DOI: 10.1016/s1097-2765(04)00161-3. Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

10.1016/s1097-2765(04)00161-3

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

Lee, T., Hoofnagle, A. N., Kabuyama, Y., Stroud, J., Min, X., Goldsmith, E. J., Chen, L., Resing, K. A., & Ahn, N. G. (2004). Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry. Molecular Cell, 14(1), 43â55.

Authors 9

Thomas Lee (first)
Andrew N Hoofnagle (additional)
Yukihito Kabuyama (additional)
James Stroud (additional)
Xiaoshan Min (additional)
Elizabeth J Goldsmith (additional)
Lin Chen (additional)
Katheryn A Resing (additional)
Natalie G Ahn (additional)

References 34 Referenced 252

10.1093/emboj/18.19.5347 / EMBO J. / Two co-existing mechanisms for nuclear import of MAP kinase by Adachi (1999)
10.1016/S0968-0004(96)30032-7 / Trends Biochem. Sci. / A conserved motif at the amino termini of MEK5 might mediate high affinity interaction with the cognate MAPKs by Bardwell (1996)
10.1074/jbc.M108145200 / J. Biol. Chem. / Specificity determinants in MAPK signaling to transcription factors by Barsyte-Lovejoy (2002)
10.1016/S0969-2126(99)80173-7 / Structure Fold. Des. / The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation by Bellon (1999)
10.1107/S0907444998003254 / Acta Crystallogr. D Biol. Crystallogr. / Crystallography & NMR system by Brunger (1998)
10.1016/S0092-8674(00)80351-7 / Cell / Activation mechanism of the MAP kinase ERK2 by dual phosphorylation by Canagarajah (1997)
10.1242/jcs.108.11.3599 / J. Cell Sci. / Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction by Cano (1995)
10.1016/S1097-2765(02)00525-7 / Mol. Cell / Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b by Chang (2002)
10.1093/emboj/19.6.1301 / EMBO J. / Molecular determinants that mediate selective activation of p38 MAP kinase isoforms by Enslen (2000)
10.1074/jbc.M102512200 / J. Biol. Chem. / Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues by Fantz (2001)
10.1093/emboj/16.8.1901 / EMBO J. / Interaction of MAP kinase with MAP kinase kinase by Fukuda (1997)
10.1074/jbc.M007697200 / J. Biol. Chem. / Selective targeting of MAPKs to the ETS domain transcription factor SAP-1 by Galanis (2001)
10.1016/S0021-9258(18)54548-8 / J. Biol. Chem. / Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases by Gonzalez (1991)
10.1074/jbc.M304229200 / J. Biol. Chem. / A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates by Ho (2003)
10.1073/pnas.98.3.956 / Proc. Natl. Acad. Sci. USA / Changes in protein conformational mobility upon activation of ERK2, as detected by hydrogen exchange by Hoofnagle (2001)
10.1146/annurev.biophys.32.110601.142417 / Annu. Rev. Biophys. Biomol. Struct. / Protein analysis by hydrogen exchange mass spectrometry by Hoofnagle (2003)
{'key': '10.1016/S1097-2765(04)00161-3_BIB17', 'first-page': '283', 'article-title': 'Practical methods for deuterium exchange/mass spectrometry', 'volume': '250', 'author': 'Hoofnagle', 'year': '2003', 'journal-title': 'Methods Mol. Biol'} / Methods Mol. Biol / Practical methods for deuterium exchange/mass spectrometry by Hoofnagle (2003)
10.1101/gad.13.2.163 / Genes Dev. / Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase by Jacobs (1999)
10.1107/S0108767390010224 / Acta Crystallogr. A / Improved methods for building protein models in electron density maps and the location of errors in these models by Jones (1991)
10.1101/gad.8.24.2996 / Genes Dev. / JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation by Kallunki (1994)
10.1016/S0092-8674(00)81189-7 / Cell / Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation by Khokhlatchev (1998)
10.1074/jbc.275.22.16609 / J. Biol. Chem. / ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions by MacKenzie (2000)
10.1074/jbc.M106012200 / J. Biol. Chem. / Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells by Matsubayashi (2001)
10.1038/ncb822 / Nat. Cell Biol. / Molecular interpretation of ERK signal duration by immediate early gene products by Murphy (2002)
10.1016/S1044-0305(99)00037-9 / J. Am. Soc. Mass Spectrom. / Probing protein kinase structure by deuterium exchange mass spectrometry by Resing (1999)
10.1083/jcb.142.6.1533 / J. Cell Biol. / Activation of the MKK/ERK pathway during somatic cell mitosis. Direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen by Shapiro (1998)
10.1016/S0968-0004(00)01627-3 / Trends Biochem. Sci. / Docking domains and substrate-specificity determination for MAP kinases by Sharrocks (2000)
10.1038/35000065 / Nat. Cell Biol. / A conserved docking motif in MAP kinases common to substrates, activators and regulators by Tanoue (2000)
10.1242/jcs.114.19.3433 / J. Cell Sci. / The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases by Volmat (2001)
10.1073/pnas.112495999 / Proc. Natl. Acad. Sci. USA / ERK2 enters the nucleus by a carrier-independent mechanism by Whitehurst (2002)
10.1093/emboj/17.6.1740 / EMBO J. / Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1 by Yang (1998)
10.1128/MCB.18.2.710 / Mol. Cell. Biol. / The Elk1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif by Yang (1998)
10.1128/MCB.19.10.7245 / Mol. Cell. Biol. / The JIP group of MAP kinase scaffold proteins by Yasuda (1999)
10.1038/367704a0 / Nature / Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution by Zhang (1994)

Dates

Type	When
Created	21 years, 4 months ago (April 8, 2004, 5:08 a.m.)
Deposited	4 years, 2 months ago (June 15, 2021, 8:50 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 19, 2025, 7:10 a.m.)
Issued	21 years, 5 months ago (April 1, 2004)
Published	21 years, 5 months ago (April 1, 2004)
Published Print	21 years, 5 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Lee_2004, title={Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry}, volume={14}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/s1097-2765(04)00161-3}, DOI={10.1016/s1097-2765(04)00161-3}, number={1}, journal={Molecular Cell}, publisher={Elsevier BV}, author={Lee, Thomas and Hoofnagle, Andrew N and Kabuyama, Yukihito and Stroud, James and Min, Xiaoshan and Goldsmith, Elizabeth J and Chen, Lin and Resing, Katheryn A and Ahn, Natalie G}, year={2004}, month=apr, pages={43–55} }

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      "volume": "142",
      "author": "Shapiro",
      "year": "1998",
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      "volume": "2",
      "author": "Tanoue",
      "year": "2000",
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