DOI: 10.1016/s1534-5807(03)00060-1. Visualization of the Spatial and Temporal Dynamics of Intracellular Signaling

Visualization of the Spatial and Temporal Dynamics of Intracellular Signaling

10.1016/s1534-5807(03)00060-1

Crossref journal-article

Elsevier BV

Developmental Cell (78)

Bibliography

Miyawaki, A. (2003). Visualization of the Spatial and Temporal Dynamics of Intracellular Signaling. Developmental Cell, 4(3), 295â305.

Authors 1

Atsushi Miyawaki (first)

References 75 Referenced 395

10.1038/349694a0 / Nature / Fluorescence ratio imaging of cyclic AMP in single cells by Adams (1991)
{'key': '10.1016/S1534-5807(03)00060-1_BIB2', 'series-title': 'Imaging Neurons', 'article-title': 'How calcium indicators work', 'author': 'Adams', 'year': '2000'} / Imaging Neurons / How calcium indicators work by Adams (2000)
10.1126/science.289.5488.2338 / Science / Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in bidopsis det3 mutant by Allen (2000)
10.1073/pnas.97.22.11984 / Proc. Natl. Acad. Sci. USA / Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral by Baird (2000)
10.1002/j.1460-2075.1996.tb00799.x / EMBO J. / Imaging the intracellular trafficking and state of the AB5 quaternary structure of cholera toxin by Bastiaens (1996)
10.1016/S0006-3495(94)80652-6 / Biophys. J. / Intrinsic cytosolic calcium buffering properties of single rat cardiac myocytes by Berlin (1994)
10.1038/35036035 / Nat. Rev. Mol. Cell Biol. / The versatility and universality of calcium signaling by Berridge (2000)
10.1016/S0021-9258(17)44447-4 / J. Biol. Chem. / Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes by Buxton (1983)
10.1073/pnas.082243699 / Proc. Natl. Acad. Sci. USA / A monomeric red fluorescent protein by Campbell (2002)
10.1074/jbc.273.52.35000 / J. Biol. Chem. / Endocytosis of functional epidermal growth factoa receptor-green fluoresent protein chimera by Carter (1998)
10.1126/science.8303295 / Science / Green fluorescent protein as a marker for gene expression by Chalfie (1994)
10.1038/ncb783 / Nat. Cell Biol. / Ras signalling on the endoplasmic reticulum and the Golgi by Chiu (2002)
10.1016/S0962-8924(99)01558-5 / Trends Cell Biol. / Akaps by Colledge (1999)
10.1016/S0960-9822(99)80398-4 / Curr. Biol. / Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon by Emmanouilidou (1999)
10.1016/S0960-9822(02)01239-3 / Curr. Biol. / Genetically expressed cameleon in Drosophila melanogaster is used to visualize olfactory information in projection neurons by Fiala (2002)
10.1002/andp.19484370105 / Ann. Phys. / Intermolecular energy migration and fluorescence by Förster (1948)
10.1016/S0006-3495(01)76265-0 / Biophys. J. / Homo-FRET microscopy in living cells to measure monomer-dimer transition of GFP-tagged proteins by Gautier (2001)
10.1016/S0006-3495(98)77976-7 / Biophys. J. / Quantitative fluorescence resonance energy transfer measurements using fluorescence microscopy by Gordon (1998)
10.1074/jbc.M102815200 / J. Biol. Chem. / Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications by Griesbeck (2001)
10.1016/S0955-0674(99)80024-6 / Curr. Opin. Cell Biol. / Epidermal growth factor receptors by Hackel (1999)
10.1038/84443 / Nat. Biotechnol. / Imaging FRET between spectrally similar GFP molecules in single cells by Harpur (2001)
{'key': '10.1016/S1534-5807(03)00060-1_BIB22', 'series-title': 'Fluorescent and Luminescent Probes for Biological Activity', 'article-title': 'Intracellular ion indicators', 'author': 'Haugland', 'year': '1999'} / Fluorescent and Luminescent Probes for Biological Activity / Intracellular ion indicators by Haugland (1999)
10.1016/S0006-3495(96)79653-4 / Biophys. J. / Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons by Helmchen (1996)
10.1126/science.284.5419.1527 / Science / Spatiotemporal dynamics of Inositol 1, 4, 5-trisphosphate that underlies complex Ca2+ mobilization patterns by Hirose (1999)
10.1073/pnas.051631298 / Proc. Natl. Acad. Sci. USA / Spatiotemporal dynamics of guanosine 3′, 5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator by Honda (2001)
10.1016/S0092-8674(00)81688-8 / Cell / Signaling—2000 and beyond by Hunter (2000)
10.1126/science.1585175 / Science / Solution structure of a calmodulin-target peptide complex by multidimensional NMR by Ikura (1992)
10.1074/jbc.M205411200 / J. Biol. Chem. / A molecular sensor detects signal transduction from caveolae in living cells by Issiki (2002)
10.1128/MCB.22.18.6582-6591.2002 / Mol. Cell. Biol. / Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells by Itoh (2002)
10.1126/science.1055835 / Science / Receptor-mediated activation of heterotrimeric G-proteins in living cells by Janetopoulos (2001)
10.1146/annurev.bb.18.060189.001415 / Annu. Rev. Biophys. Biophys. Chem. / Luminescence digital imaging microscopy by Jovin (1989)
10.1016/S0896-6273(00)81196-4 / Neuron / Optical imaging of calcium transients in neurons and pharyngeal muscles of C. elegans by Kerr (2000)
10.1016/0092-8674(89)90985-9 / Cell / A ras-related gene with transformation suppressor activity by Kitayama (1989)
10.1126/science.290.5490.333 / Science / Localized Rac activation dynamics visualized in living cells by Kraynov (2000)
10.1016/S0896-6273(00)00056-8 / Neuron / A genetically encoded ratiometric indicator for chloride by Kuner (2000)
10.1074/jbc.M104341200 / J. Biol. Chem. / A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo by Kurokawa (2001)
10.1073/pnas.062552299 / Proc. Natl. Acad. Sci. USA / Diversity and evolution of the green fluorescent protein family by Labas (2002)
Lakowicz, J.R. (1999). Energy transfer. In Principles of Fluorescence Spectroscopy. (Kluwer Academic/Plenum), pp. 368–391. (10.1007/978-1-4757-3061-6_13)
10.1038/35073068 / Nat. Rev. / Studying protein dynamics in living cells by Lippincott-Schwartz (2001)
10.1038/42264 / Nature / Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin by Miyawaki (1997)
10.1073/pnas.96.5.2135 / Proc. Natl. Acad. Sci. USA / Dynamic and quantitative Ca2+ measurements using improved cameleons by Miyawaki (1999)
10.1016/S0076-6879(00)27297-2 / Methods Enzymol. / Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein by Miyawaki (2000)
10.1021/bi002263b / Biochemistry / Red fluorescent protein from Discosoma as a fusion tag and a partner for fluorescence resonance energy transfer by Mizuno (2001)
10.1038/35082594 / Nature / Spatio-temporal images of growth-factor-induced activation of Ras and Rap1 by Mochizuki (2001)
10.1038/73767 / Nat. Biotechnol. / A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo by Nagai (2000)
10.1038/nbt0102-87 / Nat. Biotechnol. / A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications by Nagai (2002)
10.1126/science.283.5410.2085 / Science / Imaging protein kinase Cα activation in cells by Ng (1999)
10.1093/emboj/cdg087 / EMBO J. / Mechanism of the spatio-temporal regulation of Ras and Rap1 by Ohba (2003)
10.1016/S0143-4160(97)90014-2 / Cell Calcium / Novel fluorescent indicator proteins for monitoring free intracellular Ca2+ by Persechini (1997)
10.1093/protein/7.1.109 / Protein Eng. / A calmodulin-target peptide hybrid molecule with unique calcium-binding properties by Porumb (1994)
10.1016/0378-1119(92)90691-H / Gene / Primary structure of the Aequorea victoria green fluorescent protein by Prasher (1992)
10.1523/JNEUROSCI.22-21-09399.2002 / J. Neurosci. / Differential regulation of active zone density during long-term strengthening of Drosophila neuromuscular junctions by Reiff (2002)
10.1074/jbc.272.20.13270 / J. Biol. Chem. / Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence by Romoser (1997)
10.1046/j.0953-816x.2001.01617.x / Eur. J. Neurosci. / Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein by Sakai (2001)
10.1021/ac0006167 / Anal. Chem. / Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase Iα and green fluorescent proteins by Sato (2000)
10.1038/nbt0302-287 / Nat. Biotechnol. / Fluorescent indicators for imaging protein phosphorylation in single living cells by Sato (2002)
10.1016/S0006-3495(02)75467-2 / Biophys. J. / Multicolor imaging of Ca2+ and protein kinase C signals using novel epifluorescence microscopy by Sawano (2002)
10.1016/S1534-5807(02)00224-1 / Dev. Cell / Lateral propagation of EGF signaling after local stimulation is dependent on receptor density by Sawano (2002)
10.1002/jcp.1030590302 / J. Cell Comp. Physiol. / Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea by Shimomura (1962)
10.1016/S0960-9822(01)00646-7 / Curr. Biol. / Signaling complexes by Smith (2002)
10.1146/annurev.bi.47.070178.004131 / Annu. Rev. Biochem. / Fluorescence energy transfer as a spectroscopic ruler by Stryer (1978)
10.1073/pnas.211564598 / Proc. Natl. Acad. Sci. USA / Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells by Ting (2001)
10.1038/nsb728 / Nat. Struct. Biol. / FRET-based in vivo Ca2+ imaging by a new calmodulin-GFP fusion molecule by Truong (2001)
10.1146/annurev.ne.12.030189.001303 / Annu. Rev. Neurosci. / Fluorescent probes cell signaling by Tsien (1989)
10.1016/0962-8924(93)90124-J / Trends Cell Biol. / FRET for studying intracellular signalling by Tsien (1993)
10.1146/annurev.biochem.67.1.509 / Annu. Rev. Biochem. / The green fluorescent protein by Tsien (1998)
10.1074/jbc.M007194200 / J. Biol. Chem. / Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer by van der Wal (2001)
10.1038/ncb0102-e15 / Nat. Cell Biol. / Imaging into the future by van Roessel (2002)
10.1126/science.290.5496.1567 / Science / Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane by Verveer (2000)
10.1126/science.1069982 / Science / Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes by Zaccolo (2002)
10.1038/71345 / Nat. Cell Biol. / A genetically encoded, fluorescent indicator for cyclic AMP in living cells by Zaccolo (2000)
10.1126/science.1068539 / Science / Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells by Zacharias (2002)
10.1073/pnas.211566798 / Proc. Natl. Acad. Sci. USA / Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering by Zhang (2001)
10.1038/nrm976 / Nat. Rev. Mol. Cell Biol. / Creating new fluorescent probes for cell biology by Zhang (2002)
10.1074/jbc.272.50.31929 / J. Biol. Chem. / Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution by Zhao (1997)

Dates

Type	When
Created	21 years, 4 months ago (April 14, 2004, 5:27 a.m.)
Deposited	2 years, 6 months ago (Feb. 5, 2023, 5:09 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 3, 2025, 12:12 a.m.)
Issued	22 years, 5 months ago (March 1, 2003)
Published	22 years, 5 months ago (March 1, 2003)
Published Print	22 years, 5 months ago (March 1, 2003)

Funders 0

None

BibTeX

@article{Miyawaki_2003, title={Visualization of the Spatial and Temporal Dynamics of Intracellular Signaling}, volume={4}, ISSN={1534-5807}, url={http://dx.doi.org/10.1016/s1534-5807(03)00060-1}, DOI={10.1016/s1534-5807(03)00060-1}, number={3}, journal={Developmental Cell}, publisher={Elsevier BV}, author={Miyawaki, Atsushi}, year={2003}, month=mar, pages={295–305} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        3
      ]
    ],
    "date-time": "2025-08-03T04:12:28Z",
    "timestamp": 1754194348747
  },
  "reference-count": 75,
  "publisher": "Elsevier BV",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            3,
            1
          ]
        ],
        "date-time": "2003-03-01T00:00:00Z",
        "timestamp": 1046476800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 3791,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            3,
            1
          ]
        ],
        "date-time": "2003-03-01T00:00:00Z",
        "timestamp": 1046476800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            3,
            1
          ]
        ],
        "date-time": "2003-03-01T00:00:00Z",
        "timestamp": 1046476800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            3,
            1
          ]
        ],
        "date-time": "2003-03-01T00:00:00Z",
        "timestamp": 1046476800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            3,
            1
          ]
        ],
        "date-time": "2003-03-01T00:00:00Z",
        "timestamp": 1046476800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            3,
            1
          ]
        ],
        "date-time": "2003-03-01T00:00:00Z",
        "timestamp": 1046476800000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        3
      ]
    ]
  },
  "DOI": "10.1016/s1534-5807(03)00060-1",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        14
      ]
    ],
    "date-time": "2004-04-14T09:27:06Z",
    "timestamp": 1081934826000
  },
  "page": "295-305",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 395,
  "title": "Visualization of the Spatial and Temporal Dynamics of Intracellular Signaling",
  "prefix": "10.1016",
  "volume": "4",
  "author": [
    {
      "given": "Atsushi",
      "family": "Miyawaki",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "694",
      "DOI": "10.1038/349694a0",
      "article-title": "Fluorescence ratio imaging of cyclic AMP in single cells",
      "volume": "349",
      "author": "Adams",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB2",
      "series-title": "Imaging Neurons",
      "article-title": "How calcium indicators work",
      "author": "Adams",
      "year": "2000"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "2338",
      "DOI": "10.1126/science.289.5488.2338",
      "article-title": "Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in bidopsis det3 mutant",
      "volume": "289",
      "author": "Allen",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "11984",
      "DOI": "10.1073/pnas.97.22.11984",
      "article-title": "Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral",
      "volume": "97",
      "author": "Baird",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "4246",
      "DOI": "10.1002/j.1460-2075.1996.tb00799.x",
      "article-title": "Imaging the intracellular trafficking and state of the AB5 quaternary structure of cholera toxin",
      "volume": "15",
      "author": "Bastiaens",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1775",
      "DOI": "10.1016/S0006-3495(94)80652-6",
      "article-title": "Intrinsic cytosolic calcium buffering properties of single rat cardiac myocytes",
      "volume": "67",
      "author": "Berlin",
      "year": "1994",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1038/35036035",
      "article-title": "The versatility and universality of calcium signaling",
      "volume": "1",
      "author": "Berridge",
      "year": "2000",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "10233",
      "DOI": "10.1016/S0021-9258(17)44447-4",
      "article-title": "Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes",
      "volume": "258",
      "author": "Buxton",
      "year": "1983",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "7877",
      "DOI": "10.1073/pnas.082243699",
      "article-title": "A monomeric red fluorescent protein",
      "volume": "99",
      "author": "Campbell",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "35000",
      "DOI": "10.1074/jbc.273.52.35000",
      "article-title": "Endocytosis of functional epidermal growth factoa receptor-green fluoresent protein chimera",
      "volume": "273",
      "author": "Carter",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "802",
      "DOI": "10.1126/science.8303295",
      "article-title": "Green fluorescent protein as a marker for gene expression",
      "volume": "263",
      "author": "Chalfie",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "343",
      "DOI": "10.1038/ncb783",
      "article-title": "Ras signalling on the endoplasmic reticulum and the Golgi",
      "volume": "4",
      "author": "Chiu",
      "year": "2002",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "216",
      "DOI": "10.1016/S0962-8924(99)01558-5",
      "article-title": "Akaps",
      "volume": "9",
      "author": "Colledge",
      "year": "1999",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "915",
      "DOI": "10.1016/S0960-9822(99)80398-4",
      "article-title": "Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon",
      "volume": "9",
      "author": "Emmanouilidou",
      "year": "1999",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1877",
      "DOI": "10.1016/S0960-9822(02)01239-3",
      "article-title": "Genetically expressed cameleon in Drosophila melanogaster is used to visualize olfactory information in projection neurons",
      "volume": "12",
      "author": "Fiala",
      "year": "2002",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1002/andp.19484370105",
      "article-title": "Intermolecular energy migration and fluorescence",
      "volume": "2",
      "author": "F\u00f6rster",
      "year": "1948",
      "journal-title": "Ann. Phys."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "3000",
      "DOI": "10.1016/S0006-3495(01)76265-0",
      "article-title": "Homo-FRET microscopy in living cells to measure monomer-dimer transition of GFP-tagged proteins",
      "volume": "80",
      "author": "Gautier",
      "year": "2001",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "2702",
      "DOI": "10.1016/S0006-3495(98)77976-7",
      "article-title": "Quantitative fluorescence resonance energy transfer measurements using fluorescence microscopy",
      "volume": "74",
      "author": "Gordon",
      "year": "1998",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "29188",
      "DOI": "10.1074/jbc.M102815200",
      "article-title": "Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications",
      "volume": "276",
      "author": "Griesbeck",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "184",
      "DOI": "10.1016/S0955-0674(99)80024-6",
      "article-title": "Epidermal growth factor receptors",
      "volume": "11",
      "author": "Hackel",
      "year": "1999",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1038/84443",
      "article-title": "Imaging FRET between spectrally similar GFP molecules in single cells",
      "volume": "19",
      "author": "Harpur",
      "year": "2001",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB22",
      "series-title": "Fluorescent and Luminescent Probes for Biological Activity",
      "article-title": "Intracellular ion indicators",
      "author": "Haugland",
      "year": "1999"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1069",
      "DOI": "10.1016/S0006-3495(96)79653-4",
      "article-title": "Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons",
      "volume": "70",
      "author": "Helmchen",
      "year": "1996",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1527",
      "DOI": "10.1126/science.284.5419.1527",
      "article-title": "Spatiotemporal dynamics of Inositol 1, 4, 5-trisphosphate that underlies complex Ca2+ mobilization patterns",
      "volume": "284",
      "author": "Hirose",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "2437",
      "DOI": "10.1073/pnas.051631298",
      "article-title": "Spatiotemporal dynamics of guanosine 3\u2032, 5\u2032-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator",
      "volume": "98",
      "author": "Honda",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1016/S0092-8674(00)81688-8",
      "article-title": "Signaling\u20142000 and beyond",
      "volume": "100",
      "author": "Hunter",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "632",
      "DOI": "10.1126/science.1585175",
      "article-title": "Solution structure of a calmodulin-target peptide complex by multidimensional NMR",
      "volume": "256",
      "author": "Ikura",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "43389",
      "DOI": "10.1074/jbc.M205411200",
      "article-title": "A molecular sensor detects signal transduction from caveolae in living cells",
      "volume": "277",
      "author": "Issiki",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "6582",
      "DOI": "10.1128/MCB.22.18.6582-6591.2002",
      "article-title": "Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells",
      "volume": "22",
      "author": "Itoh",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "2408",
      "DOI": "10.1126/science.1055835",
      "article-title": "Receptor-mediated activation of heterotrimeric G-proteins in living cells",
      "volume": "291",
      "author": "Janetopoulos",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1146/annurev.bb.18.060189.001415",
      "article-title": "Luminescence digital imaging microscopy",
      "volume": "18",
      "author": "Jovin",
      "year": "1989",
      "journal-title": "Annu. Rev. Biophys. Biophys. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "583",
      "DOI": "10.1016/S0896-6273(00)81196-4",
      "article-title": "Optical imaging of calcium transients in neurons and pharyngeal muscles of C. elegans",
      "volume": "26",
      "author": "Kerr",
      "year": "2000",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/0092-8674(89)90985-9",
      "article-title": "A ras-related gene with transformation suppressor activity",
      "volume": "56",
      "author": "Kitayama",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1126/science.290.5490.333",
      "article-title": "Localized Rac activation dynamics visualized in living cells",
      "volume": "290",
      "author": "Kraynov",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1016/S0896-6273(00)00056-8",
      "article-title": "A genetically encoded ratiometric indicator for chloride",
      "volume": "27",
      "author": "Kuner",
      "year": "2000",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "31305",
      "DOI": "10.1074/jbc.M104341200",
      "article-title": "A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo",
      "volume": "276",
      "author": "Kurokawa",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "4256",
      "DOI": "10.1073/pnas.062552299",
      "article-title": "Diversity and evolution of the green fluorescent protein family",
      "volume": "99",
      "author": "Labas",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB38",
      "doi-asserted-by": "crossref",
      "unstructured": "Lakowicz, J.R. (1999). Energy transfer. In Principles of Fluorescence Spectroscopy. (Kluwer Academic/Plenum), pp. 368\u2013391.",
      "DOI": "10.1007/978-1-4757-3061-6_13"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "444",
      "DOI": "10.1038/35073068",
      "article-title": "Studying protein dynamics in living cells",
      "volume": "2",
      "author": "Lippincott-Schwartz",
      "year": "2001",
      "journal-title": "Nat. Rev."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "882",
      "DOI": "10.1038/42264",
      "article-title": "Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin",
      "volume": "388",
      "author": "Miyawaki",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "2135",
      "DOI": "10.1073/pnas.96.5.2135",
      "article-title": "Dynamic and quantitative Ca2+ measurements using improved cameleons",
      "volume": "96",
      "author": "Miyawaki",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1016/S0076-6879(00)27297-2",
      "article-title": "Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein",
      "volume": "327",
      "author": "Miyawaki",
      "year": "2000",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "2502",
      "DOI": "10.1021/bi002263b",
      "article-title": "Red fluorescent protein from Discosoma as a fusion tag and a partner for fluorescence resonance energy transfer",
      "volume": "40",
      "author": "Mizuno",
      "year": "2001",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "1065",
      "DOI": "10.1038/35082594",
      "article-title": "Spatio-temporal images of growth-factor-induced activation of Ras and Rap1",
      "volume": "411",
      "author": "Mochizuki",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "313",
      "DOI": "10.1038/73767",
      "article-title": "A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo",
      "volume": "18",
      "author": "Nagai",
      "year": "2000",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "87",
      "DOI": "10.1038/nbt0102-87",
      "article-title": "A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications",
      "volume": "20",
      "author": "Nagai",
      "year": "2002",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "2085",
      "DOI": "10.1126/science.283.5410.2085",
      "article-title": "Imaging protein kinase C\u03b1 activation in cells",
      "volume": "183",
      "author": "Ng",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "859",
      "DOI": "10.1093/emboj/cdg087",
      "article-title": "Mechanism of the spatio-temporal regulation of Ras and Rap1",
      "volume": "22",
      "author": "Ohba",
      "year": "2003",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1016/S0143-4160(97)90014-2",
      "article-title": "Novel fluorescent indicator proteins for monitoring free intracellular Ca2+",
      "volume": "22",
      "author": "Persechini",
      "year": "1997",
      "journal-title": "Cell Calcium"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1093/protein/7.1.109",
      "article-title": "A calmodulin-target peptide hybrid molecule with unique calcium-binding properties",
      "volume": "7",
      "author": "Porumb",
      "year": "1994",
      "journal-title": "Protein Eng."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1016/0378-1119(92)90691-H",
      "article-title": "Primary structure of the Aequorea victoria green fluorescent protein",
      "volume": "111",
      "author": "Prasher",
      "year": "1992",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "9399",
      "DOI": "10.1523/JNEUROSCI.22-21-09399.2002",
      "article-title": "Differential regulation of active zone density during long-term strengthening of Drosophila neuromuscular junctions",
      "volume": "22",
      "author": "Reiff",
      "year": "2002",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "13270",
      "DOI": "10.1074/jbc.272.20.13270",
      "article-title": "Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence",
      "volume": "272",
      "author": "Romoser",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "2314",
      "DOI": "10.1046/j.0953-816x.2001.01617.x",
      "article-title": "Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein",
      "volume": "13",
      "author": "Sakai",
      "year": "2001",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "5918",
      "DOI": "10.1021/ac0006167",
      "article-title": "Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase I\u03b1 and green fluorescent proteins",
      "volume": "72",
      "author": "Sato",
      "year": "2000",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1038/nbt0302-287",
      "article-title": "Fluorescent indicators for imaging protein phosphorylation in single living cells",
      "volume": "20",
      "author": "Sato",
      "year": "2002",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "1076",
      "DOI": "10.1016/S0006-3495(02)75467-2",
      "article-title": "Multicolor imaging of Ca2+ and protein kinase C signals using novel epifluorescence microscopy",
      "volume": "82",
      "author": "Sawano",
      "year": "2002",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "245",
      "DOI": "10.1016/S1534-5807(02)00224-1",
      "article-title": "Lateral propagation of EGF signaling after local stimulation is dependent on receptor density",
      "volume": "3",
      "author": "Sawano",
      "year": "2002",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1002/jcp.1030590302",
      "article-title": "Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea",
      "volume": "59",
      "author": "Shimomura",
      "year": "1962",
      "journal-title": "J. Cell Comp. Physiol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "R32",
      "DOI": "10.1016/S0960-9822(01)00646-7",
      "article-title": "Signaling complexes",
      "volume": "12",
      "author": "Smith",
      "year": "2002",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "819",
      "DOI": "10.1146/annurev.bi.47.070178.004131",
      "article-title": "Fluorescence energy transfer as a spectroscopic ruler",
      "volume": "47",
      "author": "Stryer",
      "year": "1978",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "15003",
      "DOI": "10.1073/pnas.211564598",
      "article-title": "Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells",
      "volume": "98",
      "author": "Ting",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "1069",
      "DOI": "10.1038/nsb728",
      "article-title": "FRET-based in vivo Ca2+ imaging by a new calmodulin-GFP fusion molecule",
      "volume": "8",
      "author": "Truong",
      "year": "2001",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1146/annurev.ne.12.030189.001303",
      "article-title": "Fluorescent probes cell signaling",
      "volume": "12",
      "author": "Tsien",
      "year": "1989",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "242",
      "DOI": "10.1016/0962-8924(93)90124-J",
      "article-title": "FRET for studying intracellular signalling",
      "volume": "3",
      "author": "Tsien",
      "year": "1993",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1146/annurev.biochem.67.1.509",
      "article-title": "The green fluorescent protein",
      "volume": "67",
      "author": "Tsien",
      "year": "1998",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB67",
      "doi-asserted-by": "crossref",
      "first-page": "15337",
      "DOI": "10.1074/jbc.M007194200",
      "article-title": "Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer",
      "volume": "276",
      "author": "van der Wal",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB68",
      "doi-asserted-by": "crossref",
      "first-page": "E15",
      "DOI": "10.1038/ncb0102-e15",
      "article-title": "Imaging into the future",
      "volume": "4",
      "author": "van Roessel",
      "year": "2002",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "1567",
      "DOI": "10.1126/science.290.5496.1567",
      "article-title": "Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane",
      "volume": "290",
      "author": "Verveer",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "1711",
      "DOI": "10.1126/science.1069982",
      "article-title": "Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes",
      "volume": "295",
      "author": "Zaccolo",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1038/71345",
      "article-title": "A genetically encoded, fluorescent indicator for cyclic AMP in living cells",
      "volume": "2",
      "author": "Zaccolo",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB72",
      "doi-asserted-by": "crossref",
      "first-page": "913",
      "DOI": "10.1126/science.1068539",
      "article-title": "Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells",
      "volume": "296",
      "author": "Zacharias",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB73",
      "doi-asserted-by": "crossref",
      "first-page": "14997",
      "DOI": "10.1073/pnas.211566798",
      "article-title": "Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering",
      "volume": "98",
      "author": "Zhang",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB74",
      "doi-asserted-by": "crossref",
      "first-page": "906",
      "DOI": "10.1038/nrm976",
      "article-title": "Creating new fluorescent probes for cell biology",
      "volume": "3",
      "author": "Zhang",
      "year": "2002",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/S1534-5807(03)00060-1_BIB75",
      "doi-asserted-by": "crossref",
      "first-page": "31929",
      "DOI": "10.1074/jbc.272.50.31929",
      "article-title": "Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution",
      "volume": "272",
      "author": "Zhao",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    }
  ],
  "container-title": "Developmental Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1534580703000601?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1534580703000601?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        2,
        5
      ]
    ],
    "date-time": "2023-02-05T22:09:14Z",
    "timestamp": 1675634954000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1534580703000601"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        3
      ]
    ]
  },
  "references-count": 75,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          2003,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "S1534580703000601"
  ],
  "URL": "http://dx.doi.org/10.1016/S1534-5807(03)00060-1",
  "relation": {},
  "ISSN": [
    "1534-5807"
  ],
  "subject": [],
  "container-title-short": "Developmental Cell",
  "published": {
    "date-parts": [
      [
        2003,
        3
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Visualization of the Spatial and Temporal Dynamics of Intracellular Signaling",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Developmental Cell",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/S1534-5807(03)00060-1",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2003 Cell Press. Published by Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}