DOI: 10.1016/s1359-0278(98)00016-9. Protein hydration and unfolding – insights from experimental partial specific volumes and unfolded protein models

Protein hydration and unfolding – insights from experimental partial specific volumes and unfolded protein models

10.1016/s1359-0278(98)00016-9

Crossref journal-article

Elsevier BV

Folding and Design (78)

Bibliography

Murphy, L. R., Matubayasi, N., Payne, V. A., & Levy, R. M. (1998). Protein hydration and unfolding â insights from experimental partial specific volumes and unfolded protein models. Folding and Design, 3(2), 105â118.

Authors 4

Lynne Reed Murphy (first)
Nobuyuki Matubayasi (additional)
Vilia A Payne (additional)
Ronald M Levy (additional)

References 82 Referenced 96

10.1038/319199a0 / Nature / Solvation energy in protein folding and binding by Eisenberg (1986)
10.1073/pnas.84.10.3086 / Proc. Natl Acad. Sci. USA / Accessible surface area as a measure of the thermodynamic parameters of hydration of peptides by Ooi (1987)
10.1093/oxfordjournals.jbchem.a122215 / J. Biochem / Effects of hydrated water on protein unfolding by Ooi (1988)
{'key': '10.1016/S1359-0278(98)00016-9_bib4', 'first-page': '346', 'article-title': 'Thermodynamic properties of globular proteins and the principle of stabilization of their native structure', 'volume': '1040', 'author': 'Khechinashvili', 'year': '1990', 'journal-title': 'Biochem. Biophys. Acta'} / Biochem. Biophys. Acta / Thermodynamic properties of globular proteins and the principle of stabilization of their native structure by Khechinashvili (1990)
10.1016/S0022-2836(05)80197-4 / J. Mol. Biol / Heat capacity of proteins I. Partial molar heat capacity of individual amino acid residues in aqueous solution: hydration effect by Makhatadze (1990)
10.1006/jmbi.1993.1416 / J. Mol. Biol / Contribution of hydration to protein folding thermodynamics I. The enthalpy of hydration by Makhatadze (1993)
10.1016/0301-4622(94)00050-6 / Biophys. Chem / Hydration effects in protein unfolding by Makhatadze (1994)
10.1016/S0022-2836(05)80198-6 / J. Mol. Biol / Heat capacity of proteins II. Partial molar heat capacity of unfolded polypeptide chains of proteins: protein unfolding effects by Privalov (1990)
10.1016/0022-2836(92)90555-X / J. Mol. Biol / Contribution of hydration and non-covalent interactions to the heat capacity effect on protein unfolding by Privalov (1992)
10.1006/jmbi.1993.1417 / J. Mol. Biol / Contribution of hydration to protein folding thermodynamics II. The entropy and Gibbs energy of hydration by Privalov (1993)
10.1021/bi00231a019 / Biochemistry / Contributions to the thermodynamics of protein folding from the reduction in water-accessible nonpolar surface area by Livingstone (1991)
10.1002/prot.340100305 / Proteins / Empirical solvation models can be used to differentiate native from near-native conformations of bovine pancreatic trypsin inhibitor by Vila (1991)
10.1016/0022-2836(92)90988-V / J. Mol. Biol / Thermodynamics of unfolding of the α-amylase inhibitor tendamistat. Correlation between accessible surface area and heat capacity by Renner (1992)
10.1021/bi00131a009 / Biochemistry / Use of liquid hydrocarbon and amide transfer data to estimate contributions to thermodynamic functions of protein folding from the removal of nonpolar and polar surface from water by Spolar (1992)
10.1016/0022-2836(92)90229-D / J. Mol. Biol / Analysis of the heat capacity dependence of protein folding by Yang (1992)
10.1006/abbi.1993.1271 / Arch. Biochem. Biophys / Structural thermodynamics: prediction of protein stability and protein binding affinities by Freire (1993)
10.1002/pro.5560021204 / Protein Sci / Thermodynamics of bovine pancreatic trypsin inhibitor folding by Makhatadze (1993)
10.1002/prot.340200307 / Proteins / Polar and nonpolar atomic environments in the protein core: implications for folding and binding by Koehl (1994)
10.1002/pro.5560040707 / Protein Sci / Thermodynamics of the temperature-induced unfolding of globular proteins by Khechinashvili (1995)
10.1002/pro.5560041020 / Protein Sci / Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding by Myers (1995)
10.1002/(SICI)1097-0282(199611)39:5<619::AID-BIP1>3.0.CO;2-Z / Biopolymers / On volume changes accompanying conformational transitions of biopolymers by Chalikian (1996)
10.1002/(SICI)1097-0134(199610)26:2<123::AID-PROT2>3.0.CO;2-H / Proteins / The enthalpy change in protein folding and binding: refinement of parameters for structure-based calculations by Hilser (1996)
10.1074/jbc.272.2.701 / J. Biol. Chem / Additivity principles in biochemistry by Dill (1997)
10.1101/SQB.1972.036.01.008 / Cold Spring Harbor Symp. Quant. Biol / Protein structure, ribonuclease-S and nucleotide interactions by Richards (1971)
10.1016/0022-2836(71)90324-X / J. Mol. Biol / The interpretation of protein structures: estimation of static accessibility by Lee (1971)
10.1016/0022-2836(73)90011-9 / J. Mol. Biol / Environment and exposure to solvent of protein atoms. Lysozyme and insulin by Shrake (1973)
10.1038/254304a0 / Nature / Structural invariants in protein folding by Chothia (1975)
10.1016/0022-2836(76)90191-1 / J. Mol. Biol / The nature of the accessible and buried surfaces in proteins by Chothia (1976)
10.1021/j100092a040 / J. Phys. Chem / Thermodynamics of the hydration shell. 1. Excess energy of a hydrophobic solute by Matubayasi (1994)
10.1021/jp951618b / J. Phys. Chem / Thermodynamics of the hydration shell. 2. Excess volume and compressibility of a hydrophobic solute by Matubayasi (1996)
10.1016/S0969-2126(00)00065-4 / Structure / Volume changes on protein folding by Harpaz (1994)
{'key': '10.1016/S1359-0278(98)00016-9_bib32', 'series-title': 'Physical Chemistry', 'first-page': '217', 'article-title': 'Transport Phenomena', 'author': 'Tinoco', 'year': '1985'} / Physical Chemistry / Transport Phenomena by Tinoco (1985)
10.1016/0022-2836(84)90231-6 / J. Mol. Biol / Solvent accessible surface area and excluded volume in proteins. Analytical equations for overlapping spheres and implications for the hydrophobic effect by Richmond (1984)
10.1002/(SICI)1097-0134(199607)25:3<389::AID-PROT10>3.3.CO;2-S / Proteins / Hydrophobic patches on the surfaces of protein structures by Lijnzaad (1996)
10.1080/00268977700101881 / Mol. Phys / Liquid water. II. Experimental atom pair-correlation functions of liquid deuterium oxide by Palinkas (1977)
10.1126/science.217.4564.1033 / Science / Atom pair distribution functions of liquid water at 25°C from neutron diffraction by Narten (1982)
10.1021/j150643a008 / J. Chem. Phys / Hydration and mobility of ions in solution by Impey (1983)
10.1021/bi00156a031 / Biochemistry / Molecular dynamics simulation of solvated protein at high pressure by Kitchen (1992)
{'key': '10.1016/S1359-0278(98)00016-9_bib39', 'first-page': '557', 'article-title': 'On the nature of the protein interior', 'volume': '229', 'author': 'Klapper', 'year': '1971', 'journal-title': 'Biochem. Biophys. Acta'} / Biochem. Biophys. Acta / On the nature of the protein interior by Klapper (1971)
10.1016/0022-2836(74)90570-1 / J. Mol. Biol / The interpretation of protein structures: total volume, group volume distributions and packing density by Richards (1974)
10.1002/bip.360220607 / Biopolymers / Improved technique for calculating X-ray scattering intensity of biopolymers in solution: evaluation of the form, volume, and surface of a particle by Pavlov (1983)
10.1021/bi00369a034 / Biochemistry / Compressibility-structure relationship of globular proteins by Gekko (1986)
10.1007/BF00649565 / J. Sol. Chem / Partial molar volumes of molecules of arbitrary shape and the effect of hydrogen bonding with water by Kharakoz (1992)
10.1006/jmbi.1996.0423 / J. Mol. Biol / The hydration of globular proteins as derived from volume and compressibility measurements: cross correlating thermodynamic and structural data by Chalikian (1996)
10.1002/(SICI)1097-0134(199601)24:1<81::AID-PROT6>3.0.CO;2-R / Proteins / High pressure effects on protein structure and function by Mozhaev (1996)
{'key': '10.1016/S1359-0278(98)00016-9_bib46', 'series-title': 'High-Pressure Effects in Molecular Biophysics and Enzymology', 'first-page': '33', 'article-title': 'Use of partial molar volumes of model compounds in the interpretation of high-pressure effects on proteins', 'author': 'Prehoda', 'year': '1996'} / High-Pressure Effects in Molecular Biophysics and Enzymology / Use of partial molar volumes of model compounds in the interpretation of high-pressure effects on proteins by Prehoda (1996)
10.1016/0022-2836(78)90223-1 / J. Mol. Biol / Volume occupation, environment and accessibility in proteins. Environment and molecular area of RNase-S by Finney (1978)
10.1006/jmbi.1995.0351 / J. Mol. Biol / The volume of atoms on the protein surface: calculated from simulation, using Voronoi polyhedra by Gerstein (1995)
10.1002/(SICI)1097-0282(199706)41:7<785::AID-BIP7>3.0.CO;2-L / Biopolymers / On the volume of macromolecules by Paci (1997)
10.1016/0022-2836(87)90038-6 / J. Mol. Biol / Interior and surface of monomeric proteins by Miller (1987)
10.1002/bip.360301102 / Biopolymers / Partial molar volumes of polypeptides and their constituent groups in aqueous solution over a broad temperature range by Makhatadze (1990)
10.1146/annurev.bb.06.060177.001055 / Annu. Rev. Biophys. Bioeng / Areas, volumes, packing, and protein structure by Richards (1977)
10.1021/bi00806a045 / Biochemistry / Thermodynamics of protein denaturation. Effect of pressure on the denaturation of ribonuclease A by Brandts (1970)
10.1021/bi00789a002 / Biochemistry / Reversible pressure-temperature denaturation of chymotrypsinogen by Hawley (1971)
10.1021/bi00745a028 / Biochemistry / Pressure denaturation of metmyoglobin by Zip (1973)
10.1016/0301-4622(94)00098-5 / Biophys. Chem / An alternative interpretation of the heat capacity changes associated with protein unfolding by Hinz (1994)
10.1016/S0065-3233(08)60608-7 / Adv. Protein Chem / Some factors in the interpretation of protein denaturation by Kauzmann (1959)
10.1126/science.4023714 / Science / Hydrophobicity of amino acid residues in globular proteins by Rose (1985)
10.1006/jmbi.1995.0666 / J. Mol. Biol / The refined X-ray structure of muconate lactonizing enzyme from Pseudomonas putida at 1.85 å resolution by Helin (1995)
10.1021/jp962977p / J. Phys. Chem / Monte Carlo study of the effect of pressure on hydrophobic association by Payne (1997)
10.1021/bi00015a001 / Biochemistry / Evidence for a molten globule-like transition state in protein folding from determination of activation volumes by Vidugiris (1995)
10.1096/fasebj.10.1.8566538 / FASEB J / Spectroscopic and volumetric investigation of cytochrome c unfolding at alkaline pH: characterization of the base-induced unfolded state by Chalikian (1996)
10.1002/bip.360250906 / Biopolymers / Estimation of the stability of globular proteins by Ahmad (1986)
10.1073/pnas.88.12.5154 / Proc. Natl Acad. Sci. USA / Isoenthalpic and isoentropic temperatures and the thermodynamics of protein denaturation by Lee (1991)
10.1016/S0022-2836(77)80200-3 / J. Mol. Biol / The Protein Data Bank: a computer-based archival file for macromolecular structures by Bernstein (1977)
{'key': '10.1016/S1359-0278(98)00016-9_bib66', 'series-title': 'Crystallographic Databases -\xa0 Information Content, Software Systems, Scientific Applications', 'first-page': '107', 'author': 'Abola', 'year': '1987'} / Crystallographic Databases - Information Content, Software Systems, Scientific Applications by Abola (1987)
10.1016/S0022-2836(05)80134-2 / J. Mol. Biol / SCOP: a structural classification of proteins database for the investigation of sequences and structures by Murzin (1995)
{'key': '10.1016/S1359-0278(98)00016-9_bib68', 'series-title': 'Handbook of Biochemistry', 'first-page': 'C3', 'article-title': 'Molecular weights of proteins and some other materials Including sedimentation, diffusion and frictional coefficients and Partial Specific Volumes', 'author': 'Smith', 'year': '1970'} / Handbook of Biochemistry / Molecular weights of proteins and some other materials Including sedimentation, diffusion and frictional coefficients and Partial Specific Volumes by Smith (1970)
{'key': '10.1016/S1359-0278(98)00016-9_bib69', 'series-title': 'Proteins', 'author': 'Creighton', 'year': '1983'} / Proteins by Creighton (1983)
{'key': '10.1016/S1359-0278(98)00016-9_bib70', 'series-title': 'Thermodynamic Data for Biochemistry and Biotechnology', 'author': 'Hinz', 'year': '1986'} / Thermodynamic Data for Biochemistry and Biotechnology by Hinz (1986)
10.1107/S0021889883010985 / J. Appl. Crystallogr / Analytical molecular surface calculation by Connolly (1983)
10.1021/ja00291a006 / J. Am. Chem. Soc / Computation of molecular volume by Connolly (1985)
{'key': '10.1016/S1359-0278(98)00016-9_bib73', 'article-title': 'Molecular surfaces: a review', 'volume': '2', 'author': 'Connolly', 'year': '1996', 'journal-title': 'NetSci'} / NetSci / Molecular surfaces: a review by Connolly (1996)
10.1002/jcc.540111009 / J. Comp. Chem / Conserving energy during molecular dynamics simulations of water, proteins and proteins in water by Kitchen (1990)
10.1021/bi00573a001 / Biochemistry / Picosecond dynamics of tyrosine sidechains in proteins by McCammon (1979)
10.1002/jcc.540070216 / J. Comp. Chem / An all atom force field for simulations of proteins and nucleic acids by Weiner (1986)
10.1016/0022-2836(75)90148-5 / J. Mol. Biol / Volume occupation, environment and accessibility in proteins. The problem of the protein surface by Finney (1975)
10.1016/0022-2836(82)90155-3 / J. Mol. Biol / Calculation of protein volumes: an alternative to the Voronoi procedure by Gellatly (1982)
10.1107/S0021889885010779 / J. Appl. Crystallogr / Molecular surface triangulation by Connolly (1985)
10.1002/jcc.540120314 / J. Comp. Chem / Algorithms for calculating excluded volume and its derivatives as a function of molecular conformation and their use in energy minimization by Kundrot (1991)
{'key': '10.1016/S1359-0278(98)00016-9_bib81', 'series-title': 'Water and Aqueous Solutions', 'author': 'Ben-Naim', 'year': '1974'} / Water and Aqueous Solutions by Ben-Naim (1974)
10.1063/1.1734478 / J. Chem. Phys / Ion-solvent interaction. II. Partial molar volume and electrostriction: a thermodynamic approach by Padova (1963)

Dates

Type	When
Created	20 years, 1 month ago (July 7, 2005, 11:24 a.m.)
Deposited	6 years, 5 months ago (March 5, 2019, 12:51 p.m.)
Indexed	6 days, 1 hour ago (Aug. 22, 2025, 12:46 a.m.)
Issued	27 years, 4 months ago (April 1, 1998)
Published	27 years, 4 months ago (April 1, 1998)
Published Print	27 years, 4 months ago (April 1, 1998)

Funders 0

None

BibTeX

@article{Murphy_1998, title={Protein hydration and unfolding – insights from experimental partial specific volumes and unfolded protein models}, volume={3}, ISSN={1359-0278}, url={http://dx.doi.org/10.1016/s1359-0278(98)00016-9}, DOI={10.1016/s1359-0278(98)00016-9}, number={2}, journal={Folding and Design}, publisher={Elsevier BV}, author={Murphy, Lynne Reed and Matubayasi, Nobuyuki and Payne, Vilia A and Levy, Ronald M}, year={1998}, month=apr, pages={105–118} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        22
      ]
    ],
    "date-time": "2025-08-22T04:46:46Z",
    "timestamp": 1755838006816
  },
  "reference-count": 82,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            4,
            1
          ]
        ],
        "date-time": "1998-04-01T00:00:00Z",
        "timestamp": 891388800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            19
          ]
        ],
        "date-time": "2013-07-19T00:00:00Z",
        "timestamp": 1374192000000
      },
      "content-version": "vor",
      "delay-in-days": 5588,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  },
  "DOI": "10.1016/s1359-0278(98)00016-9",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        7,
        7
      ]
    ],
    "date-time": "2005-07-07T15:24:27Z",
    "timestamp": 1120749867000
  },
  "page": "105-118",
  "source": "Crossref",
  "is-referenced-by-count": 96,
  "title": "Protein hydration and unfolding \u2013 insights from experimental partial specific volumes and unfolded protein models",
  "prefix": "10.1016",
  "volume": "3",
  "author": [
    {
      "given": "Lynne Reed",
      "family": "Murphy",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Nobuyuki",
      "family": "Matubayasi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Vilia A",
      "family": "Payne",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ronald M",
      "family": "Levy",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1038/319199a0",
      "article-title": "Solvation energy in protein folding and binding",
      "volume": "319",
      "author": "Eisenberg",
      "year": "1986",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "3086",
      "DOI": "10.1073/pnas.84.10.3086",
      "article-title": "Accessible surface area as a measure of the thermodynamic parameters of hydration of peptides",
      "volume": "84",
      "author": "Ooi",
      "year": "1987",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "114",
      "DOI": "10.1093/oxfordjournals.jbchem.a122215",
      "article-title": "Effects of hydrated water on protein unfolding",
      "volume": "103",
      "author": "Ooi",
      "year": "1988",
      "journal-title": "J. Biochem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib4",
      "first-page": "346",
      "article-title": "Thermodynamic properties of globular proteins and the principle of stabilization of their native structure",
      "volume": "1040",
      "author": "Khechinashvili",
      "year": "1990",
      "journal-title": "Biochem. Biophys. Acta"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1016/S0022-2836(05)80197-4",
      "article-title": "Heat capacity of proteins I. Partial molar heat capacity of individual amino acid residues in aqueous solution: hydration effect",
      "volume": "213",
      "author": "Makhatadze",
      "year": "1990",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "639",
      "DOI": "10.1006/jmbi.1993.1416",
      "article-title": "Contribution of hydration to protein folding thermodynamics I. The enthalpy of hydration",
      "volume": "232",
      "author": "Makhatadze",
      "year": "1993",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1016/0301-4622(94)00050-6",
      "article-title": "Hydration effects in protein unfolding",
      "volume": "51",
      "author": "Makhatadze",
      "year": "1994",
      "journal-title": "Biophys. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1016/S0022-2836(05)80198-6",
      "article-title": "Heat capacity of proteins II. Partial molar heat capacity of unfolded polypeptide chains of proteins: protein unfolding effects",
      "volume": "213",
      "author": "Privalov",
      "year": "1990",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "715",
      "DOI": "10.1016/0022-2836(92)90555-X",
      "article-title": "Contribution of hydration and non-covalent interactions to the heat capacity effect on protein unfolding",
      "volume": "224",
      "author": "Privalov",
      "year": "1992",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "660",
      "DOI": "10.1006/jmbi.1993.1417",
      "article-title": "Contribution of hydration to protein folding thermodynamics II. The entropy and Gibbs energy of hydration",
      "volume": "232",
      "author": "Privalov",
      "year": "1993",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "4237",
      "DOI": "10.1021/bi00231a019",
      "article-title": "Contributions to the thermodynamics of protein folding from the reduction in water-accessible nonpolar surface area",
      "volume": "30",
      "author": "Livingstone",
      "year": "1991",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1002/prot.340100305",
      "article-title": "Empirical solvation models can be used to differentiate native from near-native conformations of bovine pancreatic trypsin inhibitor",
      "volume": "10",
      "author": "Vila",
      "year": "1991",
      "journal-title": "Proteins"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "769",
      "DOI": "10.1016/0022-2836(92)90988-V",
      "article-title": "Thermodynamics of unfolding of the \u03b1-amylase inhibitor tendamistat. Correlation between accessible surface area and heat capacity",
      "volume": "223",
      "author": "Renner",
      "year": "1992",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "3947",
      "DOI": "10.1021/bi00131a009",
      "article-title": "Use of liquid hydrocarbon and amide transfer data to estimate contributions to thermodynamic functions of protein folding from the removal of nonpolar and polar surface from water",
      "volume": "31",
      "author": "Spolar",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "889",
      "DOI": "10.1016/0022-2836(92)90229-D",
      "article-title": "Analysis of the heat capacity dependence of protein folding",
      "volume": "227",
      "author": "Yang",
      "year": "1992",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1006/abbi.1993.1271",
      "article-title": "Structural thermodynamics: prediction of protein stability and protein binding affinities",
      "volume": "303",
      "author": "Freire",
      "year": "1993",
      "journal-title": "Arch. Biochem. Biophys"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "2028",
      "DOI": "10.1002/pro.5560021204",
      "article-title": "Thermodynamics of bovine pancreatic trypsin inhibitor folding",
      "volume": "2",
      "author": "Makhatadze",
      "year": "1993",
      "journal-title": "Protein Sci"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "264",
      "DOI": "10.1002/prot.340200307",
      "article-title": "Polar and nonpolar atomic environments in the protein core: implications for folding and binding",
      "volume": "20",
      "author": "Koehl",
      "year": "1994",
      "journal-title": "Proteins"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "1315",
      "DOI": "10.1002/pro.5560040707",
      "article-title": "Thermodynamics of the temperature-induced unfolding of globular proteins",
      "volume": "4",
      "author": "Khechinashvili",
      "year": "1995",
      "journal-title": "Protein Sci"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "2138",
      "DOI": "10.1002/pro.5560041020",
      "article-title": "Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding",
      "volume": "4",
      "author": "Myers",
      "year": "1995",
      "journal-title": "Protein Sci"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1002/(SICI)1097-0282(199611)39:5<619::AID-BIP1>3.0.CO;2-Z",
      "article-title": "On volume changes accompanying conformational transitions of biopolymers",
      "volume": "39",
      "author": "Chalikian",
      "year": "1996",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1002/(SICI)1097-0134(199610)26:2<123::AID-PROT2>3.0.CO;2-H",
      "article-title": "The enthalpy change in protein folding and binding: refinement of parameters for structure-based calculations",
      "volume": "26",
      "author": "Hilser",
      "year": "1996",
      "journal-title": "Proteins"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "701",
      "DOI": "10.1074/jbc.272.2.701",
      "article-title": "Additivity principles in biochemistry",
      "volume": "272",
      "author": "Dill",
      "year": "1997",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "35",
      "DOI": "10.1101/SQB.1972.036.01.008",
      "article-title": "Protein structure, ribonuclease-S and nucleotide interactions",
      "volume": "36",
      "author": "Richards",
      "year": "1971",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "379",
      "DOI": "10.1016/0022-2836(71)90324-X",
      "article-title": "The interpretation of protein structures: estimation of static accessibility",
      "volume": "55",
      "author": "Lee",
      "year": "1971",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1016/0022-2836(73)90011-9",
      "article-title": "Environment and exposure to solvent of protein atoms. Lysozyme and insulin",
      "volume": "79",
      "author": "Shrake",
      "year": "1973",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "304",
      "DOI": "10.1038/254304a0",
      "article-title": "Structural invariants in protein folding",
      "volume": "254",
      "author": "Chothia",
      "year": "1975",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0022-2836(76)90191-1",
      "article-title": "The nature of the accessible and buried surfaces in proteins",
      "volume": "105",
      "author": "Chothia",
      "year": "1976",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "10640",
      "DOI": "10.1021/j100092a040",
      "article-title": "Thermodynamics of the hydration shell. 1. Excess energy of a hydrophobic solute",
      "volume": "98",
      "author": "Matubayasi",
      "year": "1994",
      "journal-title": "J. Phys. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "2681",
      "DOI": "10.1021/jp951618b",
      "article-title": "Thermodynamics of the hydration shell. 2. Excess volume and compressibility of a hydrophobic solute",
      "volume": "100",
      "author": "Matubayasi",
      "year": "1996",
      "journal-title": "J. Phys. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1016/S0969-2126(00)00065-4",
      "article-title": "Volume changes on protein folding",
      "volume": "2",
      "author": "Harpaz",
      "year": "1994",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib32",
      "series-title": "Physical Chemistry",
      "first-page": "217",
      "article-title": "Transport Phenomena",
      "author": "Tinoco",
      "year": "1985"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1016/0022-2836(84)90231-6",
      "article-title": "Solvent accessible surface area and excluded volume in proteins. Analytical equations for overlapping spheres and implications for the hydrophobic effect",
      "volume": "178",
      "author": "Richmond",
      "year": "1984",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "389",
      "DOI": "10.1002/(SICI)1097-0134(199607)25:3<389::AID-PROT10>3.3.CO;2-S",
      "article-title": "Hydrophobic patches on the surfaces of protein structures",
      "volume": "25",
      "author": "Lijnzaad",
      "year": "1996",
      "journal-title": "Proteins"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "526",
      "DOI": "10.1080/00268977700101881",
      "article-title": "Liquid water. II. Experimental atom pair-correlation functions of liquid deuterium oxide",
      "volume": "34",
      "author": "Palinkas",
      "year": "1977",
      "journal-title": "Mol. Phys"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1033",
      "DOI": "10.1126/science.217.4564.1033",
      "article-title": "Atom pair distribution functions of liquid water at 25\u00b0C from neutron diffraction",
      "volume": "217",
      "author": "Narten",
      "year": "1982",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "5071",
      "DOI": "10.1021/j150643a008",
      "article-title": "Hydration and mobility of ions in solution",
      "volume": "87",
      "author": "Impey",
      "year": "1983",
      "journal-title": "J. Chem. Phys"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "10083",
      "DOI": "10.1021/bi00156a031",
      "article-title": "Molecular dynamics simulation of solvated protein at high pressure",
      "volume": "31",
      "author": "Kitchen",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib39",
      "first-page": "557",
      "article-title": "On the nature of the protein interior",
      "volume": "229",
      "author": "Klapper",
      "year": "1971",
      "journal-title": "Biochem. Biophys. Acta"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0022-2836(74)90570-1",
      "article-title": "The interpretation of protein structures: total volume, group volume distributions and packing density",
      "volume": "82",
      "author": "Richards",
      "year": "1974",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "1507",
      "DOI": "10.1002/bip.360220607",
      "article-title": "Improved technique for calculating X-ray scattering intensity of biopolymers in solution: evaluation of the form, volume, and surface of a particle",
      "volume": "22",
      "author": "Pavlov",
      "year": "1983",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "6563",
      "DOI": "10.1021/bi00369a034",
      "article-title": "Compressibility-structure relationship of globular proteins",
      "volume": "25",
      "author": "Gekko",
      "year": "1986",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "569",
      "DOI": "10.1007/BF00649565",
      "article-title": "Partial molar volumes of molecules of arbitrary shape and the effect of hydrogen bonding with water",
      "volume": "21",
      "author": "Kharakoz",
      "year": "1992",
      "journal-title": "J. Sol. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "588",
      "DOI": "10.1006/jmbi.1996.0423",
      "article-title": "The hydration of globular proteins as derived from volume and compressibility measurements: cross correlating thermodynamic and structural data",
      "volume": "260",
      "author": "Chalikian",
      "year": "1996",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1002/(SICI)1097-0134(199601)24:1<81::AID-PROT6>3.0.CO;2-R",
      "article-title": "High pressure effects on protein structure and function",
      "volume": "24",
      "author": "Mozhaev",
      "year": "1996",
      "journal-title": "Proteins"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib46",
      "series-title": "High-Pressure Effects in Molecular Biophysics and Enzymology",
      "first-page": "33",
      "article-title": "Use of partial molar volumes of model compounds in the interpretation of high-pressure effects on proteins",
      "author": "Prehoda",
      "year": "1996"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "415",
      "DOI": "10.1016/0022-2836(78)90223-1",
      "article-title": "Volume occupation, environment and accessibility in proteins. Environment and molecular area of RNase-S",
      "volume": "119",
      "author": "Finney",
      "year": "1978",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "955",
      "DOI": "10.1006/jmbi.1995.0351",
      "article-title": "The volume of atoms on the protein surface: calculated from simulation, using Voronoi polyhedra",
      "volume": "249",
      "author": "Gerstein",
      "year": "1995",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "785",
      "DOI": "10.1002/(SICI)1097-0282(199706)41:7<785::AID-BIP7>3.0.CO;2-L",
      "article-title": "On the volume of macromolecules",
      "volume": "41",
      "author": "Paci",
      "year": "1997",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1016/0022-2836(87)90038-6",
      "article-title": "Interior and surface of monomeric proteins",
      "volume": "196",
      "author": "Miller",
      "year": "1987",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "1001",
      "DOI": "10.1002/bip.360301102",
      "article-title": "Partial molar volumes of polypeptides and their constituent groups in aqueous solution over a broad temperature range",
      "volume": "30",
      "author": "Makhatadze",
      "year": "1990",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1146/annurev.bb.06.060177.001055",
      "article-title": "Areas, volumes, packing, and protein structure",
      "volume": "6",
      "author": "Richards",
      "year": "1977",
      "journal-title": "Annu. Rev. Biophys. Bioeng"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "1038",
      "DOI": "10.1021/bi00806a045",
      "article-title": "Thermodynamics of protein denaturation. Effect of pressure on the denaturation of ribonuclease A",
      "volume": "9",
      "author": "Brandts",
      "year": "1970",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "2436",
      "DOI": "10.1021/bi00789a002",
      "article-title": "Reversible pressure-temperature denaturation of chymotrypsinogen",
      "volume": "10",
      "author": "Hawley",
      "year": "1971",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "4217",
      "DOI": "10.1021/bi00745a028",
      "article-title": "Pressure denaturation of metmyoglobin",
      "volume": "12",
      "author": "Zip",
      "year": "1973",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "275",
      "DOI": "10.1016/0301-4622(94)00098-5",
      "article-title": "An alternative interpretation of the heat capacity changes associated with protein unfolding",
      "volume": "52",
      "author": "Hinz",
      "year": "1994",
      "journal-title": "Biophys. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0065-3233(08)60608-7",
      "article-title": "Some factors in the interpretation of protein denaturation",
      "volume": "14",
      "author": "Kauzmann",
      "year": "1959",
      "journal-title": "Adv. Protein Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "834",
      "DOI": "10.1126/science.4023714",
      "article-title": "Hydrophobicity of amino acid residues in globular proteins",
      "volume": "229",
      "author": "Rose",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "918",
      "DOI": "10.1006/jmbi.1995.0666",
      "article-title": "The refined X-ray structure of muconate lactonizing enzyme from Pseudomonas putida at 1.85 \u00e5 resolution",
      "volume": "254",
      "author": "Helin",
      "year": "1995",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "2054",
      "DOI": "10.1021/jp962977p",
      "article-title": "Monte Carlo study of the effect of pressure on hydrophobic association",
      "volume": "101",
      "author": "Payne",
      "year": "1997",
      "journal-title": "J. Phys. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "4909",
      "DOI": "10.1021/bi00015a001",
      "article-title": "Evidence for a molten globule-like transition state in protein folding from determination of activation volumes",
      "volume": "34",
      "author": "Vidugiris",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "164",
      "DOI": "10.1096/fasebj.10.1.8566538",
      "article-title": "Spectroscopic and volumetric investigation of cytochrome c unfolding at alkaline pH: characterization of the base-induced unfolded state",
      "volume": "10",
      "author": "Chalikian",
      "year": "1996",
      "journal-title": "FASEB J"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "1623",
      "DOI": "10.1002/bip.360250906",
      "article-title": "Estimation of the stability of globular proteins",
      "volume": "25",
      "author": "Ahmad",
      "year": "1986",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "5154",
      "DOI": "10.1073/pnas.88.12.5154",
      "article-title": "Isoenthalpic and isoentropic temperatures and the thermodynamics of protein denaturation",
      "volume": "88",
      "author": "Lee",
      "year": "1991",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "535",
      "DOI": "10.1016/S0022-2836(77)80200-3",
      "article-title": "The Protein Data Bank: a computer-based archival file for macromolecular structures",
      "volume": "112",
      "author": "Bernstein",
      "year": "1977",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib66",
      "series-title": "Crystallographic Databases -\u00a0 Information Content, Software Systems, Scientific Applications",
      "first-page": "107",
      "author": "Abola",
      "year": "1987"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "536",
      "DOI": "10.1016/S0022-2836(05)80134-2",
      "article-title": "SCOP: a structural classification of proteins database for the investigation of sequences and structures",
      "volume": "247",
      "author": "Murzin",
      "year": "1995",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib68",
      "series-title": "Handbook of Biochemistry",
      "first-page": "C3",
      "article-title": "Molecular weights of proteins and some other materials Including sedimentation, diffusion and frictional coefficients and Partial Specific Volumes",
      "author": "Smith",
      "year": "1970"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib69",
      "series-title": "Proteins",
      "author": "Creighton",
      "year": "1983"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib70",
      "series-title": "Thermodynamic Data for Biochemistry and Biotechnology",
      "author": "Hinz",
      "year": "1986"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "548",
      "DOI": "10.1107/S0021889883010985",
      "article-title": "Analytical molecular surface calculation",
      "volume": "16",
      "author": "Connolly",
      "year": "1983",
      "journal-title": "J. Appl. Crystallogr"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "1118",
      "DOI": "10.1021/ja00291a006",
      "article-title": "Computation of molecular volume",
      "volume": "107",
      "author": "Connolly",
      "year": "1985",
      "journal-title": "J. Am. Chem. Soc"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib73",
      "article-title": "Molecular surfaces: a review",
      "volume": "2",
      "author": "Connolly",
      "year": "1996",
      "journal-title": "NetSci"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "1169",
      "DOI": "10.1002/jcc.540111009",
      "article-title": "Conserving energy during molecular dynamics simulations of water, proteins and proteins in water",
      "volume": "11",
      "author": "Kitchen",
      "year": "1990",
      "journal-title": "J. Comp. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "927",
      "DOI": "10.1021/bi00573a001",
      "article-title": "Picosecond dynamics of tyrosine sidechains in proteins",
      "volume": "18",
      "author": "McCammon",
      "year": "1979",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "230",
      "DOI": "10.1002/jcc.540070216",
      "article-title": "An all atom force field for simulations of proteins and nucleic acids",
      "volume": "7",
      "author": "Weiner",
      "year": "1986",
      "journal-title": "J. Comp. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "721",
      "DOI": "10.1016/0022-2836(75)90148-5",
      "article-title": "Volume occupation, environment and accessibility in proteins. The problem of the protein surface",
      "volume": "96",
      "author": "Finney",
      "year": "1975",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1016/0022-2836(82)90155-3",
      "article-title": "Calculation of protein volumes: an alternative to the Voronoi procedure",
      "volume": "161",
      "author": "Gellatly",
      "year": "1982",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "499",
      "DOI": "10.1107/S0021889885010779",
      "article-title": "Molecular surface triangulation",
      "volume": "18",
      "author": "Connolly",
      "year": "1985",
      "journal-title": "J. Appl. Crystallogr"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "402",
      "DOI": "10.1002/jcc.540120314",
      "article-title": "Algorithms for calculating excluded volume and its derivatives as a function of molecular conformation and their use in energy minimization",
      "volume": "12",
      "author": "Kundrot",
      "year": "1991",
      "journal-title": "J. Comp. Chem"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib81",
      "series-title": "Water and Aqueous Solutions",
      "author": "Ben-Naim",
      "year": "1974"
    },
    {
      "key": "10.1016/S1359-0278(98)00016-9_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "1552",
      "DOI": "10.1063/1.1734478",
      "article-title": "Ion-solvent interaction. II. Partial molar volume and electrostriction: a thermodynamic approach",
      "volume": "39",
      "author": "Padova",
      "year": "1963",
      "journal-title": "J. Chem. Phys"
    }
  ],
  "container-title": "Folding and Design",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1359027898000169?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1359027898000169?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        3,
        5
      ]
    ],
    "date-time": "2019-03-05T17:51:29Z",
    "timestamp": 1551808289000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1359027898000169"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  },
  "references-count": 82,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1998,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "S1359027898000169"
  ],
  "URL": "http://dx.doi.org/10.1016/S1359-0278(98)00016-9",
  "relation": {},
  "ISSN": [
    "1359-0278"
  ],
  "subject": [],
  "container-title-short": "Folding and Design",
  "published": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  }
}