DOI: 10.1016/j.cell.2004.11.042. mRNA Helicase Activity of the Ribosome

mRNA Helicase Activity of the Ribosome

10.1016/j.cell.2004.11.042

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Takyar, S., Hickerson, R. P., & Noller, H. F. (2005). mRNA Helicase Activity of the Ribosome. Cell, 120(1), 49â58.

Authors 3

Seyedtaghi Takyar (first)
Robyn P. Hickerson (additional)
Harry F. Noller (additional)

References 34 Referenced 433

10.1038/10695 / Nat. Struct. Biol. / EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome by Agrawal (1999)
10.1073/pnas.96.25.14177 / Proc. Natl. Acad. Sci. USA / Programmed ribosomal frameshifting by Alam (1999)
10.1111/j.1432-1033.1992.tb17406.x / Eur. J. Biochem. / Isolation and functional analysis of histidine-tagged elongation factor Tu by Boon (1992)
10.1016/0092-8674(89)90124-4 / Cell / Characterization of an efficient coronavirus ribosomal frameshifting signal by Brierley (1989)
Brierley, I., and Pennell, S. (2001). Structure and function of the stimulatory RNAs involved in programmed eukaryotic-1 ribosomal frameshifting. In Cold Spring Harbor Symposia on Quantitative Biology: The Ribosome (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 233–248. (10.1101/sqb.2001.66.233)
10.1017/S1355838299990714 / RNA / Efficient reconstitution of functional Escherichia coli 30S ribosomal subunits from a complete set of recombinant small subunit ribosomal proteins by Culver (1999)
10.1017/S0033583502003864 / Q. Rev. Biophys. / Helicase mechanisms and the coupling of helicases within macromolecular machines. Part II by Delagoutte (2003)
10.1073/pnas.45.4.482 / Proc. Natl. Acad. Sci. USA / Secondary structure in ribonucleic acids by Doty (1959)
10.1111/j.1432-1033.1975.tb02285.x / Eur. J. Biochem. / The secondary structure and poly(A) content of globin messenger RNA as a pure RNA and in polyribosome-derived ribonucleoprotein complexes by Favre (1975)
10.1038/35018597 / Nature / A ratchet-like inter-subunit reorganization of the ribosome during translocation by Frank (2000)
10.1038/376441a0 / Nature / A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome by Frank (1995)
10.1016/S1097-2765(02)00523-3 / Mol. Cell / Accurate translocation of mRNA by the ribosome requires a peptidyl group or its analog on the tRNA moving into the 30S P site by Fredrick (2002)
10.1126/science.1084571 / Science / Catalysis of ribosomal translocation by sparsomycin by Fredrick (2003)
10.1016/0014-5793(71)80177-1 / FEBS Lett. / Stimulation of “non-enzymic” translocation in ribosomes by p-chloromercuribenzoate by Gavrilova (1971)
10.1016/S0076-6879(88)64058-4 / Methods Enzymol. / Extension inhibition analysis of translation initiation complexes by Hartz (1988)
10.1021/bi00690a009 / Biochemistry / Determination of secondary structure in rabbit globin messenger RNA by thermal denaturation by Holder (1975)
10.1093/emboj/17.12.3478 / EMBO J. / EF-G-catalyzed translocation of anticodon stem-loop analogs of transfer RNA in the ribosome by Joseph (1998)
10.1073/pnas.82.2.488 / Proc. Natl. Acad. Sci. USA / Rapid and efficient site-specific mutagenesis without phenotypic selection by Kunkel (1985)
10.1006/jmbi.1993.1644 / J. Mol. Biol. / Sliding clamps of DNA polymerases by Kuriyan (1993)
10.1093/nar/16.8.3405 / Nucleic Acids Res. / An extended RNA/RNA duplex structure within the coding region of mRNA does not block translational elongation by Lingelbach (1988)
10.1038/237082a0 / Nature / Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein by Min Jou (1972)
10.1016/0092-8674(89)90128-1 / Cell / Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites by Moazed (1989)
10.1093/nar/27.14.2957 / Nucleic Acids Res. / Nucleic acid duplex stability by Nakano (1999)
10.1093/emboj/17.24.7490 / EMBO J. / Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E. coli ribosome by Pape (1998)
10.1016/S0021-9258(18)91792-8 / J. Biol. Chem. / Studies on the formation of transfer ribonucleic acid-ribosome complexes. VI. Oligopeptide synthesis and translocation on ribosomes in the presence and absence of soluble transfer factors by Pestka (1969)
10.1016/0300-9084(91)90135-N / Biochimie / How does the mRNA pass through the ribosome? by Shatsky (1991)
10.1016/S0022-2836(02)01196-8 / J. Mol. Biol. / EFG-independent translocation of the mRNA:tRNA complex is promoted by modification of the ribosome with thiol-specific reagents by Southworth (2002)
10.1093/nar/21.8.1713 / Nucleic Acids Res. / Translational control by a long range RNA-RNA interaction; a basepair substitution analysis by van Himbergen (1993)
10.1016/S0092-8674(00)80716-3 / Cell / Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism by Velankar (1999)
10.1016/S0092-8674(01)00203-3 / Cell / A general model for nucleic acid helicases and their “coupling” within macromolecular machines by von Hippel (2001)
10.1038/35030006 / Nature / Structure of the 30S ribosomal subunit by Wimberly (2000)
10.1021/bi9809425 / Biochemistry / Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs by Xia (1998)
10.1073/pnas.76.4.1658 / Proc. Natl. Acad. Sci. USA / Enzyme-catalyzed DNA unwinding by Yarranton (1979)
10.1016/S0092-8674(01)00435-4 / Cell / The path of messenger RNA through the ribosome by Yusupova (2001)

Dates

Type	When
Created	20 years, 7 months ago (Jan. 14, 2005, 2:44 p.m.)
Deposited	4 years, 1 month ago (July 3, 2021, 10:28 p.m.)
Indexed	3 weeks ago (Aug. 6, 2025, 9:09 a.m.)
Issued	20 years, 7 months ago (Jan. 1, 2005)
Published	20 years, 7 months ago (Jan. 1, 2005)
Published Print	20 years, 7 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Takyar_2005, title={mRNA Helicase Activity of the Ribosome}, volume={120}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/j.cell.2004.11.042}, DOI={10.1016/j.cell.2004.11.042}, number={1}, journal={Cell}, publisher={Elsevier BV}, author={Takyar, Seyedtaghi and Hickerson, Robyn P. and Noller, Harry F.}, year={2005}, month=jan, pages={49–58} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T13:09:11Z",
    "timestamp": 1754485751629
  },
  "reference-count": 34,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            1,
            1
          ]
        ],
        "date-time": "2005-01-01T00:00:00Z",
        "timestamp": 1104537600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 3119,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2005,
        1
      ]
    ]
  },
  "DOI": "10.1016/j.cell.2004.11.042",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        1,
        14
      ]
    ],
    "date-time": "2005-01-14T19:44:53Z",
    "timestamp": 1105731893000
  },
  "page": "49-58",
  "source": "Crossref",
  "is-referenced-by-count": 433,
  "title": "mRNA Helicase Activity of the Ribosome",
  "prefix": "10.1016",
  "volume": "120",
  "author": [
    {
      "given": "Seyedtaghi",
      "family": "Takyar",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Robyn P.",
      "family": "Hickerson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Harry F.",
      "family": "Noller",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.cell.2004.11.042_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "643",
      "DOI": "10.1038/10695",
      "article-title": "EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome",
      "volume": "6",
      "author": "Agrawal",
      "year": "1999",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "14177",
      "DOI": "10.1073/pnas.96.25.14177",
      "article-title": "Programmed ribosomal frameshifting",
      "volume": "96",
      "author": "Alam",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1111/j.1432-1033.1992.tb17406.x",
      "article-title": "Isolation and functional analysis of histidine-tagged elongation factor Tu",
      "volume": "210",
      "author": "Boon",
      "year": "1992",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1016/0092-8674(89)90124-4",
      "article-title": "Characterization of an efficient coronavirus ribosomal frameshifting signal",
      "volume": "57",
      "author": "Brierley",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB5",
      "doi-asserted-by": "crossref",
      "unstructured": "Brierley, I., and Pennell, S. (2001). Structure and function of the stimulatory RNAs involved in programmed eukaryotic-1 ribosomal frameshifting. In Cold Spring Harbor Symposia on Quantitative Biology: The Ribosome (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 233\u2013248.",
      "DOI": "10.1101/sqb.2001.66.233"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "832",
      "DOI": "10.1017/S1355838299990714",
      "article-title": "Efficient reconstitution of functional Escherichia coli 30S ribosomal subunits from a complete set of recombinant small subunit ribosomal proteins",
      "volume": "5",
      "author": "Culver",
      "year": "1999",
      "journal-title": "RNA"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1017/S0033583502003864",
      "article-title": "Helicase mechanisms and the coupling of helicases within macromolecular machines. Part II",
      "volume": "36",
      "author": "Delagoutte",
      "year": "2003",
      "journal-title": "Q. Rev. Biophys."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "482",
      "DOI": "10.1073/pnas.45.4.482",
      "article-title": "Secondary structure in ribonucleic acids",
      "volume": "45",
      "author": "Doty",
      "year": "1959",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1111/j.1432-1033.1975.tb02285.x",
      "article-title": "The secondary structure and poly(A) content of globin messenger RNA as a pure RNA and in polyribosome-derived ribonucleoprotein complexes",
      "volume": "57",
      "author": "Favre",
      "year": "1975",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "318",
      "DOI": "10.1038/35018597",
      "article-title": "A ratchet-like inter-subunit reorganization of the ribosome during translocation",
      "volume": "406",
      "author": "Frank",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "441",
      "DOI": "10.1038/376441a0",
      "article-title": "A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome",
      "volume": "376",
      "author": "Frank",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1125",
      "DOI": "10.1016/S1097-2765(02)00523-3",
      "article-title": "Accurate translocation of mRNA by the ribosome requires a peptidyl group or its analog on the tRNA moving into the 30S P site",
      "volume": "9",
      "author": "Fredrick",
      "year": "2002",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1159",
      "DOI": "10.1126/science.1084571",
      "article-title": "Catalysis of ribosomal translocation by sparsomycin",
      "volume": "300",
      "author": "Fredrick",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "324",
      "DOI": "10.1016/0014-5793(71)80177-1",
      "article-title": "Stimulation of \u201cnon-enzymic\u201d translocation in ribosomes by p-chloromercuribenzoate",
      "volume": "17",
      "author": "Gavrilova",
      "year": "1971",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "419",
      "DOI": "10.1016/S0076-6879(88)64058-4",
      "article-title": "Extension inhibition analysis of translation initiation complexes",
      "volume": "164",
      "author": "Hartz",
      "year": "1988",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "4209",
      "DOI": "10.1021/bi00690a009",
      "article-title": "Determination of secondary structure in rabbit globin messenger RNA by thermal denaturation",
      "volume": "14",
      "author": "Holder",
      "year": "1975",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "3478",
      "DOI": "10.1093/emboj/17.12.3478",
      "article-title": "EF-G-catalyzed translocation of anticodon stem-loop analogs of transfer RNA in the ribosome",
      "volume": "17",
      "author": "Joseph",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "488",
      "DOI": "10.1073/pnas.82.2.488",
      "article-title": "Rapid and efficient site-specific mutagenesis without phenotypic selection",
      "volume": "82",
      "author": "Kunkel",
      "year": "1985",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "915",
      "DOI": "10.1006/jmbi.1993.1644",
      "article-title": "Sliding clamps of DNA polymerases",
      "volume": "234",
      "author": "Kuriyan",
      "year": "1993",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "3405",
      "DOI": "10.1093/nar/16.8.3405",
      "article-title": "An extended RNA/RNA duplex structure within the coding region of mRNA does not block translational elongation",
      "volume": "16",
      "author": "Lingelbach",
      "year": "1988",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "82",
      "DOI": "10.1038/237082a0",
      "article-title": "Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein",
      "volume": "237",
      "author": "Min Jou",
      "year": "1972",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "585",
      "DOI": "10.1016/0092-8674(89)90128-1",
      "article-title": "Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites",
      "volume": "57",
      "author": "Moazed",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "2957",
      "DOI": "10.1093/nar/27.14.2957",
      "article-title": "Nucleic acid duplex stability",
      "volume": "27",
      "author": "Nakano",
      "year": "1999",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "7490",
      "DOI": "10.1093/emboj/17.24.7490",
      "article-title": "Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E. coli ribosome",
      "volume": "17",
      "author": "Pape",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1533",
      "DOI": "10.1016/S0021-9258(18)91792-8",
      "article-title": "Studies on the formation of transfer ribonucleic acid-ribosome complexes. VI. Oligopeptide synthesis and translocation on ribosomes in the presence and absence of soluble transfer factors",
      "volume": "244",
      "author": "Pestka",
      "year": "1969",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "937",
      "DOI": "10.1016/0300-9084(91)90135-N",
      "article-title": "How does the mRNA pass through the ribosome?",
      "volume": "73",
      "author": "Shatsky",
      "year": "1991",
      "journal-title": "Biochimie"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1016/S0022-2836(02)01196-8",
      "article-title": "EFG-independent translocation of the mRNA:tRNA complex is promoted by modification of the ribosome with thiol-specific reagents",
      "volume": "324",
      "author": "Southworth",
      "year": "2002",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "1713",
      "DOI": "10.1093/nar/21.8.1713",
      "article-title": "Translational control by a long range RNA-RNA interaction; a basepair substitution analysis",
      "volume": "21",
      "author": "van Himbergen",
      "year": "1993",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1016/S0092-8674(00)80716-3",
      "article-title": "Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism",
      "volume": "97",
      "author": "Velankar",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1016/S0092-8674(01)00203-3",
      "article-title": "A general model for nucleic acid helicases and their \u201ccoupling\u201d within macromolecular machines",
      "volume": "104",
      "author": "von Hippel",
      "year": "2001",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "327",
      "DOI": "10.1038/35030006",
      "article-title": "Structure of the 30S ribosomal subunit",
      "volume": "407",
      "author": "Wimberly",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "14719",
      "DOI": "10.1021/bi9809425",
      "article-title": "Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs",
      "volume": "37",
      "author": "Xia",
      "year": "1998",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1658",
      "DOI": "10.1073/pnas.76.4.1658",
      "article-title": "Enzyme-catalyzed DNA unwinding",
      "volume": "76",
      "author": "Yarranton",
      "year": "1979",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.cell.2004.11.042_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1016/S0092-8674(01)00435-4",
      "article-title": "The path of messenger RNA through the ribosome",
      "volume": "106",
      "author": "Yusupova",
      "year": "2001",
      "journal-title": "Cell"
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867404011468?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867404011468?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        4
      ]
    ],
    "date-time": "2021-07-04T02:28:57Z",
    "timestamp": 1625365737000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867404011468"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2005,
        1
      ]
    ]
  },
  "references-count": 34,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2005,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867404011468"
  ],
  "URL": "http://dx.doi.org/10.1016/j.cell.2004.11.042",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1023383.270703",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1023383.276656",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1023383.285811",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1023383.295716",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2005,
        1
      ]
    ]
  }
}