DOI: 10.1016/j.cell.2007.09.008. Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

10.1016/j.cell.2007.09.008

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S.-G., Lee, H., & Lee, J.-O. (2007). Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide. Cell, 130(6), 1071â1082.

Authors 8

Mi Sun Jin (first)
Sung Eun Kim (additional)
Jin Young Heo (additional)
Mi Eun Lee (additional)
Ho Min Kim (additional)
Sang-Gi Paik (additional)
Hayyoung Lee (additional)
Jie-Oh Lee (additional)

References 65 Referenced 1,086

10.1038/nri1391 / Nat. Rev. Immunol. / Toll-like receptor signalling by Akira (2004)
10.1038/nm732 / Nat. Med. / Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice by Alexopoulou (2002)
10.1128/jb.176.8.2151-2157.1994 / J. Bacteriol. / Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins by Belisle (1994)
10.1073/pnas.0505077102 / Proc. Natl. Acad. Sci. USA / The molecular structure of the Toll-like receptor 3 ligand-binding domain by Bell (2005)
10.1152/ajpcell.1994.266.6.C1684 / Am. J. Physiol. / Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets by Berg (1994)
10.4049/jimmunol.135.3.1900 / J. Immunol. / Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes by Bessler (1985)
10.4049/jimmunol.170.7.3451 / J. Immunol. / Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling by Bochud (2003)
10.1038/nature05907 / Nature / CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor by Borg (2007)
10.1016/0304-4157(75)90013-1 / Biochim. Biophys. Acta / Covalent lipoprotein from the outer membrane of Escherichia coli by Braun (1975)
10.1107/S0907444998003254 / Acta Crystallogr. D Biol. Crystallogr. / Crystallography & NMR system: A new software suite for macromolecular structure determination by Brünger (1998)
10.1074/jbc.M512525200 / J. Biol. Chem. / TLR1- and TLR6-independent recognition of bacterial lipopeptides by Buwitt-Beckmann (2006)
10.1016/S0966-842X(99)01641-8 / Trends Microbiol. / Interactions between mycoplasma lipoproteins and the host immune system by Chambaud (1999)
10.1093/nar/gkg500 / Nucleic Acids Res. / Multiple sequence alignment with the Clustal series of programs by Chenna (2003)
10.1126/science.1115253 / Science / Crystal structure of human toll-like receptor 3 (TLR3) ectodomain by Choe (2005)
10.4049/jimmunol.170.8.4134 / J. Immunol. / Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives by Deininger (2003)
10.1086/342845 / J. Infect. Dis. / Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation by Echchannaoui (2002)
10.1074/jbc.M602057200 / J. Biol. Chem. / Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling by Gautam (2006)
10.1146/annurev.biochem.76.060305.151318 / Annu. Rev. Biochem. / Structure and function of toll receptors and their ligands by Gay (2007)
10.1074/jbc.M405311200 / J. Biol. Chem. / Human but not murine toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides by Grabiec (2004)
10.1111/j.1432-1033.1973.tb02757.x / Eur. J. Biochem. / Covalent binding of lipid to protein. Diglyceride and amide-linked fatty acid at the N-terminal end of the murein-lipoprotein of the Escherichia coli outer membrane by Hantke (1973)
10.1128/IAI.02083-05 / Infect. Immun. / Evidence of immunostimulating lipoprotein existing in the natural lipoteichoic acid fraction by Hashimoto (2007)
10.1128/mr.60.2.316-341.1996 / Microbiol. Rev. / Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis by Henderson (1996)
10.1038/nature03253 / Nature / CD36 is a sensor of diacylglycerides by Hoebe (2005)
10.1016/j.bbrc.2004.12.162 / Biochem. Biophys. Res. Commun. / The CD14 region spanning amino acids 57–64 is critical for interaction with the extracellular Toll-like receptor 2 domain by Iwaki (2005)
10.1107/S0108767390010224 / Acta Crystallogr. A / Improved methods for building protein models in electron density maps and the location of errors in these models by Jones (1991)
10.1006/jmbi.1998.1643 / J. Mol. Biol. / Structural diversity of leucine-rich repeat proteins by Kajava (1998)
10.1111/j.1574-695X.2001.tb01586.x / FEMS Immunol. Med. Microbiol. / Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients by Kang (2001)
10.1074/jbc.M608471200 / J. Biol. Chem. / Structural diversity of the hagfish variable lymphocyte receptors by Kim (2007)
10.1016/j.cell.2007.08.002 / Cell / Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran by Kim (2007)
10.1074/jbc.M414607200 / J. Biol. Chem. / Crystal structure of CD14 and its implications for lipopolysaccharide signaling by Kim (2005)
10.1016/j.immuni.2005.09.008 / Immunity / Pathogen recognition: TLRs throw us a curve by Kirk (2005)
10.1016/S0959-440X(01)00266-4 / Curr. Opin. Struct. Biol. / The leucine-rich repeat as a protein recognition motif by Kobe (2001)
10.1038/ni1479 / Nat. Immunol. / Ligand-induced conformational changes allosterically activate Toll-like receptor 9 by Latz (2007)
10.1128/IAI.68.11.6398-6401.2000 / Infect. Immun. / A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection by Lorenz (2000)
10.1093/bioinformatics/18.4.641 / Bioinformatics / DOLOP–database of bacterial lipoproteins by Madan Babu (2002)
10.1002/eji.200425336 / Eur. J. Immunol. / Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1 by Manukyan (2005)
10.1186/1471-2164-8-124 / BMC Genomics / Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors by Matsushima (2007)
10.1107/S0907444905001617 / Acta Crystallogr. D Biol. Crystallogr. / Likelihood-enhanced fast translation functions by McCoy (2005)
10.1074/jbc.M304766200 / J. Biol. Chem. / Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2 by Meng (2003)
10.1093/oxfordjournals.jbchem.a132631 / J. Biochem. (Tokyo) / A novel peptidoglycan-associated lipoprotein found in the cell envelope of Pseudomonas aeruginosa and Escherichia coli by Mizuno (1979)
10.1177/09680519050110061001 / J. Endotoxin Res. / Structure/function relationships of lipoteichoic acids by Morath (2005)
10.1002/1521-4141(2002012)32:12<3337::AID-IMMU3337>3.0.CO;2-I / Eur. J. Immunol. / Differential recognition of structural details of bacterial lipopeptides by toll-like receptors by Morr (2002)
10.1084/jem.185.11.1951 / J. Exp. Med. / Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration by Mühlradt (1997)
10.1111/j.1462-5822.2006.00756.x / Cell. Microbiol. / CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex by Nakata (2006)
10.1183/09031936.03.00061703 / Eur. Respir. J. / The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease by Ogus (2004)
10.1074/jbc.M504320200 / J. Biol. Chem. / Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination by Omueti (2005)
10.4049/jimmunol.178.10.6387 / J. Immunol. / The Polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components by Omueti (2007)
10.1038/nri2079 / Nat. Rev. Immunol. / The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling by O'Neill (2007)
10.1073/pnas.250476497 / Proc. Natl. Acad. Sci. USA / The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors by Ozinsky (2000)
10.1146/annurev.immunol.24.021605.090542 / Annu. Rev. Immunol. / The evolution of adaptive immunity by Pancer (2006)
10.1073/pnas.0502272102 / Proc. Natl. Acad. Sci. USA / The evolution of vertebrate Toll-like receptors by Roach (2005)
10.1042/bj2670795 / Biochem. J. / Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides by Seifert (1990)
10.4049/jimmunol.160.11.5455 / J. Immunol. / Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide by Sellati (1998)
10.4049/jimmunol.165.11.6538 / J. Immunol. / The N-terminal lipopeptide of a 44-kDa membrane-bound lipoprotein of Mycoplasma salivarium is responsible for the expression of intercellular adhesion molecule-1 on the cell surface of normal human gingival fibroblasts by Shibata (2000)
10.1111/j.1348-0421.2003.tb03404.x / Microbiol. Immunol. / Mycobacterial infection in TLR2 and TLR6 knockout mice by Sugawara (2003)
10.4049/jimmunol.165.10.5392 / J. Immunol. / Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection by Takeuchi (2000)
10.1093/intimm/13.7.933 / Int. Immunol. / Discrimination of bacterial lipoproteins by Toll-like receptor 6 by Takeuchi (2001)
10.4049/jimmunol.169.1.10 / J. Immunol. / Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins by Takeuchi (2002)
10.1089/cmb.2005.12.1316 / J. Comput. Biol. / The victor/FRST function for model quality estimation by Tosatto (2005)
10.1074/jbc.M602794200 / J. Biol. Chem. / Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting by Triantafilou (2006)
10.1146/annurev.cellbio.21.122303.115827 / Annu. Rev. Cell Dev. Biol. / Recognition and signaling by toll-like receptors by West (2006)
10.1111/j.1399-3011.1992.tb00299.x / Int. J. Pept. Protein Res. / Solid phase peptide synthesis of lipopeptide vaccines eliciting epitope-specific B-, T-helper and T-killer cell response by Wiesmüller (1992)
10.1107/S0909049502017235 / J. Synchrotron Radiat. / An overview of the CCP4 project in protein crystallography: an example of a collaborative project by Winn (2003)
10.1038/35040600 / Nature / Structural basis for signal transduction by the Toll/interleukin-1 receptor domains by Xu (2000)
10.1016/S0021-9258(19)81587-9 / J. Biol. Chem. / Purification and characterization of a peptidoglycan-associated lipoprotein from Haemophilus influenzae by Zlotnick (1988)

Dates

Type	When
Created	17 years, 11 months ago (Sept. 21, 2007, 7:13 a.m.)
Deposited	2 years, 6 months ago (Jan. 28, 2023, 11:14 a.m.)
Indexed	2 days ago (Aug. 23, 2025, 9:31 p.m.)
Issued	17 years, 11 months ago (Sept. 1, 2007)
Published	17 years, 11 months ago (Sept. 1, 2007)
Published Print	17 years, 11 months ago (Sept. 1, 2007)

Funders 0

None

BibTeX

@article{Jin_2007, title={Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide}, volume={130}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2007.09.008}, DOI={10.1016/j.cell.2007.09.008}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Jin, Mi Sun and Kim, Sung Eun and Heo, Jin Young and Lee, Mi Eun and Kim, Ho Min and Paik, Sang-Gi and Lee, Hayyoung and Lee, Jie-Oh}, year={2007}, month=sep, pages={1071–1082} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        24
      ]
    ],
    "date-time": "2025-08-24T01:31:02Z",
    "timestamp": 1755999062089
  },
  "reference-count": 65,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            9,
            1
          ]
        ],
        "date-time": "2007-09-01T00:00:00Z",
        "timestamp": 1188604800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 2146,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            9,
            1
          ]
        ],
        "date-time": "2007-09-01T00:00:00Z",
        "timestamp": 1188604800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            9,
            1
          ]
        ],
        "date-time": "2007-09-01T00:00:00Z",
        "timestamp": 1188604800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            9,
            1
          ]
        ],
        "date-time": "2007-09-01T00:00:00Z",
        "timestamp": 1188604800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            9,
            1
          ]
        ],
        "date-time": "2007-09-01T00:00:00Z",
        "timestamp": 1188604800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            9,
            1
          ]
        ],
        "date-time": "2007-09-01T00:00:00Z",
        "timestamp": 1188604800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        9
      ]
    ]
  },
  "DOI": "10.1016/j.cell.2007.09.008",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        9,
        21
      ]
    ],
    "date-time": "2007-09-21T11:13:29Z",
    "timestamp": 1190373209000
  },
  "page": "1071-1082",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 1086,
  "title": "Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide",
  "prefix": "10.1016",
  "volume": "130",
  "author": [
    {
      "given": "Mi Sun",
      "family": "Jin",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Sung Eun",
      "family": "Kim",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jin Young",
      "family": "Heo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mi Eun",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ho Min",
      "family": "Kim",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Sang-Gi",
      "family": "Paik",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hayyoung",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jie-Oh",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.cell.2007.09.008_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "499",
      "DOI": "10.1038/nri1391",
      "article-title": "Toll-like receptor signalling",
      "volume": "4",
      "author": "Akira",
      "year": "2004",
      "journal-title": "Nat. Rev. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "878",
      "DOI": "10.1038/nm732",
      "article-title": "Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice",
      "volume": "8",
      "author": "Alexopoulou",
      "year": "2002",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "2151",
      "DOI": "10.1128/jb.176.8.2151-2157.1994",
      "article-title": "Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins",
      "volume": "176",
      "author": "Belisle",
      "year": "1994",
      "journal-title": "J.\u00a0Bacteriol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "10976",
      "DOI": "10.1073/pnas.0505077102",
      "article-title": "The molecular structure of the Toll-like receptor 3 ligand-binding domain",
      "volume": "102",
      "author": "Bell",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "C1684",
      "DOI": "10.1152/ajpcell.1994.266.6.C1684",
      "article-title": "Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets",
      "volume": "266",
      "author": "Berg",
      "year": "1994",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "1900",
      "DOI": "10.4049/jimmunol.135.3.1900",
      "article-title": "Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes",
      "volume": "135",
      "author": "Bessler",
      "year": "1985",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "3451",
      "DOI": "10.4049/jimmunol.170.7.3451",
      "article-title": "Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling",
      "volume": "170",
      "author": "Bochud",
      "year": "2003",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "44",
      "DOI": "10.1038/nature05907",
      "article-title": "CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor",
      "volume": "448",
      "author": "Borg",
      "year": "2007",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1016/0304-4157(75)90013-1",
      "article-title": "Covalent lipoprotein from the outer membrane of Escherichia coli",
      "volume": "415",
      "author": "Braun",
      "year": "1975",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1107/S0907444998003254",
      "article-title": "Crystallography & NMR system: A new software suite for macromolecular structure determination",
      "volume": "54",
      "author": "Br\u00fcnger",
      "year": "1998",
      "journal-title": "Acta Crystallogr. D\u00a0Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "9049",
      "DOI": "10.1074/jbc.M512525200",
      "article-title": "TLR1- and TLR6-independent recognition of bacterial lipopeptides",
      "volume": "281",
      "author": "Buwitt-Beckmann",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "493",
      "DOI": "10.1016/S0966-842X(99)01641-8",
      "article-title": "Interactions between mycoplasma lipoproteins and the host immune system",
      "volume": "7",
      "author": "Chambaud",
      "year": "1999",
      "journal-title": "Trends Microbiol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "3497",
      "DOI": "10.1093/nar/gkg500",
      "article-title": "Multiple sequence alignment with the Clustal series of programs",
      "volume": "31",
      "author": "Chenna",
      "year": "2003",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1126/science.1115253",
      "article-title": "Crystal structure of human toll-like receptor 3 (TLR3) ectodomain",
      "volume": "309",
      "author": "Choe",
      "year": "2005",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "4134",
      "DOI": "10.4049/jimmunol.170.8.4134",
      "article-title": "Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives",
      "volume": "170",
      "author": "Deininger",
      "year": "2003",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "798",
      "DOI": "10.1086/342845",
      "article-title": "Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation",
      "volume": "186",
      "author": "Echchannaoui",
      "year": "2002",
      "journal-title": "J. Infect. Dis."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "30132",
      "DOI": "10.1074/jbc.M602057200",
      "article-title": "Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling",
      "volume": "281",
      "author": "Gautam",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1146/annurev.biochem.76.060305.151318",
      "article-title": "Structure and function of toll receptors and their ligands",
      "volume": "76",
      "author": "Gay",
      "year": "2007",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "48004",
      "DOI": "10.1074/jbc.M405311200",
      "article-title": "Human but not murine toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides",
      "volume": "279",
      "author": "Grabiec",
      "year": "2004",
      "journal-title": "J.\u00a0Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1111/j.1432-1033.1973.tb02757.x",
      "article-title": "Covalent binding of lipid to protein. Diglyceride and amide-linked fatty acid at the N-terminal end of the murein-lipoprotein of the Escherichia coli outer membrane",
      "volume": "34",
      "author": "Hantke",
      "year": "1973",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1926",
      "DOI": "10.1128/IAI.02083-05",
      "article-title": "Evidence of immunostimulating lipoprotein existing in the natural lipoteichoic acid fraction",
      "volume": "75",
      "author": "Hashimoto",
      "year": "2007",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "316",
      "DOI": "10.1128/mr.60.2.316-341.1996",
      "article-title": "Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis",
      "volume": "60",
      "author": "Henderson",
      "year": "1996",
      "journal-title": "Microbiol. Rev."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "523",
      "DOI": "10.1038/nature03253",
      "article-title": "CD36 is a sensor of diacylglycerides",
      "volume": "433",
      "author": "Hoebe",
      "year": "2005",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/j.bbrc.2004.12.162",
      "article-title": "The CD14 region spanning amino acids 57\u201364 is critical for interaction with the extracellular Toll-like receptor 2 domain",
      "volume": "328",
      "author": "Iwaki",
      "year": "2005",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "article-title": "Improved methods for building protein models in electron density maps and the location of errors in these models",
      "volume": "47",
      "author": "Jones",
      "year": "1991",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "519",
      "DOI": "10.1006/jmbi.1998.1643",
      "article-title": "Structural diversity of leucine-rich repeat proteins",
      "volume": "277",
      "author": "Kajava",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1111/j.1574-695X.2001.tb01586.x",
      "article-title": "Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients",
      "volume": "31",
      "author": "Kang",
      "year": "2001",
      "journal-title": "FEMS Immunol. Med. Microbiol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "6726",
      "DOI": "10.1074/jbc.M608471200",
      "article-title": "Structural diversity of the hagfish variable lymphocyte receptors",
      "volume": "282",
      "author": "Kim",
      "year": "2007",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "906",
      "DOI": "10.1016/j.cell.2007.08.002",
      "article-title": "Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran",
      "volume": "130",
      "author": "Kim",
      "year": "2007",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "11347",
      "DOI": "10.1074/jbc.M414607200",
      "article-title": "Crystal structure of CD14 and its implications for lipopolysaccharide signaling",
      "volume": "280",
      "author": "Kim",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1016/j.immuni.2005.09.008",
      "article-title": "Pathogen recognition: TLRs throw us a curve",
      "volume": "23",
      "author": "Kirk",
      "year": "2005",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "725",
      "DOI": "10.1016/S0959-440X(01)00266-4",
      "article-title": "The leucine-rich repeat as a protein recognition motif",
      "volume": "11",
      "author": "Kobe",
      "year": "2001",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "772",
      "DOI": "10.1038/ni1479",
      "article-title": "Ligand-induced conformational changes allosterically activate Toll-like receptor 9",
      "volume": "8",
      "author": "Latz",
      "year": "2007",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "6398",
      "DOI": "10.1128/IAI.68.11.6398-6401.2000",
      "article-title": "A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection",
      "volume": "68",
      "author": "Lorenz",
      "year": "2000",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1093/bioinformatics/18.4.641",
      "article-title": "DOLOP\u2013database of bacterial lipoproteins",
      "volume": "18",
      "author": "Madan Babu",
      "year": "2002",
      "journal-title": "Bioinformatics"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "911",
      "DOI": "10.1002/eji.200425336",
      "article-title": "Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1",
      "volume": "35",
      "author": "Manukyan",
      "year": "2005",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "124",
      "DOI": "10.1186/1471-2164-8-124",
      "article-title": "Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors",
      "volume": "8",
      "author": "Matsushima",
      "year": "2007",
      "journal-title": "BMC Genomics"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "458",
      "DOI": "10.1107/S0907444905001617",
      "article-title": "Likelihood-enhanced fast translation functions",
      "volume": "61",
      "author": "McCoy",
      "year": "2005",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "39822",
      "DOI": "10.1074/jbc.M304766200",
      "article-title": "Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2",
      "volume": "278",
      "author": "Meng",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "991",
      "DOI": "10.1093/oxfordjournals.jbchem.a132631",
      "article-title": "A novel peptidoglycan-associated lipoprotein found in the cell envelope of Pseudomonas aeruginosa and Escherichia coli",
      "volume": "86",
      "author": "Mizuno",
      "year": "1979",
      "journal-title": "J. Biochem. (Tokyo)"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "348",
      "DOI": "10.1177/09680519050110061001",
      "article-title": "Structure/function relationships of lipoteichoic acids",
      "volume": "11",
      "author": "Morath",
      "year": "2005",
      "journal-title": "J. Endotoxin Res."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "3337",
      "DOI": "10.1002/1521-4141(2002012)32:12<3337::AID-IMMU3337>3.0.CO;2-I",
      "article-title": "Differential recognition of structural details of bacterial lipopeptides by toll-like receptors",
      "volume": "32",
      "author": "Morr",
      "year": "2002",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "1951",
      "DOI": "10.1084/jem.185.11.1951",
      "article-title": "Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration",
      "volume": "185",
      "author": "M\u00fchlradt",
      "year": "1997",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "1899",
      "DOI": "10.1111/j.1462-5822.2006.00756.x",
      "article-title": "CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex",
      "volume": "8",
      "author": "Nakata",
      "year": "2006",
      "journal-title": "Cell. Microbiol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "219",
      "DOI": "10.1183/09031936.03.00061703",
      "article-title": "The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease",
      "volume": "23",
      "author": "Ogus",
      "year": "2004",
      "journal-title": "Eur. Respir. J."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "36616",
      "DOI": "10.1074/jbc.M504320200",
      "article-title": "Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination",
      "volume": "280",
      "author": "Omueti",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "6387",
      "DOI": "10.4049/jimmunol.178.10.6387",
      "article-title": "The Polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components",
      "volume": "178",
      "author": "Omueti",
      "year": "2007",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1038/nri2079",
      "article-title": "The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling",
      "volume": "7",
      "author": "O'Neill",
      "year": "2007",
      "journal-title": "Nat. Rev. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "13766",
      "DOI": "10.1073/pnas.250476497",
      "article-title": "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors",
      "volume": "97",
      "author": "Ozinsky",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "497",
      "DOI": "10.1146/annurev.immunol.24.021605.090542",
      "article-title": "The evolution of adaptive immunity",
      "volume": "24",
      "author": "Pancer",
      "year": "2006",
      "journal-title": "Annu. Rev. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "9577",
      "DOI": "10.1073/pnas.0502272102",
      "article-title": "The evolution of vertebrate Toll-like receptors",
      "volume": "102",
      "author": "Roach",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "795",
      "DOI": "10.1042/bj2670795",
      "article-title": "Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides",
      "volume": "267",
      "author": "Seifert",
      "year": "1990",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "5455",
      "DOI": "10.4049/jimmunol.160.11.5455",
      "article-title": "Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent\u00a0pathway distinct from that used by lipopolysaccharide",
      "volume": "160",
      "author": "Sellati",
      "year": "1998",
      "journal-title": "J.\u00a0Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "6538",
      "DOI": "10.4049/jimmunol.165.11.6538",
      "article-title": "The N-terminal lipopeptide of a 44-kDa membrane-bound lipoprotein of Mycoplasma salivarium is responsible for the expression of intercellular adhesion molecule-1 on the cell surface of normal human gingival fibroblasts",
      "volume": "165",
      "author": "Shibata",
      "year": "2000",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "327",
      "DOI": "10.1111/j.1348-0421.2003.tb03404.x",
      "article-title": "Mycobacterial infection in TLR2 and TLR6 knockout mice",
      "volume": "47",
      "author": "Sugawara",
      "year": "2003",
      "journal-title": "Microbiol. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "5392",
      "DOI": "10.4049/jimmunol.165.10.5392",
      "article-title": "Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection",
      "volume": "165",
      "author": "Takeuchi",
      "year": "2000",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "933",
      "DOI": "10.1093/intimm/13.7.933",
      "article-title": "Discrimination of bacterial lipoproteins by Toll-like receptor 6",
      "volume": "13",
      "author": "Takeuchi",
      "year": "2001",
      "journal-title": "Int. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.4049/jimmunol.169.1.10",
      "article-title": "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins",
      "volume": "169",
      "author": "Takeuchi",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "1316",
      "DOI": "10.1089/cmb.2005.12.1316",
      "article-title": "The victor/FRST function for model quality estimation",
      "volume": "12",
      "author": "Tosatto",
      "year": "2005",
      "journal-title": "J. Comput. Biol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "31002",
      "DOI": "10.1074/jbc.M602794200",
      "article-title": "Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting",
      "volume": "281",
      "author": "Triantafilou",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "409",
      "DOI": "10.1146/annurev.cellbio.21.122303.115827",
      "article-title": "Recognition and signaling by toll-like receptors",
      "volume": "22",
      "author": "West",
      "year": "2006",
      "journal-title": "Annu. Rev. Cell Dev. Biol."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1111/j.1399-3011.1992.tb00299.x",
      "article-title": "Solid phase peptide synthesis of lipopeptide vaccines eliciting epitope-specific B-, T-helper and T-killer cell response",
      "volume": "40",
      "author": "Wiesm\u00fcller",
      "year": "1992",
      "journal-title": "Int. J. Pept. Protein Res."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "23",
      "DOI": "10.1107/S0909049502017235",
      "article-title": "An overview of the CCP4 project in protein crystallography: an example of a collaborative project",
      "volume": "10",
      "author": "Winn",
      "year": "2003",
      "journal-title": "J. Synchrotron Radiat."
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1038/35040600",
      "article-title": "Structural basis for signal transduction by the Toll/interleukin-1 receptor domains",
      "volume": "408",
      "author": "Xu",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2007.09.008_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "9790",
      "DOI": "10.1016/S0021-9258(19)81587-9",
      "article-title": "Purification and characterization of a peptidoglycan-associated lipoprotein from Haemophilus influenzae",
      "volume": "263",
      "author": "Zlotnick",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S009286740701152X?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S009286740701152X?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        1,
        28
      ]
    ],
    "date-time": "2023-01-28T16:14:15Z",
    "timestamp": 1674922455000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S009286740701152X"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        9
      ]
    ]
  },
  "references-count": 65,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2007,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "S009286740701152X"
  ],
  "URL": "http://dx.doi.org/10.1016/j.cell.2007.09.008",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1091080.544467",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1091080.559756",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1091080.545992",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2007,
        9
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Cell",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/j.cell.2007.09.008",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2007 Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}