DOI: 10.1016/j.ccr.2006.03.014. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

10.1016/j.ccr.2006.03.014

Crossref journal-article

Elsevier BV

Cancer Cell (78)

Bibliography

Toledo, F., Krummel, K. A., Lee, C. J., Liu, C.-W., Rodewald, L.-W., Tang, M., & Wahl, G. M. (2006). A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell, 9(4), 273â285.

Authors 7

Franck Toledo (first)
Kurt A. Krummel (additional)
Crystal J. Lee (additional)
Chung-Wen Liu (additional)
Luo-Wei Rodewald (additional)
Mengjia Tang (additional)
Geoffrey M. Wahl (additional)

References 52 Referenced 149

10.1038/sj.onc.1205015 / Oncogene / The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells by Baptiste (2002)
10.1074/jbc.M008879200 / J. Biol. Chem. / A role for the polyproline domain of p53 in its regulation by Mdm2 by Berger (2001)
10.1016/j.cell.2004.11.022 / Cell / A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans by Bond (2004)
10.1038/sj.onc.1202281 / Oncogene / Comparative study of the p53-mdm2 and p53-MDMX interfaces by Bottger (1999)
10.4161/cc.3.7.997 / Cell Cycle / Dynamics in the p53-Mdm2 ubiquitination pathway by Brooks (2004)
10.1074/jbc.M306938200 / J. Biol. Chem. / Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses by Chao (2003)
{'key': '10.1016/j.ccr.2006.03.014_bib7', 'first-page': '8664', 'article-title': 'Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets', 'volume': '63', 'author': 'Chavez-Reyes', 'year': '2003', 'journal-title': 'Cancer Res.'} / Cancer Res. / Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets by Chavez-Reyes (2003)
10.1038/sj.emboj.7600812 / EMBO J. / ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage by Chen (2005)
10.1126/science.1092734 / Science / Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis by Chipuk (2004)
10.1128/MCB.24.13.5835-5843.2004 / Mol. Cell. Biol. / Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity by Danovi (2004)
10.1038/356215a0 / Nature / Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours by Donehower (1992)
10.1128/MCB.23.23.8846-8861.2003 / Mol. Cell. Biol. / The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53 by Dornan (2003)
10.1042/0264-6021:3590459 / Biochem. J. / Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover by Dumaz (2001)
10.1038/sj.onc.1206726 / Oncogene / The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions by Edwards (2003)
{'key': '10.1016/j.ccr.2006.03.014_bib15', 'first-page': '3221', 'article-title': 'mdmx is a negative regulator of p53 activity in vivo', 'volume': '62', 'author': 'Finch', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / mdmx is a negative regulator of p53 activity in vivo by Finch (2002)
10.1073/pnas.0508476103 / Proc. Natl. Acad. Sci. USA / Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo by Francoz (2006)
10.1074/jbc.C200150200 / J. Biol. Chem. / Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 by Gu (2002)
10.1038/sj.onc.1202282 / Oncogene / Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation by Hengstermann (1998)
10.4161/cc.4.6.1696 / Cell Cycle / p53QS: an old mutant teaches us new tricks by Johnson (2005)
10.1038/378206a0 / Nature / Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 by Jones (1995)
10.1074/jbc.M308295200 / J. Biol. Chem. / DNA damage-induced MDMX degradation is mediated by MDM2 by Kawai (2003)
10.1073/pnas.0503068102 / Proc. Natl. Acad. Sci. USA / The C-terminal lysines fine-tune p53 stress responses in a mouse model, but are not required for stability control or transactivation by Krummel (2005)
10.1073/pnas.210171597 / Proc. Natl. Acad. Sci. USA / Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study by Lev Bar-Or (2000)
10.1073/pnas.2030930100 / Proc. Natl. Acad. Sci. USA / HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 by Linares (2003)
10.1038/ng1282 / Nat. Genet. / Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice by Liu (2004)
10.1016/0092-8674(93)90719-7 / Cell / p53-dependent apoptosis modulates the cytotoxicity of anticancer agents by Lowe (1993)
10.4161/cc.3.7.999 / Cell Cycle / KeePin' the p53 family in good shape by Mantovani (2004)
10.1016/j.bbrc.2005.03.151 / Biochem. Biophys. Res. Commun. / Mdmx as an essential regulator of p53 activity by Marine (2005)
10.1073/pnas.0334477100 / Proc. Natl. Acad. Sci. USA / Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation by McCoy (2003)
10.1016/j.molcel.2005.04.024 / Mol. Cell / Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 by Meulmeester (2005)
10.1128/MCB.22.15.5527-5538.2002 / Mol. Cell. Biol. / Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development by Migliorini (2002)
10.1038/sj.cdd.4400736 / Cell Death Differ. / Neuronal life and death: an essential role for the p53 family by Miller (2000)
10.1038/378203a0 / Nature / Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 by Montes de Oca Luna (1995)
10.1038/sj.onc.1208354 / Oncogene / p53 must be competent for transcriptional regulation to suppress tumor formation by Nister (2005)
10.1073/pnas.94.26.14602 / Proc. Natl. Acad. Sci. USA / Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells by O'Gorman (1997)
10.1128/MCB.25.21.9608-9620.2005 / Mol. Cell. Biol. / DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation by Okamoto (2005)
10.1038/ng714 / Nat. Genet. / Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 by Parant (2001)
10.1073/pnas.0408595102 / Proc. Natl. Acad. Sci. USA / Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage by Pereg (2005)
10.1073/pnas.0408744102 / Proc. Natl. Acad. Sci. USA / The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development by Ren (2005)
10.1038/sj.onc.1203500 / Oncogene / Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain by Roth (2000)
10.1038/sj.onc.1201263 / Oncogene / The polyproline region of p53 is required to activate apoptosis but not growth arrest by Sakamuro (1997)
10.1038/sj.onc.1206925 / Oncogene / Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth by Steinman (2004)
10.1038/sj.onc.1208930 / Oncogene / Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development by Steinman (2005)
10.1038/sj.emboj.7600145 / EMBO J. / Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation by Stommel (2004)
10.1016/j.cell.2004.06.004 / Cell / Yin Yang 1 is a negative regulator of p53 by Sui (2004)
10.1126/science.1092472 / Science / In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 by Vassilev (2004)
10.1093/emboj/17.16.4668 / EMBO J. / The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression by Venot (1998)
10.1038/nrc864 / Nat. Rev. Cancer / Live or let die: the cell's response to p53 by Vousden (2002)
{'key': '10.1016/j.ccr.2006.03.014_bib49', 'series-title': '25 Years of p53 Research', 'first-page': '73', 'article-title': 'Gatekeepers of the guardian: p53 regulation by post-translational modification, mdm2 and mdmx', 'author': 'Wahl', 'year': '2005'} / 25 Years of p53 Research / Gatekeepers of the guardian: p53 regulation by post-translational modification, mdm2 and mdmx by Wahl (2005)
10.1073/pnas.93.26.15335 / Proc. Natl. Acad. Sci. USA / Identification of a novel p53 functional domain that is necessary for efficient growth suppression by Walker (1996)
10.1073/pnas.0508500103 / Proc. Natl. Acad. Sci. USA / Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development by Xiong (2006)
10.1038/sj.onc.1202533 / Oncogene / Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity by Zhu (1999)

Dates

Type	When
Created	19 years, 4 months ago (April 11, 2006, 12:44 p.m.)
Deposited	6 years, 7 months ago (Jan. 17, 2019, 12:50 a.m.)
Indexed	1 month ago (July 31, 2025, 11:47 p.m.)
Issued	19 years, 5 months ago (April 1, 2006)
Published	19 years, 5 months ago (April 1, 2006)
Published Print	19 years, 5 months ago (April 1, 2006)

Funders 0

None

BibTeX

@article{Toledo_2006, title={A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network}, volume={9}, ISSN={1535-6108}, url={http://dx.doi.org/10.1016/j.ccr.2006.03.014}, DOI={10.1016/j.ccr.2006.03.014}, number={4}, journal={Cancer Cell}, publisher={Elsevier BV}, author={Toledo, Franck and Krummel, Kurt A. and Lee, Crystal J. and Liu, Chung-Wen and Rodewald, Luo-Wei and Tang, Mengjia and Wahl, Geoffrey M.}, year={2006}, month=apr, pages={273–285} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        1
      ]
    ],
    "date-time": "2025-08-01T03:47:01Z",
    "timestamp": 1754020021760
  },
  "reference-count": 52,
  "publisher": "Elsevier BV",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            4,
            1
          ]
        ],
        "date-time": "2006-04-01T00:00:00Z",
        "timestamp": 1143849600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            8,
            22
          ]
        ],
        "date-time": "2013-08-22T00:00:00Z",
        "timestamp": 1377129600000
      },
      "content-version": "vor",
      "delay-in-days": 2700,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2006,
        4
      ]
    ]
  },
  "DOI": "10.1016/j.ccr.2006.03.014",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        4,
        11
      ]
    ],
    "date-time": "2006-04-11T16:44:24Z",
    "timestamp": 1144773864000
  },
  "page": "273-285",
  "source": "Crossref",
  "is-referenced-by-count": 149,
  "title": "A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network",
  "prefix": "10.1016",
  "volume": "9",
  "author": [
    {
      "given": "Franck",
      "family": "Toledo",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Kurt A.",
      "family": "Krummel",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Crystal J.",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Chung-Wen",
      "family": "Liu",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Luo-Wei",
      "family": "Rodewald",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mengjia",
      "family": "Tang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Geoffrey M.",
      "family": "Wahl",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.ccr.2006.03.014_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1038/sj.onc.1205015",
      "article-title": "The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells",
      "volume": "21",
      "author": "Baptiste",
      "year": "2002",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "3785",
      "DOI": "10.1074/jbc.M008879200",
      "article-title": "A role for the polyproline domain of p53 in its regulation by Mdm2",
      "volume": "276",
      "author": "Berger",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "591",
      "DOI": "10.1016/j.cell.2004.11.022",
      "article-title": "A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans",
      "volume": "119",
      "author": "Bond",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1038/sj.onc.1202281",
      "article-title": "Comparative study of the p53-mdm2 and p53-MDMX interfaces",
      "volume": "18",
      "author": "Bottger",
      "year": "1999",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "895",
      "DOI": "10.4161/cc.3.7.997",
      "article-title": "Dynamics in the p53-Mdm2 ubiquitination pathway",
      "volume": "3",
      "author": "Brooks",
      "year": "2004",
      "journal-title": "Cell Cycle"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "41028",
      "DOI": "10.1074/jbc.M306938200",
      "article-title": "Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses",
      "volume": "278",
      "author": "Chao",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib7",
      "first-page": "8664",
      "article-title": "Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets",
      "volume": "63",
      "author": "Chavez-Reyes",
      "year": "2003",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "3411",
      "DOI": "10.1038/sj.emboj.7600812",
      "article-title": "ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage",
      "volume": "24",
      "author": "Chen",
      "year": "2005",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "1010",
      "DOI": "10.1126/science.1092734",
      "article-title": "Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis",
      "volume": "303",
      "author": "Chipuk",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "5835",
      "DOI": "10.1128/MCB.24.13.5835-5843.2004",
      "article-title": "Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity",
      "volume": "24",
      "author": "Danovi",
      "year": "2004",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1038/356215a0",
      "article-title": "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours",
      "volume": "356",
      "author": "Donehower",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "8846",
      "DOI": "10.1128/MCB.23.23.8846-8861.2003",
      "article-title": "The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53",
      "volume": "23",
      "author": "Dornan",
      "year": "2003",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "459",
      "DOI": "10.1042/0264-6021:3590459",
      "article-title": "Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover",
      "volume": "359",
      "author": "Dumaz",
      "year": "2001",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "4517",
      "DOI": "10.1038/sj.onc.1206726",
      "article-title": "The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions",
      "volume": "22",
      "author": "Edwards",
      "year": "2003",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib15",
      "first-page": "3221",
      "article-title": "mdmx is a negative regulator of p53 activity in vivo",
      "volume": "62",
      "author": "Finch",
      "year": "2002",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "3232",
      "DOI": "10.1073/pnas.0508476103",
      "article-title": "Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo",
      "volume": "103",
      "author": "Francoz",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "19251",
      "DOI": "10.1074/jbc.C200150200",
      "article-title": "Mutual dependence of MDM2 and MDMX in their functional inactivation of p53",
      "volume": "277",
      "author": "Gu",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "2933",
      "DOI": "10.1038/sj.onc.1202282",
      "article-title": "Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation",
      "volume": "17",
      "author": "Hengstermann",
      "year": "1998",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "731",
      "DOI": "10.4161/cc.4.6.1696",
      "article-title": "p53QS: an old mutant teaches us new tricks",
      "volume": "4",
      "author": "Johnson",
      "year": "2005",
      "journal-title": "Cell Cycle"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "206",
      "DOI": "10.1038/378206a0",
      "article-title": "Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53",
      "volume": "378",
      "author": "Jones",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "45946",
      "DOI": "10.1074/jbc.M308295200",
      "article-title": "DNA damage-induced MDMX degradation is mediated by MDM2",
      "volume": "278",
      "author": "Kawai",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "10188",
      "DOI": "10.1073/pnas.0503068102",
      "article-title": "The C-terminal lysines fine-tune p53 stress responses in a mouse model, but are not required for stability control or transactivation",
      "volume": "102",
      "author": "Krummel",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "11250",
      "DOI": "10.1073/pnas.210171597",
      "article-title": "Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study",
      "volume": "97",
      "author": "Lev Bar-Or",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "12009",
      "DOI": "10.1073/pnas.2030930100",
      "article-title": "HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53",
      "volume": "100",
      "author": "Linares",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1038/ng1282",
      "article-title": "Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice",
      "volume": "36",
      "author": "Liu",
      "year": "2004",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "957",
      "DOI": "10.1016/0092-8674(93)90719-7",
      "article-title": "p53-dependent apoptosis modulates the cytotoxicity of anticancer agents",
      "volume": "74",
      "author": "Lowe",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.4161/cc.3.7.999",
      "article-title": "KeePin' the p53 family in good shape",
      "volume": "3",
      "author": "Mantovani",
      "year": "2004",
      "journal-title": "Cell Cycle"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "750",
      "DOI": "10.1016/j.bbrc.2005.03.151",
      "article-title": "Mdmx as an essential regulator of p53 activity",
      "volume": "331",
      "author": "Marine",
      "year": "2005",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "1645",
      "DOI": "10.1073/pnas.0334477100",
      "article-title": "Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation",
      "volume": "100",
      "author": "McCoy",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "565",
      "DOI": "10.1016/j.molcel.2005.04.024",
      "article-title": "Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2",
      "volume": "18",
      "author": "Meulmeester",
      "year": "2005",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "5527",
      "DOI": "10.1128/MCB.22.15.5527-5538.2002",
      "article-title": "Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development",
      "volume": "22",
      "author": "Migliorini",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "880",
      "DOI": "10.1038/sj.cdd.4400736",
      "article-title": "Neuronal life and death: an essential role for the p53 family",
      "volume": "7",
      "author": "Miller",
      "year": "2000",
      "journal-title": "Cell Death Differ."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "203",
      "DOI": "10.1038/378203a0",
      "article-title": "Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53",
      "volume": "378",
      "author": "Montes de Oca Luna",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "3563",
      "DOI": "10.1038/sj.onc.1208354",
      "article-title": "p53 must be competent for transcriptional regulation to suppress tumor formation",
      "volume": "24",
      "author": "Nister",
      "year": "2005",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "14602",
      "DOI": "10.1073/pnas.94.26.14602",
      "article-title": "Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells",
      "volume": "94",
      "author": "O'Gorman",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "9608",
      "DOI": "10.1128/MCB.25.21.9608-9620.2005",
      "article-title": "DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation",
      "volume": "25",
      "author": "Okamoto",
      "year": "2005",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "92",
      "DOI": "10.1038/ng714",
      "article-title": "Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53",
      "volume": "29",
      "author": "Parant",
      "year": "2001",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "5056",
      "DOI": "10.1073/pnas.0408595102",
      "article-title": "Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage",
      "volume": "102",
      "author": "Pereg",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "565",
      "DOI": "10.1073/pnas.0408744102",
      "article-title": "The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development",
      "volume": "102",
      "author": "Ren",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "1834",
      "DOI": "10.1038/sj.onc.1203500",
      "article-title": "Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain",
      "volume": "19",
      "author": "Roth",
      "year": "2000",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "887",
      "DOI": "10.1038/sj.onc.1201263",
      "article-title": "The polyproline region of p53 is required to activate apoptosis but not growth arrest",
      "volume": "15",
      "author": "Sakamuro",
      "year": "1997",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1038/sj.onc.1206925",
      "article-title": "Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth",
      "volume": "23",
      "author": "Steinman",
      "year": "2004",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "7935",
      "DOI": "10.1038/sj.onc.1208930",
      "article-title": "Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development",
      "volume": "24",
      "author": "Steinman",
      "year": "2005",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "1547",
      "DOI": "10.1038/sj.emboj.7600145",
      "article-title": "Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation",
      "volume": "23",
      "author": "Stommel",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "859",
      "DOI": "10.1016/j.cell.2004.06.004",
      "article-title": "Yin Yang 1 is a negative regulator of p53",
      "volume": "117",
      "author": "Sui",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "844",
      "DOI": "10.1126/science.1092472",
      "article-title": "In vivo activation of the p53 pathway by small-molecule antagonists of MDM2",
      "volume": "303",
      "author": "Vassilev",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "4668",
      "DOI": "10.1093/emboj/17.16.4668",
      "article-title": "The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression",
      "volume": "17",
      "author": "Venot",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "594",
      "DOI": "10.1038/nrc864",
      "article-title": "Live or let die: the cell's response to p53",
      "volume": "2",
      "author": "Vousden",
      "year": "2002",
      "journal-title": "Nat. Rev. Cancer"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib49",
      "series-title": "25 Years of p53 Research",
      "first-page": "73",
      "article-title": "Gatekeepers of the guardian: p53 regulation by post-translational modification, mdm2 and mdmx",
      "author": "Wahl",
      "year": "2005"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "15335",
      "DOI": "10.1073/pnas.93.26.15335",
      "article-title": "Identification of a novel p53 functional domain that is necessary for efficient growth suppression",
      "volume": "93",
      "author": "Walker",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "3226",
      "DOI": "10.1073/pnas.0508500103",
      "article-title": "Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development",
      "volume": "103",
      "author": "Xiong",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.ccr.2006.03.014_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "2149",
      "DOI": "10.1038/sj.onc.1202533",
      "article-title": "Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity",
      "volume": "18",
      "author": "Zhu",
      "year": "1999",
      "journal-title": "Oncogene"
    }
  ],
  "container-title": "Cancer Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1535610806000882?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1535610806000882?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        1,
        17
      ]
    ],
    "date-time": "2019-01-17T05:50:21Z",
    "timestamp": 1547704221000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1535610806000882"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        4
      ]
    ]
  },
  "references-count": 52,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2006,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "S1535610806000882"
  ],
  "URL": "http://dx.doi.org/10.1016/j.ccr.2006.03.014",
  "relation": {},
  "ISSN": [
    "1535-6108"
  ],
  "subject": [],
  "container-title-short": "Cancer Cell",
  "published": {
    "date-parts": [
      [
        2006,
        4
      ]
    ]
  }
}