DOI: 10.1016/j.ceb.2004.06.005. Not just a sink: endosomes in control of signal transduction

Not just a sink: endosomes in control of signal transduction

10.1016/j.ceb.2004.06.005

Crossref journal-article

Elsevier BV

Current Opinion in Cell Biology (78)

Bibliography

Miaczynska, M., Pelkmans, L., & Zerial, M. (2004). Not just a sink: endosomes in control of signal transduction. Current Opinion in Cell Biology, 16(4), 400â406.

Authors 3

Marta Miaczynska (first)
Lucas Pelkmans (additional)
Marino Zerial (additional)

References 73 Referenced 436

10.1038/35052055 / Nat Rev Mol Cell Biol / Rab proteins as membrane organizers by Zerial (2001)
10.1038/35096054 / Nat Rev Mol Cell Biol / The endocytic pathway: a mosaic of domains by Gruenberg (2001)
10.1016/S0092-8674(03)00118-1 / Cell / Membrane domains in the secretory and endocytic pathways by Pfeffer (2003)
10.1006/excr.2001.5401 / Exp Cell Res / Mosaic organization of the endocytic pathway by Miaczynska (2002)
10.1002/j.1460-2075.1994.tb06747.x / EMBO J / Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma by Di Guglielmo (1994)
10.1016/S0962-8924(00)89116-3 / Trends Cell Biol / Compartmentalized signal transduction by receptor tyrosine kinases by Baass (1995)
10.1523/JNEUROSCI.16-24-07950.1996 / J Neurosci / Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes by Grimes (1996)
10.1126/science.274.5295.2086 / Science / Control of EGF receptor signaling by clathrin-mediated endocytosis by Vieira (1996)
10.1074/jbc.273.2.685 / J Biol Chem / Essential role for G-protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase by Daaka (1998)
10.1016/S0960-9822(00)00785-5 / Curr Biol / Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy by Sorkin (2000)
10.1038/nbt0402-370 / Nat Biotechnol / Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors by Schoeberl (2002)
10.1128/MCB.23.16.5803-5815.2003 / Mol Cell Biol / Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling by Pennock (2003)
10.1128/MCB.22.20.7279-7290.2002 / Mol Cell Biol / Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival by Wang (2002)
10.1074/jbc.M311494200 / J Biol Chem / Platelet-derived growth factor receptor-mediated signal transduction from endosomes by Wang (2004)
10.1091/mbc.12.6.1897 / Mol Biol Cell / Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking by Burke (2001)
10.1034/j.1600-0854.2001.020103.x / Traffic / Regulation of receptor tyrosine kinase signaling by endocytic trafficking by Wiley (2001)
10.1016/S0014-4827(03)00002-8 / Exp Cell Res / Trafficking of the ErbB receptors and its influence on signaling by Wiley (2003)
10.1083/jcb.112.1.55 / J Cell Biol / Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathways by Sorkin (1991)
10.1128/MCB.18.9.5042 / Mol Cell Biol / ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner by Olayioye (1998)
10.1128/MCB.19.10.6845 / Mol Cell Biol / Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers by Muthuswamy (1999)
{'key': '10.1016/j.ceb.2004.06.005_BIB21', 'first-page': '1130', 'article-title': 'Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects', 'volume': '63', 'author': 'Hendriks', 'year': '2003', 'journal-title': 'Cancer Res'} / Cancer Res / Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects by Hendriks (2003)
10.1074/jbc.270.9.4334 / J Biol Chem / Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction by French (1995)
10.1046/j.1471-4159.2003.01603.x / J Neurochem / Receptor tyrosine kinase and G-protein-coupled receptor signaling and sorting within endosomes by Grimes (2003)
10.1016/j.lfs.2003.09.008 / Life Sci / Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway by von Zastrow (2003)
10.1126/science.290.5496.1574 / Science / Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 by McDonald (2000)
10.1074/jbc.M313333200 / J Biol Chem / Regulation of angiotensin II type 1A receptor intracellular retention, degradation and recycling by Rab5, Rab7 and Rab11 GTPases by Dale (2004)
10.1074/jbc.275.15.11130 / J Biol Chem / Type-specific sorting of G-protein-coupled receptors after endocytosis by Tsao (2000)
10.1242/jcs.115.3.455 / J Cell Sci / The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals by Luttrell (2002)
10.1038/9048 / Nat Cell Biol / Endocytic vesicles move at the tips of actin tails in cultured mast cells by Merrifield (1999)
10.1083/jcb.148.3.519 / J Cell Biol / Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP by Taunton (2000)
10.1038/ncb935 / Nat Cell Biol / RhoD regulates endosome dynamics through Diaphanous-related formin and Src tyrosine kinase by Gasman (2003)
10.1083/jcb.152.5.959 / J Cell Biol / Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules by Verhey (2001)
10.1042/0264-6021:3500901 / Biochem J / Diffusion control of protein phosphorylation in signal transduction pathways by Kholodenko (2000)
10.1242/jeb.00298 / J Exp Biol / Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors by Kholodenko (2003)
10.1002/neu.10323 / J Neurobiol / Signaling endosome hypothesis: A cellular mechanism for long distance communication by Howe (2004)
10.1016/S0896-6273(03)00397-0 / Neuron / NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals by Delcroix (2003)
10.1016/S0896-6273(03)00266-6 / Neuron / Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons by Ye (2003)
10.1038/nn720 / Nat Neurosci / Neurotrophins use the Erk5 pathway to mediate a retrograde survival response by Watson (2001)
10.1016/S0959-4388(02)00326-4 / Curr Opin Neurobiol / Retrograde neurotrophin signaling: Trk-ing along the axon by Ginty (2002)
10.1002/neu.10322 / J Neurobiol / Retrograde transport of neurotrophins: fact and function by Campenot (2004)
10.1083/jcb.138.2.411 / J Cell Biol / Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures by Senger (1997)
10.1126/science.290.5496.1567 / Science / Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane by Verveer (2000)
10.1126/science.1064913 / Science / Retrograde support of neuronal survival without retrograde transport of nerve growth factor by MacInnis (2002)
10.1016/S0955-0674(02)00370-8 / Curr Opin Cell Biol / T-cell activation: a multidimensional signaling network by Tseng (2002)
10.1146/annurev.cellbio.19.111301.153011 / Annu Rev Cell Dev Biol / Adhesion-dependent cell mechanosensitivity by Bershadsky (2003)
10.1038/42408 / Nature / Functional rafts in cell membranes by Simons (1997)
10.1126/science.1071491 / Science / Cell biology. The different hues of lipid rafts by van Meer (2002)
10.1038/35036052 / Nat Rev Mol Cell Biol / Lipid rafts and signal transduction by Simons (2000)
10.1038/nrm1017 / Nat Rev Mol Cell Biol / Caveolae — from ultrastructure to molecular mechanisms by Parton (2003)
10.1074/jbc.273.10.5419 / J Biol Chem / Caveolins, a family of scaffolding proteins for organizing ‘preassembled signaling complexes’ at the plasma membrane by Okamoto (1998)
10.1074/jbc.R200020200 / J Biol Chem / Multiple functions of caveolin-1 by Liu (2002)
10.1034/j.1600-0854.2003.00128.x / Traffic / Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms by Parton (2003)
10.1038/35074539 / Nat Cell Biol / Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER by Pelkmans (2001)
10.1038/ncb975 / Nat Cell Biol / Distinct endocytic pathways regulate TGF-β receptor signalling and turnover by Di Guglielmo (2003)
10.1016/S0092-8674(00)81701-8 / Cell / SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor by Tsukazaki (1998)
Itoh F, Divecha N, Brocks L, Oomen L, Janssen H, Calafat J, Itoh S, Dijke Pt P: The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-β/Smad signalling. Genes Cells 2002, 7:321-331. (10.1046/j.1365-2443.2002.00519.x)
10.1074/jbc.M107983200 / J Biol Chem / Early endosomal regulation of Smad-dependent signaling in endothelial cells by Panopoulou (2002)
10.1242/jcs.00177 / J Cell Sci / SARA, a FYVE domain protein, affects Rab5-mediated endocytosis by Hu (2002)
10.1016/S1534-5807(02)00364-7 / Dev Cell / Localization of the MP1–MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction by Teis (2002)
10.1038/nrm973 / Nat Rev Mol Cell Biol / Receptor downregulation and multivesicular-body sorting by Katzmann (2002)
10.1083/jcb.200103071 / J Cell Biol / Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells by Kleijmeer (2001)
10.1016/S0092-8674(04)00117-5 / Cell / APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment by Miaczynska (2004)
10.1083/jcb.153.7.1511 / J Cell Biol / Nucleocytoplasmic shuttling of endocytic proteins by Vecchi (2001)
10.1016/S0968-0004(03)00064-1 / Trends Biochem Sci / Metabolic pathways in the post-genome era by Papin (2003)
10.1038/ncb1054 / Nat Cell Biol / Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis by Sato (2003)
10.1126/science.1067566 / Science / Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum by Haj (2002)
10.1091/mbc.01-11-0552 / Mol Biol Cell / Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells by Jiang (2002)
10.1128/MCB.22.14.5128-5140.2002 / Mol Cell Biol / H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis by Roy (2002)
10.1016/S0955-0674(03)00016-4 / Curr Opin Cell Biol / Ras pathway signaling on endomembranes by Bivona (2003)
10.1038/nature01806 / Nature / Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1 by Bivona (2003)
10.1016/S0092-8674(02)00797-3 / Cell / Endoplasmic-reticulum-mediated phagocytosis is a mechanism of entry into macrophages by Gagnon (2002)
10.1038/nature01912 / Nature / Phagosomes are competent organelles for antigen cross-presentation by Houde (2003)
10.1038/nature01911 / Nature / ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells by Guermonprez (2003)

Dates

Type	When
Created	21 years, 2 months ago (June 22, 2004, 1:29 p.m.)
Deposited	4 years, 2 months ago (June 23, 2021, 12:26 p.m.)
Indexed	5 days, 7 hours ago (Aug. 23, 2025, 1 a.m.)
Issued	21 years ago (Aug. 1, 2004)
Published	21 years ago (Aug. 1, 2004)
Published Print	21 years ago (Aug. 1, 2004)

Funders 0

None

BibTeX

@article{Miaczynska_2004, title={Not just a sink: endosomes in control of signal transduction}, volume={16}, ISSN={0955-0674}, url={http://dx.doi.org/10.1016/j.ceb.2004.06.005}, DOI={10.1016/j.ceb.2004.06.005}, number={4}, journal={Current Opinion in Cell Biology}, publisher={Elsevier BV}, author={Miaczynska, Marta and Pelkmans, Lucas and Zerial, Marino}, year={2004}, month=aug, pages={400–406} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        23
      ]
    ],
    "date-time": "2025-08-23T05:00:31Z",
    "timestamp": 1755925231571
  },
  "reference-count": 73,
  "publisher": "Elsevier BV",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            8,
            1
          ]
        ],
        "date-time": "2004-08-01T00:00:00Z",
        "timestamp": 1091318400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        8
      ]
    ]
  },
  "DOI": "10.1016/j.ceb.2004.06.005",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        22
      ]
    ],
    "date-time": "2004-06-22T17:29:16Z",
    "timestamp": 1087925356000
  },
  "page": "400-406",
  "source": "Crossref",
  "is-referenced-by-count": 436,
  "title": "Not just a sink: endosomes in control of signal transduction",
  "prefix": "10.1016",
  "volume": "16",
  "author": [
    {
      "given": "Marta",
      "family": "Miaczynska",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Lucas",
      "family": "Pelkmans",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marino",
      "family": "Zerial",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1038/35052055",
      "article-title": "Rab proteins as membrane organizers",
      "volume": "2",
      "author": "Zerial",
      "year": "2001",
      "journal-title": "Nat Rev Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "721",
      "DOI": "10.1038/35096054",
      "article-title": "The endocytic pathway: a mosaic of domains",
      "volume": "2",
      "author": "Gruenberg",
      "year": "2001",
      "journal-title": "Nat Rev Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1016/S0092-8674(03)00118-1",
      "article-title": "Membrane domains in the secretory and endocytic pathways",
      "volume": "112",
      "author": "Pfeffer",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "8",
      "DOI": "10.1006/excr.2001.5401",
      "article-title": "Mosaic organization of the endocytic pathway",
      "volume": "272",
      "author": "Miaczynska",
      "year": "2002",
      "journal-title": "Exp Cell Res"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "4269",
      "DOI": "10.1002/j.1460-2075.1994.tb06747.x",
      "article-title": "Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma",
      "volume": "13",
      "author": "Di Guglielmo",
      "year": "1994",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "465",
      "DOI": "10.1016/S0962-8924(00)89116-3",
      "article-title": "Compartmentalized signal transduction by receptor tyrosine kinases",
      "volume": "5",
      "author": "Baass",
      "year": "1995",
      "journal-title": "Trends Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "7950",
      "DOI": "10.1523/JNEUROSCI.16-24-07950.1996",
      "article-title": "Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes",
      "volume": "16",
      "author": "Grimes",
      "year": "1996",
      "journal-title": "J Neurosci"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "2086",
      "DOI": "10.1126/science.274.5295.2086",
      "article-title": "Control of EGF receptor signaling by clathrin-mediated endocytosis",
      "volume": "274",
      "author": "Vieira",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "685",
      "DOI": "10.1074/jbc.273.2.685",
      "article-title": "Essential role for G-protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase",
      "volume": "273",
      "author": "Daaka",
      "year": "1998",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1395",
      "DOI": "10.1016/S0960-9822(00)00785-5",
      "article-title": "Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy",
      "volume": "10",
      "author": "Sorkin",
      "year": "2000",
      "journal-title": "Curr Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1038/nbt0402-370",
      "article-title": "Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors",
      "volume": "20",
      "author": "Schoeberl",
      "year": "2002",
      "journal-title": "Nat Biotechnol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB12_1",
      "doi-asserted-by": "crossref",
      "first-page": "5803",
      "DOI": "10.1128/MCB.23.16.5803-5815.2003",
      "article-title": "Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling",
      "volume": "23",
      "author": "Pennock",
      "year": "2003",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "7279",
      "DOI": "10.1128/MCB.22.20.7279-7290.2002",
      "article-title": "Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival",
      "volume": "22",
      "author": "Wang",
      "year": "2002",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "8038",
      "DOI": "10.1074/jbc.M311494200",
      "article-title": "Platelet-derived growth factor receptor-mediated signal transduction from endosomes",
      "volume": "279",
      "author": "Wang",
      "year": "2004",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1897",
      "DOI": "10.1091/mbc.12.6.1897",
      "article-title": "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking",
      "volume": "12",
      "author": "Burke",
      "year": "2001",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "12",
      "DOI": "10.1034/j.1600-0854.2001.020103.x",
      "article-title": "Regulation of receptor tyrosine kinase signaling by endocytic trafficking",
      "volume": "2",
      "author": "Wiley",
      "year": "2001",
      "journal-title": "Traffic"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "78",
      "DOI": "10.1016/S0014-4827(03)00002-8",
      "article-title": "Trafficking of the ErbB receptors and its influence on signaling",
      "volume": "284",
      "author": "Wiley",
      "year": "2003",
      "journal-title": "Exp Cell Res"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1083/jcb.112.1.55",
      "article-title": "Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathways",
      "volume": "112",
      "author": "Sorkin",
      "year": "1991",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "5042",
      "DOI": "10.1128/MCB.18.9.5042",
      "article-title": "ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner",
      "volume": "18",
      "author": "Olayioye",
      "year": "1998",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "6845",
      "DOI": "10.1128/MCB.19.10.6845",
      "article-title": "Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers",
      "volume": "19",
      "author": "Muthuswamy",
      "year": "1999",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB21",
      "first-page": "1130",
      "article-title": "Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects",
      "volume": "63",
      "author": "Hendriks",
      "year": "2003",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "4334",
      "DOI": "10.1074/jbc.270.9.4334",
      "article-title": "Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction",
      "volume": "270",
      "author": "French",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1046/j.1471-4159.2003.01603.x",
      "article-title": "Receptor tyrosine kinase and G-protein-coupled receptor signaling and sorting within endosomes",
      "volume": "84",
      "author": "Grimes",
      "year": "2003",
      "journal-title": "J Neurochem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1016/j.lfs.2003.09.008",
      "article-title": "Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway",
      "volume": "74",
      "author": "von Zastrow",
      "year": "2003",
      "journal-title": "Life Sci"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1574",
      "DOI": "10.1126/science.290.5496.1574",
      "article-title": "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3",
      "volume": "290",
      "author": "McDonald",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB26_1",
      "doi-asserted-by": "crossref",
      "first-page": "13110",
      "DOI": "10.1074/jbc.M313333200",
      "article-title": "Regulation of angiotensin II type 1A receptor intracellular retention, degradation and recycling by Rab5, Rab7 and Rab11 GTPases",
      "volume": "279",
      "author": "Dale",
      "year": "2004",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "11130",
      "DOI": "10.1074/jbc.275.15.11130",
      "article-title": "Type-specific sorting of G-protein-coupled receptors after endocytosis",
      "volume": "275",
      "author": "Tsao",
      "year": "2000",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "455",
      "DOI": "10.1242/jcs.115.3.455",
      "article-title": "The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals",
      "volume": "115",
      "author": "Luttrell",
      "year": "2002",
      "journal-title": "J Cell Sci"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "72",
      "DOI": "10.1038/9048",
      "article-title": "Endocytic vesicles move at the tips of actin tails in cultured mast cells",
      "volume": "1",
      "author": "Merrifield",
      "year": "1999",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "519",
      "DOI": "10.1083/jcb.148.3.519",
      "article-title": "Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP",
      "volume": "148",
      "author": "Taunton",
      "year": "2000",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1038/ncb935",
      "article-title": "RhoD regulates endosome dynamics through Diaphanous-related formin and Src tyrosine kinase",
      "volume": "5",
      "author": "Gasman",
      "year": "2003",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "959",
      "DOI": "10.1083/jcb.152.5.959",
      "article-title": "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules",
      "volume": "152",
      "author": "Verhey",
      "year": "2001",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "901",
      "DOI": "10.1042/0264-6021:3500901",
      "article-title": "Diffusion control of protein phosphorylation in signal transduction pathways",
      "volume": "350",
      "author": "Kholodenko",
      "year": "2000",
      "journal-title": "Biochem J"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB34_1",
      "doi-asserted-by": "crossref",
      "first-page": "2073",
      "DOI": "10.1242/jeb.00298",
      "article-title": "Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors",
      "volume": "206",
      "author": "Kholodenko",
      "year": "2003",
      "journal-title": "J Exp Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1002/neu.10323",
      "article-title": "Signaling endosome hypothesis: A cellular mechanism for long distance communication",
      "volume": "58",
      "author": "Howe",
      "year": "2004",
      "journal-title": "J Neurobiol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB36_1",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1016/S0896-6273(03)00397-0",
      "article-title": "NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals",
      "volume": "39",
      "author": "Delcroix",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB37_1",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/S0896-6273(03)00266-6",
      "article-title": "Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons",
      "volume": "39",
      "author": "Ye",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "981",
      "DOI": "10.1038/nn720",
      "article-title": "Neurotrophins use the Erk5 pathway to mediate a retrograde survival response",
      "volume": "4",
      "author": "Watson",
      "year": "2001",
      "journal-title": "Nat Neurosci"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "268",
      "DOI": "10.1016/S0959-4388(02)00326-4",
      "article-title": "Retrograde neurotrophin signaling: Trk-ing along the axon",
      "volume": "12",
      "author": "Ginty",
      "year": "2002",
      "journal-title": "Curr Opin Neurobiol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1002/neu.10322",
      "article-title": "Retrograde transport of neurotrophins: fact and function",
      "volume": "58",
      "author": "Campenot",
      "year": "2004",
      "journal-title": "J Neurobiol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1083/jcb.138.2.411",
      "article-title": "Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures",
      "volume": "138",
      "author": "Senger",
      "year": "1997",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "1567",
      "DOI": "10.1126/science.290.5496.1567",
      "article-title": "Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane",
      "volume": "290",
      "author": "Verveer",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "1536",
      "DOI": "10.1126/science.1064913",
      "article-title": "Retrograde support of neuronal survival without retrograde transport of nerve growth factor",
      "volume": "295",
      "author": "MacInnis",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "575",
      "DOI": "10.1016/S0955-0674(02)00370-8",
      "article-title": "T-cell activation: a multidimensional signaling network",
      "volume": "14",
      "author": "Tseng",
      "year": "2002",
      "journal-title": "Curr Opin Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "677",
      "DOI": "10.1146/annurev.cellbio.19.111301.153011",
      "article-title": "Adhesion-dependent cell mechanosensitivity",
      "volume": "19",
      "author": "Bershadsky",
      "year": "2003",
      "journal-title": "Annu Rev Cell Dev Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "569",
      "DOI": "10.1038/42408",
      "article-title": "Functional rafts in cell membranes",
      "volume": "387",
      "author": "Simons",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "855",
      "DOI": "10.1126/science.1071491",
      "article-title": "Cell biology. The different hues of lipid rafts",
      "volume": "296",
      "author": "van Meer",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1038/35036052",
      "article-title": "Lipid rafts and signal transduction",
      "volume": "1",
      "author": "Simons",
      "year": "2000",
      "journal-title": "Nat Rev Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "162",
      "DOI": "10.1038/nrm1017",
      "article-title": "Caveolae \u2014 from ultrastructure to molecular mechanisms",
      "volume": "4",
      "author": "Parton",
      "year": "2003",
      "journal-title": "Nat Rev Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "5419",
      "DOI": "10.1074/jbc.273.10.5419",
      "article-title": "Caveolins, a family of scaffolding proteins for organizing \u2018preassembled signaling complexes\u2019 at the plasma membrane",
      "volume": "273",
      "author": "Okamoto",
      "year": "1998",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "41295",
      "DOI": "10.1074/jbc.R200020200",
      "article-title": "Multiple functions of caveolin-1",
      "volume": "277",
      "author": "Liu",
      "year": "2002",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB52_1",
      "doi-asserted-by": "crossref",
      "first-page": "724",
      "DOI": "10.1034/j.1600-0854.2003.00128.x",
      "article-title": "Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms",
      "volume": "4",
      "author": "Parton",
      "year": "2003",
      "journal-title": "Traffic"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1038/35074539",
      "article-title": "Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER",
      "volume": "3",
      "author": "Pelkmans",
      "year": "2001",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB54_1",
      "doi-asserted-by": "crossref",
      "first-page": "410",
      "DOI": "10.1038/ncb975",
      "article-title": "Distinct endocytic pathways regulate TGF-\u03b2 receptor signalling and turnover",
      "volume": "5",
      "author": "Di Guglielmo",
      "year": "2003",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1016/S0092-8674(00)81701-8",
      "article-title": "SARA, a FYVE domain protein that recruits Smad2 to the TGF\u03b2 receptor",
      "volume": "95",
      "author": "Tsukazaki",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB56",
      "doi-asserted-by": "crossref",
      "unstructured": "Itoh F, Divecha N, Brocks L, Oomen L, Janssen H, Calafat J, Itoh S, Dijke Pt P: The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-\u03b2/Smad signalling. Genes Cells 2002, 7:321-331.",
      "DOI": "10.1046/j.1365-2443.2002.00519.x"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "18046",
      "DOI": "10.1074/jbc.M107983200",
      "article-title": "Early endosomal regulation of Smad-dependent signaling in endothelial cells",
      "volume": "277",
      "author": "Panopoulou",
      "year": "2002",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "4755",
      "DOI": "10.1242/jcs.00177",
      "article-title": "SARA, a FYVE domain protein, affects Rab5-mediated endocytosis",
      "volume": "115",
      "author": "Hu",
      "year": "2002",
      "journal-title": "J Cell Sci"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB59_1",
      "doi-asserted-by": "crossref",
      "first-page": "803",
      "DOI": "10.1016/S1534-5807(02)00364-7",
      "article-title": "Localization of the MP1\u2013MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction",
      "volume": "3",
      "author": "Teis",
      "year": "2002",
      "journal-title": "Dev Cell"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "893",
      "DOI": "10.1038/nrm973",
      "article-title": "Receptor downregulation and multivesicular-body sorting",
      "volume": "3",
      "author": "Katzmann",
      "year": "2002",
      "journal-title": "Nat Rev Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1083/jcb.200103071",
      "article-title": "Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells",
      "volume": "155",
      "author": "Kleijmeer",
      "year": "2001",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB62_1",
      "doi-asserted-by": "crossref",
      "first-page": "445",
      "DOI": "10.1016/S0092-8674(04)00117-5",
      "article-title": "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment",
      "volume": "116",
      "author": "Miaczynska",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "1511",
      "DOI": "10.1083/jcb.153.7.1511",
      "article-title": "Nucleocytoplasmic shuttling of endocytic proteins",
      "volume": "153",
      "author": "Vecchi",
      "year": "2001",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "250",
      "DOI": "10.1016/S0968-0004(03)00064-1",
      "article-title": "Metabolic pathways in the post-genome era",
      "volume": "28",
      "author": "Papin",
      "year": "2003",
      "journal-title": "Trends Biochem Sci"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "1016",
      "DOI": "10.1038/ncb1054",
      "article-title": "Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis",
      "volume": "5",
      "author": "Sato",
      "year": "2003",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "1708",
      "DOI": "10.1126/science.1067566",
      "article-title": "Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum",
      "volume": "295",
      "author": "Haj",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB67",
      "doi-asserted-by": "crossref",
      "first-page": "1522",
      "DOI": "10.1091/mbc.01-11-0552",
      "article-title": "Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells",
      "volume": "13",
      "author": "Jiang",
      "year": "2002",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB68",
      "doi-asserted-by": "crossref",
      "first-page": "5128",
      "DOI": "10.1128/MCB.22.14.5128-5140.2002",
      "article-title": "H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis",
      "volume": "22",
      "author": "Roy",
      "year": "2002",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "136",
      "DOI": "10.1016/S0955-0674(03)00016-4",
      "article-title": "Ras pathway signaling on endomembranes",
      "volume": "15",
      "author": "Bivona",
      "year": "2003",
      "journal-title": "Curr Opin Cell Biol"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "694",
      "DOI": "10.1038/nature01806",
      "article-title": "Phospholipase C\u03b3 activates Ras on the Golgi apparatus by means of RasGRP1",
      "volume": "424",
      "author": "Bivona",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1016/S0092-8674(02)00797-3",
      "article-title": "Endoplasmic-reticulum-mediated phagocytosis is a mechanism of entry into macrophages",
      "volume": "110",
      "author": "Gagnon",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB72",
      "doi-asserted-by": "crossref",
      "first-page": "402",
      "DOI": "10.1038/nature01912",
      "article-title": "Phagosomes are competent organelles for antigen cross-presentation",
      "volume": "425",
      "author": "Houde",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ceb.2004.06.005_BIB73",
      "doi-asserted-by": "crossref",
      "first-page": "397",
      "DOI": "10.1038/nature01911",
      "article-title": "ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells",
      "volume": "425",
      "author": "Guermonprez",
      "year": "2003",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Current Opinion in Cell Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0955067404000742?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0955067404000742?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        23
      ]
    ],
    "date-time": "2021-06-23T16:26:02Z",
    "timestamp": 1624465562000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0955067404000742"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        8
      ]
    ]
  },
  "references-count": 73,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2004,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S0955067404000742"
  ],
  "URL": "http://dx.doi.org/10.1016/j.ceb.2004.06.005",
  "relation": {},
  "ISSN": [
    "0955-0674"
  ],
  "subject": [],
  "container-title-short": "Current Opinion in Cell Biology",
  "published": {
    "date-parts": [
      [
        2004,
        8
      ]
    ]
  }
}