DOI: 10.1016/j.bbrc.2003.08.058. BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2

BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2

10.1016/j.bbrc.2003.08.058

Crossref journal-article

Elsevier BV

Biochemical and Biophysical Research Communications (78)

Bibliography

Lee, M.-H., Kwon, T.-G., Park, H.-S., Wozney, J. M., & Ryoo, H.-M. (2003). BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochemical and Biophysical Research Communications, 309(3), 689â694.

Authors 5

Mi-Hye Lee (first)
Tae-Geon Kwon (additional)
Hyo-Sang Park (additional)
John M Wozney (additional)
Hyun-Mo Ryoo (additional)

References 26 Referenced 331

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10.1074/jbc.272.35.22046 / J. Biol. Chem. / A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts by Namiki (1997)
10.1006/excr.1997.3680 / Exp. Cell. Res. / Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts by Akiyama (1997)
10.1006/bbrc.1997.7325 / Biochem. Biophys. Res. Commun. / Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts by Yamamoto (1997)
10.1074/jbc.273.4.1872 / J. Biol. Chem. / Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12 by Nishimura (1998)
10.1006/dbio.1998.9197 / Dev. Biol. / A BMP-inducible gene, Dlx5, regulates osteoblast differentiation and mesoderm induction by Miyama (1999)
{'key': '10.1016/j.bbrc.2003.08.058_BIB8', 'first-page': '681', 'article-title': 'Differential regulation of Dlx gene expression by a BMP morphogenetic gradient', 'volume': '45', 'author': 'Luo', 'year': '2001', 'journal-title': 'Int. J. Dev. Biol.'} / Int. J. Dev. Biol. / Differential regulation of Dlx gene expression by a BMP morphogenetic gradient by Luo (2001)
M.H. Lee, Y.J. Kim, H.J. Kim, H.D. Park, A.R. Kang, H.M. Kyung, J.H. Sung, J.M. Wozney, H.J. Kim, H.M. Ryoo, BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-β1 opposes the BMP-2-induced osteoblast differentiation by suppression of the Dlx5 expression, J. Biol. Chem. 278 (2003) (in press) (10.1074/jbc.M211386200)
10.1002/(SICI)1097-4644(19990401)73:1<114::AID-JCB13>3.0.CO;2-M / J. Cell. Biochem. / Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation by Lee (1999)
10.1128/MCB.20.23.8783-8792.2000 / Mol. Cell. Biol. / Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12 by Lee (2000)
10.1016/S0092-8674(01)00622-5 / Cell / The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation by Nakashima (2002)
10.1210/mend.11.11.0011 / Mol. Endocrinol. / Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression by Ryoo (1997)
10.1046/j.1365-2443.2001.00466.x / Genes Cells / Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Masx and Dlx5 by Shirakabe (2001)
10.1359/jbmr.2002.17.6.1008 / J. Bone Miner. Res. / Overexpression of Dlx5 in chicken calvarial cells accelerates osteoblastic differentiation by Tadic (2002)
10.1242/dev.126.17.3795 / Development / Craniofacial, vestibular and bone defects in mice lacking the distal-less-related gene Dlx5 by Acampora (1999)
10.1101/gad.988402 / Genes Dev. / The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development by Robledo (2002)
10.1016/S0092-8674(00)80257-3 / Cell / Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation by Ducy (1997)
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10.1073/pnas.180309597 / Proc. Natl. Acad. Sci. USA / A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia by Zhang (2000)
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10.1016/S0092-8674(00)80249-4 / Cell / The missing bone by Rodan (1997)
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10.1126/science.3201241 / Science / Novel regulators of bone formation: molecular clones and activities by Wozney (1988)
10.1073/pnas.87.6.2220 / Proc. Natl. Acad. Sci. USA / Recombinant human bone morphogenetic protein induces bone formation by Wang (1990)
10.1074/jbc.M203750200 / J. Biol. Chem. / The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2 by Kim (2003)

Dates

Type	When
Created	21 years, 11 months ago (Sept. 11, 2003, 7:30 p.m.)
Deposited	4 years, 2 months ago (June 10, 2021, 2:57 p.m.)
Indexed	6 days, 17 hours ago (Aug. 29, 2025, 5:50 a.m.)
Issued	22 years ago (Sept. 1, 2003)
Published	22 years ago (Sept. 1, 2003)
Published Print	22 years ago (Sept. 1, 2003)

Funders 0

None

BibTeX

@article{Lee_2003, title={BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2}, volume={309}, ISSN={0006-291X}, url={http://dx.doi.org/10.1016/j.bbrc.2003.08.058}, DOI={10.1016/j.bbrc.2003.08.058}, number={3}, journal={Biochemical and Biophysical Research Communications}, publisher={Elsevier BV}, author={Lee, Mi-Hye and Kwon, Tae-Geon and Park, Hyo-Sang and Wozney, John M and Ryoo, Hyun-Mo}, year={2003}, month=sep, pages={689–694} }

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