DOI: 10.1016/j.cell.2006.09.039. The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore

The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore

10.1016/j.cell.2006.09.039

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M., & Desai, A. (2006). The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore. Cell, 127(5), 983â997.

Authors 4

Iain M. Cheeseman (first)
Joshua S. Chappie (additional)
Elizabeth M. Wilson-Kubalek (additional)
Arshad Desai (additional)

References 32 Referenced 912

10.1083/jcb.200109063 / J. Cell Biol. / Implication of a novel multiprotein Dam1p complex in outer kinetochore function by Cheeseman (2001)
10.1016/S0092-8674(02)00973-X / Cell / Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p by Cheeseman (2002)
10.1101/gad.1234104 / Genes Dev. / A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension by Cheeseman (2004)
10.1074/jbc.M504070200 / J. Biol. Chem. / Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore by Ciferri (2005)
10.1016/S0092-8674(03)00115-6 / Cell / Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling by Cleveland (2003)
10.1101/gad.1144403 / Genes Dev. / Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes by De Wulf (2003)
10.1091/mbc.e04-09-0852 / Mol. Biol. Cell / Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites by DeLuca (2005)
10.1016/j.cell.2006.09.047 / Cell / Kinetochore microtubule dynamics and attachment stability are regulated by Hecl by DeLuca (2006)
10.1016/S0092-8674(00)80960-5 / Cell / Kin I kinesins are microtubule-destabilizing enzymes by Desai (1999)
10.1101/gad.1126303 / Genes Dev. / KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans by Desai (2003)
10.1091/mbc.e05-03-0239 / Mol. Biol. Cell / Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore by Emanuele (2005)
10.1083/jcb.200105093 / J. Cell Biol. / Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation by Howell (2001)
10.1038/ncb1414 / Nat. Cell Biol. / Molecular architecture of a kinetochore-microtubule attachment site by Joglekar (2006)
10.1093/emboj/cdg001 / EMBO J. / Repeat motifs of tau bind to the insides of microtubules in the absence of taxol by Kar (2003)
10.1083/jcb.200509158 / J. Cell Biol. / The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation by Kline (2006)
10.1016/j.ceb.2004.12.009 / Curr. Opin. Cell Biol. / Kinetochore-spindle microtubule interactions during mitosis by Kline-Smith (2005)
10.1083/jcb.200301088 / J. Cell Biol. / Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics by Maddox (2003)
10.1242/jcs.01536 / J. Cell Sci. / The dynamic kinetochore-microtubule interface by Maiato (2004)
10.1038/ncb1207 / Nat. Cell Biol. / Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres by Maiato (2005)
10.1016/j.cub.2003.12.058 / Curr. Biol. / The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment by McCleland (2004)
10.1091/mbc.e03-06-0419 / Mol. Biol. Cell / Interactions between centromere complexes in Saccharomyces cerevisiae by Nekrasov (2003)
10.1038/ncb1187 / Nat. Cell Biol. / A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 by Obuse (2004)
10.1016/j.tcb.2005.07.005 / Trends Cell Biol. / The spindle checkpoint: tension versus attachment by Pinsky (2005)
10.1016/S1534-5807(02)00255-1 / Dev. Cell / Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E by Putkey (2002)
10.1016/S0074-7696(08)61672-1 / Int. Rev. Cytol. / The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber by Rieder (1982)
10.1016/S0962-8924(98)01299-9 / Trends Cell Biol. / The vertebrate cell kinetochore and its roles during mitosis by Rieder (1998)
10.1038/sj.emboj.7600761 / EMBO J. / The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast by Sanchez-Perez (2005)
{'key': '10.1016/j.cell.2006.09.039_bib27', 'series-title': 'Mitosis: The Movement of Chromosomes in Cell Division', 'author': 'Schrader', 'year': '1953'} / Mitosis: The Movement of Chromosomes in Cell Division by Schrader (1953)
10.1006/prep.2000.1363 / Protein Expr. Purif. / A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli by Tan (2001)
10.1016/S0092-8674(02)00633-5 / Cell / Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections by Tanaka (2002)
10.1073/pnas.0501168102 / Proc. Natl. Acad. Sci. USA / Molecular organization of the Ndc80 complex, an essential kinetochore component by Wei (2005)
10.1083/jcb.152.2.349 / J. Cell Biol. / The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation by Wigge (2001)

Dates

Type	When
Created	18 years, 8 months ago (Dec. 1, 2006, 7:12 a.m.)
Deposited	2 years, 6 months ago (Jan. 28, 2023, 9:29 a.m.)
Indexed	58 minutes ago (Aug. 26, 2025, 2:59 a.m.)
Issued	18 years, 8 months ago (Dec. 1, 2006)
Published	18 years, 8 months ago (Dec. 1, 2006)
Published Print	18 years, 8 months ago (Dec. 1, 2006)

Funders 0

None

BibTeX

@article{Cheeseman_2006, title={The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore}, volume={127}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2006.09.039}, DOI={10.1016/j.cell.2006.09.039}, number={5}, journal={Cell}, publisher={Elsevier BV}, author={Cheeseman, Iain M. and Chappie, Joshua S. and Wilson-Kubalek, Elizabeth M. and Desai, Arshad}, year={2006}, month=dec, pages={983–997} }

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