DOI: 10.1016/j.bbrc.2005.08.094. Thirty years of microbial P450 monooxygenase research: Peroxo-heme intermediates—The central bus station in heme oxygenase catalysis

Thirty years of microbial P450 monooxygenase research: Peroxo-heme intermediates—The central bus station in heme oxygenase catalysis

10.1016/j.bbrc.2005.08.094

Crossref journal-article

Elsevier BV

Biochemical and Biophysical Research Communications (78)

Bibliography

Sligar, S. G., Makris, T. M., & Denisov, I. G. (2005). Thirty years of microbial P450 monooxygenase research: Peroxo-heme intermediatesâThe central bus station in heme oxygenase catalysis. Biochemical and Biophysical Research Communications, 338(1), 346â354.

Authors 3

Stephen G. Sligar (first)
Thomas M. Makris (additional)
Ilia G. Denisov (additional)

References 51 Referenced 78

10.1021/ja01625a095 / J. Am. Chem. Soc. / Mechanism of the pyrocatechase reaction by Hayaishi (1955)
{'key': '10.1016/j.bbrc.2005.08.094_bib2', 'series-title': 'Oxygen and life. Oxygenases, Oxidases and Lipid Mediators, International Congress Series', 'author': 'Ishimura', 'year': '2002'} / Oxygen and life. Oxygenases, Oxidases and Lipid Mediators, International Congress Series by Ishimura (2002)
10.1089/dna.1991.10.1 / DNA Cell Biol. / The P450 superfamily—update on new sequences, gene-mapping, and recommended nomenclature by Nebert (1991)
10.1146/annurev.pharmtox.45.120403.100030 / Annu. Rev. Pharmacol. Toxicol. / Cytochrome P450: nature’s most versatile biological catalyst by Coon (2005)
10.1021/cr0307143 / Chem. Rev. / Structure and chemistry of cytochrome P450 by Denisov (2005)
10.1016/S0006-291X(71)80193-6 / Biochem. Biophys. Res. Commun. / A specific role of reduced adrenodoxin in adrenal mitochondrial steroid hydroxylases by Huang (1971)
10.1021/bi00669a029 / Biochemistry / Coupling of spin, substrate, and redox equilibria in cytochrome P450 by Sligar (1976)
{'key': '10.1016/j.bbrc.2005.08.094_bib8', 'series-title': 'Molecular Mechanisms of Oxygen Activation', 'first-page': '561', 'article-title': 'Bacterial monooxygenases—the P450 cytochrome system', 'author': 'Gunsalus', 'year': '1974'} / Molecular Mechanisms of Oxygen Activation / Bacterial monooxygenases—the P450 cytochrome system by Gunsalus (1974)
10.1016/0003-9861(72)90315-3 / Arch. Biochem. Biophys. / Pseudomonas putida cytochrome P-450. Characterization of an oxygenated form of the hemoprotein by Peterson (1972)
10.1016/S0006-291X(77)80131-9 / Biochem. Biophys. Res. Commun. / P 450cam: oxygenated complexes stabilized at low temperature by Eisenstein (1977)
{'key': '10.1016/j.bbrc.2005.08.094_bib11', 'series-title': 'Symposium on Microsomes and Drug Oxidations', 'year': '1976'} / Symposium on Microsomes and Drug Oxidations (1976)
10.1016/0022-5193(77)90152-7 / J. Theor. Biol. / On the mechanism of compound I formation from peroxidases and catalases by Jones (1977)
10.1016/0005-2795(78)90090-9 / Biochim. Biophys. Acta / Electron capture at the iron–oxygen centre in single crystals of oxymyoglobin studied by electron spin resonance spectroscopy by Symons (1978)
10.1016/0014-5793(79)80730-9 / FEBS Lett. / Intermediate spin-states in one-electron reduction of oxygen–hemoprotein complexes at low temperature by Gasyna (1979)
{'key': '10.1016/j.bbrc.2005.08.094_bib15', 'first-page': '97', 'article-title': 'ESR spectroscopy of unstable intermediates of the reduction of oxygen complexes of cytochrome P450 and other hemoproteins', 'volume': '95', 'author': 'Davydov', 'year': '1983', 'journal-title': 'Stud. Biophys.'} / Stud. Biophys. / ESR spectroscopy of unstable intermediates of the reduction of oxygen complexes of cytochrome P450 and other hemoproteins by Davydov (1983)
10.1016/0167-4838(85)90218-3 / Biochim. Biophys. Acta / Electron spin and electron nuclear double resonance of the [FeO2]− [ferrite] center from irradiated oxyhemo- and oxymyoglobin by Kappl (1985)
10.1016/0167-4838(86)90004-X / Biochim. Biophys. Acta / Spin-density distribution in the [FeO2]-complex. Electron spin resonance of myoglobin single crystals by Leibl (1986)
10.1016/0014-5793(91)81398-R / FEBS Lett. / EPR-spectroscopy of reduced oxyferrous-P450cam by Davydov (1991)
10.1016/S0898-8838(08)60150-6 / Adv. Inorg. Chem. / Coming to grips with reactive intermediates by Downs (1998)
10.1016/0014-5793(74)80522-3 / FEBS Lett. / Studies on the conformational changes of metalloproteins induced by electrons in water–ethylene glycol solutions at low temperatures. Haemoglobin by Blumenfeld (1974)
10.1021/ja9918829 / J. Am. Chem. Soc. / EPR and ENDOR of catalytic intermediates in cryoreduced native and mutant oxy-cytochromes P450cam: mutation-induced changes in the proton delivery system by Davydov (1999)
10.1074/jbc.M010219200 / J. Biol. Chem. / Cryotrapped reaction intermediates of cytochrome P450 studied by radiolytic reduction with phosphorus-32 by Denisov (2001)
10.1021/ja003583l / J. Am. Chem. Soc. / Hydroxylation of camphor by reduced oxy-cytochrome P450cam: mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes by Davydov (2001)
10.1016/S0076-6879(02)57670-9 / Meth. Enzymol. / Cryoradiolysis for the study of P450 reaction intermediates by Denisov (2002)
10.1016/S0162-0134(01)00328-2 / J. Inorg. Biochem. / Characterization of the oxygenated intermediate of the thermophilic cytochrome P450CYP119 by Denisov (2001)
10.1016/S0014-5793(02)03674-8 / FEBS Lett. / Cryogenic absorption spectra of hydroperoxo-ferric heme oxygenase, the active intermediate of enzymatic heme oxygenation by Denisov (2002)
10.1074/jbc.M207949200 / J. Biol. Chem. / Formation and decay of hydroperoxo–ferric heme complex in horseradish peroxidase studied by cryoradiolysis by Denisov (2002)
10.1021/ja036949d / J. Am. Chem. Soc. / Resonance Raman spectroscopic studies of hydroperoxo-myoglobin at cryogenic temperatures by Ibrahim (2003)
{'key': '10.1016/j.bbrc.2005.08.094_bib29', 'first-page': '577', 'article-title': 'Systematic trends in the spectroscopic properties of low-spin ferric ligand adducts of cytochrome P-450 and chloroperoxidase: the transition from normal to hyper spectra', 'volume': '16', 'author': 'Dawson', 'year': '1992', 'journal-title': 'New J. Chem.'} / New J. Chem. / Systematic trends in the spectroscopic properties of low-spin ferric ligand adducts of cytochrome P-450 and chloroperoxidase: the transition from normal to hyper spectra by Dawson (1992)
10.1021/ar0202565 / Acc. Chem. Res. / ENDOR of metalloenzymes by Hoffman (2003)
10.1021/cr020628n / Chem. Rev. / Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates by Costas (2004)
10.1016/S0010-8545(00)00332-5 / Coord. Chem. Rev. / Electronic structures of active sites in electron transfer metalloproteins: contributions to reactivity by Solomon (2000)
T.M. Makris, I.G. Denisov, Q. Ma, J.P. Quintana, D.T. Keane, S.G. Sligar, XANES and EXAFS studies of the hydroperoxo–ferriheme intermediate in cytochrome P450 CYP101, J. Am. Chem. Soc. (2005) submitted.
10.1016/j.ccr.2004.03.019 / Coord. Chem. Rev. / Atomic resolution crystallography and XAFS by Strange (2005)
10.1016/S0021-9258(18)33913-9 / J. Biol. Chem. / Endogenous cysteine ligation in ferric and ferrous cytochrome P-450. Direct evidence from x-ray absorption spectroscopy by Hahn (1982)
10.1021/ja00285a052 / J. Am. Chem. Soc. / Oxygenated cytochrome P-450-CAM and chloroperoxidase: direct evidence for sulfur donor ligation trans to dioxygen and structural characterization using EXAFS spectroscopy by Dawson (1986)
10.1021/cr980389x / Chem. Rev. / Role of the heme active site and protein environment in structure, spectra, and function of the cytochrome P450s by Loew (2000)
10.1021/ja0171963 / J. Am. Chem. Soc. / Searching for the second oxidant in the catalytic cycle of cytochrome P450: A theoretical investigation of the iron(III)–hydroperoxo species and its epoxidation pathways by Ogliaro (2002)
10.1073/pnas.98.2.479 / Proc. Natl. Acad. Sci. USA / Simultaneous observation of the O·O and Fe·O2 stretching modes in oxyhemoglobins by Das (2001)
10.1021/ja012621d / J. Am. Chem. Soc. / Electronic structure and reactivity of low-spin Fe(III)–hydroperoxo complexes: comparison to activated bleomycin by Lehnert (2002)
10.1073/pnas.0336792100 / Proc. Natl. Acad. Sci. USA / Non-heme iron enzymes: contrasts to heme catalysis by Solomon (2003)
10.1021/cr9900275 / Chem. Rev. / Geometric and electronic structure/function correlations in non-heme iron enzymes by Solomon (2000)
10.1016/0006-291X(85)90432-2 / Biochem. Biophys. Res. Commun. / P450cam gene cloning and expression in Pseudomonas putida and Escherichia coli by Koga (1985)
10.1021/bi00112a008 / Biochemistry / Crystal structure of the cytochrome P-450cam active site mutant Thr252Ala by Raag (1991)
10.1093/oxfordjournals.jbchem.a022848 / J. Biochem. (Tokyo) / X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center by Hishiki (2000)
10.1006/bbrc.1995.1310 / Biochem. Biophys. Res. Commun. / Role of Thr-252 in cytochrome P450cam—a study with unnatural amino-acid mutagenesis by Kimata (1995)
10.1016/S0021-9258(17)41772-8 / J. Biol. Chem. / A role for Asp-251 in cytochrome P-450cam oxygen activation by Gerber (1994)
10.1007/978-94-011-5442-0_5 / Catalysis by Metal Complexes, v.19, Oxygenases and Model Systems / Heme monooxygenases. A chemical mechanism for cytochrome P450 oxygen activation by Shimada (1997)
10.1126/science.287.5458.1615 / Science / The catalytic pathway of cytochrome p450cam at atomic resolution by Schlichting (2000)
10.1016/0006-291X(74)90565-8 / Biochem. Biophys. Res. Commun. / Superoxide anion production by the autoxidation of cytochrome P450cam by Sligar (1974)
10.1016/S0021-9258(17)39800-9 / J. Biol. Chem. / On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction by Gorsky (1984)

Dates

Type	When
Created	20 years ago (Aug. 25, 2005, 7:29 a.m.)
Deposited	4 years, 1 month ago (July 16, 2021, 2:22 p.m.)
Indexed	2 months ago (July 2, 2025, 8:45 a.m.)
Issued	19 years, 9 months ago (Dec. 1, 2005)
Published	19 years, 9 months ago (Dec. 1, 2005)
Published Print	19 years, 9 months ago (Dec. 1, 2005)

Funders 0

None

BibTeX

@article{Sligar_2005, title={Thirty years of microbial P450 monooxygenase research: Peroxo-heme intermediates—The central bus station in heme oxygenase catalysis}, volume={338}, ISSN={0006-291X}, url={http://dx.doi.org/10.1016/j.bbrc.2005.08.094}, DOI={10.1016/j.bbrc.2005.08.094}, number={1}, journal={Biochemical and Biophysical Research Communications}, publisher={Elsevier BV}, author={Sligar, Stephen G. and Makris, Thomas M. and Denisov, Ilia G.}, year={2005}, month=dec, pages={346–354} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        2
      ]
    ],
    "date-time": "2025-07-02T12:45:41Z",
    "timestamp": 1751460341649
  },
  "reference-count": 51,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            12,
            1
          ]
        ],
        "date-time": "2005-12-01T00:00:00Z",
        "timestamp": 1133395200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2005,
        12
      ]
    ]
  },
  "DOI": "10.1016/j.bbrc.2005.08.094",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        8,
        25
      ]
    ],
    "date-time": "2005-08-25T11:29:37Z",
    "timestamp": 1124969377000
  },
  "page": "346-354",
  "source": "Crossref",
  "is-referenced-by-count": 78,
  "title": "Thirty years of microbial P450 monooxygenase research: Peroxo-heme intermediates\u2014The central bus station in heme oxygenase catalysis",
  "prefix": "10.1016",
  "volume": "338",
  "author": [
    {
      "given": "Stephen G.",
      "family": "Sligar",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Thomas M.",
      "family": "Makris",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ilia G.",
      "family": "Denisov",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "5450",
      "DOI": "10.1021/ja01625a095",
      "article-title": "Mechanism of the pyrocatechase reaction",
      "volume": "77",
      "author": "Hayaishi",
      "year": "1955",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib2",
      "series-title": "Oxygen and life. Oxygenases, Oxidases and Lipid Mediators, International Congress Series",
      "author": "Ishimura",
      "year": "2002"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1089/dna.1991.10.1",
      "article-title": "The P450 superfamily\u2014update on new sequences, gene-mapping, and recommended nomenclature",
      "volume": "10",
      "author": "Nebert",
      "year": "1991",
      "journal-title": "DNA Cell Biol."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1146/annurev.pharmtox.45.120403.100030",
      "article-title": "Cytochrome P450: nature\u2019s most versatile biological catalyst",
      "volume": "45",
      "author": "Coon",
      "year": "2005",
      "journal-title": "Annu. Rev. Pharmacol. Toxicol."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "2253",
      "DOI": "10.1021/cr0307143",
      "article-title": "Structure and chemistry of cytochrome P450",
      "volume": "105",
      "author": "Denisov",
      "year": "2005",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "1065",
      "DOI": "10.1016/S0006-291X(71)80193-6",
      "article-title": "A specific role of reduced adrenodoxin in adrenal mitochondrial steroid hydroxylases",
      "volume": "44",
      "author": "Huang",
      "year": "1971",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "5399",
      "DOI": "10.1021/bi00669a029",
      "article-title": "Coupling of spin, substrate, and redox equilibria in cytochrome P450",
      "volume": "15",
      "author": "Sligar",
      "year": "1976",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib8",
      "series-title": "Molecular Mechanisms of Oxygen Activation",
      "first-page": "561",
      "article-title": "Bacterial monooxygenases\u2014the P450 cytochrome system",
      "author": "Gunsalus",
      "year": "1974"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1016/0003-9861(72)90315-3",
      "article-title": "Pseudomonas putida cytochrome P-450. Characterization of an oxygenated form of the hemoprotein",
      "volume": "149",
      "author": "Peterson",
      "year": "1972",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "1377",
      "DOI": "10.1016/S0006-291X(77)80131-9",
      "article-title": "P 450cam: oxygenated complexes stabilized at low temperature",
      "volume": "77",
      "author": "Eisenstein",
      "year": "1977",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib11",
      "series-title": "Symposium on Microsomes and Drug Oxidations",
      "year": "1976"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "457",
      "DOI": "10.1016/0022-5193(77)90152-7",
      "article-title": "On the mechanism of compound I formation from peroxidases and catalases",
      "volume": "69",
      "author": "Jones",
      "year": "1977",
      "journal-title": "J. Theor. Biol."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1016/0005-2795(78)90090-9",
      "article-title": "Electron capture at the iron\u2013oxygen centre in single crystals of oxymyoglobin studied by electron spin resonance spectroscopy",
      "volume": "535",
      "author": "Symons",
      "year": "1978",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "213",
      "DOI": "10.1016/0014-5793(79)80730-9",
      "article-title": "Intermediate spin-states in one-electron reduction of oxygen\u2013hemoprotein complexes at low temperature",
      "volume": "106",
      "author": "Gasyna",
      "year": "1979",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib15",
      "first-page": "97",
      "article-title": "ESR spectroscopy of unstable intermediates of the reduction of oxygen complexes of cytochrome P450 and other hemoproteins",
      "volume": "95",
      "author": "Davydov",
      "year": "1983",
      "journal-title": "Stud. Biophys."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "327",
      "DOI": "10.1016/0167-4838(85)90218-3",
      "article-title": "Electron spin and electron nuclear double resonance of the [FeO2]\u2212 [ferrite] center from irradiated oxyhemo- and oxymyoglobin",
      "volume": "827",
      "author": "Kappl",
      "year": "1985",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "20",
      "DOI": "10.1016/0167-4838(86)90004-X",
      "article-title": "Spin-density distribution in the [FeO2]-complex. Electron spin resonance of myoglobin single crystals",
      "volume": "870",
      "author": "Leibl",
      "year": "1986",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1016/0014-5793(91)81398-R",
      "article-title": "EPR-spectroscopy of reduced oxyferrous-P450cam",
      "volume": "295",
      "author": "Davydov",
      "year": "1991",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1016/S0898-8838(08)60150-6",
      "article-title": "Coming to grips with reactive intermediates",
      "volume": "46",
      "author": "Downs",
      "year": "1998",
      "journal-title": "Adv. Inorg. Chem."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "246",
      "DOI": "10.1016/0014-5793(74)80522-3",
      "article-title": "Studies on the conformational changes of metalloproteins induced by electrons in water\u2013ethylene glycol solutions at low temperatures. Haemoglobin",
      "volume": "49",
      "author": "Blumenfeld",
      "year": "1974",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "10654",
      "DOI": "10.1021/ja9918829",
      "article-title": "EPR and ENDOR of catalytic intermediates in cryoreduced native and mutant oxy-cytochromes P450cam: mutation-induced changes in the proton delivery system",
      "volume": "121",
      "author": "Davydov",
      "year": "1999",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "11648",
      "DOI": "10.1074/jbc.M010219200",
      "article-title": "Cryotrapped reaction intermediates of cytochrome P450 studied by radiolytic reduction with phosphorus-32",
      "volume": "276",
      "author": "Denisov",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "1403",
      "DOI": "10.1021/ja003583l",
      "article-title": "Hydroxylation of camphor by reduced oxy-cytochrome P450cam: mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes",
      "volume": "123",
      "author": "Davydov",
      "year": "2001",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1016/S0076-6879(02)57670-9",
      "article-title": "Cryoradiolysis for the study of P450 reaction intermediates",
      "volume": "357",
      "author": "Denisov",
      "year": "2002",
      "journal-title": "Meth. Enzymol."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1016/S0162-0134(01)00328-2",
      "article-title": "Characterization of the oxygenated intermediate of the thermophilic cytochrome P450CYP119",
      "volume": "87",
      "author": "Denisov",
      "year": "2001",
      "journal-title": "J. Inorg. Biochem."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "203",
      "DOI": "10.1016/S0014-5793(02)03674-8",
      "article-title": "Cryogenic absorption spectra of hydroperoxo-ferric heme oxygenase, the active intermediate of enzymatic heme oxygenation",
      "volume": "532",
      "author": "Denisov",
      "year": "2002",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "42706",
      "DOI": "10.1074/jbc.M207949200",
      "article-title": "Formation and decay of hydroperoxo\u2013ferric heme complex in horseradish peroxidase studied by cryoradiolysis",
      "volume": "277",
      "author": "Denisov",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "13714",
      "DOI": "10.1021/ja036949d",
      "article-title": "Resonance Raman spectroscopic studies of hydroperoxo-myoglobin at cryogenic temperatures",
      "volume": "125",
      "author": "Ibrahim",
      "year": "2003",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib29",
      "first-page": "577",
      "article-title": "Systematic trends in the spectroscopic properties of low-spin ferric ligand adducts of cytochrome P-450 and chloroperoxidase: the transition from normal to hyper spectra",
      "volume": "16",
      "author": "Dawson",
      "year": "1992",
      "journal-title": "New J. Chem."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "522",
      "DOI": "10.1021/ar0202565",
      "article-title": "ENDOR of metalloenzymes",
      "volume": "36",
      "author": "Hoffman",
      "year": "2003",
      "journal-title": "Acc. Chem. Res."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1021/cr020628n",
      "article-title": "Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates",
      "volume": "104",
      "author": "Costas",
      "year": "2004",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1016/S0010-8545(00)00332-5",
      "article-title": "Electronic structures of active sites in electron transfer metalloproteins: contributions to reactivity",
      "volume": "200\u2013202",
      "author": "Solomon",
      "year": "2000",
      "journal-title": "Coord. Chem. Rev."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib33",
      "unstructured": "T.M. Makris, I.G. Denisov, Q. Ma, J.P. Quintana, D.T. Keane, S.G. Sligar, XANES and EXAFS studies of the hydroperoxo\u2013ferriheme intermediate in cytochrome P450 CYP101, J. Am. Chem. Soc. (2005) submitted."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1016/j.ccr.2004.03.019",
      "article-title": "Atomic resolution crystallography and XAFS",
      "volume": "249",
      "author": "Strange",
      "year": "2005",
      "journal-title": "Coord. Chem. Rev."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "10934",
      "DOI": "10.1016/S0021-9258(18)33913-9",
      "article-title": "Endogenous cysteine ligation in ferric and ferrous cytochrome P-450. Direct evidence from x-ray absorption spectroscopy",
      "volume": "257",
      "author": "Hahn",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "8114",
      "DOI": "10.1021/ja00285a052",
      "article-title": "Oxygenated cytochrome P-450-CAM and chloroperoxidase: direct evidence for sulfur donor ligation trans to dioxygen and structural characterization using EXAFS spectroscopy",
      "volume": "108",
      "author": "Dawson",
      "year": "1986",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "407",
      "DOI": "10.1021/cr980389x",
      "article-title": "Role of the heme active site and protein environment in structure, spectra, and function of the cytochrome P450s",
      "volume": "100",
      "author": "Loew",
      "year": "2000",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "2806",
      "DOI": "10.1021/ja0171963",
      "article-title": "Searching for the second oxidant in the catalytic cycle of cytochrome P450: A theoretical investigation of the iron(III)\u2013hydroperoxo species and its epoxidation pathways",
      "volume": "124",
      "author": "Ogliaro",
      "year": "2002",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "479",
      "DOI": "10.1073/pnas.98.2.479",
      "article-title": "Simultaneous observation of the O\u00b7O and Fe\u00b7O2 stretching modes in oxyhemoglobins",
      "volume": "98",
      "author": "Das",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "10810",
      "DOI": "10.1021/ja012621d",
      "article-title": "Electronic structure and reactivity of low-spin Fe(III)\u2013hydroperoxo complexes: comparison to activated bleomycin",
      "volume": "124",
      "author": "Lehnert",
      "year": "2002",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "3589",
      "DOI": "10.1073/pnas.0336792100",
      "article-title": "Non-heme iron enzymes: contrasts to heme catalysis",
      "volume": "100",
      "author": "Solomon",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1021/cr9900275",
      "article-title": "Geometric and electronic structure/function correlations in non-heme iron enzymes",
      "volume": "100",
      "author": "Solomon",
      "year": "2000",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "412",
      "DOI": "10.1016/0006-291X(85)90432-2",
      "article-title": "P450cam gene cloning and expression in Pseudomonas putida and Escherichia coli",
      "volume": "130",
      "author": "Koga",
      "year": "1985",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "11420",
      "DOI": "10.1021/bi00112a008",
      "article-title": "Crystal structure of the cytochrome P-450cam active site mutant Thr252Ala",
      "volume": "30",
      "author": "Raag",
      "year": "1991",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "965",
      "DOI": "10.1093/oxfordjournals.jbchem.a022848",
      "article-title": "X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center",
      "volume": "128",
      "author": "Hishiki",
      "year": "2000",
      "journal-title": "J. Biochem. (Tokyo)"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "96",
      "DOI": "10.1006/bbrc.1995.1310",
      "article-title": "Role of Thr-252 in cytochrome P450cam\u2014a study with unnatural amino-acid mutagenesis",
      "volume": "208",
      "author": "Kimata",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "4260",
      "DOI": "10.1016/S0021-9258(17)41772-8",
      "article-title": "A role for Asp-251 in cytochrome P-450cam oxygen activation",
      "volume": "269",
      "author": "Gerber",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib48",
      "series-title": "Catalysis by Metal Complexes, v.19, Oxygenases and Model Systems",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1007/978-94-011-5442-0_5",
      "article-title": "Heme monooxygenases. A chemical mechanism for cytochrome P450 oxygen activation",
      "author": "Shimada",
      "year": "1997"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "1615",
      "DOI": "10.1126/science.287.5458.1615",
      "article-title": "The catalytic pathway of cytochrome p450cam at atomic resolution",
      "volume": "287",
      "author": "Schlichting",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "290",
      "DOI": "10.1016/0006-291X(74)90565-8",
      "article-title": "Superoxide anion production by the autoxidation of cytochrome P450cam",
      "volume": "61",
      "author": "Sligar",
      "year": "1974",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.bbrc.2005.08.094_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "6812",
      "DOI": "10.1016/S0021-9258(17)39800-9",
      "article-title": "On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction",
      "volume": "259",
      "author": "Gorsky",
      "year": "1984",
      "journal-title": "J. Biol. Chem."
    }
  ],
  "container-title": "Biochemical and Biophysical Research Communications",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0006291X05018073?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0006291X05018073?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        16
      ]
    ],
    "date-time": "2021-07-16T18:22:17Z",
    "timestamp": 1626459737000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0006291X05018073"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2005,
        12
      ]
    ]
  },
  "references-count": 51,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2005,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "S0006291X05018073"
  ],
  "URL": "http://dx.doi.org/10.1016/j.bbrc.2005.08.094",
  "relation": {},
  "ISSN": [
    "0006-291X"
  ],
  "subject": [],
  "container-title-short": "Biochemical and Biophysical Research Communications",
  "published": {
    "date-parts": [
      [
        2005,
        12
      ]
    ]
  }
}