DOI: 10.1016/j.cell.2005.04.010. Multiple Mechanisms Confining RNA Polymerase II Ubiquitylation to Polymerases Undergoing Transcriptional Arrest

Multiple Mechanisms Confining RNA Polymerase II Ubiquitylation to Polymerases Undergoing Transcriptional Arrest

10.1016/j.cell.2005.04.010

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Somesh, B. P., Reid, J., Liu, W.-F., SÃ¸gaard, T. M. M., Erdjument-Bromage, H., Tempst, P., & Svejstrup, J. Q. (2005). Multiple Mechanisms Confining RNA Polymerase II Ubiquitylation to Polymerases Undergoing Transcriptional Arrest. Cell, 121(6), 913â923.

Authors 7

Baggavalli P. Somesh (first)
James Reid (additional)
Wei-Feng Liu (additional)
T. Max M. Søgaard (additional)
Hediye Erdjument-Bromage (additional)
Paul Tempst (additional)
Jesper Q. Svejstrup (additional)

References 43 Referenced 189

10.1016/j.tig.2003.08.008 / Trends Genet. / Running with RNA polymerase: eukaryotic transcript elongation by Arndt (2003)
10.1074/jbc.272.23.14747 / J. Biol. Chem. / Transcription elongation through DNA arrest sites. A multistep process involving both RNA polymerase II subunit RPB9 and TFIIS by Awrey (1997)
10.1128/MCB.19.10.6972 / Mol. Cell. Biol. / Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae by Beaudenon (1999)
10.1016/0092-8674(85)90150-3 / Cell / DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall by Bohr (1985)
10.1073/pnas.93.21.11586 / Proc. Natl. Acad. Sci. USA / UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells by Bregman (1996)
10.1101/gad.935901 / Genes Dev. / Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain by Cho (2001)
10.1126/science.1059493 / Science / Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution by Cramer (2001)
10.1073/pnas.87.6.2122 / Proc. Natl. Acad. Sci. USA / Purification and lipid-layer crystallization of yeast RNA polymerase II by Edwards (1990)
10.1016/0092-8674(91)90298-D / Cell / CTD kinase associated with yeast RNA polymerase II initiation factor b by Feaver (1991)
10.1016/S1097-2765(01)00250-7 / Mol. Cell / The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II by Ferdous (2001)
10.1074/jbc.272.39.24105 / J. Biol. Chem. / Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II by Gavva (1997)
10.1073/pnas.0305411101 / Proc. Natl. Acad. Sci. USA / Physical and functional association of RNA polymerase II and the proteasome by Gillette (2004)
10.1126/science.1059495 / Science / Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution by Gnatt (2001)
10.1016/S0092-8674(03)00316-7 / Cell / The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage by Groisman (2003)
10.1016/S0021-9258(20)88252-0 / J. Biol. Chem. / Localization of DNA repair synthesis by human cell extracts to a short region at the site of a lesion by Hansson (1989)
10.1016/0092-8674(95)90028-4 / Cell / The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH by Henning (1995)
10.1073/pnas.94.8.3656 / Proc. Natl. Acad. Sci. USA / The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase by Huibregtse (1997)
10.1074/jbc.M402218200 / J. Biol. Chem. / C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats by Jones (2004)
10.1074/jbc.275.9.6530 / J. Biol. Chem. / The 8-nucleotide-long RNA:DNA hybrid is a primary stability determinant of the RNA polymerase II elongation complex by Kireeva (2000)
10.1016/S1097-2765(00)80187-2 / Mol. Cell / An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae by Kobor (1999)
10.1101/gad.824700 / Genes Dev. / Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription by Komarnitsky (2000)
10.1016/S1097-2765(04)00235-7 / Mol. Cell / Ssu72 Is an RNA polymerase II CTD phosphatase by Krishnamurthy (2004)
10.1073/pnas.072068399 / Proc. Natl. Acad. Sci. USA / Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro by Lee (2002)
10.1073/pnas.91.6.2362 / Proc. Natl. Acad. Sci. USA / Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II by Li (1994)
10.1016/S0921-8777(01)00097-0 / Mutat. Res. / Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation by Luo (2001)
10.1073/pnas.96.11.6054 / Proc. Natl. Acad. Sci. USA / Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain by Mitsui (1999)
10.1038/nbt849 / Nat. Biotechnol. / A proteomics approach to understanding protein ubiquitination by Peng (2003)
10.1016/S0968-0004(00)01681-9 / Trends Biochem. Sci. / Ubiquitin in chains by Pickart (2000)
10.1146/annurev.biochem.70.1.503 / Annu. Rev. Biochem. / Mechanisms underlying ubiquitination by Pickart (2001)
10.1074/jbc.273.9.5184 / J. Biol. Chem. / Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair by Ratner (1998)
10.1074/jbc.C400185200 / J. Biol. Chem. / DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro by Reid (2004)
10.1038/13732 / Nat. Biotechnol. / A generic protein purification method for protein complex characterization and proteome exploration by Rigaut (1999)
10.1002/j.1460-2075.1990.tb08141.x / EMBO J. / Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins by Seufert (1990)
{'key': '10.1016/j.cell.2005.04.010_bib34', 'series-title': 'Guide to Yeast Genetics and Molecular Biology', 'first-page': '3', 'article-title': 'Getting started with yeast', 'author': 'Sherman', 'year': '1991'} / Guide to Yeast Genetics and Molecular Biology / Getting started with yeast by Sherman (1991)
10.1016/S0092-8674(00)00011-8 / Cell / Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain by Spence (2000)
10.1038/nrm703 / Nat. Rev. Mol. Cell Biol. / Mechanisms of transcription-coupled DNA repair by Svejstrup (2002)
10.1242/jcs.00271 / J. Cell Sci. / Rescue of arrested RNA polymerase II complexes by Svejstrup (2003)
10.1016/j.bbaexp.2003.10.012 / Biochim. Biophys. Acta / The RNA polymerase II transcription cycle: cycling through chromatin by Svejstrup (2004)
10.1074/jbc.273.12.6769 / J. Biol. Chem. / Characterization of the residues phosphorylated in vitro by different C-terminal domain kinases by Trigon (1998)
10.1016/0092-8674(92)90390-X / Cell / ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne’s syndrome and preferential repair of active genes by Troelstra (1992)
10.1002/j.1460-2075.1994.tb06871.x / EMBO J. / RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6 by van Gool (1994)
10.1016/S1046-2023(02)00030-0 / Methods / Isolation and mass spectrometry of transcription factor complexes by Winkler (2002)
10.1038/415929a / Nature / A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage by Woudstra (2002)

Dates

Type	When
Created	20 years, 2 months ago (June 17, 2005, 7:07 p.m.)
Deposited	2 years, 7 months ago (Jan. 28, 2023, 8:33 a.m.)
Indexed	4 days, 21 hours ago (Aug. 31, 2025, 7:19 p.m.)
Issued	20 years, 3 months ago (June 1, 2005)
Published	20 years, 3 months ago (June 1, 2005)
Published Print	20 years, 3 months ago (June 1, 2005)

Funders 0

None

BibTeX

@article{Somesh_2005, title={Multiple Mechanisms Confining RNA Polymerase II Ubiquitylation to Polymerases Undergoing Transcriptional Arrest}, volume={121}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2005.04.010}, DOI={10.1016/j.cell.2005.04.010}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Somesh, Baggavalli P. and Reid, James and Liu, Wei-Feng and Søgaard, T. Max M. and Erdjument-Bromage, Hediye and Tempst, Paul and Svejstrup, Jesper Q.}, year={2005}, month=jun, pages={913–923} }

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      "volume": "15",
      "author": "Cho",
      "year": "2001",
      "journal-title": "Genes Dev."
    },
    {
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      "first-page": "1863",
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      "volume": "292",
      "author": "Cramer",
      "year": "2001",
      "journal-title": "Science"
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    {
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      "DOI": "10.1016/0092-8674(91)90298-D",
      "article-title": "CTD kinase associated with yeast RNA polymerase II initiation factor b",
      "volume": "67",
      "author": "Feaver",
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    {
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      "volume": "14",
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      "DOI": "10.1073/pnas.072068399",
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      "volume": "99",
      "author": "Lee",
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      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "article-title": "Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II",
      "volume": "91",
      "author": "Li",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1016/S0921-8777(01)00097-0",
      "article-title": "Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation",
      "volume": "486",
      "author": "Luo",
      "year": "2001",
      "journal-title": "Mutat. Res."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "6054",
      "DOI": "10.1073/pnas.96.11.6054",
      "article-title": "Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain",
      "volume": "96",
      "author": "Mitsui",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1038/nbt849",
      "article-title": "A proteomics approach to understanding protein ubiquitination",
      "volume": "21",
      "author": "Peng",
      "year": "2003",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "544",
      "DOI": "10.1016/S0968-0004(00)01681-9",
      "article-title": "Ubiquitin in chains",
      "volume": "25",
      "author": "Pickart",
      "year": "2000",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "503",
      "DOI": "10.1146/annurev.biochem.70.1.503",
      "article-title": "Mechanisms underlying ubiquitination",
      "volume": "70",
      "author": "Pickart",
      "year": "2001",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "5184",
      "DOI": "10.1074/jbc.273.9.5184",
      "article-title": "Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair",
      "volume": "273",
      "author": "Ratner",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "29875",
      "DOI": "10.1074/jbc.C400185200",
      "article-title": "DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro",
      "volume": "279",
      "author": "Reid",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "1030",
      "DOI": "10.1038/13732",
      "article-title": "A generic protein purification method for protein complex characterization and proteome exploration",
      "volume": "17",
      "author": "Rigaut",
      "year": "1999",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "543",
      "DOI": "10.1002/j.1460-2075.1990.tb08141.x",
      "article-title": "Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins",
      "volume": "9",
      "author": "Seufert",
      "year": "1990",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib34",
      "series-title": "Guide to Yeast Genetics and Molecular Biology",
      "first-page": "3",
      "article-title": "Getting started with yeast",
      "author": "Sherman",
      "year": "1991"
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1016/S0092-8674(00)00011-8",
      "article-title": "Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain",
      "volume": "102",
      "author": "Spence",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1038/nrm703",
      "article-title": "Mechanisms of transcription-coupled DNA repair",
      "volume": "3",
      "author": "Svejstrup",
      "year": "2002",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1242/jcs.00271",
      "article-title": "Rescue of arrested RNA polymerase II complexes",
      "volume": "116",
      "author": "Svejstrup",
      "year": "2003",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "64",
      "DOI": "10.1016/j.bbaexp.2003.10.012",
      "article-title": "The RNA polymerase II transcription cycle: cycling through chromatin",
      "volume": "1677",
      "author": "Svejstrup",
      "year": "2004",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "6769",
      "DOI": "10.1074/jbc.273.12.6769",
      "article-title": "Characterization of the residues phosphorylated in vitro by different C-terminal domain kinases",
      "volume": "273",
      "author": "Trigon",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1016/0092-8674(92)90390-X",
      "article-title": "ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne\u2019s syndrome and preferential repair of active genes",
      "volume": "71",
      "author": "Troelstra",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "5361",
      "DOI": "10.1002/j.1460-2075.1994.tb06871.x",
      "article-title": "RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6",
      "volume": "13",
      "author": "van Gool",
      "year": "1994",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1016/S1046-2023(02)00030-0",
      "article-title": "Isolation and mass spectrometry of transcription factor complexes",
      "volume": "26",
      "author": "Winkler",
      "year": "2002",
      "journal-title": "Methods"
    },
    {
      "key": "10.1016/j.cell.2005.04.010_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "929",
      "DOI": "10.1038/415929a",
      "article-title": "A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage",
      "volume": "415",
      "author": "Woudstra",
      "year": "2002",
      "journal-title": "Nature"
    }
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