Crossref
journal-article
Elsevier BV
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (78)
References
199
Referenced
358
10.1242/jcs.00792
/ J. Cell. Sci. / Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells by Zaidel-Bar (2003)10.1016/S0092-8674(02)00971-6
/ Cell / Integrins: bidirectional, allosteric signaling machines by Hynes (2002)10.1146/annurev.pharmtox.42.090401.151133
/ Annu. Rev. Pharmacol. Toxicol. / Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members by Juliano (2002)10.1016/S0962-8924(01)02152-3
/ Trends Cell Biol. / Integrin signaling revisited by Schwartz (2001)10.1038/71397
/ Nat. Cell Biol. / Complexity and specificity of integrin signalling by Giancotti (2000)10.1242/jcs.00373
/ J. Cell. Sci. / Focal adhesion kinase: the first ten years by Parsons (2003)10.1016/S0955-0674(02)00368-X
/ Curr. Opin. Cell Biol. / Integrin signaling: it's where the action is by Damsky (2002)10.1016/S0167-4889(01)00123-9
/ Biochim. Biophys. Acta / Biochemical signals and biological responses elicited by the focal adhesion kinase by Schaller (2001){'key': '10.1016/j.bbamcr.2004.04.008_BIB9', 'first-page': '1163', 'article-title': 'Focal adhesion kinase: protein interactions and cellular functions', 'volume': '17', 'author': 'Abbi', 'year': '2002', 'journal-title': 'Histol. Histopathol.'}
/ Histol. Histopathol. / Focal adhesion kinase: protein interactions and cellular functions by Abbi (2002)10.2741/1114
/ Front. Biosci. / Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility by Hanks (2003)10.2741/1116
/ Front. Biosci. / Roles of FAK family kinases in nervous system by Xiong (2003)10.2741/1115
/ Front. Biosci. / Focal adhesion kinase in cancer by Hecker (2003)10.1517/14656566.4.2.227
/ Expert Opin. Pharmacother. / Focal adhesion kinase as a potential target in oncology by McLean (2003)10.1023/A:1023725029589
/ Cancer Metastasis Rev. / FAK regulates biological processes important for the pathogenesis of cancer by Gabarra-Niecko (2003)10.1016/S0079-6107(98)00052-2
/ Prog. Biophys. Mol. Biol. / Signaling through focal adhesion kinase by Schlaepfer (1999)10.1038/35046659
/ Nat. Cell Biol. / Paxillin and focal adhesion signalling by Turner (2000)10.1038/sj.onc.1204786
/ Oncogene / Paxillin: a focal adhesion-associated adaptor protein by Schaller (2001)10.1038/sj.onc.1204785
/ Oncogene / Functions of the adapter protein Cas: signal convergence and the determination of cellular responses by Bouton (2001)10.1128/MCB.21.5.1565-1572.2001
/ Mol. Cell. Biol. / Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells by Taylor (2001)10.1091/mbc.E02-08-0508
/ Mol. Biol. Cell / Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling by Walker (2003)10.1046/j.1471-4159.2003.01519.x
/ J. Neurochem. / Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin by Messina (2003)10.1128/MCB.22.22.7731-7743.2002
/ Mol. Cell. Biol. / Alternative splicing controls the mechanisms of FAK autophosphorylation by Toutant (2002){'key': '10.1016/j.bbamcr.2004.04.008_BIB23', 'first-page': '41', 'article-title': 'Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site', 'volume': '11', 'author': 'Ruest', 'year': '2000', 'journal-title': 'Cell Growth Differ.'}
/ Cell Growth Differ. / Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site by Ruest (2000)10.1074/jbc.M101678200
/ J. Biol. Chem. / The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase by Izaguirre (2001)10.1016/S0167-4889(02)00308-7
/ Biochim. Biophys. Acta / Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation by Katz (2002)10.1091/mbc.10.8.2507
/ Mol. Biol. Cell / Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation by Shen (1999)10.1128/MCB.22.3.901-915.2002
/ Mol. Cell. Biol. / The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling by Hagel (2002)10.1091/mbc.12.12.4066
/ Mol. Biol. Cell / Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression by Zhao (2001)10.1016/S1097-2765(03)00179-5
/ Mol. Cell / Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression by Zhao (2003)10.1083/jcb.200302001
/ J. Cell Biol. / Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation by Giannone (2003)10.1128/MCB.20.15.5758-5765.2000
/ Mol. Cell. Biol. / The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation by Wennerberg (2000)10.1091/mbc.E03-01-0046
/ Mol. Biol. Cell / A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397 by Shi (2003)10.1126/science.285.5430.1028
/ Science / Integrin signaling by Giancotti (1999)10.1073/pnas.2336149100
/ Proc. Natl. Acad. Sci. U. S. A. / Src kinase activation by direct interaction with the integrin {beta} cytoplasmic domain by Arias-Salgado (2003)10.1038/35010517
/ Nat. Cell Biol. / FAK integrates growth-factor and integrin signals to promote cell migration by Sieg (2000)10.1038/sj.onc.1205904
/ Oncogene / Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397 by Leu (2002)10.1128/MCB.23.22.8030-8041.2003
/ Mol. Cell. Biol. / Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction by Cooper (2003)10.1074/jbc.M106175200
/ J. Biol. Chem. / Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion by Poullet (2001)10.1074/jbc.M300277200
/ J. Biol. Chem. / Signaling between focal adhesion kinase and trio by Medley (2003)10.1074/jbc.M308562200
/ J. Biol. Chem. / PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation by Kadare (2003)10.1016/S0969-2126(02)00907-3
/ Structure / Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography by Nowakowski (2002)10.1042/bj20020065
/ Biochem. J. / Characterization of an activated mutant of focal adhesion kinase: ‘SuperFAK’ by Gabarra-Niecko (2002)10.1091/mbc.E02-05-0295
/ Mol. Biol. Cell / Regulation of focal adhesion kinase by a novel protein inhibitor FIP200 by Abbi (2002)10.1093/emboj/cdg503
/ EMBO J. / Negative regulation of FAK signaling by SOCS proteins by Liu (2003)10.1074/jbc.273.33.21125
/ J. Biol. Chem. / Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion by Yu (1998)10.1093/emboj/cdg492
/ EMBO J. / integrin-cytoskeleton Force-dependent linkage formation requires downregulation of focal complex dynamics by Shp2 by VonWichert (2003)10.1083/jcb.200211118
/ J. Cell Biol. / Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion by Chiarugi (2003)10.1083/jcb.200206049
/ J. Cell Biol. / PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration by Zeng (2003)10.1074/jbc.M212396200
/ J. Biol. Chem. / Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases by Katz (2003)10.1083/jcb.147.3.611
/ J. Cell Biol. / Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase by Renshaw (1999)10.1038/nsb755
/ Nat. Struct. Biol. / The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin by Hayashi (2002)10.1128/MCB.22.8.2751-2760.2002
/ Mol. Cell. Biol. / Structural insight into the mechanisms of targeting, signaling of focal adhesion kinase by Liu (2002)10.1091/mbc.12.1.1
/ Mol. Biol. Cell / Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas) by Ma (2001)10.1074/jbc.M210876200
/ J. Biol. Chem. / Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation by Hunger-Glaser (2003)10.1083/jcb.200109079
/ J. Cell Biol. / Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling by Eliceiri (2002)10.1093/emboj/cdg416
/ EMBO J. / Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors by Finnemann (2003)10.1073/pnas.95.23.13658
/ Proc. Natl. Acad. Sci. U. S. A. / Involvement of focal adhesion kinase in invasin-mediated uptake by Alrutz (1998)10.1128/IAI.68.11.6423-6430.2000
/ Infect. Immun. / Involvement of focal adhesion kinase in Escherichia coli invasion of human brain microvascular endothelial cells by Reddy (2000)10.1242/jcs.115.13.2689
/ J. Cell. Sci. / Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake by Bruce-Staskal (2002)10.1016/S0092-8674(03)00605-6
/ Cell / Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration by Xie (2003)10.1038/ncb0703-599
/ Nat. Cell Biol. / Conserved microtubule-actin interactions in cell movement and morphogenesis by Rodriguez (2003)10.1242/jcs.114.21.3795
/ J. Cell. Sci. / Cell motility: can Rho GTPases and microtubules point the way? by Wittmann (2001)10.1126/science.1091325
/ Science / Spatial regulation of microtubule stabilization in migrating cells by integrin facilitated Rho signaling by Palazzo (2004)10.1242/jcs.00094
/ J. Cell. Sci. / Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation by Sun (2002)10.1038/35074500
/ Nat. Cell Biol. / Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain by Chen (2001)10.1038/35000008
/ Nat. Cell Biol. / Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation by Miao (2000)10.1038/ncb823
/ Nat. Cell Biol. / EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas) by Carter (2002){'key': '10.1016/j.bbamcr.2004.04.008_BIB68', 'first-page': '1989', 'article-title': 'Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK', 'volume': '11', 'author': 'Furuta', 'year': '1995', 'journal-title': 'Oncogene'}
/ Oncogene / Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK by Furuta (1995){'key': '10.1016/j.bbamcr.2004.04.008_BIB69', 'series-title': 'The Anotomical Basis of Mouse Development', 'author': 'Kaufman', 'year': '1999'}
/ The Anotomical Basis of Mouse Development by Kaufman (1999){'key': '10.1016/j.bbamcr.2004.04.008_BIB70', 'series-title': 'Mosue Development, Patterning, Morphogenesis, and Organogenesis', 'author': 'Roussant', 'year': '2002'}
/ Mosue Development, Patterning, Morphogenesis, and Organogenesis by Roussant (2002)10.1006/bbrc.1995.1503
/ Biochem. Biophys. Res. Commun. / Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells by Ilic (1995)10.4049/jimmunol.171.11.6178
/ J. Immunol. / Alterations in granule matrix and cell surface of focal adhesion kinase-deficient mast cells by Vial (2003)10.1161/01.RES.0000055016.36679.23
/ Circ. Res. / Focal adhesion kinase is required for blood vessel morphogenesis by Ilic (2003)10.1038/377539a0
/ Nature / Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice by Ilic (1995)10.1073/pnas.201201198
/ Proc. Natl. Acad. Sci. U. S. A. / Focal adhesion kinase is involved in mechanosensing during fibroblast migration by Wang (2001)10.1006/excr.1996.0038
/ Exp. Cell Res. / Impairment of mobility in endodermal cells by FAK deficiency by Ilic (1996)10.1016/S0955-0674(98)80043-4
/ Curr. Opin. Cell Biol. / Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors by Damsky (1998)10.1016/S0002-9440(10)61677-X
/ Am. J. Pathol. / Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro by Ilic (2001)10.1242/dev.119.4.1079
/ Development / Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin by George (1993)10.1002/(SICI)1097-0177(199610)207:2<145::AID-AJA3>3.0.CO;2-H
/ Dev. Dyn. / Mesodermal development in mouse embryos mutant for fibronectin by Georges-Labouesse (1996)10.1016/S0955-0674(99)00017-4
/ Curr. Opin. Cell Biol. / Fibronectin fibrillogenesis: a paradigm for extracellular matrix assembly by Schwarzbauer (1999)10.1074/jbc.273.40.25533
/ J. Biol. Chem. / Control of cell cycle progression by fibronectin matrix architecture by Sechler (1998)10.1016/S0955-0674(99)80037-4
/ Curr. Opin. Cell Biol. / Bidirectional signaling between the cytoskeleton and integrins by Schoenwaelder (1999)10.1242/jcs.00845
/ J. Cell. Sci. / FAK promotes organization of fibronectin matrix and fibrillar adhesions by Ilic (2004)10.1016/S0896-6273(03)00666-4
/ Neuron / FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies by Beggs (2003)10.1523/JNEUROSCI.22-15-06309.2002
/ J. Neurosci. / Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage by Gorski (2002)10.1002/jcb.240550113
/ J. Cell. Biochem. / Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II by Polte (1994)10.1182/blood.V90.8.3073
/ Blood / Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells by George (1997)10.1038/377539a0
/ Nature / Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice by Ilic (1995)10.1161/01.RES.0000059260.91342.6E
/ Circ. Res. / The FAKs about blood vessel assembly by Bohnsack (2003)10.1093/emboj/18.4.934
/ EMBO J. / JunB is essential for mammalian placentation by Schorpp-Kistner (1999)10.1074/jbc.M303771200
/ J. Biol. Chem. / An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells by Sundberg (2003)10.1074/jbc.M006162200
/ J. Biol. Chem. / Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression by Lebrun (2000)10.1083/jcb.149.3.741
/ J. Cell Biol. / Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase by Almeida (2000)10.1083/jcb.145.7.1461
/ J. Cell Biol. / Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle by Oktay (1999)10.1038/sj.onc.1203932
/ Oncogene / A role for FAK in the concanavalin a-dependent secretion of matrix metalloproteinase-2 and -9 by Sein (2000){'key': '10.1016/j.bbamcr.2004.04.008_BIB97', 'first-page': '7079', 'article-title': 'Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells', 'volume': '61', 'author': 'Hauck', 'year': '2001', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells by Hauck (2001)10.1083/jcb.200212114
/ J. Cell Biol. / Differential regulation of cell motility and invasion by FAK by Hsia (2003)10.1016/S0955-0674(97)80068-3
/ Curr. Opin. Cell Biol. / AP-1 function and regulation by Karin (1997)10.1006/dbio.1995.1214
/ Dev. Biol. / Molecular analysis and developmental expression of the focal adhesion kinase pp125FAK in Xenopus laevis by Hens (1995)10.1091/mbc.E02-08-0537
/ Mol. Biol. Cell / Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis by Crawford (2003)10.1006/dbio.2001.0467
/ Dev. Biol. / Roles for zebrafish focal adhesion kinase in notochord and somite morphogenesis by Henry (2001)10.1074/jbc.274.41.29196
/ J. Biol. Chem. / Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster by Fujimoto (1999)10.1074/jbc.274.50.35621
/ J. Biol. Chem. / DFak56 is a novel Drosophila melanogaster focal adhesion kinase by Palmer (1999)10.1073/pnas.96.26.14978
/ Proc. Natl. Acad. Sci. U. S. A. / Expression of DFak56, a drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo by Fox (1999)10.1016/S0925-4773(01)00393-8
/ Mech. Dev. / Command and control: regulatory pathways controlling invasive behavior of the border cells by Montell (2001)10.1016/S1534-5807(02)00142-9
/ Dev. Cell / DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis by Cohen (2002)10.1074/jbc.M108504200
/ J. Biol. Chem. / Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase by Chikumi (2002)10.1074/jbc.M302381200
/ J. Biol. Chem. / Direct interaction of focal adhesion kinase with p190RhoGEF by Zhai (2003)10.1074/jbc.M003839200
/ J. Biol. Chem. / Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules by van Horck (2001)10.1073/pnas.070552297
/ Proc. Natl. Acad. Sci. U. S. A. / The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton by Randazzo (2000)10.1091/mbc.E02-01-0018
/ Mol. Biol. Cell / The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly by Liu (2002)10.1074/jbc.M302278200
/ J. Biol. Chem. / The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1 by Kruljac-Letunic (2003)10.1038/nature01082
/ Nature / Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions by Ling (2002)10.1016/S0955-0674(99)00067-8
/ Curr. Opin. Cell Biol. / Focal adhesions—the cytoskeletal connection by Critchley (2000)10.1038/nature01147
/ Nature / Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin by Di Paolo (2002)10.1016/S1097-2765(02)00823-7
/ Mol. Cell / Structural determinants of integrin recognition by talin by Garcia-Alvarez (2003)10.1038/ncb829
/ Nat. Cell Biol. / Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling by Avizienyte (2002)10.1242/jcs.113.20.3673
/ J. Cell. Sci. / Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover by Ren (2000)10.1074/jbc.M204429200
/ J. Biol. Chem. / Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells by Chen (2002)10.1074/jbc.M203063200
/ J. Biol. Chem. / Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate by Huang (2002)10.1093/emboj/18.9.2459
/ EMBO J. / Src family kinases are required for integrin but not PDGFR signal transduction by Klinghoffer (1999)10.1083/jcb.152.1.97
/ J. Cell Biol. / Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells by Klingbeil (2001)10.1128/MCB.19.7.4806
/ Mol. Cell. Biol. / Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2 by Owen (1999)10.1242/jcs.112.16.2677
/ J. Cell. Sci. / Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration by Sieg (1999)10.1073/pnas.052018099
/ Proc. Natl. Acad. Sci. U. S. A. / The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells by Li (2002)10.1128/MCB.22.8.2427-2440.2002
/ Mol. Cell. Biol. / SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading by Cary (2002)10.1074/jbc.M100984200
/ J. Biol. Chem. / Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397 by Salazar (2001)10.1074/jbc.M307936200
/ J. Biol. Chem. / Human cytomegalovirus chemokine US28 induced SMC migration is mediated by focal adhesion kinase and Src by Streblow (2003)10.1083/jcb.200212141
/ J. Cell Biol. / PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation by Slack-Davis (2003)10.1038/sj.onc.1205840
/ Oncogene / A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated by Takino (2002)10.1038/nature01745
/ Nature / JNK phosphorylates paxillin and regulates cell migration by Huang (2003)10.1074/jbc.M213115200
/ J. Biol. Chem. / Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts by Funakoshi-Tago (2003)10.1083/jcb.jcb.200302126
/ J. Cell Biol. / FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration by McKean (2003)10.1006/bbrc.2001.6321
/ Biochem. Biophys. Res. Commun. / A role for focal adhesion kinase in hyluronan-dependent MMP-2 secretion in a human small-cell lung carcinoma cell line, QG90 by Zhang (2002)10.1093/emboj/19.12.2911
/ EMBO J. / Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src by Fincham (2000)10.1074/jbc.M206087200
/ J. Biol. Chem. / MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression by Yujiri (2003)10.1093/emboj/cdg322
/ EMBO J. / MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts by Cuevas (2003)10.1074/jbc.M108893200
/ J. Biol. Chem. / Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts by Dourdin (2001)10.1016/S0960-9822(03)00544-X
/ Curr. Biol. / A novel role for FAK as a protease-targeting adaptor protein. Regulation by p42 ERK and Src by Carragher (2003)10.1074/jbc.M203952200
/ J. Biol. Chem. / Calcium oscillations trigger focal adhesion disassembly in human U87 astrocytoma cells by Giannone (2002)10.1074/jbc.274.32.22393
/ J. Biol. Chem. / A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins by Bagrodia (1999)10.1128/MCB.20.17.6354-6363.2000
/ Mol. Cell. Biol. / Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly by Zhao (2000){'key': '10.1016/j.bbamcr.2004.04.008_BIB144', 'first-page': '215', 'article-title': 'Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses', 'volume': '9', 'author': 'Lark', 'year': '2003', 'journal-title': 'Clin. Cancer Res.'}
/ Clin. Cancer Res. / Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses by Lark (2003)10.1038/sj.onc.1204208
/ Oncogene / Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells by Slack (2001)10.1074/jbc.M009329200
/ J. Biol. Chem. / The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase by Hauck (2001)10.1074/jbc.C100760200
/ J. Biol. Chem. / v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion by Hauck (2002)10.1002/cncr.10992
/ Cancer / Elevated focal adhesion kinase expression facilitates oral tumor cell invasion by Schneider (2002)10.1002/jcb.10025
/ J. Cell. Biochem. / FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation by Roy (2002)10.1074/jbc.M302720200
/ J. Biol. Chem. / v-Src rescues actin-based cytoskeletal architecture and cell motility, and induces enhanced anchorage-independence during oncogenic transformation of focal adhesion kinase-null fibroblasts by Moissoglu (2003)10.1093/emboj/17.20.5933
/ EMBO J. / Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration by Sieg (1998)10.1016/S0960-9822(00)00537-6
/ Curr. Biol. / Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism by Arthur (2000)10.1091/mbc.12.9.2711
/ Mol. Biol. Cell / RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity by Arthur (2001)10.1038/sj.onc.1202850
/ Oncogene / RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases by Aguirre-Ghiso (1999)10.1093/emboj/cdf631
/ EMBO J. / FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth by Hauck (2002){'key': '10.1016/j.bbamcr.2004.04.008_BIB156', 'first-page': '900', 'article-title': 'Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells', 'volume': '58', 'author': 'Shibata', 'year': '1998', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells by Shibata (1998)10.1083/jcb.200111032
/ J. Cell Biol. / Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold by Cho (2002)10.1074/jbc.M307526200
/ J. Biol. Chem. / SRC phosphorylates cas on tyrosine 253 to promote migration of transformed cells by Goldberg (2003)10.1038/sj.onc.1205298
/ Oncogene / Src kinase contributes to the metastatic spread of carcinoma cells by Boyer (2002)10.1074/jbc.M306274200
/ J. Biol. Chem. / Alphavbeta6-Fyn signaling promotes oral cancer progression by Li (2003)10.1074/jbc.M205307200
/ J. Biol. Chem. / Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth by Abdel-Ghany (2002){'key': '10.1016/j.bbamcr.2004.04.008_BIB162', 'first-page': '1915', 'article-title': 'Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase', 'volume': '62', 'author': 'Wick', 'year': '2002', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase by Wick (2002)10.1074/jbc.M005450200
/ J. Biol. Chem. / Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells by Hauck (2000)10.1128/MCB.19.9.6120
/ Mol. Cell. Biol. / Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase by Nolan (1999)10.1083/jcb.143.2.547
/ J. Cell Biol. / Extracellular matrix survival signals transduced by focal adheison kinase suppress p53-mediated apoptosis by Ilic (1998)10.1074/jbc.274.38.26901
/ J. Biol. Chem. / Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin–Darby canine kidney cells by Chan (1999)10.1089/15230860260196290
/ Antioxid. Redox Signal. / Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation by Kasahara (2002)10.1042/bj20020665
/ Biochem. J. / Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis by Kabir (2002)10.1074/jbc.275.21.16309
/ J. Biol. Chem. / Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60 by Sonoda (2000)10.1074/jbc.M910027199
/ J. Biol. Chem. / The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells by Xu (2000)10.1074/jbc.M205002200
/ J. Biol. Chem. / Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells by Golubovskaya (2002)10.1152/ajpheart.2000.279.6.H2916
/ Am. J. Physiol, Heart Circ. Physiol. / Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway by Pham (2000)10.1006/jmcc.2000.1119
/ J. Mol. Cell. Cardiol. / Outside–in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes by Ogawa (2000)10.1074/jbc.M006124200
/ J. Biol. Chem. / Integrin activation and focal complex formation in cardiac hypertrophy by Laser (2000)10.1161/01.RES.0000081595.25297.1B
/ Circ. Res. / Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes by Torsoni (2003)10.1161/01.RES.87.7.558
/ Circ. Res. / Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart by Franchini (2000)10.1161/01.RES.87.8.710
/ Circ. Res. / Focal adhesion kinase is involved in angiotensin II-mediated protein synthesis in cultured vascular smooth muscle cells by Govindarajan (2000)10.1152/ajpheart.2000.278.5.H1695
/ Am. J. Physiol, Heart Circ. Physiol. / Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase by Eble (2000)10.1074/jbc.M909099199
/ J. Biol. Chem. / A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes by Taylor (2000)10.1091/mbc.12.8.2290
/ Mol. Biol. Cell / Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy by Kovacic-Milivojevic (2001)10.1161/hy0202.102834
/ Hypertension / Src autophosphorylation is an early event in pressure-mediated signaling pathways in isolated resistance arteries by Rice (2002)10.1161/01.RES.0000023201.41774.EA
/ Circ. Res. / GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes by Heidkamp (2002){'key': '10.1016/j.bbamcr.2004.04.008_BIB183', 'first-page': '755', 'article-title': 'Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines', 'volume': '1', 'author': 'Golubovskaya', 'year': '2003', 'journal-title': 'Mol. Cancer Res.'}
/ Mol. Cancer Res. / Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines by Golubovskaya (2003){'key': '10.1016/j.bbamcr.2004.04.008_BIB184', 'first-page': '91', 'article-title': 'The effects of inducible overexpression of FAK-related non-kinase (FRNK) on a transformed epithelial cell line', 'volume': '23', 'author': 'Kornberg', 'year': '2003', 'journal-title': 'Anticancer Res.'}
/ Anticancer Res. / The effects of inducible overexpression of FAK-related non-kinase (FRNK) on a transformed epithelial cell line by Kornberg (2003){'key': '10.1016/j.bbamcr.2004.04.008_BIB185', 'first-page': '1655', 'article-title': 'Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway', 'volume': '59', 'author': 'Zheng', 'year': '1999', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway by Zheng (1999)10.1016/S0092-8674(00)00116-1
/ Cell / Signal transduction by the JNK group of MAP kinases by Davis (2000)10.1016/S0959-8049(00)00175-1
/ Eur. J. Cancer / Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme by Ozanne (2000)10.1042/0264-6021:3600255
/ Biochem. J. / Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells by Abu-Ghazaleh (2001)10.1006/excr.2000.5102
/ Exp. Cell Res. / VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase by Qi (2001)10.1074/jbc.M301253200
/ J. Biol. Chem. / Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the Focal Adhesion Kinase FAK and RAFTK/Pyk2 by Karsenty Avraham (2003){'key': '10.1016/j.bbamcr.2004.04.008_BIB191', 'first-page': '2157', 'article-title': 'Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells', 'volume': '9', 'author': 'Haskell', 'year': '2003', 'journal-title': 'Clin. Cancer Res.'}
/ Clin. Cancer Res. / Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells by Haskell (2003)10.1074/jbc.M209922200
/ J. Biol. Chem. / Endothelial barrier strengthening by activation of focal adhesion kinase by Quadri (2003)10.1038/sj.onc.1202957
/ Oncogene / Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells by Agochiya (1999)10.1242/jcs.113.23.4221
/ J. Cell. Sci. / p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo by Wang (2000){'key': '10.1016/j.bbamcr.2004.04.008_BIB195', 'first-page': '2699', 'article-title': 'Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples', 'volume': '62', 'author': 'Hecker', 'year': '2002', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples by Hecker (2002){'key': '10.1016/j.bbamcr.2004.04.008_BIB196', 'first-page': '2417', 'article-title': 'Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes', 'volume': '6', 'author': 'Cance', 'year': '2000', 'journal-title': 'Clin. Cancer Res.'}
/ Clin. Cancer Res. / Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes by Cance (2000)10.1083/jcb.147.1.89
/ J. Cell Biol. / Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling by Aguirre Ghiso (1999)10.1091/mbc.12.4.863
/ Mol. Biol. Cell / Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo by Aguirre-Ghiso (2001)10.1038/sj.onc.1205342
/ Oncogene / Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo by Aguirre Ghiso (2002)
Dates
Type | When |
---|---|
Created | 21 years, 2 months ago (May 29, 2004, 10:39 p.m.) |
Deposited | 4 years, 2 months ago (June 22, 2021, 1:38 p.m.) |
Indexed | 2 weeks, 5 days ago (Aug. 6, 2025, 9:42 a.m.) |
Issued | 21 years, 1 month ago (July 1, 2004) |
Published | 21 years, 1 month ago (July 1, 2004) |
Published Print | 21 years, 1 month ago (July 1, 2004) |
@article{Schlaepfer_2004, title={Control of motile and invasive cell phenotypes by focal adhesion kinase}, volume={1692}, ISSN={0167-4889}, url={http://dx.doi.org/10.1016/j.bbamcr.2004.04.008}, DOI={10.1016/j.bbamcr.2004.04.008}, number={2–3}, journal={Biochimica et Biophysica Acta (BBA) - Molecular Cell Research}, publisher={Elsevier BV}, author={Schlaepfer, David D and Mitra, Satyajit K and Ilic, Dusko}, year={2004}, month=jul, pages={77–102} }