DOI: 10.1016/j.bbrc.2004.07.021. Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro

Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro

10.1016/j.bbrc.2004.07.021

Crossref journal-article

Elsevier BV

Biochemical and Biophysical Research Communications (78)

Bibliography

McLean, P. J., Klucken, J., Shin, Y., & Hyman, B. T. (2004). Geldanamycin induces Hsp70 and prevents Î±-synuclein aggregation and toxicity in vitro. Biochemical and Biophysical Research Communications, 321(3), 665â669.

Authors 4

Pamela J. McLean (first)
Jochen Klucken (additional)
Youngah Shin (additional)
Bradley T. Hyman (additional)

References 18 Referenced 150

10.1093/hmg/9.19.2811 / Hum. Mol. Genet. / Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila by Chan (2000)
10.1038/502 / Nat. Genet. / Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1 by Cummings (1998)
10.1126/science.1067389 / Science / Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson’s disease by Auluck (2002)
10.1097/00005072-199804000-00005 / J. Neuropathol. Exp. Neurol. / Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson’s disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity by Irizarry (1998)
10.1038/42166 / Nature / Alpha-synuclein in Lewy bodies by Spillantini (1997)
10.1074/jbc.M400255200 / J. Biol. Chem. / Hsp70 reduces alpha-synuclein aggregation and toxicity by Klucken (2004)
10.1046/j.1471-4159.2002.01190.x / J. Neurochem. / TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation by McLean (2002)
10.1093/hmg/10.12.1307 / Human. Mol. Genet. / Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington’s disease by Sittler (2001)
10.1038/nm1102-1185 / Nat. Med. / Pharmacological prevention of parkinson disease in Drosophila by Auluck (2002)
10.1093/hmg/ddh083 / Hum. Mol. Genet. / CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation by Petrucelli (2004)
10.1016/S0306-4522(01)00113-0 / Neuroscience / α-Synuclein-enhanced green fluorescent protein fusion proteins form proteasomal sensitive inclusions in primary neurons by McLean (2001)
10.1074/jbc.275.12.8812 / J. Biol. Chem. / Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson’s disease-linked mutations by McLean (2000)
10.1038/8820 / Nat. Genet. / Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions by Engelender (1999)
10.1046/j.1471-4159.2001.00301.x / J. Neurochem. / Interaction of α-synuclein and synphilin-1: effect of Parkinson’s disease associated mutations by Kawamata (2001)
10.1002/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B / Ann. Neurol. / Synphilin-1 is present in Lewy bodies in Parkinson’s disease by Wakabayashi (2000)
10.1007/BF00687787 / Acta. Neuropathol. (Berl.) / Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study by Kuzuhara (1988)
10.1021/bi030086j / Biochemistry / Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson’s disease by Volles (2003)
10.1146/annurev.neuro.26.010302.081142 / Annu. Rev. Neurosci. / Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders by Caughey (2003)

Dates

Type	When
Created	21 years, 1 month ago (July 22, 2004, 7:34 a.m.)
Deposited	6 years, 6 months ago (Feb. 7, 2019, 9:03 p.m.)
Indexed	9 months, 2 weeks ago (Nov. 19, 2024, 10:51 a.m.)
Issued	21 years, 1 month ago (Aug. 1, 2004)
Published	21 years, 1 month ago (Aug. 1, 2004)
Published Print	21 years, 1 month ago (Aug. 1, 2004)

Funders 0

None

BibTeX

@article{McLean_2004, title={Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro}, volume={321}, ISSN={0006-291X}, url={http://dx.doi.org/10.1016/j.bbrc.2004.07.021}, DOI={10.1016/j.bbrc.2004.07.021}, number={3}, journal={Biochemical and Biophysical Research Communications}, publisher={Elsevier BV}, author={McLean, Pamela J. and Klucken, Jochen and Shin, Youngah and Hyman, Bradley T.}, year={2004}, month=aug, pages={665–669} }

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