaryotic posttermination ribosomal complexes",
      "volume": "131",
      "author": "Pisarev",
      "year": "2007",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib101",
      "doi-asserted-by": "crossref",
      "first-page": "1609",
      "DOI": "10.1038/emboj.2008.90",
      "article-title": "Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes",
      "volume": "27",
      "author": "Pisarev",
      "year": "2008",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib102",
      "doi-asserted-by": "crossref",
      "first-page": "1237",
      "DOI": "10.1016/j.cell.2008.10.037",
      "article-title": "Translation initiation on mammalian mRNAs with structured 5\u2032UTRs requires DExH-box protein DHX29",
      "volume": "135",
      "author": "Pisareva",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib103",
      "doi-asserted-by": "crossref",
      "first-page": "3149",
      "DOI": "10.1101/gad.439507",
      "article-title": "The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation",
      "volume": "21",
      "author": "Poyry",
      "year": "2007",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib104",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "369",
      "article-title": "Signaling to translation initiation",
      "author": "Raught",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib105",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "345",
      "article-title": "eIF2\u03b1 phosphorylation in celluar stress responses and disease",
      "author": "Ron",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib106",
      "doi-asserted-by": "crossref",
      "first-page": "448",
      "DOI": "10.1016/j.stem.2008.03.013",
      "article-title": "A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation",
      "volume": "2",
      "author": "Sampath",
      "year": "2008",
      "journal-title": "Cell Stem Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib107",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "401",
      "article-title": "Translational control in cancer development and progression",
      "author": "Schneider",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib108",
      "doi-asserted-by": "crossref",
      "first-page": "1092",
      "DOI": "10.1038/nsmb1177",
      "article-title": "Structure of the ribosome-bound cricket paralysis virus IRES RNA",
      "volume": "13",
      "author": "Schuler",
      "year": "2006",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib109",
      "doi-asserted-by": "crossref",
      "first-page": "9564",
      "DOI": "10.1073/pnas.0800418105",
      "article-title": "Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions",
      "volume": "105",
      "author": "Schutz",
      "year": "2008",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib110",
      "doi-asserted-by": "crossref",
      "first-page": "4900",
      "DOI": "10.1128/MCB.21.15.4900-4908.2001",
      "article-title": "Linking the 3\u2032 poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p",
      "volume": "21",
      "author": "Searfoss",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib111",
      "doi-asserted-by": "crossref",
      "first-page": "58",
      "DOI": "10.1038/nature07228",
      "article-title": "Widespread changes in protein synthesis induced by microRNAs",
      "volume": "455",
      "author": "Selbach",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib112",
      "doi-asserted-by": "crossref",
      "first-page": "1935",
      "DOI": "10.1126/science.1131127",
      "article-title": "Structure of the 70S ribosome complexed with mRNA and tRNA",
      "volume": "313",
      "author": "Selmer",
      "year": "2006",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib113",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1016/j.cub.2005.01.048",
      "article-title": "Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo",
      "volume": "15",
      "author": "Semotok",
      "year": "2005",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib114",
      "doi-asserted-by": "crossref",
      "first-page": "1015",
      "DOI": "10.1016/S0092-8674(02)01171-6",
      "article-title": "Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity",
      "volume": "111",
      "author": "Shin",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib115",
      "doi-asserted-by": "crossref",
      "first-page": "416",
      "DOI": "10.1038/nature07192",
      "article-title": "Structure of the 30S translation initiation complex",
      "volume": "455",
      "author": "Simonetti",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib116",
      "doi-asserted-by": "crossref",
      "first-page": "1513",
      "DOI": "10.1126/science.1118977",
      "article-title": "Structural roles for human translation factor eIF3 in initiation of protein synthesis",
      "volume": "310",
      "author": "Siridechadilok",
      "year": "2005",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib117",
      "doi-asserted-by": "crossref",
      "first-page": "721",
      "DOI": "10.1016/j.molcel.2007.11.018",
      "article-title": "New modes of translational control in development, behavior, and disease",
      "volume": "28",
      "author": "Sonenberg",
      "year": "2007",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib118",
      "doi-asserted-by": "crossref",
      "first-page": "1008",
      "DOI": "10.1038/sj.emboj.7600102",
      "article-title": "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation",
      "volume": "23",
      "author": "Spahn",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib119",
      "doi-asserted-by": "crossref",
      "first-page": "1017",
      "DOI": "10.1016/S1097-2765(00)80230-0",
      "article-title": "Maskin is a CPEB-associated factor that transiently interacts with elF-4E",
      "volume": "4",
      "author": "Stebbins-Boaz",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib120",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/j.molcel.2005.09.012",
      "article-title": "MicroRNAs and viral infection",
      "volume": "20",
      "author": "Sullivan",
      "year": "2005",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib121",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1016/j.cell.2006.09.014",
      "article-title": "Dendritic protein synthesis, synaptic plasticity, and memory",
      "volume": "127",
      "author": "Sutton",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib122",
      "doi-asserted-by": "crossref",
      "first-page": "10556",
      "DOI": "10.1128/MCB.25.23.10556-10565.2005",
      "article-title": "Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation",
      "volume": "25",
      "author": "Svitkin",
      "year": "2005",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib123",
      "doi-asserted-by": "crossref",
      "first-page": "922",
      "DOI": "10.1038/nature05603",
      "article-title": "eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans",
      "volume": "445",
      "author": "Syntichaki",
      "year": "2007",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib124",
      "doi-asserted-by": "crossref",
      "first-page": "2414",
      "DOI": "10.1101/gad.480508",
      "article-title": "eIF3a cooperates with sequences 5\u2032 of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA",
      "volume": "22",
      "author": "Szamecz",
      "year": "2008",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib125",
      "doi-asserted-by": "crossref",
      "first-page": "836",
      "DOI": "10.1038/nsmb.1445",
      "article-title": "Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2",
      "volume": "15",
      "author": "Terenin",
      "year": "2008",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib126",
      "doi-asserted-by": "crossref",
      "first-page": "875",
      "DOI": "10.1038/nature05878",
      "article-title": "Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation",
      "volume": "447",
      "author": "Thermann",
      "year": "2007",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib127",
      "series-title": "Translational Control in Biology and Medicine",
      "first-page": "486",
      "article-title": "Translational control in development",
      "author": "Thompson",
      "year": "2007"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib128",
      "doi-asserted-by": "crossref",
      "first-page": "8639",
      "DOI": "10.1158/0008-5472.CAN-04-2677",
      "article-title": "Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities",
      "volume": "64",
      "author": "Topisirovic",
      "year": "2004",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib129",
      "doi-asserted-by": "crossref",
      "first-page": "200",
      "DOI": "10.1038/nature02866",
      "article-title": "Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity",
      "volume": "431",
      "author": "Um",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib130",
      "doi-asserted-by": "crossref",
      "first-page": "786",
      "DOI": "10.1101/gad.1065403",
      "article-title": "The yeast eIF3 subunits TIF32/a and NIP1/c and eIF5 make critical connections with the 40S ribosome in\u00a0vivo",
      "volume": "17",
      "author": "Val\u00e1\u0161ek",
      "year": "2003",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib131",
      "doi-asserted-by": "crossref",
      "first-page": "1931",
      "DOI": "10.1126/science.1149460",
      "article-title": "Switching from repression to activation: microRNAs can up-regulate translation",
      "volume": "318",
      "author": "Vasudevan",
      "year": "2007",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib132",
      "doi-asserted-by": "crossref",
      "first-page": "11269",
      "DOI": "10.1073/pnas.0400541101",
      "article-title": "Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells",
      "volume": "101",
      "author": "Vattem",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib133",
      "doi-asserted-by": "crossref",
      "first-page": "1857",
      "DOI": "10.1101/gad.1566707",
      "article-title": "Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system",
      "volume": "21",
      "author": "Wakiyama",
      "year": "2007",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib134",
      "doi-asserted-by": "crossref",
      "first-page": "461",
      "DOI": "10.1101/gad.1375006",
      "article-title": "Assembly of an active translation initiation factor complex by a viral protein",
      "volume": "20",
      "author": "Walsh",
      "year": "2006",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib135",
      "doi-asserted-by": "crossref",
      "first-page": "2648",
      "DOI": "10.1128/MCB.01631-07",
      "article-title": "Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells",
      "volume": "28",
      "author": "Walsh",
      "year": "2008",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib136",
      "doi-asserted-by": "crossref",
      "first-page": "598",
      "DOI": "10.1038/nature06716",
      "article-title": "Following translation by single ribosomes one codon at a time",
      "volume": "452",
      "author": "Wen",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib137",
      "doi-asserted-by": "crossref",
      "first-page": "3232",
      "DOI": "10.1101/gad.1604407",
      "article-title": "Dissecting eIF4E action in tumorigenesis",
      "volume": "21",
      "author": "Wendel",
      "year": "2007",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib138",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1038/nature05584",
      "article-title": "14\u20133-3sigma controls mitotic translation to facilitate cytokinesis",
      "volume": "446",
      "author": "Wilker",
      "year": "2007",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib139",
      "doi-asserted-by": "crossref",
      "first-page": "26",
      "DOI": "10.1128/MCB.23.1.26-37.2003",
      "article-title": "The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation",
      "volume": "23",
      "author": "Yang",
      "year": "2003",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib140",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1038/nature05281",
      "article-title": "Structural basis for messenger RNA movement on the ribosome",
      "volume": "444",
      "author": "Yusupova",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib141",
      "doi-asserted-by": "crossref",
      "first-page": "4573",
      "DOI": "10.1242/dev.02649",
      "article-title": "Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4",
      "volume": "133",
      "author": "Zaessinger",
      "year": "2006",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.cell.2009.01.042_bib142",
      "doi-asserted-by": "crossref",
      "first-page": "843",
      "DOI": "10.1016/j.cell.2008.06.053",
      "article-title": "In vivo imaging of oskar mRNA transport reveals the mechanism of posterior localization",
      "volume": "134",
      "author": "Zimyanin",
      "year": "2008",
      "journal-title": "Cell"
    }
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