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Stetson, D. B., Ko, J. S., Heidmann, T., & Medzhitov, R. (2008). Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity. Cell, 134(4), 587–598.

Authors 4
  1. Daniel B. Stetson (first)
  2. Joan S. Ko (additional)
  3. Thierry Heidmann (additional)
  4. Ruslan Medzhitov (additional)
References 57 Referenced 1,103
  1. 10.1038/ng0806-866 / Nat. Genet. / Nucleic acid by-products and chronic inflammation by Alarcon-Riquelme (2006)
  2. 10.1016/j.molcel.2006.06.005 / Mol. Cell / The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death by Chowdhury (2006)
  3. 10.1016/j.immuni.2006.07.013 / Immunity / Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus by Christensen (2006)
  4. 10.1016/j.idc.2006.09.008 / Infect. Dis. Clin. North Am. / Role of endogenous retroviruses in autoimmune diseases by Colmegna (2006)
  5. 10.1136/jmg.40.3.183 / J. Med. Genet. / Cree encephalitis is allelic with Aicardi-Goutieres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism by Crow (2003)
  6. 10.1038/ng1845 / Nat. Genet. / Mutations in the gene encoding the 3′-5′DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus by Crow (2006)
  7. 10.1038/ng1842 / Nat. Genet. / Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection by Crow (2006)
  8. 10.1038/ng1353 / Nat. Genet. / Identification of autonomous IAP LTR retrotransposons mobile in mammalian cells by Dewannieux (2004)
  9. 10.1038/74184 / Nat. Genet. / Human LINE retrotransposons generate processed pseudogenes by Esnault (2000)
  10. 10.1016/j.cell.2007.06.033 / Cell / Multistep pathogenesis of autoimmune disease by Goodnow (2007)
  11. 10.1073/pnas.0709160104 / Proc. Natl. Acad. Sci. USA / Danger-free autoimmune disease in Aire-deficient mice by Gray (2007)
  12. 10.1038/nature03464 / Nature / IRF-7 is the master regulator of type-I interferon-dependent immune responses by Honda (2005)
  13. 10.1093/emboj/18.13.3868 / EMBO J. / A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein by Hoss (1999)
  14. 10.1038/ni1282 / Nat. Immunol. / A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA by Ishii (2006)
  15. 10.1038/ni1118 / Nat. Immunol. / Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 by Kawai (2004)
  16. 10.4049/jimmunol.179.7.4711 / J. Immunol. / Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination by Koyama (2007)
  17. 10.1084/jem.20060792 / J. Exp. Med. / Essential role of IPS-1 in innate immune responses against RNA viruses by Kumar (2006)
  18. 10.1038/nature06116 / Nature / Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide by Lande (2007)
  19. 10.1038/416603a / Nature / Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors by Leadbetter (2002)
  20. 10.1007/s00109-007-0199-9 / J. Mol. Med. / A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus by Lee-Kirsch (2007)
  21. 10.1038/ng2091 / Nat. Genet. / Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus by Lee-Kirsch (2007)
  22. 10.1016/S0021-9258(18)94303-6 / J. Biol. Chem. / Properties of deoxyribonuclease 3 from mammalian tissues by Lindahl (1969)
  23. 10.1186/1471-2164-4-19 / BMC Genomics / Development and validation of a T7 based linear amplification for genomic DNA by Liu (2003)
  24. 10.1016/S0966-842X(99)01565-6 / Trends Microbiol. / The pathogenic potential of endogenous retroviruses: facts and fantasies by Lower (1999)
  25. 10.1146/annurev.immunol.22.012703.104514 / Annu. Rev. Immunol. / Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease by Marshak-Rothstein (2007)
  26. 10.1002/art.21677 / Arthritis Rheum. / Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a Toll-like receptor 9-independent pathway by Martin (2006)
  27. 10.1074/jbc.274.28.19655 / J. Biol. Chem. / Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3′→5′ exonucleases by Mazur (1999)
  28. 10.1074/jbc.M100623200 / J. Biol. Chem. / Excision of 3′ termini by the Trex1 and TREX2 3′→5′ exonucleases. Characterization of the recombinant proteins by Mazur (2001)
  29. 10.1128/MCB.24.15.6719-6727.2004 / Mol. Cell. Biol. / Gene-targeted mice lacking the Trex1 (DNase III) 3′→5′ DNA exonuclease develop inflammatory myocarditis by Morita (2004)
  30. 10.1038/76032 / Nat. Genet. / Features of systemic lupus erythematosus in Dnase1-deficient mice by Napirei (2000)
  31. 10.1136/mp.56.1.11 / Mol. Pathol. / Demystified. Human endogenous retroviruses by Nelson (2003)
  32. 10.1084/jem.20051654 / J. Exp. Med. / Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation by Okabe (2005)
  33. 10.1146/annurev.genet.35.102401.091032 / Annu. Rev. Genet. / Biology of mammalian L1 retrotransposons by Ostertag (2001)
  34. 10.1016/j.coi.2006.09.014 / Curr. Opin. Immunol. / Systemic lupus erythematosus: all roads lead to type I interferons by Pascual (2006)
  35. 10.1016/j.immuni.2007.08.012 / Immunity / Innate recognition of viruses by Pichlmair (2007)
  36. 10.1126/science.1124978 / Science / Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication by Pisitkun (2006)
  37. 10.1086/513443 / Am. J. Hum. Genet. / Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome by Rice (2007)
  38. 10.1086/521373 / Am. J. Hum. Genet. / Clinical and molecular phenotype of Aicardi-Goutieres syndrome by Rice (2007)
  39. 10.1038/ng2082 / Nat. Genet. / C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy by Richards (2007)
  40. 10.1002/1098-2264(2000)9999:9999<::AID-GCC1066>3.0.CO;2-F / Genes Chromosomes Cancer / Transcriptional activation of short interspersed elements by DNA-damaging agents by Rudin (2001)
  41. 10.1016/j.jpeds.2005.01.033 / J. Pediatr. / Genetic syndromes mimic congenital infections by Sanchis (2005)
  42. 10.1016/S1074-7613(00)00053-4 / Immunity / Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction by Sato (2000)
  43. 10.1038/nature03326 / Nature / Toll-like receptor 3 promotes cross-priming to virus-infected cells by Schulz (2005)
  44. 10.1038/nrm804 / Nat. Rev. Mol. Cell Biol. / The 3′ 5′ exonucleases by Shevelev (2002)
  45. 10.1146/annurev.biochem.67.1.227 / Annu. Rev. Biochem. / How cells respond to interferons by Stark (1998)
  46. 10.1016/j.immuni.2005.12.003 / Immunity / Recognition of cytosolic DNA activates an IRF3-dependent innate immune response by Stetson (2006)
  47. 10.1016/j.immuni.2006.08.007 / Immunity / Type I interferons in host defense by Stetson (2006)
  48. 10.1016/S0966-842X(99)01616-9 / Trends Microbiol. / The pathogenic potential of endogenous retroviruses: a sceptical view by Stoye (1999)
  49. 10.1073/pnas.0603912103 / Proc. Natl. Acad. Sci. USA / A Tlr7 translocation accelerates systemic autoimmunity in murine lupus by Subramanian (2006)
  50. 10.1016/j.immuni.2006.04.004 / Immunity / The specific and essential role of MAVS in antiviral innate immune responses by Sun (2006)
  51. 10.1038/nature01850 / Nature / Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence by Takaoka (2003)
  52. 10.1038/nature06013 / Nature / DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response by Takaoka (2007)
  53. 10.1146/annurev.immunol.21.120601.141126 / Annu. Rev. Immunol. / Toll-like receptors by Takeda (2003)
  54. 10.1146/annurev.immunol.23.021704.115843 / Annu. Rev. Immunol. / Type I interferons (alpha/beta) in immunity and autoimmunity by Theofilopoulos (2005)
  55. 10.1016/j.cell.2007.10.017 / Cell / Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease by Yang (2007)
  56. 10.1038/91070 / Nat. Genet. / Mutation of DNASE1 in people with systemic lupus erythematosus by Yasutomo (2001)
  57. 10.1038/ni1146 / Nat. Immunol. / Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA by Yoshida (2005)
Dates
Type When
Created 16 years, 11 months ago (Sept. 7, 2008, 9:52 a.m.)
Deposited 3 years, 11 months ago (Sept. 15, 2021, 6:53 p.m.)
Indexed 1 day, 14 hours ago (Aug. 23, 2025, 9:40 p.m.)
Issued 17 years ago (Aug. 1, 2008)
Published 17 years ago (Aug. 1, 2008)
Published Print 17 years ago (Aug. 1, 2008)
Funders 0

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@article{Stetson_2008, title={Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity}, volume={134}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2008.06.032}, DOI={10.1016/j.cell.2008.06.032}, number={4}, journal={Cell}, publisher={Elsevier BV}, author={Stetson, Daniel B. and Ko, Joan S. and Heidmann, Thierry and Medzhitov, Ruslan}, year={2008}, month=aug, pages={587–598} }