DOI: 10.1016/s1535-6108(03)00085-0. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

10.1016/s1535-6108(03)00085-0

Crossref journal-article

Elsevier BV

Cancer Cell (78)

Bibliography

Pennacchietti, S., Michieli, P., Galluzzo, M., Mazzone, M., Giordano, S., & Comoglio, P. M. (2003). Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell, 3(4), 347â361.

Authors 6

Selma Pennacchietti (first)
Paolo Michieli (additional)
Maria Galluzzo (additional)
Massimiliano Mazzone (additional)
Silvia Giordano (additional)
Paolo M. Comoglio (additional)

References 97 Referenced 1,108

10.1046/j.1432-1327.1999.00507.x / Eur. J. Biochem. / Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype by Aguirre Ghiso (1999)
10.1002/(SICI)1520-6408(1996)18:3<254::AID-DVG6>3.0.CO;2-8 / Dev. Genet. / Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis by Andermarcher (1996)
10.1074/jbc.274.41.29274 / J. Biol. Chem. / A peptide representing the carboxyl-terminal tail of the met receptor inhibits kinase activity and invasive growth by Bardelli (1999)
{'key': '10.1016/S1535-6108(03)00085-0_BIB4', 'first-page': '230', 'article-title': 'Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells', 'volume': '212', 'author': 'Birchmeier', 'year': '1997', 'journal-title': 'Ciba Found. Symp.'} / Ciba Found. Symp. / Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells by Birchmeier (1997)
{'key': '10.1016/S1535-6108(03)00085-0_BIB5', 'first-page': '257', 'article-title': 'Hypoxia-inducible factor', 'volume': '19', 'author': 'Blagosklonny', 'year': '2001', 'journal-title': 'Int. J. Oncol.'} / Int. J. Oncol. / Hypoxia-inducible factor by Blagosklonny (2001)
10.1016/S0021-9258(18)99953-9 / J. Biol. Chem. / Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF by Boccaccio (1994)
10.1038/34657 / Nature / Induction of epithelial tubules by growth factor HGF depends on the STAT pathway by Boccaccio (1998)
10.1002/hep.1840190115 / Hepatology / c-met mRNA overexpression in human hepatocellular carcinoma by Boix (1994)
10.1083/jcb.131.6.1573 / J. Cell Biol. / Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells by Brinkmann (1995)
{'key': '10.1016/S1535-6108(03)00085-0_BIB10', 'first-page': '941', 'article-title': 'Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma', 'volume': '56', 'author': 'Brizel', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma by Brizel (1996)
10.1016/S0360-3016(97)00101-6 / Int. J. Radiat. Oncol. Biol. Phys. / Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck by Brizel (1997)
{'key': '10.1016/S1535-6108(03)00085-0_BIB12', 'first-page': '8903', 'article-title': 'Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors', 'volume': '61', 'author': 'Cairns', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors by Cairns (2001)
10.1038/nrc865 / Nature Rev. Cancer / Dissemination and growth of cancer cells in metastatic sites by Chambers (2002)
10.1172/JCI0215392 / J. Clin. Invest. / Invasive growth by Comoglio (2002)
10.1016/S0021-9258(17)42091-6 / J. Biol. Chem. / Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum by Crepaldi (1994)
10.1042/bj3270419 / Biochem. J. / Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells by Damert (1997)
10.1038/sj.onc.1202231 / Oncogene / Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor by Date (1998)
{'key': '10.1016/S1535-6108(03)00085-0_BIB18', 'first-page': '2549', 'article-title': 'Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas', 'volume': '7', 'author': 'Di Renzo', 'year': '1992', 'journal-title': 'Oncogene'} / Oncogene / Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas by Di Renzo (1992)
{'key': '10.1016/S1535-6108(03)00085-0_BIB19', 'first-page': '147', 'article-title': 'Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer', 'volume': '1', 'author': 'Di Renzo', 'year': '1995', 'journal-title': 'Clin. Cancer Res.'} / Clin. Cancer Res. / Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer by Di Renzo (1995)
10.1038/sj.onc.1203455 / Oncogene / Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas by Di Renzo (2000)
{'issue': 'Suppl. 3', 'key': '10.1016/S1535-6108(03)00085-0_BIB21', 'first-page': '59', 'article-title': 'Angiogenesis research', 'volume': '9', 'author': 'Folkman', 'year': '1999', 'journal-title': 'Forum (Genova)'} / Forum (Genova) / Angiogenesis research by Folkman (1999)
10.1038/sj.onc.1203620 / Oncogene / Cross-talk between the proto-oncogenes Met and Ron by Follenzi (2000)
10.1128/MCB.16.9.4604 / Mol. Cell. Biol. / Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 by Forsythe (1996)
10.1083/jcb.124.4.619 / J. Cell Biol. / Disruption of epithelial cell-matrix interactions induces apoptosis by Frisch (1994)
10.1016/S0955-0674(00)00251-9 / Curr. Opin. Cell Biol. / Anoikis mechanisms by Frisch (2001)
10.1016/S0021-9258(18)99954-0 / J. Biol. Chem. / Structure and inducible regulation of the human MET promoter by Gambarotta (1994)
{'key': '10.1016/S1535-6108(03)00085-0_BIB27', 'first-page': '1911', 'article-title': 'Ets up-regulates MET transcription', 'volume': '13', 'author': 'Gambarotta', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / Ets up-regulates MET transcription by Gambarotta (1996)
10.1074/jbc.272.38.23659 / J. Biol. Chem. / Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes by Gerber (1997)
10.1073/pnas.86.15.5844 / Proc. Natl. Acad. Sci. USA / Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement by Gherardi (1989)
10.1038/ncb843 / Nat. Cell Biol. / The semaphorin 4D receptor controls invasive growth by coupling with Met by Giordano (2002)
10.1038/379088a0 / Nature / Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours by Graeber (1996)
10.1016/S0092-8674(00)81683-9 / Cell / The hallmarks of cancer by Hanahan (2000)
10.1038/418244a / Nature / RNA interference by Hannon (2002)
10.1038/nrc704 / Nature Rev. Cancer / Hypoxia-a key regulatory factor in tumor growth by Harris (2002)
10.1093/jnci/93.4.266 / J. Natl. Cancer Inst. / Tumor hypoxia by Höckel (2001)
{'key': '10.1016/S1535-6108(03)00085-0_BIB36', 'first-page': '4509', 'article-title': 'Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix', 'volume': '56', 'author': 'Höckel', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix by Höckel (1996)
{'key': '10.1016/S1535-6108(03)00085-0_BIB37', 'first-page': '4525', 'article-title': 'Hypoxic cervical cancers with low apoptotic index are highly aggressive', 'volume': '59', 'author': 'Höckel', 'year': '1999', 'journal-title': 'Cancer Res.'} / Cancer Res. / Hypoxic cervical cancers with low apoptotic index are highly aggressive by Höckel (1999)
10.1182/blood.V95.1.189 / Blood / Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide by Kimura (2000)
10.1128/MCB.19.9.5902 / Mol. Cell. Biol. / The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells by Koochekpour (1999)
10.1074/jbc.270.22.13333 / J. Biol. Chem. / Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia by Levy (1995)
10.1038/35077241 / Nature / The microenvironment of the tumour-host interface by Liotta (2001)
{'key': '10.1016/S1535-6108(03)00085-0_BIB42', 'first-page': '181', 'article-title': 'Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas', 'volume': '7', 'author': 'Liu', 'year': '1992', 'journal-title': 'Oncogene'} / Oncogene / Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas by Liu (1992)
10.1016/S0021-9258(19)78113-7 / J. Biol. Chem. / Interaction of hepatocyte growth factor with heparan-sulfate. Elucidation of the major heparan sulfate structural determinants by Lyon (1994)
10.1006/excr.1999.4804 / Exp. Cell Res. / Both increased stability and transcription contribute to the induction of the urokinase plasminogen activator receptor (uPAR) message by hypoxia by Maity (2000)
10.1016/S1535-6108(02)00044-2 / Cancer Cell / The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal carcinoma by Maranchie (2002)
{'key': '10.1016/S1535-6108(03)00085-0_BIB46', 'first-page': '198', 'article-title': 'Hgf', 'volume': '212', 'author': 'Matsumoto', 'year': '1997', 'journal-title': 'Ciba Found. Symp.'} / Ciba Found. Symp. / Hgf by Matsumoto (1997)
10.1038/20459 / Nature / The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis by Maxwell (1999)
10.1091/mbc.7.4.495 / Mol. Biol. Cell / The tyrosine kinase receptors Ron and Sea control “scattering” and morphogenesis of liver progenitor cells in vitro by Medico (1996)
10.1093/emboj/18.2.363 / EMBO J. / A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases by Meyer (1999)
10.1038/sj.onc.1202899 / Oncogene / Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists by Michieli (1999)
10.1080/15216540252774766 / IUBMB Life / HIF-1 and AP-1 cooperate to increase gene expression in hypoxia by Michiels (2001)
10.1016/S0021-9258(17)37062-X / J. Biol. Chem. / Proteolytic activation of hepatocyte growth factor in response to tissue injury by Miyazawa (1994)
10.1016/0092-8674(91)90363-4 / Cell / Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor by Montesano (1991)
10.1038/sj.onc.1205622 / Oncogene / K252a inhibits the oncogenic properties of Met, the HGF receptor by Morotti (2002)
10.1073/pnas.83.17.6489 / Proc. Natl. Acad. Sci. USA / Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures by Nakamura (1986)
10.1038/342440a0 / Nature / Molecular cloning and expression of human hepatocyte growth factor by Nakamura (1989)
10.1128/MCB.11.4.1793 / Mol. Cell. Biol. / The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation by Naldini (1991)
10.1002/j.1460-2075.1992.tb05588.x / EMBO J. / Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor by Naldini (1992)
10.1074/jbc.270.40.23774 / J. Biol. Chem. / Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene by Norris (1995)
10.1016/0092-8674(94)90200-3 / Cell / Angiostatin by O'Reilly (1994)
10.1034/j.1600-0463.2002.100305.x / APMIS / Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas by Oh (2002)
10.1101/gad.242602 / Genes Dev. / CD44 is required for two consecutive steps in HGF/c-Met signaling by Orian-Rousseau (2002)
{'key': '10.1016/S1535-6108(03)00085-0_BIB63', 'first-page': '307', 'article-title': 'Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas', 'volume': '59', 'author': 'Park', 'year': '1999', 'journal-title': 'Cancer Res.'} / Cancer Res. / Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas by Park (1999)
10.1074/jbc.M204529200 / J. Biol. Chem. / Oxygen-mediated regulation of tumor cell invasiveness. Involvement of a nitric oxide signaling pathway by Postovit (2002)
10.1242/jcs.111.2.237 / J. Cell Sci. / Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF by Prat (1998)
10.1016/S0021-9258(19)61441-9 / J. Biol. Chem. / Nonhypoxic pathway mediates the induction of Hypoxia-Inducible Factor 1α in vascular smooth muscle cells by Richard (2000)
{'key': '10.1016/S1535-6108(03)00085-0_BIB67', 'first-page': '1847', 'article-title': 'Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor', 'volume': '62', 'author': 'Rofstad', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor by Rofstad (2002)
{'key': '10.1016/S1535-6108(03)00085-0_BIB68', 'first-page': '357', 'article-title': 'Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product', 'volume': '1155', 'author': 'Rubin', 'year': '1993', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta / Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product by Rubin (1993)
10.1002/(SICI)1096-9896(199611)180:3<266::AID-PATH658>3.0.CO;2-Q / J. Pathol. / Expression of Met protein in thyroid tumours by Ruco (1996)
10.1074/jbc.M207160200 / J. Biol. Chem. / Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways by Sánchez-Elsner (2002)
10.1038/373699a0 / Nature / Scatter factor/hepatocyte growth factor is essential for liver development by Schmidt (1995)
10.1038/sj.onc.1202547 / Oncogene / Novel mutations of the MET proto-oncogene in papillary renal carcinomas by Schmidt (1999)
10.1016/S0092-8674(01)00518-9 / Cell / HIF-1, O2, and the 3 PHDs by Semenza (2001)
10.1038/sj.onc.1203404 / Oncogene / Transcriptional activation of the hepatocyte growth factor receptor (c-met) gene by its ligand (hepatocyte growth factor) is mediated through AP-1 by Seol (2000)
10.1038/359843a0 / Nature / Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis by Shweiki (1992)
{'key': '10.1016/S1535-6108(03)00085-0_BIB76', 'first-page': '81', 'article-title': 'Regulation of cell movement', 'volume': '1072', 'author': 'Stoker', 'year': '1991', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta / Regulation of cell movement by Stoker (1991)
10.1038/327239a0 / Nature / Scatter factor is a fibroblast-derived modulator of epithelial cell motility by Stoker (1987)
10.1038/bjc.1998.586 / Br. J. Cancer / Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix by Sundfor (1998)
10.1093/carcin/22.9.1363 / Carcinogenesis / Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells by Tacchini (2001)
10.1073/pnas.93.12.5866 / Proc. Natl. Acad. Sci. USA / Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development by Takayama (1996)
10.1038/nrc779 / Nature Rev. Cancer / Scatter-factor and semaphorin receptors by Trusolino (2002)
10.1016/S0092-8674(01)00567-0 / Cell / A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth by Trusolino (2001)
10.1038/373702a0 / Nature / Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor by Uehara (1995)
{'key': '10.1016/S1535-6108(03)00085-0_BIB84', 'first-page': '119', 'article-title': 'Met-hgf/sf', 'volume': '212', 'author': 'Vande Woude', 'year': '1997', 'journal-title': 'Ciba Found. Symp.'} / Ciba Found. Symp. / Met-hgf/sf by Vande Woude (1997)
{'key': '10.1016/S1535-6108(03)00085-0_BIB85', 'first-page': '6449', 'article-title': 'Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors', 'volume': '49', 'author': 'Vaupel', 'year': '1989', 'journal-title': 'Cancer Res.'} / Cancer Res. / Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors by Vaupel (1989)
{'key': '10.1016/S1535-6108(03)00085-0_BIB86', 'first-page': '7394', 'article-title': 'Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts', 'volume': '61', 'author': 'Vukovic', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts by Vukovic (2001)
10.1038/384173a0 / Nature / Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis by Weidner (1996)
10.1002/(SICI)1097-0142(19971015)80:8+<1529::AID-CNCR2>3.0.CO;2-F / Cancer / General mechanisms of metastasis by Woodhouse (1997)
10.1083/jcb.128.1.171 / J. Cell Biol. / Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros by Woolf (1995)
10.1074/jbc.M003894200 / J. Biol. Chem. / Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium by Xu (2000)
10.1074/jbc.M011344200 / J. Biol. Chem. / Molecular regulation of the endothelin-1 gene by hypoxia by Yamashita (2001)
10.1016/S0021-9258(19)36912-1 / J. Biol. Chem. / Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury by Yanagita (1993)
10.1083/jcb.131.1.215 / J. Cell Biol. / Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland by Yang (1995)
10.1093/jnci/82.5.371 / J. Natl. Cancer Inst. / Effects of reoxygenation of cells from hypoxic regions of solid tumors by Young (1990)
10.1073/pnas.85.24.9533 / Proc. Natl. Acad. Sci. USA / Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells by Young (1988)
10.1126/science.1068327 / Science / Effect of p53 status on tumor response to antiangiogenic therapy by Yu (2002)
{'key': '10.1016/S1535-6108(03)00085-0_BIB97', 'article-title': 'Cobalt inhibits the interaction between hypoxia inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia inducible factor-alpha', 'volume': 'in press', 'author': 'Yuan', 'year': '2003', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / Cobalt inhibits the interaction between hypoxia inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia inducible factor-alpha by Yuan (2003)

Dates

Type	When
Created	21 years, 4 months ago (April 14, 2004, 5:27 a.m.)
Deposited	4 years, 2 months ago (June 15, 2021, 11:47 a.m.)
Indexed	2 weeks, 1 day ago (Aug. 22, 2025, 12:46 a.m.)
Issued	22 years, 5 months ago (April 1, 2003)
Published	22 years, 5 months ago (April 1, 2003)
Published Print	22 years, 5 months ago (April 1, 2003)

Funders 0

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BibTeX

@article{Pennacchietti_2003, title={Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene}, volume={3}, ISSN={1535-6108}, url={http://dx.doi.org/10.1016/s1535-6108(03)00085-0}, DOI={10.1016/s1535-6108(03)00085-0}, number={4}, journal={Cancer Cell}, publisher={Elsevier BV}, author={Pennacchietti, Selma and Michieli, Paolo and Galluzzo, Maria and Mazzone, Massimiliano and Giordano, Silvia and Comoglio, Paolo M.}, year={2003}, month=apr, pages={347–361} }

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      "author": "Blagosklonny",
      "year": "2001",
      "journal-title": "Int. J. Oncol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "12846",
      "DOI": "10.1016/S0021-9258(18)99953-9",
      "article-title": "Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF",
      "volume": "269",
      "author": "Boccaccio",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "285",
      "DOI": "10.1038/34657",
      "article-title": "Induction of epithelial tubules by growth factor HGF depends on the STAT pathway",
      "volume": "391",
      "author": "Boccaccio",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1002/hep.1840190115",
      "article-title": "c-met mRNA overexpression in human hepatocellular carcinoma",
      "volume": "19",
      "author": "Boix",
      "year": "1994",
      "journal-title": "Hepatology"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "1573",
      "DOI": "10.1083/jcb.131.6.1573",
      "article-title": "Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells",
      "volume": "131",
      "author": "Brinkmann",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB10",
      "first-page": "941",
      "article-title": "Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma",
      "volume": "56",
      "author": "Brizel",
      "year": "1996",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "285",
      "DOI": "10.1016/S0360-3016(97)00101-6",
      "article-title": "Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck",
      "volume": "38",
      "author": "Brizel",
      "year": "1997",
      "journal-title": "Int. J. Radiat. Oncol. Biol. Phys."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB12",
      "first-page": "8903",
      "article-title": "Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors",
      "volume": "61",
      "author": "Cairns",
      "year": "2001",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1038/nrc865",
      "article-title": "Dissemination and growth of cancer cells in metastatic sites",
      "volume": "2",
      "author": "Chambers",
      "year": "2002",
      "journal-title": "Nature Rev. Cancer"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "857",
      "DOI": "10.1172/JCI0215392",
      "article-title": "Invasive growth",
      "volume": "109",
      "author": "Comoglio",
      "year": "2002",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1750",
      "DOI": "10.1016/S0021-9258(17)42091-6",
      "article-title": "Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum",
      "volume": "269",
      "author": "Crepaldi",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "419",
      "DOI": "10.1042/bj3270419",
      "article-title": "Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells",
      "volume": "327",
      "author": "Damert",
      "year": "1997",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "3045",
      "DOI": "10.1038/sj.onc.1202231",
      "article-title": "Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor",
      "volume": "17",
      "author": "Date",
      "year": "1998",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB18",
      "first-page": "2549",
      "article-title": "Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas",
      "volume": "7",
      "author": "Di Renzo",
      "year": "1992",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB19",
      "first-page": "147",
      "article-title": "Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer",
      "volume": "1",
      "author": "Di Renzo",
      "year": "1995",
      "journal-title": "Clin. Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "1547",
      "DOI": "10.1038/sj.onc.1203455",
      "article-title": "Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas",
      "volume": "19",
      "author": "Di Renzo",
      "year": "2000",
      "journal-title": "Oncogene"
    },
    {
      "issue": "Suppl. 3",
      "key": "10.1016/S1535-6108(03)00085-0_BIB21",
      "first-page": "59",
      "article-title": "Angiogenesis research",
      "volume": "9",
      "author": "Folkman",
      "year": "1999",
      "journal-title": "Forum (Genova)"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "3041",
      "DOI": "10.1038/sj.onc.1203620",
      "article-title": "Cross-talk between the proto-oncogenes Met and Ron",
      "volume": "19",
      "author": "Follenzi",
      "year": "2000",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "4604",
      "DOI": "10.1128/MCB.16.9.4604",
      "article-title": "Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1",
      "volume": "16",
      "author": "Forsythe",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1083/jcb.124.4.619",
      "article-title": "Disruption of epithelial cell-matrix interactions induces apoptosis",
      "volume": "124",
      "author": "Frisch",
      "year": "1994",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "555",
      "DOI": "10.1016/S0955-0674(00)00251-9",
      "article-title": "Anoikis mechanisms",
      "volume": "13",
      "author": "Frisch",
      "year": "2001",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "12852",
      "DOI": "10.1016/S0021-9258(18)99954-0",
      "article-title": "Structure and inducible regulation of the human MET promoter",
      "volume": "269",
      "author": "Gambarotta",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB27",
      "first-page": "1911",
      "article-title": "Ets up-regulates MET transcription",
      "volume": "13",
      "author": "Gambarotta",
      "year": "1996",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "23659",
      "DOI": "10.1074/jbc.272.38.23659",
      "article-title": "Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes",
      "volume": "272",
      "author": "Gerber",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "5844",
      "DOI": "10.1073/pnas.86.15.5844",
      "article-title": "Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement",
      "volume": "86",
      "author": "Gherardi",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "720",
      "DOI": "10.1038/ncb843",
      "article-title": "The semaphorin 4D receptor controls invasive growth by coupling with Met",
      "volume": "4",
      "author": "Giordano",
      "year": "2002",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1038/379088a0",
      "article-title": "Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours",
      "volume": "379",
      "author": "Graeber",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/S0092-8674(00)81683-9",
      "article-title": "The hallmarks of cancer",
      "volume": "100",
      "author": "Hanahan",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "244",
      "DOI": "10.1038/418244a",
      "article-title": "RNA interference",
      "volume": "418",
      "author": "Hannon",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "38",
      "DOI": "10.1038/nrc704",
      "article-title": "Hypoxia-a key regulatory factor in tumor growth",
      "volume": "2",
      "author": "Harris",
      "year": "2002",
      "journal-title": "Nature Rev. Cancer"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1093/jnci/93.4.266",
      "article-title": "Tumor hypoxia",
      "volume": "93",
      "author": "H\u00f6ckel",
      "year": "2001",
      "journal-title": "J. Natl. Cancer Inst."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB36",
      "first-page": "4509",
      "article-title": "Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix",
      "volume": "56",
      "author": "H\u00f6ckel",
      "year": "1996",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB37",
      "first-page": "4525",
      "article-title": "Hypoxic cervical cancers with low apoptotic index are highly aggressive",
      "volume": "59",
      "author": "H\u00f6ckel",
      "year": "1999",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1182/blood.V95.1.189",
      "article-title": "Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide",
      "volume": "95",
      "author": "Kimura",
      "year": "2000",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "5902",
      "DOI": "10.1128/MCB.19.9.5902",
      "article-title": "The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells",
      "volume": "19",
      "author": "Koochekpour",
      "year": "1999",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "13333",
      "DOI": "10.1074/jbc.270.22.13333",
      "article-title": "Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia",
      "volume": "270",
      "author": "Levy",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1038/35077241",
      "article-title": "The microenvironment of the tumour-host interface",
      "volume": "411",
      "author": "Liotta",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB42",
      "first-page": "181",
      "article-title": "Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas",
      "volume": "7",
      "author": "Liu",
      "year": "1992",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "11216",
      "DOI": "10.1016/S0021-9258(19)78113-7",
      "article-title": "Interaction of hepatocyte growth factor with heparan-sulfate. Elucidation of the major heparan sulfate structural determinants",
      "volume": "269",
      "author": "Lyon",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "250",
      "DOI": "10.1006/excr.1999.4804",
      "article-title": "Both increased stability and transcription contribute to the induction of the urokinase plasminogen activator receptor (uPAR) message by hypoxia",
      "volume": "255",
      "author": "Maity",
      "year": "2000",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "247",
      "DOI": "10.1016/S1535-6108(02)00044-2",
      "article-title": "The contribution of VHL substrate binding and HIF1-\u03b1 to the phenotype of VHL loss in renal carcinoma",
      "volume": "1",
      "author": "Maranchie",
      "year": "2002",
      "journal-title": "Cancer Cell"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB46",
      "first-page": "198",
      "article-title": "Hgf",
      "volume": "212",
      "author": "Matsumoto",
      "year": "1997",
      "journal-title": "Ciba Found. Symp."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1038/20459",
      "article-title": "The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis",
      "volume": "399",
      "author": "Maxwell",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1091/mbc.7.4.495",
      "article-title": "The tyrosine kinase receptors Ron and Sea control \u201cscattering\u201d and morphogenesis of liver progenitor cells in vitro",
      "volume": "7",
      "author": "Medico",
      "year": "1996",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "363",
      "DOI": "10.1093/emboj/18.2.363",
      "article-title": "A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases",
      "volume": "18",
      "author": "Meyer",
      "year": "1999",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "5221",
      "DOI": "10.1038/sj.onc.1202899",
      "article-title": "Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists",
      "volume": "18",
      "author": "Michieli",
      "year": "1999",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1080/15216540252774766",
      "article-title": "HIF-1 and AP-1 cooperate to increase gene expression in hypoxia",
      "volume": "52",
      "author": "Michiels",
      "year": "2001",
      "journal-title": "IUBMB Life"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "8966",
      "DOI": "10.1016/S0021-9258(17)37062-X",
      "article-title": "Proteolytic activation of hepatocyte growth factor in response to tissue injury",
      "volume": "269",
      "author": "Miyazawa",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "901",
      "DOI": "10.1016/0092-8674(91)90363-4",
      "article-title": "Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor",
      "volume": "67",
      "author": "Montesano",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "4885",
      "DOI": "10.1038/sj.onc.1205622",
      "article-title": "K252a inhibits the oncogenic properties of Met, the HGF receptor",
      "volume": "21",
      "author": "Morotti",
      "year": "2002",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "6489",
      "DOI": "10.1073/pnas.83.17.6489",
      "article-title": "Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures",
      "volume": "83",
      "author": "Nakamura",
      "year": "1986",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "440",
      "DOI": "10.1038/342440a0",
      "article-title": "Molecular cloning and expression of human hepatocyte growth factor",
      "volume": "342",
      "author": "Nakamura",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "1793",
      "DOI": "10.1128/MCB.11.4.1793",
      "article-title": "The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation",
      "volume": "11",
      "author": "Naldini",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "4825",
      "DOI": "10.1002/j.1460-2075.1992.tb05588.x",
      "article-title": "Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor",
      "volume": "11",
      "author": "Naldini",
      "year": "1992",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "23774",
      "DOI": "10.1074/jbc.270.40.23774",
      "article-title": "Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene",
      "volume": "270",
      "author": "Norris",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "315",
      "DOI": "10.1016/0092-8674(94)90200-3",
      "article-title": "Angiostatin",
      "volume": "79",
      "author": "O'Reilly",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1034/j.1600-0463.2002.100305.x",
      "article-title": "Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas",
      "volume": "110",
      "author": "Oh",
      "year": "2002",
      "journal-title": "APMIS"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "3074",
      "DOI": "10.1101/gad.242602",
      "article-title": "CD44 is required for two consecutive steps in HGF/c-Met signaling",
      "volume": "16",
      "author": "Orian-Rousseau",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB63",
      "first-page": "307",
      "article-title": "Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas",
      "volume": "59",
      "author": "Park",
      "year": "1999",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "35730",
      "DOI": "10.1074/jbc.M204529200",
      "article-title": "Oxygen-mediated regulation of tumor cell invasiveness. Involvement of a nitric oxide signaling pathway",
      "volume": "277",
      "author": "Postovit",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "237",
      "DOI": "10.1242/jcs.111.2.237",
      "article-title": "Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF",
      "volume": "111",
      "author": "Prat",
      "year": "1998",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "26765",
      "DOI": "10.1016/S0021-9258(19)61441-9",
      "article-title": "Nonhypoxic pathway mediates the induction of Hypoxia-Inducible Factor 1\u03b1 in vascular smooth muscle cells",
      "volume": "275",
      "author": "Richard",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB67",
      "first-page": "1847",
      "article-title": "Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor",
      "volume": "62",
      "author": "Rofstad",
      "year": "2002",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB68",
      "first-page": "357",
      "article-title": "Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product",
      "volume": "1155",
      "author": "Rubin",
      "year": "1993",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1002/(SICI)1096-9896(199611)180:3<266::AID-PATH658>3.0.CO;2-Q",
      "article-title": "Expression of Met protein in thyroid tumours",
      "volume": "180",
      "author": "Ruco",
      "year": "1996",
      "journal-title": "J. Pathol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "43799",
      "DOI": "10.1074/jbc.M207160200",
      "article-title": "Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways",
      "volume": "277",
      "author": "S\u00e1nchez-Elsner",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "699",
      "DOI": "10.1038/373699a0",
      "article-title": "Scatter factor/hepatocyte growth factor is essential for liver development",
      "volume": "373",
      "author": "Schmidt",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB72",
      "doi-asserted-by": "crossref",
      "first-page": "2343",
      "DOI": "10.1038/sj.onc.1202547",
      "article-title": "Novel mutations of the MET proto-oncogene in papillary renal carcinomas",
      "volume": "18",
      "author": "Schmidt",
      "year": "1999",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB73",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0092-8674(01)00518-9",
      "article-title": "HIF-1, O2, and the 3 PHDs",
      "volume": "107",
      "author": "Semenza",
      "year": "2001",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB74",
      "doi-asserted-by": "crossref",
      "first-page": "1132",
      "DOI": "10.1038/sj.onc.1203404",
      "article-title": "Transcriptional activation of the hepatocyte growth factor receptor (c-met) gene by its ligand (hepatocyte growth factor) is mediated through AP-1",
      "volume": "19",
      "author": "Seol",
      "year": "2000",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB75",
      "doi-asserted-by": "crossref",
      "first-page": "843",
      "DOI": "10.1038/359843a0",
      "article-title": "Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis",
      "volume": "359",
      "author": "Shweiki",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB76",
      "first-page": "81",
      "article-title": "Regulation of cell movement",
      "volume": "1072",
      "author": "Stoker",
      "year": "1991",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB77",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1038/327239a0",
      "article-title": "Scatter factor is a fibroblast-derived modulator of epithelial cell motility",
      "volume": "327",
      "author": "Stoker",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB78",
      "doi-asserted-by": "crossref",
      "first-page": "822",
      "DOI": "10.1038/bjc.1998.586",
      "article-title": "Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix",
      "volume": "78",
      "author": "Sundfor",
      "year": "1998",
      "journal-title": "Br. J. Cancer"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB79",
      "doi-asserted-by": "crossref",
      "first-page": "1363",
      "DOI": "10.1093/carcin/22.9.1363",
      "article-title": "Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells",
      "volume": "22",
      "author": "Tacchini",
      "year": "2001",
      "journal-title": "Carcinogenesis"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB80",
      "doi-asserted-by": "crossref",
      "first-page": "5866",
      "DOI": "10.1073/pnas.93.12.5866",
      "article-title": "Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development",
      "volume": "93",
      "author": "Takayama",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB81",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1038/nrc779",
      "article-title": "Scatter-factor and semaphorin receptors",
      "volume": "4",
      "author": "Trusolino",
      "year": "2002",
      "journal-title": "Nature Rev. Cancer"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB82",
      "doi-asserted-by": "crossref",
      "first-page": "643",
      "DOI": "10.1016/S0092-8674(01)00567-0",
      "article-title": "A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth",
      "volume": "107",
      "author": "Trusolino",
      "year": "2001",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB83",
      "doi-asserted-by": "crossref",
      "first-page": "702",
      "DOI": "10.1038/373702a0",
      "article-title": "Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor",
      "volume": "373",
      "author": "Uehara",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB84",
      "first-page": "119",
      "article-title": "Met-hgf/sf",
      "volume": "212",
      "author": "Vande Woude",
      "year": "1997",
      "journal-title": "Ciba Found. Symp."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB85",
      "first-page": "6449",
      "article-title": "Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors",
      "volume": "49",
      "author": "Vaupel",
      "year": "1989",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB86",
      "first-page": "7394",
      "article-title": "Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts",
      "volume": "61",
      "author": "Vukovic",
      "year": "2001",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB87",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1038/384173a0",
      "article-title": "Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis",
      "volume": "384",
      "author": "Weidner",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB88",
      "doi-asserted-by": "crossref",
      "first-page": "1529",
      "DOI": "10.1002/(SICI)1097-0142(19971015)80:8+<1529::AID-CNCR2>3.0.CO;2-F",
      "article-title": "General mechanisms of metastasis",
      "volume": "80",
      "author": "Woodhouse",
      "year": "1997",
      "journal-title": "Cancer"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB89",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1083/jcb.128.1.171",
      "article-title": "Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros",
      "volume": "128",
      "author": "Woolf",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB90",
      "doi-asserted-by": "crossref",
      "first-page": "24583",
      "DOI": "10.1074/jbc.M003894200",
      "article-title": "Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium",
      "volume": "275",
      "author": "Xu",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB91",
      "doi-asserted-by": "crossref",
      "first-page": "12645",
      "DOI": "10.1074/jbc.M011344200",
      "article-title": "Molecular regulation of the endothelin-1 gene by hypoxia",
      "volume": "276",
      "author": "Yamashita",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB92",
      "doi-asserted-by": "crossref",
      "first-page": "21212",
      "DOI": "10.1016/S0021-9258(19)36912-1",
      "article-title": "Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury",
      "volume": "268",
      "author": "Yanagita",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB93",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1083/jcb.131.1.215",
      "article-title": "Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland",
      "volume": "131",
      "author": "Yang",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB94",
      "doi-asserted-by": "crossref",
      "first-page": "338",
      "DOI": "10.1093/jnci/82.5.371",
      "article-title": "Effects of reoxygenation of cells from hypoxic regions of solid tumors",
      "volume": "82",
      "author": "Young",
      "year": "1990",
      "journal-title": "J. Natl. Cancer Inst."
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB95",
      "doi-asserted-by": "crossref",
      "first-page": "9533",
      "DOI": "10.1073/pnas.85.24.9533",
      "article-title": "Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells",
      "volume": "85",
      "author": "Young",
      "year": "1988",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB96",
      "doi-asserted-by": "crossref",
      "first-page": "1526",
      "DOI": "10.1126/science.1068327",
      "article-title": "Effect of p53 status on tumor response to antiangiogenic therapy",
      "volume": "295",
      "author": "Yu",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1535-6108(03)00085-0_BIB97",
      "article-title": "Cobalt inhibits the interaction between hypoxia inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia inducible factor-alpha",
      "volume": "in press",
      "author": "Yuan",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    }
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