DOI: 10.1016/j.cell.2005.10.025. Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex

Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex

10.1016/j.cell.2005.10.025

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Keogh, M.-C., Kurdistani, S. K., Morris, S. A., Ahn, S. H., Podolny, V., Collins, S. R., Schuldiner, M., Chin, K., Punna, T., Thompson, N. J., Boone, C., Emili, A., Weissman, J. S., Hughes, T. R., Strahl, B. D., Grunstein, M., Greenblatt, J. F., Buratowski, S., & Krogan, N. J. (2005). Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex. Cell, 123(4), 593â605.

Authors 19

Michael-Christopher Keogh (first)
Siavash K. Kurdistani (additional)
Stephanie A. Morris (additional)
Seong Hoon Ahn (additional)
Vladimir Podolny (additional)
Sean R. Collins (additional)
Maya Schuldiner (additional)
Kayu Chin (additional)
Thanuja Punna (additional)
Natalie J. Thompson (additional)
Charles Boone (additional)
Andrew Emili (additional)
Jonathan S. Weissman (additional)
Timothy R. Hughes (additional)
Brian D. Strahl (additional)
Michael Grunstein (additional)
Jack F. Greenblatt (additional)
Stephen Buratowski (additional)
Nevan J. Krogan (additional)

References 84 Referenced 686

10.1128/MCB.12.9.4142 / Mol. Cell. Biol. / Genetic interaction between transcription elongation factor TFIIS and RNA polymerase II by Archambault (1992)
10.1093/emboj/19.14.3739 / EMBO J. / Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase by Arevalo-Rodriguez (2000)
10.1038/35065138 / Nature / Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain by Bannister (2001)
10.1073/pnas.250477697 / Proc. Natl. Acad. Sci. USA / Genomewide studies of histone deacetylase function in yeast by Bernstein (2000)
10.1101/gad.940201 / Genes Dev. / Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae by Briggs (2001)
10.1101/gad.8.9.1087 / Genes Dev. / Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae by Burns (1994)
10.1038/nbt0202-163 / Nat. Biotechnol. / De novo peptide sequencing and quantitative profiling of complex protein mixtures using mass-coded abundance tagging by Cagney (2002)
10.1016/j.cell.2005.10.023 / Cell / Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription by Carrozza (2005)
10.1074/jbc.M405033200 / J. Biol. Chem. / Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1–10 by Carvin (2004)
10.1074/jbc.M111433200 / J. Biol. Chem. / Screening the yeast “disruptome” for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid by Desmoucelles (2002)
10.1074/jbc.M008159200 / J. Biol. Chem. / The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation by Eisen (2001)
10.1016/S1097-2765(01)00150-2 / Mol. Cell / Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1 by Emili (2001)
10.1007/BF00351735 / Curr. Genet. / 6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae by Exinger (1992)
10.1093/emboj/cdf590 / EMBO J. / The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores by Fischer (2002)
10.1016/S0962-8924(98)01263-X / Trends Cell Biol. / The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes by Grant (1998)
10.1093/nar/gkh878 / Nucleic Acids Res. / A high resolution protein interaction map of the yeast mediator complex by Guglielmi (2004)
10.1016/S0092-8674(03)00360-X / Cell / Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation by Hampsey (2003)
10.1098/rstb.1999.0495 / Philos. Trans. R. Soc. Lond. B Biol. Sci. / The Saccharomyces cerevisiae ubiquitin-proteasome system by Hochstrasser (1999)
10.1016/S0092-8674(00)00015-5 / Cell / Functional discovery via a compendium of expression profiles by Hughes (2000)
10.1126/science.1069473 / Science / Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail by Jacobs (2002)
10.1093/emboj/20.18.5232 / EMBO J. / Specificity of the HP1 chromodomain for the methylated N-terminus of histone H3 by Jacobs (2001)
10.1016/S0092-8674(00)80217-2 / Cell / Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters by Kadosh (1997)
10.1128/MCB.18.9.5121 / Mol. Cell. Biol. / Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo by Kadosh (1998)
10.1126/science.1087374 / Science / Transcription elongation factors repress transcription intiation from cryptic sites by Kaplan (2003)
{'key': '10.1016/j.cell.2005.10.025_bib25', 'first-page': '1', 'article-title': 'Using chromatin immunoprecipitation to map co-transcriptional mRNA processing in Saccharomyces cerevisiae', 'volume': '257', 'author': 'Keogh', 'year': '2004', 'journal-title': 'Methods Mol. Biol.'} / Methods Mol. Biol. / Using chromatin immunoprecipitation to map co-transcriptional mRNA processing in Saccharomyces cerevisiae by Keogh (2004)
10.1128/MCB.22.5.1288-1297.2002 / Mol. Cell. Biol. / Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation by Keogh (2002)
10.1128/MCB.23.19.7005-7018.2003 / Mol. Cell. Biol. / Bur1 kinase is required for efficient transcription elongation by RNA polymerase II by Keogh (2003)
Keogh, M.-C., Kim, J.A., Downey, M., Fillingham, J., Chowdhury, D., Harrison, J.C., Onishi, M., Datta, N., Galicia, S., Emili, A., et al. (2005). A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery. Nature, in press. (10.1038/nature04384)
10.1128/MCB.25.8.3305-3316.2005 / Mol. Cell. Biol. / A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation by Kizer (2005)
10.1371/journal.pbio.0020131 / PLoS Biol. / A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin by Kobor (2004)
10.1016/S0959-437X(02)00287-3 / Curr. Opin. Genet. Dev. / Histone methylation in transcriptional control by Kouzarides (2002)
10.1128/MCB.21.23.8203-8212.2001 / Mol. Cell. Biol. / Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae by Krogan (2001)
10.1074/jbc.C200023200 / J. Biol. Chem. / COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression by Krogan (2002)
10.1128/MCB.22.20.6979-6992.2002 / Mol. Cell. Biol. / RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach by Krogan (2002)
10.1016/S1097-2765(03)00091-1 / Mol. Cell / The Paf1 complex is required for Histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation by Krogan (2003)
10.1016/S1097-2765(03)00497-0 / Mol. Cell / A Snf2-family ATPase complex required for recruitment of the histone H2A variant Htz1 by Krogan (2003)
10.1128/MCB.23.12.4207-4218.2003 / Mol. Cell. Biol. / Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II by Krogan (2003)
10.1073/pnas.0405753101 / Proc. Natl. Acad. Sci. USA / Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4 by Krogan (2004)
10.1016/j.molcel.2004.11.033 / Mol. Cell / Proteasome involvement in the repair of DNA double-strand breaks by Krogan (2004)
10.1016/S1046-2023(03)00092-6 / Methods / In vivo protein-protein and protein-DNA crosslinking for genomewide binding microarray by Kurdistani (2003)
10.1038/ng907 / Nat. Genet. / Genome-wide binding map of the histone deacetylase Rpd3 in yeast by Kurdistani (2002)
{'key': '10.1016/j.cell.2005.10.025_bib42', 'first-page': '286', 'article-title': 'The many faces of histone lysine methylation', 'volume': '14', 'author': 'Lachner', 'year': '2002', 'journal-title': 'Curr. Opin. Genet. Dev.'} / Curr. Opin. Genet. Dev. / The many faces of histone lysine methylation by Lachner (2002)
10.1038/35065132 / Nature / Methylation of histone H3 lysine 9 contains a binding site for HP1 proteins by Lachner (2001)
10.1016/j.cub.2005.07.028 / Curr. Biol. / BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex by Laribee (2005)
10.1074/jbc.M005730200 / J. Biol. Chem. / Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3-Rpd3 histone deacetylase complex and is required for histone deacetylase activity by Lechner (2000)
10.1128/MCB.18.10.5771 / Mol. Cell. Biol. / Mutations in RNA polymerase II and elongation factor SII severely reduce mRNA levels in Saccharomyces cerevisiae by Lennon (1998)
10.1074/jbc.M212134200 / J. Biol. Chem. / The Set2 histone methyltransferase functions through the phosphorylated CTD of RNA polymerase II by Li (2003)
10.1074/jbc.M209294200 / J. Biol. Chem. / Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation by Li (2002)
10.1074/jbc.C100274200 / J. Biol. Chem. / A multiprotein complex that interacts with RNA polymerase II elongator by Li (2001)
10.1074/jbc.M409046200 / J. Biol. Chem. / The Soh1/Med31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae mediator by Linder (2004)
10.1074/jbc.M102176200 / J. Biol. Chem. / Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae by Loewith (2001)
10.1126/science.1090701 / Science / ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex by Mizuguchi (2004)
10.1016/j.molcel.2005.05.009 / Mol. Cell / Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription by Morillon (2005)
10.1128/MCB.22.7.1971-1980.2002 / Mol. Cell. Biol. / Ctr9, Paf1 and Leo1 are components of the Paf1 / RNA polymerase II complex by Mueller (2002)
10.1128/MCB.21.13.4089-4096.2001 / Mol. Cell. Biol. / Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase by Murray (2001)
10.1101/gad.1001502 / Genes Dev. / Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association by Ng (2002)
10.1016/S1097-2765(03)00092-3 / Mol. Cell / Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity by Ng (2003)
10.1038/nature722 / Nature / Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 by Nielsen (2002)
10.1091/mbc.8.12.2421 / Mol. Biol. Cell / SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes by Nislow (1997)
10.1101/gad.207401 / Genes Dev. / The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program by Pijnappel (2001)
10.1038/nature03242 / Nature / Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation by Pray-Grant (2005)
10.1074/jbc.M313463200 / J. Biol. Chem. / Cti6 is an Rpd3-Sin3 histone deacetylase associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae by Puig (2004)
10.1128/MCB.24.2.757-764.2004 / Mol. Cell. Biol. / Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae by Reid (2004)
10.1038/13732 / Nat. Biotechnol. / A generic protein purification method for protein complex characterisation and proteome exploration by Rigaut (1999)
10.1038/33952 / Nature / Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3 by Rundlett (1998)
10.1093/nar/gkg372 / Nucleic Acids Res. / The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation by Schaft (2003)
10.1016/j.cell.2005.08.031 / Cell / Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile by Schuldiner (2005)
10.1093/emboj/cdg179 / EMBO J. / Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes by Simic (2003)
10.1093/emboj/21.7.1764 / EMBO J. / The Paf1 complex physically and functionally associates with transcription elongation factors in vivo by Squazzo (2002)
10.1128/MCB.17.8.4490 / Mol. Cell. Biol. / Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiae by Stolinski (1997)
10.1038/47412 / Nature / The language of covalent histone modifications by Strahl (2000)
10.1016/S1097-2765(01)00301-X / Mol. Cell / Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin by Suka (2001)
10.1038/ng1017 / Nat. Genet. / Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine 16 and spreading of heterochromatin by Suka (2002)
10.1038/nature00883 / Nature / Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast by Sun (2002)
10.1093/genetics/152.3.921 / Genetics / A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae by Sun (1999)
10.1126/science.1065810 / Science / Systematic genetic analysis with ordered arrays of yeast deletion mutants by Tong (2001)
10.1126/science.1091317 / Science / Global mapping of the yeast genetic interaction network by Tong (2004)
10.1016/S0092-8674(02)00759-6 / Cell / Dot1p modulates silencing in yeast by methylation of the nucleosome core by van Leeuwen (2002)
10.1126/science.1077790 / Science / Requirement of Hos2 histone deacetylase for gene activity in yeast by Wang (2002)
10.1074/jbc.M105303200 / J. Biol. Chem. / RNA polymerase II elongator holoenzyme is composed of two discrete subunits by Winkler (2001)
10.1016/S1097-2765(00)80194-X / Mol. Cell / A novel histone acetyltransferase is an integral part of elongating RNA polymerase II holoenzyme by Wittschieben (1999)
10.1101/gad.1055503 / Genes Dev. / Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast by Xiao (2003)
10.1128/MCB.25.2.637-651.2005 / Mol. Cell. Biol. / Histone H2B ubiquitylation is associated with elongating RNA polymerase II by Xiao (2005)
10.1093/emboj/17.11.3155 / EMBO J. / Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of Gcn5p acetyltransferase by Zhang (1998)

Dates

Type	When
Created	19 years, 9 months ago (Nov. 18, 2005, 7:15 a.m.)
Deposited	4 years, 1 month ago (July 19, 2021, 9:23 p.m.)
Indexed	1 month, 2 weeks ago (July 2, 2025, 3:08 p.m.)
Issued	19 years, 9 months ago (Nov. 1, 2005)
Published	19 years, 9 months ago (Nov. 1, 2005)
Published Print	19 years, 9 months ago (Nov. 1, 2005)

Funders 0

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BibTeX

@article{Keogh_2005, title={Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex}, volume={123}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2005.10.025}, DOI={10.1016/j.cell.2005.10.025}, number={4}, journal={Cell}, publisher={Elsevier BV}, author={Keogh, Michael-Christopher and Kurdistani, Siavash K. and Morris, Stephanie A. and Ahn, Seong Hoon and Podolny, Vladimir and Collins, Sean R. and Schuldiner, Maya and Chin, Kayu and Punna, Thanuja and Thompson, Natalie J. and Boone, Charles and Emili, Andrew and Weissman, Jonathan S. and Hughes, Timothy R. and Strahl, Brian D. and Grunstein, Michael and Greenblatt, Jack F. and Buratowski, Stephen and Krogan, Nevan J.}, year={2005}, month=nov, pages={593–605} }

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      "author": "Archambault",
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      "volume": "19",
      "author": "Arevalo-Rodriguez",
      "year": "2000",
      "journal-title": "EMBO J."
    },
    {
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      "first-page": "120",
      "DOI": "10.1038/35065138",
      "article-title": "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain",
      "volume": "410",
      "author": "Bannister",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
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      "first-page": "13708",
      "DOI": "10.1073/pnas.250477697",
      "article-title": "Genomewide studies of histone deacetylase function in yeast",
      "volume": "97",
      "author": "Bernstein",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "3286",
      "DOI": "10.1101/gad.940201",
      "article-title": "Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae",
      "volume": "15",
      "author": "Briggs",
      "year": "2001",
      "journal-title": "Genes Dev."
    },
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      "first-page": "1087",
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      "volume": "8",
      "author": "Burns",
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      "journal-title": "Genes Dev."
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      "DOI": "10.1038/nbt0202-163",
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      "volume": "20",
      "author": "Cagney",
      "year": "2002",
      "journal-title": "Nat. Biotechnol."
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      "article-title": "Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription",
      "volume": "123",
      "author": "Carrozza",
      "year": "2005",
      "journal-title": "Cell"
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      "DOI": "10.1074/jbc.M405033200",
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      "volume": "279",
      "author": "Carvin",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
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      "doi-asserted-by": "crossref",
      "first-page": "27036",
      "DOI": "10.1074/jbc.M111433200",
      "article-title": "Screening the yeast \u201cdisruptome\u201d for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid",
      "volume": "277",
      "author": "Desmoucelles",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "3484",
      "DOI": "10.1074/jbc.M008159200",
      "article-title": "The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation",
      "volume": "276",
      "author": "Eisen",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1016/S1097-2765(01)00150-2",
      "article-title": "Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1",
      "volume": "7",
      "author": "Emili",
      "year": "2001",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1007/BF00351735",
      "article-title": "6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae",
      "volume": "22",
      "author": "Exinger",
      "year": "1992",
      "journal-title": "Curr. Genet."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "5843",
      "DOI": "10.1093/emboj/cdf590",
      "article-title": "The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores",
      "volume": "21",
      "author": "Fischer",
      "year": "2002",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1016/S0962-8924(98)01263-X",
      "article-title": "The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes",
      "volume": "8",
      "author": "Grant",
      "year": "1998",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "5379",
      "DOI": "10.1093/nar/gkh878",
      "article-title": "A high resolution protein interaction map of the yeast mediator complex",
      "volume": "32",
      "author": "Guglielmi",
      "year": "2004",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "429",
      "DOI": "10.1016/S0092-8674(03)00360-X",
      "article-title": "Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation",
      "volume": "113",
      "author": "Hampsey",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1513",
      "DOI": "10.1098/rstb.1999.0495",
      "article-title": "The Saccharomyces cerevisiae ubiquitin-proteasome system",
      "volume": "354",
      "author": "Hochstrasser",
      "year": "1999",
      "journal-title": "Philos. Trans. R. Soc. Lond. B Biol. Sci."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1016/S0092-8674(00)00015-5",
      "article-title": "Functional discovery via a compendium of expression profiles",
      "volume": "102",
      "author": "Hughes",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "2080",
      "DOI": "10.1126/science.1069473",
      "article-title": "Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail",
      "volume": "295",
      "author": "Jacobs",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "5232",
      "DOI": "10.1093/emboj/20.18.5232",
      "article-title": "Specificity of the HP1 chromodomain for the methylated N-terminus of histone H3",
      "volume": "20",
      "author": "Jacobs",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1016/S0092-8674(00)80217-2",
      "article-title": "Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters",
      "volume": "89",
      "author": "Kadosh",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "5121",
      "DOI": "10.1128/MCB.18.9.5121",
      "article-title": "Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo",
      "volume": "18",
      "author": "Kadosh",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "1096",
      "DOI": "10.1126/science.1087374",
      "article-title": "Transcription elongation factors repress transcription intiation from cryptic sites",
      "volume": "301",
      "author": "Kaplan",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib25",
      "first-page": "1",
      "article-title": "Using chromatin immunoprecipitation to map co-transcriptional mRNA processing in Saccharomyces cerevisiae",
      "volume": "257",
      "author": "Keogh",
      "year": "2004",
      "journal-title": "Methods Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "1288",
      "DOI": "10.1128/MCB.22.5.1288-1297.2002",
      "article-title": "Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation",
      "volume": "22",
      "author": "Keogh",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "7005",
      "DOI": "10.1128/MCB.23.19.7005-7018.2003",
      "article-title": "Bur1 kinase is required for efficient transcription elongation by RNA polymerase II",
      "volume": "23",
      "author": "Keogh",
      "year": "2003",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib28",
      "doi-asserted-by": "crossref",
      "unstructured": "Keogh, M.-C., Kim, J.A., Downey, M., Fillingham, J., Chowdhury, D., Harrison, J.C., Onishi, M., Datta, N., Galicia, S., Emili, A., et al. (2005). A phosphatase complex that dephosphorylates \u03b3H2AX regulates DNA damage checkpoint recovery. Nature, in press.",
      "DOI": "10.1038/nature04384"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "3305",
      "DOI": "10.1128/MCB.25.8.3305-3316.2005",
      "article-title": "A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation",
      "volume": "25",
      "author": "Kizer",
      "year": "2005",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "587",
      "DOI": "10.1371/journal.pbio.0020131",
      "article-title": "A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin",
      "volume": "2",
      "author": "Kobor",
      "year": "2004",
      "journal-title": "PLoS Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "198",
      "DOI": "10.1016/S0959-437X(02)00287-3",
      "article-title": "Histone methylation in transcriptional control",
      "volume": "12",
      "author": "Kouzarides",
      "year": "2002",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "8203",
      "DOI": "10.1128/MCB.21.23.8203-8212.2001",
      "article-title": "Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae",
      "volume": "21",
      "author": "Krogan",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "10753",
      "DOI": "10.1074/jbc.C200023200",
      "article-title": "COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression",
      "volume": "277",
      "author": "Krogan",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "6979",
      "DOI": "10.1128/MCB.22.20.6979-6992.2002",
      "article-title": "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach",
      "volume": "22",
      "author": "Krogan",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "721",
      "DOI": "10.1016/S1097-2765(03)00091-1",
      "article-title": "The Paf1 complex is required for Histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation",
      "volume": "11",
      "author": "Krogan",
      "year": "2003",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1565",
      "DOI": "10.1016/S1097-2765(03)00497-0",
      "article-title": "A Snf2-family ATPase complex required for recruitment of the histone H2A variant Htz1",
      "volume": "12",
      "author": "Krogan",
      "year": "2003",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "4207",
      "DOI": "10.1128/MCB.23.12.4207-4218.2003",
      "article-title": "Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II",
      "volume": "23",
      "author": "Krogan",
      "year": "2003",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "13513",
      "DOI": "10.1073/pnas.0405753101",
      "article-title": "Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4",
      "volume": "101",
      "author": "Krogan",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "1027",
      "DOI": "10.1016/j.molcel.2004.11.033",
      "article-title": "Proteasome involvement in the repair of DNA double-strand breaks",
      "volume": "16",
      "author": "Krogan",
      "year": "2004",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "90",
      "DOI": "10.1016/S1046-2023(03)00092-6",
      "article-title": "In vivo protein-protein and protein-DNA crosslinking for genomewide binding microarray",
      "volume": "31",
      "author": "Kurdistani",
      "year": "2003",
      "journal-title": "Methods"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1038/ng907",
      "article-title": "Genome-wide binding map of the histone deacetylase Rpd3 in yeast",
      "volume": "31",
      "author": "Kurdistani",
      "year": "2002",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib42",
      "first-page": "286",
      "article-title": "The many faces of histone lysine methylation",
      "volume": "14",
      "author": "Lachner",
      "year": "2002",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "116",
      "DOI": "10.1038/35065132",
      "article-title": "Methylation of histone H3 lysine 9 contains a binding site for HP1 proteins",
      "volume": "410",
      "author": "Lachner",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "1487",
      "DOI": "10.1016/j.cub.2005.07.028",
      "article-title": "BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex",
      "volume": "15",
      "author": "Laribee",
      "year": "2005",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "40961",
      "DOI": "10.1074/jbc.M005730200",
      "article-title": "Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3-Rpd3 histone deacetylase complex and is required for histone deacetylase activity",
      "volume": "275",
      "author": "Lechner",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "5771",
      "DOI": "10.1128/MCB.18.10.5771",
      "article-title": "Mutations in RNA polymerase II and elongation factor SII severely reduce mRNA levels in Saccharomyces cerevisiae",
      "volume": "18",
      "author": "Lennon",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "8897",
      "DOI": "10.1074/jbc.M212134200",
      "article-title": "The Set2 histone methyltransferase functions through the phosphorylated CTD of RNA polymerase II",
      "volume": "278",
      "author": "Li",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "49383",
      "DOI": "10.1074/jbc.M209294200",
      "article-title": "Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation",
      "volume": "277",
      "author": "Li",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "29628",
      "DOI": "10.1074/jbc.C100274200",
      "article-title": "A multiprotein complex that interacts with RNA polymerase II elongator",
      "volume": "276",
      "author": "Li",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "49455",
      "DOI": "10.1074/jbc.M409046200",
      "article-title": "The Soh1/Med31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae mediator",
      "volume": "279",
      "author": "Linder",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "24068",
      "DOI": "10.1074/jbc.M102176200",
      "article-title": "Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae",
      "volume": "276",
      "author": "Loewith",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "343",
      "DOI": "10.1126/science.1090701",
      "article-title": "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex",
      "volume": "303",
      "author": "Mizuguchi",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "723",
      "DOI": "10.1016/j.molcel.2005.05.009",
      "article-title": "Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription",
      "volume": "18",
      "author": "Morillon",
      "year": "2005",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "1971",
      "DOI": "10.1128/MCB.22.7.1971-1980.2002",
      "article-title": "Ctr9, Paf1 and Leo1 are components of the Paf1 / RNA polymerase II complex",
      "volume": "22",
      "author": "Mueller",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "4089",
      "DOI": "10.1128/MCB.21.13.4089-4096.2001",
      "article-title": "Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase",
      "volume": "21",
      "author": "Murray",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "1518",
      "DOI": "10.1101/gad.1001502",
      "article-title": "Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association",
      "volume": "16",
      "author": "Ng",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "709",
      "DOI": "10.1016/S1097-2765(03)00092-3",
      "article-title": "Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity",
      "volume": "11",
      "author": "Ng",
      "year": "2003",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1038/nature722",
      "article-title": "Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9",
      "volume": "416",
      "author": "Nielsen",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "2421",
      "DOI": "10.1091/mbc.8.12.2421",
      "article-title": "SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes",
      "volume": "8",
      "author": "Nislow",
      "year": "1997",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "2991",
      "DOI": "10.1101/gad.207401",
      "article-title": "The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program",
      "volume": "15",
      "author": "Pijnappel",
      "year": "2001",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "434",
      "DOI": "10.1038/nature03242",
      "article-title": "Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation",
      "volume": "433",
      "author": "Pray-Grant",
      "year": "2005",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "30298",
      "DOI": "10.1074/jbc.M313463200",
      "article-title": "Cti6 is an Rpd3-Sin3 histone deacetylase associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae",
      "volume": "279",
      "author": "Puig",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "757",
      "DOI": "10.1128/MCB.24.2.757-764.2004",
      "article-title": "Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae",
      "volume": "24",
      "author": "Reid",
      "year": "2004",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "1030",
      "DOI": "10.1038/13732",
      "article-title": "A generic protein purification method for protein complex characterisation and proteome exploration",
      "volume": "17",
      "author": "Rigaut",
      "year": "1999",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1038/33952",
      "article-title": "Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3",
      "volume": "392",
      "author": "Rundlett",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "2475",
      "DOI": "10.1093/nar/gkg372",
      "article-title": "The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation",
      "volume": "31",
      "author": "Schaft",
      "year": "2003",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1016/j.cell.2005.08.031",
      "article-title": "Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile",
      "volume": "123",
      "author": "Schuldiner",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "1846",
      "DOI": "10.1093/emboj/cdg179",
      "article-title": "Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes",
      "volume": "22",
      "author": "Simic",
      "year": "2003",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "1764",
      "DOI": "10.1093/emboj/21.7.1764",
      "article-title": "The Paf1 complex physically and functionally associates with transcription elongation factors in vivo",
      "volume": "21",
      "author": "Squazzo",
      "year": "2002",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "4490",
      "DOI": "10.1128/MCB.17.8.4490",
      "article-title": "Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiae",
      "volume": "17",
      "author": "Stolinski",
      "year": "1997",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1038/47412",
      "article-title": "The language of covalent histone modifications",
      "volume": "403",
      "author": "Strahl",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1016/S1097-2765(01)00301-X",
      "article-title": "Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin",
      "volume": "8",
      "author": "Suka",
      "year": "2001",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "378",
      "DOI": "10.1038/ng1017",
      "article-title": "Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine 16 and spreading of heterochromatin",
      "volume": "32",
      "author": "Suka",
      "year": "2002",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "104",
      "DOI": "10.1038/nature00883",
      "article-title": "Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast",
      "volume": "418",
      "author": "Sun",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1093/genetics/152.3.921",
      "article-title": "A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae",
      "volume": "152",
      "author": "Sun",
      "year": "1999",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "2364",
      "DOI": "10.1126/science.1065810",
      "article-title": "Systematic genetic analysis with ordered arrays of yeast deletion mutants",
      "volume": "294",
      "author": "Tong",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "808",
      "DOI": "10.1126/science.1091317",
      "article-title": "Global mapping of the yeast genetic interaction network",
      "volume": "303",
      "author": "Tong",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "745",
      "DOI": "10.1016/S0092-8674(02)00759-6",
      "article-title": "Dot1p modulates silencing in yeast by methylation of the nucleosome core",
      "volume": "109",
      "author": "van Leeuwen",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "1412",
      "DOI": "10.1126/science.1077790",
      "article-title": "Requirement of Hos2 histone deacetylase for gene activity in yeast",
      "volume": "298",
      "author": "Wang",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "32743",
      "DOI": "10.1074/jbc.M105303200",
      "article-title": "RNA polymerase II elongator holoenzyme is composed of two discrete subunits",
      "volume": "276",
      "author": "Winkler",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib81",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1016/S1097-2765(00)80194-X",
      "article-title": "A novel histone acetyltransferase is an integral part of elongating RNA polymerase II holoenzyme",
      "volume": "4",
      "author": "Wittschieben",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "654",
      "DOI": "10.1101/gad.1055503",
      "article-title": "Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast",
      "volume": "17",
      "author": "Xiao",
      "year": "2003",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib83",
      "doi-asserted-by": "crossref",
      "first-page": "637",
      "DOI": "10.1128/MCB.25.2.637-651.2005",
      "article-title": "Histone H2B ubiquitylation is associated with elongating RNA polymerase II",
      "volume": "25",
      "author": "Xiao",
      "year": "2005",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.cell.2005.10.025_bib84",
      "doi-asserted-by": "crossref",
      "first-page": "3155",
      "DOI": "10.1093/emboj/17.11.3155",
      "article-title": "Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of Gcn5p acetyltransferase",
      "volume": "17",
      "author": "Zhang",
      "year": "1998",
      "journal-title": "EMBO J."
    }
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